lidocaine has been researched along with Hypersensitivity in 24 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Hypersensitivity: Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
Excerpt | Relevance | Reference |
---|---|---|
"Laryngeal TRPV1 plays an important role in cough sensitivity, but sensitization of capsaicin-sensitive cough receptors in the lower airway may be more responsible for the cough hypersensitivity in patients with UACS." | 7.79 | Capsaicin-sensitive cough receptors in lower airway are responsible for cough hypersensitivity in patients with upper airway cough syndrome. ( Lü, H; Qiu, Z; Wang, L; Xu, X; Yang, Z; Yu, L, 2013) |
"Nebulized lidocaine enables dosages of oral corticosteroids to be tapered in the treatment of severe asthma." | 7.71 | Inhibitory effect of lidocaine on T cells from patients with allergic asthma. ( Adachi, M; Matsuo, H; Minoguchi, K; Oda, N; Okada, S; Tanaka, A; Tasaki, T; Yokoe, T, 2002) |
"The analgesic effects on pain-related behaviors following the topical application of hangeshashinto were evaluated in an oral ulcer rat model treated with acetic acid using recently developed methods." | 3.83 | The traditional Japanese medicine hangeshashinto alleviates oral ulcer-induced pain in a rat model. ( Hattori, T; Hitomi, S; Imai, R; Inenaga, K; Kase, Y; Kubota, K; Omiya, Y; Ono, K; Terawaki, K; Yamaguchi, K, 2016) |
"Laryngeal TRPV1 plays an important role in cough sensitivity, but sensitization of capsaicin-sensitive cough receptors in the lower airway may be more responsible for the cough hypersensitivity in patients with UACS." | 3.79 | Capsaicin-sensitive cough receptors in lower airway are responsible for cough hypersensitivity in patients with upper airway cough syndrome. ( Lü, H; Qiu, Z; Wang, L; Xu, X; Yang, Z; Yu, L, 2013) |
"Nebulized lidocaine enables dosages of oral corticosteroids to be tapered in the treatment of severe asthma." | 3.71 | Inhibitory effect of lidocaine on T cells from patients with allergic asthma. ( Adachi, M; Matsuo, H; Minoguchi, K; Oda, N; Okada, S; Tanaka, A; Tasaki, T; Yokoe, T, 2002) |
"Local allergic reaction was registered in one case, no systemic reactions were noticed." | 1.37 | [The surface anesthesia in outpatient pediatric department]. ( Bolotov, IuN; Matveevskaia, ES; Minaev, SV; Neshta, ES, 2011) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 12 (50.00) | 18.7374 |
1990's | 3 (12.50) | 18.2507 |
2000's | 2 (8.33) | 29.6817 |
2010's | 6 (25.00) | 24.3611 |
2020's | 1 (4.17) | 2.80 |
Authors | Studies |
---|---|
Martis, W | 1 |
Chahal, R | 1 |
Janas-Naze, A | 1 |
Osica, P | 1 |
Gallo, L | 1 |
Yu, L | 1 |
Xu, X | 1 |
Wang, L | 1 |
Yang, Z | 1 |
Lü, H | 1 |
Qiu, Z | 1 |
Hitomi, S | 1 |
Ono, K | 1 |
Yamaguchi, K | 1 |
Terawaki, K | 1 |
Imai, R | 1 |
Kubota, K | 1 |
Omiya, Y | 1 |
Hattori, T | 1 |
Kase, Y | 1 |
Inenaga, K | 1 |
Vieira dos Santos, R | 1 |
Metz, M | 1 |
Lima, HC | 1 |
Martus, P | 1 |
Maurer, M | 1 |
Bolotov, IuN | 1 |
Minaev, SV | 1 |
Matveevskaia, ES | 1 |
Neshta, ES | 1 |
Khokhlov, VD | 1 |
Krut', MI | 1 |
Sashko, SIu | 1 |
MORRISSET, LM | 1 |
CICHA, J | 1 |
DESCOMPS, H | 1 |
LUBENS, HM | 1 |
SANKER, JF | 1 |
HOLTI, G | 1 |
HOOD, FJ | 1 |
RAJKA, G | 2 |
NOBLE, DS | 1 |
PIERCE, GF | 1 |
Downes, H | 1 |
Gerber, N | 1 |
Hirshman, CA | 1 |
Jackson, D | 1 |
Chen, AH | 1 |
Bennett, CR | 1 |
Añíbarro, B | 1 |
Seoane, FJ | 1 |
Tanaka, A | 1 |
Minoguchi, K | 1 |
Oda, N | 1 |
Yokoe, T | 1 |
Matsuo, H | 1 |
Okada, S | 1 |
Tasaki, T | 1 |
Adachi, M | 1 |
Namimatsu, A | 1 |
Go, K | 1 |
Tanimoto, H | 1 |
Okuda, M | 1 |
Fitzgerald, M | 1 |
Millard, C | 1 |
McIntosh, N | 1 |
Delorme, P | 1 |
