Page last updated: 2024-10-28

lidocaine and Hemorrhage

lidocaine has been researched along with Hemorrhage in 66 studies

Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.

Hemorrhage: Bleeding or escape of blood from a vessel.

Research Excerpts

ExcerptRelevanceReference
" The addition of epinephrine to lidocaine significantly reduced superficial bleeding."9.12Local infiltration of epinephrine-containing lidocaine with bicarbonate reduces superficial bleeding and pain during labor epidural catheter insertion: a randomized trial. ( Brummel, C; Carvalho, B; Cohen, SE; Fuller, A, 2007)
" Our aim was to examine the effect of two different analgesics, buprenorphine and carprofen, on adenosine, lidocaine, and magnesium (ALM) resuscitation in a rat model of laparotomy and non-compressible hemorrhage."8.02Buprenorphine Analgesia Reduces Survival With ALM Resuscitation in a Rat Model of Uncontrolled Hemorrhage: Concerns for Trauma-Related Research. ( Dobson, GP; Letson, HL, 2021)
"In an attempt to find a vasoconstrictor with less detrimental local and systemic effects than epinephrine, the effects of phenylephrine, a pure alpha agonist, on tissue gas tension, bleeding, infection rates, and lidocaine absorption were studied."7.67Effects of phenylephrine on tissue gas tension, bleeding, infection, and lidocaine absorption. ( Buck, DC; Canepa, CS; Demuth, RJ; Miller, M; Miller, SH, 1988)
"Hemorrhage was induced in anesthetized-ventilated animals by liver resection (60% left lateral lobe and 50% medial lobe)."5.46Adenosine, lidocaine and Mg2+ (ALM) fluid therapy attenuates systemic inflammation, platelet dysfunction and coagulopathy after non-compressible truncal hemorrhage. ( Dobson, G; Letson, H, 2017)
" The addition of epinephrine to lidocaine significantly reduced superficial bleeding."5.12Local infiltration of epinephrine-containing lidocaine with bicarbonate reduces superficial bleeding and pain during labor epidural catheter insertion: a randomized trial. ( Brummel, C; Carvalho, B; Cohen, SE; Fuller, A, 2007)
"The use of 40% DMSO with lidocaine instilled into the rectal vault for 10 minutes avoids any need for injection and is capable of decreasing the discomfort or pain experienced during probe insertion and prostate biopsy comparable to the perianal and periprostatic protocols."5.11Comparison of different local anesthesia techniques during TRUS-guided biopsies: a prospective pilot study. ( Ben-Dor, D; Cytron, S; Dorfman, D; Kesari, D; Kravchick, S; Peled, R, 2005)
" We discuss the literature that has influenced current office behavior regarding endocarditis prophylaxis, the use of electrosurgery with pacemakers, arrhythmogenic drug interactions, vasovagal syncope, lidocaine "allergy," and bleeding complications from oral anticoagulants."4.79Medical issues and emergencies in the dermatology office. ( Fader, DJ; Johnson, TM, 1997)
" We have reported that the dose of adenosine, lidocaine, and magnesium (ALM) fluid therapy for resuscitation from hemorrhagic shock is nearly 3-times higher for pigs than rats."4.31Changes in plasma alpha-1 acid glycoprotein following hemorrhagic trauma: Possible role in dose differences of ALM drug therapy in rat and pig resuscitation. ( Dobson, GP; Letson, HL; Morris, JL, 2023)
" Our aim was to examine the effect of two different analgesics, buprenorphine and carprofen, on adenosine, lidocaine, and magnesium (ALM) resuscitation in a rat model of laparotomy and non-compressible hemorrhage."4.02Buprenorphine Analgesia Reduces Survival With ALM Resuscitation in a Rat Model of Uncontrolled Hemorrhage: Concerns for Trauma-Related Research. ( Dobson, GP; Letson, HL, 2021)
"This study tested the hypothesis that the hypothalamus participates in the decompensatory phase of hemorrhage by measuring Fos immunoreactivity and by inhibiting neuronal activity in selected hypothalamic nuclei with lidocaine or cobalt chloride."3.83Hypovolemic hemorrhage induces Fos expression in the rat hypothalamus: Evidence for involvement of the lateral hypothalamus in the decompensatory phase of hemorrhage. ( Göktalay, G; Millington, WR, 2016)
"In an attempt to find a vasoconstrictor with less detrimental local and systemic effects than epinephrine, the effects of phenylephrine, a pure alpha agonist, on tissue gas tension, bleeding, infection rates, and lidocaine absorption were studied."3.67Effects of phenylephrine on tissue gas tension, bleeding, infection, and lidocaine absorption. ( Buck, DC; Canepa, CS; Demuth, RJ; Miller, M; Miller, SH, 1988)
"Pain was evaluated using 10-point Visual Analog Scale (VAS)."2.78A prospective randomized trial comparing three different analgesic techniques for pain control during transrectal ultrasound guided prostate biopsy: a single center experience. ( Anup, K; Biswajit, N; Nayan, MK; Niraj, K; Pawan, V, 2013)
"A fentanyl bolus was administered to 8 of 10 dogs treated with fentanyl and to none treated with TA."2.78Perioperative evaluation of tumescent anaesthesia technique in bitches submitted to unilateral mastectomy. ( Credie, Lde F; da Silva, LC; de Carvalho, LR; Futema, F; Garcia, JN; Gomes, GB; Luna, SP, 2013)
"Bleeding was assessed after raising the craniotomy flap."2.73Hemodynamic changes due to infiltration of the scalp with epinephrine-containing lidocaine solution: a hypotensive episode before craniotomy. ( Cheng, HL; Li, WY; Shang, RJ; Shen, JC; Shi, JX; Wang, HD; Xu, JG; Yang, JJ, 2007)
"Hemorrhage was induced in anesthetized-ventilated animals by liver resection (60% left lateral lobe and 50% medial lobe)."1.46Adenosine, lidocaine and Mg2+ (ALM) fluid therapy attenuates systemic inflammation, platelet dysfunction and coagulopathy after non-compressible truncal hemorrhage. ( Dobson, G; Letson, H, 2017)

