lidocaine has been researched along with Hypokalemia in 24 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Hypokalemia: Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A double-blind study was set up to investigate the effect of pretreatment with lignocaine on the incidence of potassium chloride infusion pain." | 9.07 | Efficacy of lignocaine in alleviating potassium chloride infusion pain. ( Khoo, ST; Kloo, ST; Lim, ET; Tweed, WA, 1992) |
| "A double-blind study was set up to investigate the effect of pretreatment with lignocaine on the incidence of potassium chloride infusion pain." | 5.07 | Efficacy of lignocaine in alleviating potassium chloride infusion pain. ( Khoo, ST; Kloo, ST; Lim, ET; Tweed, WA, 1992) |
| " Nevertheless, it is uncertain as to whether the rate-dependent changes of ventricular repolarization can be adversely modified by arrhythmogenic drugs (quinidine and procainamide) and hypokalemia, in comparison to the agents with safe therapeutic profile, such as lidocaine." | 3.88 | Effects of antiarrhythmics and hypokalemia on the rate adaptation of cardiac repolarization. ( Osadchii, OE, 2018) |
| "The clinical effects of hypokalemia including action potential prolongation and arrhythmogenicity suppressible by lidocaine were reproduced in hypokalemic (3." | 3.74 | The contribution of refractoriness to arrhythmic substrate in hypokalemic Langendorff-perfused murine hearts. ( Fraser, JA; Grace, AA; Huang, CL; Killeen, MJ; Sabir, IN, 2007) |
| "Alternans and arrhythmia occurred in hypokalaemic, but not normokalaemic (5." | 1.35 | Restitution analysis of alternans and its relationship to arrhythmogenicity in hypokalaemic Langendorff-perfused murine hearts. ( Grace, AA; Huang, CL; Li, LM; Sabir, IN, 2008) |
| "The phenotype overlaps with that of attention deficit disorder, raising the possibility of subtypes of attention deficit disorder that have a peripheral sensory cause and novel forms of therapy." | 1.34 | Hypokalemic sensory overstimulation. ( Chapman, CA; Needleman, HL; Rogers, GF; Segal, MM, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (41.67) | 18.7374 |
| 1990's | 5 (20.83) | 18.2507 |
| 2000's | 7 (29.17) | 29.6817 |
| 2010's | 2 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Osadchii, OE | 1 |
| Petit, PF | 1 |
| Hantson, P | 1 |
| Jadoul, M | 1 |
| Gillion, V | 1 |
| Sánchez Ortega, JL | 1 |
| González Pérez, P | 1 |
| Escribano Jiménez, M | 1 |
| Sabir, IN | 4 |
| Fraser, JA | 2 |
| Killeen, MJ | 2 |
| Grace, AA | 4 |
| Huang, CL | 4 |
| Goddard, CA | 1 |
| Thomas, G | 1 |
| Gray, S | 1 |
| Cass, TR | 1 |
| Li, LM | 1 |
| Takeuchi, S | 1 |
| Homma, M | 1 |
| Inoue, J | 1 |
| Kato, H | 1 |
| Murata, K | 1 |
| Ogasawara, T | 1 |
| Segal, MM | 1 |
| Rogers, GF | 1 |
| Needleman, HL | 1 |
| Chapman, CA | 1 |
| Kubota, Y | 2 |
| Toyoda, Y | 2 |
| Kubota, H | 2 |
| Asada, A | 2 |
| Meechan, JG | 1 |
| Welbury, RR | 1 |
| van Heerden, PV | 1 |
| Chew, G | 1 |
| Takagi, A | 1 |
| Wolf, PS | 1 |
| Barrillon, A | 1 |
| Grand, A | 1 |
| Lim, ET | 1 |
| Khoo, ST | 1 |
| Tweed, WA | 1 |
| Kloo, ST | 1 |
| Murakawa, M | 1 |
| Ishida, H | 1 |
| Fujimori, M | 1 |
| Bready, LL | 1 |
| Hoff, BH | 1 |
| Boyd, RC | 1 |
| Schollmeyer, P | 1 |
| Mathey, D | 1 |
| Bleifeld, W | 1 |
| Effert, S | 1 |
| Heinrich, KW | 1 |
| Merx, W | 1 |
| Grossman, JI | 1 |
| Rubin, IL | 1 |
| Nevins, MA | 1 |
| Patton, RD | 1 |
| Verstraete, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Single-dose Potassium Supplementation in ADHD Patients With Lidocaine Ineffectiveness[NCT03563573] | Phase 1/Phase 2 | 100 participants (Anticipated) | Interventional | 2018-07-01 | Enrolling by invitation | ||
| Prevalence of Lidocaine Ineffectiveness in Those With Hard-to-treat ADHD[NCT04167189] | Early Phase 1 | 28 participants (Actual) | Interventional | 2018-01-20 | Completed | ||
| Reliability Testing of a Non-invasive, Pain-free, Taste-based Assessment Approach to Lidocaine Effectiveness[NCT03680885] | Early Phase 1 | 20 participants (Actual) | Interventional | 2019-08-01 | Completed | ||
| Assessing the Frequency of Lidocaine Ineffectiveness in the General Population vs. Males With ADHD, and Females With ADHD, With or Without PMS[NCT03676725] | Early Phase 1 | 90 participants (Actual) | Interventional | 2019-08-14 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for lidocaine and Hypokalemia
| Article | Year |
|---|---|
[Brugada syndrome, bupivacaine, lidocaine, and techniques to provide local or regional anesthesia: comments on "Ventricular fibrillation in a patient with a type I Brugada syndrome ECG pattern and hypokalemia"].
