Page last updated: 2024-10-28

lidocaine and Hypertrophy

lidocaine has been researched along with Hypertrophy in 5 studies

Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.

Hypertrophy: General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA).

Research Excerpts

ExcerptRelevanceReference
"Tetracaine 2% solution applied locally is an easy, safe, inexpensive, and effective analgesia for submucosal diathermy for inferior turbinate hypertrophy."9.14Lidocaine spray versus tetracaine solution for monopolar submucosal diathermy for inferior turbinate hypertrophy. ( Bizaki, A; Bizakis, J; Bourolias, C; Drivas, E; Hajiioannou, J; Kyrmizakis, DE, 2010)
"Action and percussion myotonia was associated with weakness in these muscles, and EMG showed diffuse myotonic discharges and myopathic features."1.31Equine muscular dystrophy with myotonia. ( Cipone, M; Di Stasi, V; Gandini, G; Liguori, R; Monari, L; Montagna, P; Riva, R; Strong, PN, 2001)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19901 (20.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Martellucci, S1
Pagliuca, G1
de Vincentiis, M1
Greco, A1
Fusconi, M1
De Virgilio, A1
Rosato, C1
Gallo, A1
Hajiioannou, J1
Bizaki, A1
Bourolias, C1
Kyrmizakis, DE1
Drivas, E1
Bizakis, J1
Moss, JR1
Cofer, S1
Hersey, S1
Goudy, S1
Werkhaven, J1
Swanson, E1
Mantle, C1
Stowell, N1
Byrne, D1
Wang, L1
Labadie, R1
Montagna, P1
Liguori, R1
Monari, L1
Strong, PN1
Riva, R1
Di Stasi, V1
Gandini, G1
Cipone, M1
Noble, MI1
Eisele, JR1
Frankel, HL1
Else, W1
Guz, A1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pediatric Tonsillectomy Pain Reduction Study, a Randomized, Placebo Controlled, Double-Blind Clinical Trial Using Clonidine and Local Anesthetics[NCT00678379]Phase 3120 participants (Actual)Interventional2008-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Median Number of Pain Medication Doses

The median number of intravenous fentanyl doses administered in the PACU due to pain (NCT00678379)
Timeframe: in recovery room

Interventionnumber of doses (Median)
Normal Saline3.0
Lidocaine (1%) + Bupivacaine 0.5%3
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg3

Total Number of Post-operative Doses of Analgesics.

The total number of intravenous fentanyl doses given PACU which will be compared between the three randomized groups (arms) (NCT00678379)
Timeframe: Post-operative thru day 7

Interventionnumber of doses (Median)
Normal Saline12
Lidocaine (1%) + Bupivacaine 0.5%12
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg14

Total Time Until Discharge From Hospital.

(NCT00678379)
Timeframe: Day of Surgery

Interventionminutes (Median)
Normal Saline122
Lidocaine (1%) + Bupivacaine 0.5%111
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg120

Mean Visual Analog Scale Pain Number.

Visual analog pain scale range is 0-10 with 0=no pain and 10 = worst pain ever (NCT00678379)
Timeframe: in recovery room; post-operative days 1,3,5 & 7

,,
Interventionpain score (Mean)
In recovery roomday 1day 3day 5day 7
Lidocaine (1%) + Bupivacaine 0.5%342.522
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg35332
Normal Saline33332.5

Number and Percent of Participants Able to Tolerate a Regular Diet

The number and percent of patients whose post-operative diet has to a regular diet on post-operative days 1, 3, 5 & 7 (NCT00678379)
Timeframe: post-operative days 1,3,5 & 7.

,,
InterventionParticipants (Count of Participants)
post-op day 1post-op day 3post op day 5post op day 7
Lidocaine (1%) + Bupivacaine 0.5%481826
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg1121422
Normal Saline7182124

Number and Percent of Participants Able to Tolerate Only a Soft Diet

The number and percent of patients whose post-operative diet has only advanced to a soft diet on post-operative days 1, 3, 5 & 7 (NCT00678379)
Timeframe: post-operative days 1,3,5 & 7.

,,
InterventionParticipants (Count of Participants)
post-op day 1post-op day 3post op day 5post op day 7
Lidocaine (1%) + Bupivacaine 0.5%22261710
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg26181814
Normal Saline26181313

Number and Percent of Participants Able to Tolerate Only Liquids

The number and percent of patients whose post-operative diet has advanced to liquids only on post-op days 1, 3, 5 & 7 (NCT00678379)
Timeframe: post-operative days 1,3,5 & 7.

,,
InterventionParticipants (Count of Participants)
post-op day 1post-op day 3post op day 5post op day 7
Lidocaine (1%) + Bupivacaine 0.5%33131011
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg30231910
Normal Saline168136

Trials

3 trials available for lidocaine and Hypertrophy

ArticleYear
EMLA(®) cream as local anesthetic for radiofrequency turbinate tissue reduction.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2014, Volume: 271, Issue:10

    Topics: Adolescent; Adult; Aged; Anesthesia, Local; Anesthetics, Local; Bone Diseases; Catheter Ablation; Fe

2014
Lidocaine spray versus tetracaine solution for monopolar submucosal diathermy for inferior turbinate hypertrophy.
    B-ENT, 2010, Volume: 6, Issue:4

    Topics: Adolescent; Adult; Anesthetics, Local; Electrocoagulation; Female; Humans; Hypertrophy; Lidocaine; M

2010
Comparison of clonidine, local anesthetics, and placebo for pain reduction in pediatric tonsillectomy.
    Archives of otolaryngology--head & neck surgery, 2011, Volume: 137, Issue:6

    Topics: Adenoids; Adolescent; Age Factors; Analgesics; Anesthetics, Local; Bupivacaine; Child; Child, Presch

2011

Other Studies

2 other studies available for lidocaine and Hypertrophy

ArticleYear
Equine muscular dystrophy with myotonia.
    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2001, Volume: 112, Issue:2

    Topics: Anesthetics, Local; Animals; Apamin; Atrophy; Electromyography; Hindlimb; Horse Diseases; Horses; Hy

2001
The role of the diaphragm in the sensation of holding the breath.
    Clinical science, 1971, Volume: 41, Issue:3

    Topics: Adult; Apnea; Diaphragm; Electromyography; Female; Humans; Hypertrophy; Lidocaine; Male; Muscles; Ne

1971