Research

Studies (66)

TimeframeStudies, this research(%)All Research%
pre-199028 (42.42)18.7374
1990's8 (12.12)18.2507
2000's11 (16.67)29.6817
2010's14 (21.21)24.3611
2020's5 (7.58)2.80

Authors

AuthorsStudies
Franko, JJ1
Vu, MM1
Parsons, ME1
Conner, JR1
Lammers, DT1
Ieronimakis, N1
Reynolds, GD1
Eckert, MJ1
Bingham, JR1
Letson, HL3
Morris, JL1
Dobson, GP3
Davis, JA1
Bopp, AC1
Henwood, MK1
Baine, RE1
Cox, CC1
Grau, JW1
Haider, S1
Gemery, JM1
Gordon, RJ1
Lombard, FW1
Shi, XF1
Wang, ZJ1
Long, XG1
Shen, JF1
Letson, H1
Dobson, G1
Chatigny, F1
Groman, DB1
Martinson, SA1
Stevens, ED1
Xing, SG1
Mao, T1
Mutlu, IN1
Kocak, B1
Baykara Ulusan, M1
Ulusan, K1
Cakir, MS1
Kilickesmez, O1
Aubrun, F1
Nouette-Gaulain, K1
Fletcher, D1
Belbachir, A1
Beloeil, H1
Carles, M1
Cuvillon, P1
Dadure, C1
Lebuffe, G1
Marret, E1
Martinez, V1
Olivier, M1
Sabourdin, N1
Zetlaoui, P1
Anup, K1
Pawan, V1
Niraj, K1
Biswajit, N1
Nayan, MK1
Credie, Lde F1
Luna, SP1
Futema, F1
da Silva, LC1
Gomes, GB1
Garcia, JN1
de Carvalho, LR1
Vollmer, C1
Nommensen, J1
Watolla, M1
Bauer, I1
Picker, O1
Göktalay, G2
Millington, WR3
Najarian, DJ1
Rao, BK1
Pappert, AS1
Bajkin, BV1
Todorovic, LM1
Mishra, P1
Kaushik, M1
Dehadaray, A1
Qadri, H1
Raichurkar, A1
Seth, T1
Heslop, DJ1
Keay, KA2
Bandler, R2
Tanaka, J1
Hatakenaka, S1
Miyakubo, H1
Nomura, M1
Adolphs, J1
Schmidt, DK1
Mousa, SA1
Kamin, B1
Korsukewitz, I1
Habazettl, H1
Schäfer, M1
Welte, M1
RHYMES, R1
WILLIAMS, C1
MOORE, DC1
BRIDENBAUGH, LD1
EATHER, KF1
Kravchick, S1
Peled, R1
Ben-Dor, D1
Dorfman, D1
Kesari, D1
Cytron, S1
Brown, JW1
Whitehurst, ME1
Gordon, CJ1
Carroll, RG1
Cavun, S2
Levendusky, MC1
Resch, GE1
Veno, PA1
Kawasaki, T1
Choudhry, MA1
Schwacha, MG1
Bland, KI1
Chaudry, IH1
Yang, JJ1
Cheng, HL1
Shang, RJ1
Shen, JC1
Shi, JX1
Wang, HD1
Li, WY1
Xu, JG1
Carvalho, B1
Fuller, A1
Brummel, C1
Cohen, SE1
Jako, GJ1
Kobrine, AI1
Evans, DE1
LeGrys, DC1
Yaffe, LJ1
Bradley, ME1
Stanek, B1
Schwarz, M1
Zimpfer, M1
Raberger, G1
Boliston, TA1
Upton, JJ1
Harper, DM1
Walstatter, BS1
Lofton, BJ1
Shuler, JD1
Fader, DJ1
Johnson, TM1
Hefer, T1
Joachims, HZ1
Henderson, LA1
Rose, SD1
Singh, KB1
Rao, SV1
Schröder, T1
Kinnunen, PK1