Lokken, P | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Maternal-Fetal Monitoring of Patients With Rheumatic Heart Disease During Dental Procedure Under Local Anesthesia[NCT00482573] | Phase 1 | 31 participants (Actual) | Interventional | 2004-04-30 | Completed | ||
Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
The Efficacy of the Eutectic Mixture of Local Anesthetics (EMLA) Cream Versus the Synera Patch for Pain Reduction During Venipuncture in Children[NCT00530803] | Phase 2 | 100 participants (Actual) | Interventional | 2007-06-30 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
Intervention | Intensity score (Mean) |
---|---|
Topical KeAmLi Combo | 62.7 |
Topical Ketamine | 63.1 |
Topical Amitriptyline | 69.2 |
Topical Lidocaine | 65.8 |
Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
Intervention | mN (Mean) | |
---|---|---|
Mechanical Detection Threshold | Mechanical Pain Threshold | |
Topical Amitriptyline | 3.573423965 | 152.4768146 |
Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
Topical Ketamine | 3.464204768 | 135.9 |
Topical Lidocaine | 3.546037659 | 126.9 |
Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
Intervention | Degrees celsius (Mean) | |
---|---|---|
Warm Detection Threshold | Heat Pain Threshold | |
Topical Amitriptyline | 33.9 | 40.0 |
Topical KeAmLi Combo | 33.6 | 39.8 |
Topical Ketamine | 34.0 | 40.0 |
Topical Lidocaine | 33.7 | 39.4 |
Topical Vehicle | 33.8 | 39.7 |
The NRS (Numerical Rating Scale) is a 6-point rating scale where 0= no pain and 5 = worst pain. Blinded observers reported their own subjective evaluation of the level of pain experienced by the participants at tourniquet placement. Total number of participants subjectively evaluated as experiencing each pain level is reported. (NCT00530803)
Timeframe: before venipuncture
Intervention | Participants (Count of Participants) | |||||
---|---|---|---|---|---|---|
Participants evaluated at NRS = 0 (No pain) | Participants evaluated at NRS = 1 | Participants evaluated at NRS = 2 | Participants evaluated at NRS = 3 | Participants evaluated at NRS = 4 | Participants evaluated at NRS = 5 | |
EMLA Cream | 41 | 6 | 2 | 1 | 0 | 0 |
Synera Patch | 37 | 6 | 5 | 1 | 1 | 0 |
The NRS (Numerical Rating Scale) is a 6-point rating scale where 0= no pain and 5 = worst pain. Blinded observers reported their own subjective evaluation of the level of pain participants were experiencing 5 minutes after the venipuncture was completed. Total number of participants subjectively evaluated as experiencing each pain level is reported. (NCT00530803)
Timeframe: 5 minutes post venipuncture
Intervention | Participants (Count of Participants) | |||||
---|---|---|---|---|---|---|
Participants evaluated at NRS = 0 (No pain) | Participants evaluated at NRS = 1 | Participants evaluated at NRS = 2 | Participants evaluated at NRS = 3 | Participants evaluated at NRS = 4 | Participants evaluated at NRS = 5 | |
EMLA Cream | 45 | 3 | 1 | 1 | 0 | 0 |
Synera Patch | 45 | 4 | 1 | 0 | 0 | 0 |
The NRS (Numerical Rating Scale) is a 6-point rating scale where 0= no pain and 5 = worst pain. Blinded observers reported their own subjective evaluation of the level of pain experienced by the participants at needle insertion. Total number of participants subjectively evaluated as experiencing each pain level is reported. (NCT00530803)
Timeframe: during needle insertion
Intervention | Participants (Count of Participants) | |||||
---|---|---|---|---|---|---|
Participants evaluated at NRS = 0 (No pain) | Participants evaluated at NRS = 1 | Participants evaluated at NRS = 2 | Participants evaluated at NRS = 3 | Participants evaluated at NRS = 4 | Participants evaluated at NRS = 5 | |
