Page last updated: 2024-10-28

lidocaine and Hypertrophy

lidocaine has been researched along with Hypertrophy in 5 studies

Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.

Hypertrophy: General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA).

Research Excerpts

Excerpt	Relevance	Reference
"Tetracaine 2% solution applied locally is an easy, safe, inexpensive, and effective analgesia for submucosal diathermy for inferior turbinate hypertrophy."	9.14	Lidocaine spray versus tetracaine solution for monopolar submucosal diathermy for inferior turbinate hypertrophy. ( Bizaki, A; Bizakis, J; Bourolias, C; Drivas, E; Hajiioannou, J; Kyrmizakis, DE, 2010)
"Action and percussion myotonia was associated with weakness in these muscles, and EMG showed diffuse myotonic discharges and myopathic features."	1.31	Equine muscular dystrophy with myotonia. ( Cipone, M; Di Stasi, V; Gandini, G; Liguori, R; Monari, L; Montagna, P; Riva, R; Strong, PN, 2001)

Research

Studies (5)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (20.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (20.00)	29.6817
2010's	3 (60.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Martellucci, S	1
Pagliuca, G	1
de Vincentiis, M	1
Greco, A	1
Fusconi, M	1
De Virgilio, A	1
Rosato, C	1
Gallo, A	1
Hajiioannou, J	1
Bizaki, A	1
Bourolias, C	1
Kyrmizakis, DE	1
Drivas, E	1
Bizakis, J	1
Moss, JR	1
Cofer, S	1
Hersey, S	1
Goudy, S	1
Werkhaven, J	1
Swanson, E	1
Mantle, C	1
Stowell, N	1
Byrne, D	1
Wang, L	1
Labadie, R	1
Montagna, P	1
Liguori, R	1
Monari, L	1
Strong, PN	1
Riva, R	1
Di Stasi, V	1
Gandini, G	1
Cipone, M	1
Noble, MI	1
Eisele, JR	1
Frankel, HL	1
Else, W	1
Guz, A	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Pediatric Tonsillectomy Pain Reduction Study, a Randomized, Placebo Controlled, Double-Blind Clinical Trial Using Clonidine and Local Anesthetics[NCT00678379]			Phase 3	120 participants (Actual)	Interventional	2008-04-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Median Number of Pain Medication Doses

The median number of intravenous fentanyl doses administered in the PACU due to pain (NCT00678379)
Timeframe: in recovery room

Intervention	number of doses (Median)
Normal Saline	3.0
Lidocaine (1%) + Bupivacaine 0.5%	3
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	3

Total Number of Post-operative Doses of Analgesics.

The total number of intravenous fentanyl doses given PACU which will be compared between the three randomized groups (arms) (NCT00678379)
Timeframe: Post-operative thru day 7

Intervention	number of doses (Median)
Normal Saline	12
Lidocaine (1%) + Bupivacaine 0.5%	12
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	14

Total Time Until Discharge From Hospital.

(NCT00678379)
Timeframe: Day of Surgery

Intervention	minutes (Median)
Normal Saline	122
Lidocaine (1%) + Bupivacaine 0.5%	111
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	120

Mean Visual Analog Scale Pain Number.

Visual analog pain scale range is 0-10 with 0=no pain and 10 = worst pain ever (NCT00678379)
Timeframe: in recovery room; post-operative days 1,3,5 & 7

Intervention	pain score (Mean)
	In recovery room	day 1	day 3	day 5	day 7
Lidocaine (1%) + Bupivacaine 0.5%	3	4	2.5	2	2
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	3	5	3	3	2
Normal Saline	3	3	3	3	2.5

Number and Percent of Participants Able to Tolerate a Regular Diet

The number and percent of patients whose post-operative diet has to a regular diet on post-operative days 1, 3, 5 & 7 (NCT00678379)
Timeframe: post-operative days 1,3,5 & 7.

Intervention	Participants (Count of Participants)
	post-op day 1	post-op day 3	post op day 5	post op day 7
Lidocaine (1%) + Bupivacaine 0.5%	4	8	18	26
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	1	12	14	22
Normal Saline	7	18	21	24

Number and Percent of Participants Able to Tolerate Only a Soft Diet

The number and percent of patients whose post-operative diet has only advanced to a soft diet on post-operative days 1, 3, 5 & 7 (NCT00678379)
Timeframe: post-operative days 1,3,5 & 7.

Intervention	Participants (Count of Participants)
	post-op day 1	post-op day 3	post op day 5	post op day 7
Lidocaine (1%) + Bupivacaine 0.5%	22	26	17	10
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	26	18	18	14
Normal Saline	26	18	13	13

Number and Percent of Participants Able to Tolerate Only Liquids

The number and percent of patients whose post-operative diet has advanced to liquids only on post-op days 1, 3, 5 & 7 (NCT00678379)
Timeframe: post-operative days 1,3,5 & 7.

Intervention	Participants (Count of Participants)
	post-op day 1	post-op day 3	post op day 5	post op day 7
Lidocaine (1%) + Bupivacaine 0.5%	33	13	10	11
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	30	23	19	10
Normal Saline	16	8	13	6

Trials

3 trials available for lidocaine and Hypertrophy

Article	Year
EMLA(®) cream as local anesthetic for radiofrequency turbinate tissue reduction. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2014, Volume: 271, Issue:10 Topics: Adolescent; Adult; Aged; Anesthesia, Local; Anesthetics, Local; Bone Diseases; Catheter Ablation; Fe	2014
Lidocaine spray versus tetracaine solution for monopolar submucosal diathermy for inferior turbinate hypertrophy. B-ENT, 2010, Volume: 6, Issue:4 Topics: Adolescent; Adult; Anesthetics, Local; Electrocoagulation; Female; Humans; Hypertrophy; Lidocaine; M	2010
Comparison of clonidine, local anesthetics, and placebo for pain reduction in pediatric tonsillectomy. Archives of otolaryngology--head & neck surgery, 2011, Volume: 137, Issue:6 Topics: Adenoids; Adolescent; Age Factors; Analgesics; Anesthetics, Local; Bupivacaine; Child; Child, Presch	2011

Other Studies

2 other studies available for lidocaine and Hypertrophy

Article	Year
Equine muscular dystrophy with myotonia. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2001, Volume: 112, Issue:2 Topics: Anesthetics, Local; Animals; Apamin; Atrophy; Electromyography; Hindlimb; Horse Diseases; Horses; Hy	2001
The role of the diaphragm in the sensation of holding the breath. Clinical science, 1971, Volume: 41, Issue:3 Topics: Adult; Apnea; Diaphragm; Electromyography; Female; Humans; Hypertrophy; Lidocaine; Male; Muscles; Ne	1971