Lempinen, M1
Thorud, T1
Lund, I1
Holme, I1
Covino, BG1
Bush, DF1
Collins, PD1
Godkin, RA1
Jordan, DA1
Miller, ED1
Kennedy, KS1
Strom, CG1
Carpenter, RL1
Kopacz, DJ1
Mackey, DC1
Lillis, PJ1
Canepa, CS1
Miller, SH1
Buck, DC1
Demuth, RJ1
Miller, M1
Millar, JM1
Jago, RH1
Fawcett, DP1
Chaturachinda, K1
Pirotta, T1
Shimosato, S1
Eichbaum, FW1
Yasaka, WJ1
Bonica, JJ1
Kennedy, WF1
Akamatsu, TJ1
Gerbershagen, HU1
Khubchandani, IT1
Trimpi, HD1
Sheets, JA1
Rundle, FW1
Rintala, A1
Tammisto, T1
Görisch, I1
Boba, A1
Linkie, DM1
Plotz, EJ1
Pedersen, B1
Sugavanam, J1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pain Intensity After RObotic Assisted Urological Surgery: the PAIROU Study[NCT05575284]968 participants (Actual)Observational2022-12-01Completed
A Comparison of Lidocaine, Buffered Lidocaine, and Bacteriostatic Normal Saline for Local Anesthesia Prior to Peripheral Intravenous Catheterization[NCT01759459]Phase 4150 participants (Actual)Interventional2013-01-31Completed
A Single Center, Randomized, Double-Blind Controlled Study of Topical Endoluminal Pancreatic Duct Lidocaine for Prevention of Post-ERCP Pancreatitis[NCT00953199]506 participants (Actual)Interventional2010-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Economic Analysis of Cost of Compounding Buffered Lidocaine Versus Cost of Purchasing Regular Lidocaine and/or Bacteriostatic Normal Saline

A secondary outcome includes a pharmacoeconomic analysis that will look specifically at the cost-savings of using one agent over the other and will take into account the daily time allocated to pharmacy technicians and pharmacists for compounding and verifying buffered lidocaine. The outcome data was measured and reported in a single value dollar amount per group, tallied over a 3 month period. The dollar amounts were estimated by adding up the costs of drug purchasing, technician compounding time, and pharmacist verifying time. Buffered lidocaine required both drug purchasing and compounding time, where the lidocaine and bacteriostatic normal saline required drug purchasing alone and labor costs were not taken into account. (NCT01759459)
Timeframe: 3 months