EMLA Cream | 32 | 14 | 2 | 2 | 0 | 0 |
Synera Patch | 25 | 12 | 9 | 2 | 2 | 0 |
The Numerical Rating Scale (NRS) is a 6-point rating scale where 0= no pain and 5 = worst pain. Parents reported their own subjective evaluation of participants pain level. Each participant had only one parental assessment. Total number of parental assessment for each pain level on the 6-point NRS is reported as total number of participants experiencing that pain level. (NCT00530803)
Timeframe: immediately after venipuncture is completed
Intervention | Participants (Count of Participants) | |||||
---|---|---|---|---|---|---|
number of participants with NRS=0 (no pain) | number of participants with NRS=1 | number of participants with NRS=2 | number of participants with NRS=3 | number of participants with NRS=4 | number of participants with NRS=5 | |
EMLA Cream | 42 | 6 | 1 | 1 | 0 | 0 |
Synera Patch | 41 | 5 | 1 | 2 | 0 | 1 |
"Participants were asked to report their level of pain using a 6-point Wong-Baker FACES Pain Rating Scale ranging from 0, no pain, to 5, the most pain you can have. The Wong-Baker FACES Pain Rating Scale is a validated tool for measuring pain in patients as young as 3 years old. A FACES pain score less than or equal to 2 is considered no pain to mild pain, and is clinically acceptable. Studies have shown average FACES pain scores for children receiving vascular access with placebo to be 2.2 to 3.5." (NCT00530803)
Timeframe: immediately after completion of venipuncture
Intervention | Participants (Count of Participants) | |||||
---|---|---|---|---|---|---|
Participants with FACES Score = 0 (No pain) | Participants with FACES Score = 1 | Participants with FACES Score = 2 | Participants with FACES Score = 3 | Participants with FACES Score = 4 | Participants with FACES Score = 5 | |
EMLA Cream | 42 | 6 | 2 | 0 | 0 | 0 |
Synera Patch | 38 | 8 | 3 | 1 | 0 | 0 |
1 review available for lidocaine and Hypersensitivity
Article | Year |
---|---|
[Anaphylactic shock following administration of lidocaine after negative skin test].
Topics: Anaphylaxis; Anesthetics, Local; Angioedema; Fatal Outcome; Female; Humans; Hypersensitivity; Inject | 2012 |
2 trials available for lidocaine and Hypersensitivity
Article | Year |
---|---|
Differential effects of skin nerves on allergic skin inflammation.
Topics: Anesthetics, Local; Double-Blind Method; Humans; Hypersensitivity; Inflammation; Lidocaine; Lidocain | 2009 |
Cutaneous hypersensitivity following peripheral tissue damage in newborn infants and its reversal with topical anaesthesia.
Topics: Anesthetics, Local; Ankle Injuries; Blood Specimen Collection; Double-Blind Method; Drug Combination | 1989 |
21 other studies available for lidocaine and Hypersensitivity
Article | Year |
---|---|
Expedited awake tracheal intubation using ropivacaine topicalisation for the evacuation of a postoperative neck haematoma in the presence of lignocaine allergy.
Topics: Fiber Optic Technology; Hematoma; Humans; Hypersensitivity; Intubation, Intratracheal; Lidocaine; Ma | 2023 |
The incidence of lidocaine allergy in dentists: an evaluation of 100 general dental practitioners.
Topics: Adult; Anaphylaxis; Anesthetics, Local; Angioedema; Dentists; Female; Humans; Hypersensitivity; Inci | 2019 |
Patients affected by premature ejaculation due to glans hypersensitivity refuse circumcision as a potential definite treatment for their problem.
Topics: Adult; Anesthetics, Local; Circumcision, Male; Humans; Hypersensitivity; Lidocaine; Male; Penis; Pre | 2014 |
Capsaicin-sensitive cough receptors in lower airway are responsible for cough hypersensitivity in patients with upper airway cough syndrome.