Topics: Anesthesia, Conduction; Anesthetics, Local; Brugada Syndrome; Bupivacaine; Female; Humans; Hypokalem | 2008 |
[Toxic and adverse effects of local anesthetics/neuromuscular blocker: lidocaine, succinylcholine].
Topics: Anesthetics, Local; Drug Interactions; Humans; Hypokalemia; Hypotension; Lidocaine; Muscle Rigidity; | 1999 |
[Incompatibility and interference of the major cardiologic drugs. Their undesirable effects].
Topics: Anti-Arrhythmia Agents; Anti-Inflammatory Agents; Antihypertensive Agents; Bradycardia; Cardiac Glyc | 1976 |
[Cardiac arrhythmias. I. Pathogenesis and clinical significance].
Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillat | 1971 |
Reevaluating the use of lidocaine.
Topics: Adult; Animals; Arrhythmias, Cardiac; Cats; Central Nervous System; Depression, Chemical; Dogs; Elec | 1973 |
Management of arrhythmias in acute myocardial infarction.
Topics: Acid-Base Equilibrium; Adams-Stokes Syndrome; Arrhythmias, Cardiac; Atropine; Bradycardia; Cardiac O | 1971 |
3 trials available for lidocaine and Hypokalemia
| Article | Year |
|---|---|
Metabolic responses to oral surgery under local anesthesia and sedation with intravenous midazolam: the effects of two different local anesthetics.
Topics: Adult; Analysis of Variance; Anesthesia, Dental; Anesthesia, Intravenous; Anesthetics, Local; Blood | 1992 |
Efficacy of lignocaine in alleviating potassium chloride infusion pain.
Topics: Adult; Aged; Analgesia; Double-Blind Method; Humans; Hypokalemia; Incidence; Infusions, Intravenous; | 1992 |
The difficulty of appraisal of streptokinase treatment of myocardial infarction.
Topics: Anti-Arrhythmia Agents; Clinical Trials as Topic; Coronary Care Units; Glucocorticoids; Glucose; Hep | 1971 |
15 other studies available for lidocaine and Hypokalemia
| Article | Year |
|---|---|
Effects of antiarrhythmics and hypokalemia on the rate adaptation of cardiac repolarization.
Topics: Action Potentials; Adaptation, Physiological; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; | 2018 |
The Case | Severe hypokalemia complicated by a syncope.
Topics: Administration, Topical; Aged, 80 and over; Benzalkonium Compounds; Drug Combinations; Electrocardio | 2018 |
The contribution of refractoriness to arrhythmic substrate in hypokalemic Langendorff-perfused murine hearts.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bradycardia; Computer Simu | 2007 |
Transient alterations in transmural repolarization gradients and arrhythmogenicity in hypokalaemic Langendorff-perfused murine hearts.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Electrophysiology; Endocardium; Heart; Hypokalem | 2007 |
A quantitative analysis of the effect of cycle length on arrhythmogenicity in hypokalaemic Langendorff-perfused murine hearts.
Topics: Action Potentials; Algorithms; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Pacing | 2007 |
Restitution analysis of alternans and its relationship to arrhythmogenicity in hypokalaemic Langendorff-perfused murine hearts.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Pacing, Artificial | 2008 |
[Case of intractable ventricula fibrillation by a multicomponent dietary supplement containing ephedra and caffeine overdose].
Topics: Adult; Caffeine; Dietary Supplements; Drug Overdose; Drug Synergism; Electric Countershock; Ephedra; | 2007 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Hypokalemic sensory overstimulation.
Topics: Acoustic Stimulation; Adolescent; Anesthetics, Local; Attention Deficit Disorder with Hyperactivity; | 2007 |
Epinephrine in local anesthetics does indeed produce hypokalemia and ECG changes.
Topics: Electrocardiography; Epinephrine; Humans; Hypokalemia; Lidocaine | 1993 |
Severe hypokalaemia due to lignocaine toxicity.
Topics: Adult; Humans; Hypokalemia; Intracranial Pressure; Lidocaine; Male | 1996 |
Arrhythmias in chronic pulmonary disease.
Topics: Arrhythmias, Cardiac; Chronic Disease; Digoxin; Humans; Hypokalemia; Hypoxia; Lidocaine; Lung Diseas | 1979 |
Prevention of hypokalemia during axillary nerve block with 1% lidocaine and epinephrine 1:100,000.
Topics: Adult; Axilla; Epinephrine; Female; Humans; Hypokalemia; Lidocaine; Male; Nerve Block; Propranolol | 1988 |
Acute digitalis toxicity during TURP.
Topics: Arrhythmias, Cardiac; Digitalis Glycosides; Humans; Hypokalemia; Infusions, Parenteral; Lidocaine; M | 1985 |
[Recurrent ventricular fibrillation due to renal potassium loss (author's transl)].
Topics: Cardiac Complexes, Premature; Cell Membrane Permeability; Coronary Angiography; Electrocardiography; | 1973 |
Cardiopulmonary resuscitation. II.
Topics: Acidosis; Aftercare; Bradycardia; Heart Arrest; Humans; Hyperkalemia; Hypokalemia; Isoproterenol; Li | 1969 |