InterventionDollars (Number)
Buffered Lidocaine Cost13400
Lidocaine Cost9100
Bacteriostatic Normal Saline Cost4840

Pain Score Following Anesthetic Administration

The primary outcome measured in this study will be the level of pain reported, on a scale of 0 to 10, 0 being no pain at all and 10 being the worst pain ever felt, by the patient upon administration of the local anesthetic and upon insertion of the peripheral intravenous catheter. (NCT01759459)
Timeframe: Day 1

Interventionunits on a scale (Mean)
Lidocaine2.81
Buffered Lidocaine1.64
Bacteriostatic Normal Saline2.05

Pain Score Following Peripheral Catheter Insertion

The primary outcome measured in this study will be the level of pain reported, on a scale of 0 to 10, 0 being no pain at all and 10 being the worst pain ever felt, by the patient upon administration of the local anesthetic and upon insertion of the peripheral intravenous catheter. (NCT01759459)
Timeframe: Baseline and day 1

,,
Interventionunits on a scale (Mean)
Average pain score following medication injectionAverage pain score following IV inserti
Bacteriostatic Normal Saline2.103.05
Buffered Lidocaine1.61.81
Lidocaine2.581.81

Post ERCP Pancreatitis is the Primary Outcome.

The primary outcome of interest will be development of acute pancreatitis defined as new or worsening abdominal pain post-ERCP associated with an increase in serum amylase at least 3 times the upper limit of normal. (NCT00953199)
Timeframe: 24-48 hours post-procedure

Interventionparticipants (Number)
Lidocaine26
Normal Saline20

Serum Amylase Levels

serum amylase levels are measure by a blood draw (NCT00953199)
Timeframe: measurement is taken 2 hrs after ERCP

Interventionunits/liter (Mean)
Lidocaine130
Normal Saline128

Reviews

3 reviews available for lidocaine and Hemorrhage

ArticleYear
Perioperative Venous Thromboembolism: A Review.
    Anesthesia and analgesia, 2017, Volume: 125, Issue:2

    Topics: Anticoagulants; Aspirin; Fibrinolytic Agents; Hemorrhage; Humans; Hydroxymethylglutaryl-CoA Reductas

2017
Medical issues and emergencies in the dermatology office.
    Journal of the American Academy of Dermatology, 1997, Volume: 36, Issue:1

    Topics: Anaphylaxis; Anesthetics, Local; Anti-Arrhythmia Agents; Anticoagulants; Cerebrovascular Disorders;

1997
Circulatory adjustments under spinal anesthesia.
    International anesthesiology clinics, 1974,Spring, Volume: 12, Issue:1

    Topics: Anesthesia, Epidural; Anesthesia, Spinal; Arteries; Blood Circulation; Blood Pressure; Cardiac Outpu

1974

Trials

10 trials available for lidocaine and Hemorrhage

ArticleYear
A prospective randomized trial comparing three different analgesic techniques for pain control during transrectal ultrasound guided prostate biopsy: a single center experience.
    Minerva urologica e nefrologica = The Italian journal of urology and nephrology, 2013, Volume: 65, Issue:1

    Topics: Administration, Rectal; Aged; Analgesia; Anesthetics, Combined; Anesthetics, Local; Biopsy, Needle;

2013
Perioperative evaluation of tumescent anaesthesia technique in bitches submitted to unilateral mastectomy.
    BMC veterinary research, 2013, Sep-11, Volume: 9

    Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Dog Diseases; Dogs; Female; Fentanyl; Hemorrhage; I

2013
Preparation of nose for nasal endoscopy: cotton pledget packing versus topical spray. A prospective randomized blinded study.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2013, Volume: 270, Issue:1

    Topics: Administration, Intranasal; Adolescent; Adult; Aerosols; Aged; Anesthetics, Local; Endoscopy; Hemorr

2013
Comparison of different local anesthesia techniques during TRUS-guided biopsies: a prospective pilot study.
    Urology, 2005, Volume: 65, Issue:1

    Topics: Adenocarcinoma; Adjuvants, Anesthesia; Administration, Rectal; Aged; Anesthesia, Local; Anesthetics,