Topics: Adult; Anesthetics, Local; Capsaicin; Case-Control Studies; Cough; Dinoprostone; Enzyme-Linked Immun | 2013 |
The traditional Japanese medicine hangeshashinto alleviates oral ulcer-induced pain in a rat model.
Topics: Acetic Acid; Administration, Topical; Analgesics; Animals; Disease Models, Animal; Drugs, Chinese He | 2016 |
[The surface anesthesia in outpatient pediatric department].
Topics: Administration, Topical; Adolescent; Ambulatory Surgical Procedures; Anesthesia, Local; Anesthetics, | 2011 |
Fatal anaphylactic reaction to lidocaine.
Topics: Anaphylaxis; Humans; Hypersensitivity; Immune System Diseases; Lidocaine | 1957 |
[Contribution to the study of experimental allergy in the body].
Topics: Blood Transfusion; Castration; Humans; Hypersensitivity; Lidocaine; Male; Orchiectomy; Splenectomy; | 1962 |
[STIMULATION OF HYPOTHALAMO-HYPOPHYSIAL SECRETIONS IN MAN BY RETRO-STYLOID ANESTHETIC INFILTRATION].
Topics: Adrenocorticotropic Hormone; Anesthetics; Asthma; Autonomic Nerve Block; Eczema; Endocrinology; Huma | 1963 |
ANESTHETIC SKIN PATCH.
Topics: Adolescent; Anesthesia; Anesthesia, Local; Anesthetics; Child; Humans; Hypersensitivity; Lidocaine; | 1964 |
AN ANAPHYLACTOID REACTION TO LIGNOCAINE.
Topics: Anaphylaxis; Hypersensitivity; Lidocaine; Pharmacology; Toxicology; Vascular Diseases | 1965 |
[Some remarks on llaocaine allergy].
Topics: Humans; Hypersensitivity; Immune System Diseases; Lidocaine | 1960 |
Allergy to lignocaine. A casehistory.
Topics: Humans; Hypersensitivity; Lidocaine; Medical Records | 1961 |
[On lidocaine allergy].
Topics: Drug Hypersensitivity; Humans; Hypersensitivity; Immune System Diseases; Lidocaine | 1961 |
Intravenous lidocaine in reflex and allergic bronchoconstriction.
Topics: Aerosols; Animals; Antigens; Ascaris; Bronchial Spasm; Citrates; Dogs; Hypersensitivity; Injections, | 1980 |
Identifying true lidocaine allergy.
Topics: Anesthesia, Dental; Anesthesia, Local; Dental Anxiety; Diagnosis, Differential; Drug Hypersensitivit | 1994 |
Identifying true lidocaine allergy.
Topics: Anesthesia, Dental; Anesthesia, Local; Dental Anxiety; Diagnosis, Differential; Drug Hypersensitivit | 1994 |
Identifying true lidocaine allergy.
Topics: Anesthesia, Dental; Anesthesia, Local; Dental Anxiety; Diagnosis, Differential; Drug Hypersensitivit | 1994 |
Identifying true lidocaine allergy.
Topics: Anesthesia, Dental; Anesthesia, Local; Dental Anxiety; Diagnosis, Differential; Drug Hypersensitivit | 1994 |
Adverse reaction to lidocaine.
Topics: Adolescent; Akathisia, Drug-Induced; Anesthetics, Local; Dizziness; Double-Blind Method; Euphoria; F | 1998 |
Inhibitory effect of lidocaine on T cells from patients with allergic asthma.
Topics: Allergens; Animals; Anti-Inflammatory Agents; Asthma; CD4-Positive T-Lymphocytes; Cytokines; Dexamet | 2002 |
Mechanism of nasal secretion mediated via nerve reflex in guinea pigs and evaluation of antiallergic drugs.
Topics: Allergens; Aminopyridines; Animals; Atropine Derivatives; Bronchodilator Agents; Capsaicin; Ganglion | 1992 |
Localized heat urticaria.
Topics: Adult; Anesthetics, Local; Chlorpheniramine; Desensitization, Immunologic; Female; Histamine H1 Anta | 1969 |
[Local anesthetics and their pharmacology].
Topics: Action Potentials; Anesthetics, Local; Chemistry, Pharmaceutical; Hyperemia; Hypersensitivity; Injec | 1968 |