2005
Hemodynamic changes due to infiltration of the scalp with epinephrine-containing lidocaine solution: a hypotensive episode before craniotomy.
    Journal of neurosurgical anesthesiology, 2007, Volume: 19, Issue:1

    Topics: Adolescent; Adult; Anesthesia, General; Anesthesia, Intravenous; Anesthesia, Local; Anesthetics, Loc

2007
Local infiltration of epinephrine-containing lidocaine with bicarbonate reduces superficial bleeding and pain during labor epidural catheter insertion: a randomized trial.
    International journal of obstetric anesthesia, 2007, Volume: 16, Issue:2

    Topics: Adolescent; Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthetics, Local; Catheterizatio

2007
Infiltration with lignocaine and adrenaline in adult tonsillectomy.
    The Journal of laryngology and otology, 1980, Volume: 94, Issue:11

    Topics: Adolescent; Adult; Clinical Trials as Topic; Dissection; Epinephrine; Female; Hemorrhage; Humans; In

1980
Anesthetic blocks for loop electrosurgical excision procedure.
    The Journal of family practice, 1994, Volume: 39, Issue:3

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Electrosurgery; Female; H

1994
Prophylaxis of thromboembolic disease.
    The Medical clinics of North America, 1979, Volume: 63, Issue:6

    Topics: Abdomen; Aspirin; Clinical Trials as Topic; Dextrans; Double-Blind Method; Early Ambulation; Hemorrh

1979
[On surgical hemorrhages in relation to local anesthetics. II. Comparative clinical studies on the action of lidocaine and prilocaine].
    Der Anaesthesist, 1965, Volume: 14, Issue:6

    Topics: Anesthetics, Local; Clinical Trials as Topic; Hemorrhage; Humans; Lidocaine; Surgical Procedures, Op

1965

Other Studies

53 other studies available for lidocaine and Hemorrhage

ArticleYear
Adenosine, lidocaine, and magnesium for attenuating ischemia reperfusion injury from resuscitative endovascular balloon occlusion of the aorta in a porcine model.
    The journal of trauma and acute care surgery, 2022, 04-01, Volume: 92, Issue:4

    Topics: Adenosine; Animals; Aorta; Balloon Occlusion; Disease Models, Animal; Endovascular Procedures; Hemor

2022
Changes in plasma alpha-1 acid glycoprotein following hemorrhagic trauma: Possible role in dose differences of ALM drug therapy in rat and pig resuscitation.
    Pharmacology research & perspectives, 2023, Volume: 11, Issue:5

    Topics: Animals; Female; Hemorrhage; Lidocaine; Male; Orosomucoid; Rats; Rats, Sprague-Dawley; Shock, Hemorr

2023
Pharmacological Transection of Brain-Spinal Cord Communication Blocks Pain-Induced Hemorrhage and Locomotor Deficits after Spinal Cord Injury in Rats.
    Journal of neurotrauma, 2020, 08-01, Volume: 37, Issue:15

    Topics: Anesthetics, Local; Animals; Brain; Hemorrhage; Lidocaine; Locomotion; Pain; Pain Measurement; Rats;

2020
Buprenorphine Analgesia Reduces Survival With ALM Resuscitation in a Rat Model of Uncontrolled Hemorrhage: Concerns for Trauma-Related Research.
    Shock (Augusta, Ga.), 2021, 03-01, Volume: 55, Issue:3

    Topics: Adenosine; Analgesia; Analgesics, Opioid; Animals; Biomedical Research; Buprenorphine; Disease Model

2021
Percutaneous Injection of Lidocaine with Epinephrine for Hemostatic Control of Body Wall Iatrogenic Hemorrhage.
    Journal of vascular and interventional radiology : JVIR, 2021, Volume: 32, Issue:8

    Topics: Anesthetics, Local; Double-Blind Method; Epinephrine; Hemorrhage; Hemostatics; Humans; Iatrogenic Di

2021
Local Anesthetic Lidocaine for Gastroscopy Induces Diffuse Alveolar Hemorrhage.
    Chinese medical journal, 2017, 07-20, Volume: 130, Issue:14

    Topics: Anesthetics, Local; Female; Gastroscopy; Hemorrhage; Humans; Lidocaine; Lung Diseases; Middle Aged

2017
Adenosine, lidocaine and Mg2+ (ALM) fluid therapy attenuates systemic inflammation, platelet dysfunction and coagulopathy after non-compressible truncal hemorrhage.
    PloS one, 2017, Volume: 12, Issue:11

    Topics: Adenosine; Animals; Blood Coagulation Disorders; Blood Platelet Disorders; Cytokines; Fluid Therapy;

2017
Evaluation of tissue changes following intramuscular infiltration of lidocaine in rainbow trout Oncorhynchus mykiss.
    Journal of fish biology, 2018, Volume: 92, Issue:4

    Topics: Animals; Connective Tissue; Hemorrhage; Inflammation; Lidocaine; Muscle, Skeletal; Necrosis; Oncorhy

2018
Temporary tourniquet use after epinephrine injection to expedite wide awake emergency hand surgeries.
    The Journal of hand surgery, European volume, 2018, Volume: 43, Issue:8

    Topics: Anesthesia, Local; Anesthetics, Local; Emergencies; Epinephrine; Hand Injuries; Hemorrhage; Humans;

2018
Regional anesthesia with epinephrine-containing lidocaine reduces pericatheter bleeding after tunneled hemodialysis catheter placement.
    Hemodialysis international. International Symposium on Home Hemodialysis, 2019, Volume: 23, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Local; Catheterization; Double-Blind Method; Epinephrin

2019
Response to letter to the editor.
    The journal of trauma and acute care surgery, 2019, Volume: 86, Issue:2

    Topics: Adenosine; Animals; Hemorrhage; Lidocaine; Magnesium; Rats; Sodium Chloride

2019
Revision of expert panel's guidelines on postoperative pain management.
    Anaesthesia, critical care & pain medicine, 2019, Volume: 38, Issue:4

    Topics: Adolescent; Adult; Analgesia, Epidural; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, No

2019
Influence of thoracic epidural anesthesia on gastric oxygenation during hypothermia and hemorrhage.
    Autonomic neuroscience : basic & clinical, 2016, Volume: 195

    Topics: Anesthesia, Epidural; Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Dogs

2016
Hypovolemic hemorrhage induces Fos expression in the rat hypothalamus: Evidence for involvement of the lateral hypothalamus in the decompensatory phase of hemorrhage.
    Neuroscience, 2016, May-13, Volume: 322

    Topics: Animals; Bradycardia; Cobalt; Disease Models, Animal; Hemorrhage; Hemostatics; Hypothalamus; Hypovol

2016
A case of mucous membrane plasmacytosis successfully treated with cryotherapy.
    Dermatology online journal, 2008, Feb-28, Volume: 14, Issue:2

    Topics: AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Cryotherapy; Drug Resistance; Hemorrha

2008
Safety of local anaesthesia in dental patients taking oral anticoagulants: is it still controversial?
    The British journal of oral & maxillofacial surgery, 2012, Volume: 50, Issue:1

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anesthesia, Dental; Anesthesia, Local; Anesthe

2012
Haemorrhage-evoked compensation and decompensation are mediated by distinct caudal midline medullary regions in the urethane-anaesthetised rat.
    Neuroscience, 2002, Volume: 113, Issue:3

    Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Anesthetics, Local; Animals; Blood Pressure; Exci

2002
Noradrenaline release in the median preoptic nucleus area caused by hemorrhage in the rat.
    Brain research bulletin, 2003, May-15, Volume: 60, Issue:3

    Topics: Anesthetics, Local; Animals; Blood; Blood Pressure; Disease Models, Animal; Dose-Response Relationsh

2003
Thoracic epidural anesthesia attenuates hemorrhage-induced impairment of intestinal perfusion in rats.
    Anesthesiology, 2003, Volume: 99, Issue:3

    Topics: Acid-Base Equilibrium; Adrenergic Fibers; Anesthesia, Epidural; Anesthetics, Local; Animals; Endothe

2003
BLOOD LOSS FOLLOWING EXTRACTION OF TEETH.
    Journal of the American Dental Association (1939), 1964, Volume: 69

    Topics: Anesthesia; Anesthesia, Dental; Anesthesia, Local; Atropine; Epinephrine; Hemorrhage; Humans; Lidoca

1964
BLOCK OF THE UPPER EXTREMITY.
    Archives of surgery (Chicago, Ill. : 1960), 1965, Volume: 90

    Topics: Amputation, Surgical; Anesthesia; Anesthesia, Conduction; Anesthesiology; Arm; Brachial Plexus; Frac

1965
The Pre-Optic Anterior Hypothalamus (POAH) partially mediates the hypothermic response to hemorrhage in rats.
    Brain research, 2005, Apr-11, Volume: 1041, Issue:1

    Topics: Adaptation, Physiological; Anesthetics, Local; Animals; Body Temperature Regulation; Hemorrhage; Hyp

2005
Hemorrhage activates proopiomelanocortin neurons in the rat hypothalamus.
    Brain research, 2006, Jan-27, Volume: 1070, Issue:1

    Topics: Animals; Arcuate Nucleus of Hypothalamus; beta-Endorphin; Bradycardia; Hemorrhage; Hypotension; Hypo

2006
Lidocaine depresses splenocyte immune functions following trauma-hemorrhage in mice.
    American journal of physiology. Cell physiology, 2006, Volume: 291, Issue:5

    Topics: Animals; Bone Marrow Cells; Cell Proliferation; Cell Survival; Concanavalin A; Cytokines; Enzyme Act

2006
Postaural versus endaural exposure in tympanoplasty.
    The Laryngoscope, 1967, Volume: 77, Issue:11

    Topics: Anti-Bacterial Agents; Ear Canal; Ear, Middle; Epinephrine; Hemorrhage; Humans; Lidocaine; Mastoid;

1967
Effect of intravenous lidocaine on experimental spinal cord injury.
    Journal of neurosurgery, 1984, Volume: 60, Issue:3

    Topics: Animals; Brain; Cats; Evoked Potentials, Somatosensory; Hemorrhage; Infusions, Parenteral; Lidocaine

1984
Major complications in continuous epidural anesthesia.
    Chinese medical journal, 1980, Volume: 93, Issue:3

    Topics: Adult; Anesthesia, Epidural; Bradycardia; Female; Hemorrhage; Humans; Hypertension, Portal; Lidocain

1980
Plasma concentrations of noradrenaline and adrenaline and plasma renin activity during extradural blockade in dogs.
    British journal of anaesthesia, 1980, Volume: 52, Issue:3

    Topics: Anesthesia, Epidural; Animals; Blood Pressure; Dihydroergotamine; Dogs; Epinephrine; Female; Heart R

1980
Topical anesthesia in a patient with a history of retrobulbar hemorrhage.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1993, Volume: 111, Issue:6

    Topics: Aged; Cataract Extraction; Female; Hemorrhage; Humans; Lidocaine; Ophthalmic Solutions; Orbital Dise

1993
CO2 laser repair of permanent tracheostomy stricture.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1997, Volume: 117, Issue:3 Pt 1

    Topics: Aged; Airway Obstruction; Anesthesia, Local; Anesthetics, Local; Carbon Dioxide; Carcinoma; Cicatrix

1997
Hypotension following acute hypovolaemia depends on the caudal midline medulla.
    Neuroreport, 1998, Jun-01, Volume: 9, Issue:8

    Topics: Acute Disease; Anesthetics, Local; Animals; Blood Pressure; Cobalt; Hemorrhage; Hypotension; Lidocai

1998
Evidence that hemorrhagic hypotension is mediated by the ventrolateral periaqueductal gray region.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2001, Volume: 281, Issue:3

    Topics: Animals; Blood Pressure; Cobalt; Heart Rate; Hemorrhage; Hypotension; Lidocaine; Male; Microinjectio

2001
Pelvic urethrotomies in bulls.
    The Veterinary record, 1979, Aug-18, Volume: 105, Issue:7

    Topics: Anesthesia, Epidural; Animals; Buffaloes; Cattle; Cattle Diseases; Hemorrhage; Lidocaine; Male; Peri

1979
Xylocaine treatment in experimental pancreatitis in pigs.
    Scandinavian journal of gastroenterology, 1978, Volume: 13, Issue:7

    Topics: Acute Disease; Animals; Drug Evaluation, Preclinical; Hemorrhage; Infusions, Parenteral; Lidocaine;

1978
The effect of anesthesia on intraoperative and postoperative bleeding during abdominal prostatectomies: a comparison of neurolept anesthesia, halothane anesthesia and epidural anesthesia.
    Acta anaesthesiologica Scandinavica. Supplementum, 1975, Volume: 57

    Topics: Adult; Aged; Anesthesia, Epidural; Anesthesia, Inhalation; Blood; Bupivacaine; Diazepam; Droperidol;

1975
Clinical evaluation of local anaesthetic agents.
    British journal of anaesthesia, 1975, Volume: 47 suppl

    Topics: Age Factors; Analgesia; Anesthesia, Conduction; Anesthesia, Epidural; Anesthetics, Local; Body Weigh

1975
Awake blind nasal intubation--a dying art?
    Anaesthesia and intensive care, 1992, Volume: 20, Issue:2

    Topics: Aged; Airway Obstruction; Anesthesia, Intravenous; Female; Hemorrhage; Humans; Intubation, Intratrac

1992
Subarachnoid blockade alters homeostasis by modifying compensatory splanchnic responses to hemorrhagic hypotension.
    Anesthesiology, 1991, Volume: 75, Issue:4

    Topics: Adrenal Medulla; Anesthesia, Spinal; Animals; Dogs; Hemorrhage; Homeostasis; Hypotension; Lidocaine;

1991
A comparison of postoperative bleeding incidence between general and local anesthesia tonsillectomies.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1990, Volume: 102, Issue:6

    Topics: Adolescent; Adult; Anesthesia, General; Anesthesia, Local; Child; Epinephrine; Female; Hemorrhage; H

1990
Accuracy of laser Doppler capillary flow measurements for predicting blood loss from skin incisions in pigs.
    Anesthesia and analgesia, 1989, Volume: 68, Issue:3

    Topics: Animals; Capillaries; Epinephrine; Evaluation Studies as Topic; Felypressin; Hemorrhage; Lidocaine;

1989
Liposuction surgery under local anesthesia: limited blood loss and minimal lidocaine absorption.
    The Journal of dermatologic surgery and oncology, 1988, Volume: 14, Issue:10

    Topics: Ambulatory Surgical Procedures; Anesthesia, Local; Bicarbonates; Epinephrine; Female; Hemorrhage; Hu

1988
Effects of phenylephrine on tissue gas tension, bleeding, infection, and lidocaine absorption.
    Plastic and reconstructive surgery, 1988, Volume: 81, Issue:4

    Topics: Adsorption; Animals; Bacterial Infections; Blood Gas Monitoring, Transcutaneous; Hemorrhage; Lidocai

1988
Spinal analgesia for transurethral prostatectomy. Comparison of plain bupivacaine and hyperbaric lignocaine.
    British journal of anaesthesia, 1986, Volume: 58, Issue:8

    Topics: Aged; Anesthesia, Spinal; Bupivacaine; Hemodynamics; Hemorrhage; Humans; Intraoperative Complication

1986
Laparoscopic sterilization: an outpatient procedure.
    American journal of obstetrics and gynecology, 1973, Feb-15, Volume: 115, Issue:4

    Topics: Adult; Costs and Cost Analysis; Epinephrine; Female; Hemorrhage; Humans; Laparoscopy; Lidocaine; Met

1973
POR 8 versus adrenaline as a vasoconstrictor in scalp surgery.
    The Australian and New Zealand journal of surgery, 1972, Volume: 42, Issue:1

    Topics: Anesthesia, Local; Epinephrine; Hemorrhage; Humans; Lidocaine; Prilocaine; Scalp; Vasoconstrictor Ag

1972
Local anaesthetic effect of oxyfedrin in animals.
    British journal of anaesthesia, 1973, Volume: 45, Issue:10

    Topics: Administration, Topical; Anesthesia, Conduction; Anesthesia, Local; Anesthetics, Local; Animals; Con

1973
Circulatory effects of peridural block: 3. Effects of acute blood loss.
    Anesthesiology, 1972, Volume: 36, Issue:3

    Topics: Adult; Anesthesia, Epidural; Blood Circulation; Blood Pressure; Cardiac Output; Ephedrine; Epinephri

1972
Closed hemorrhoidectomy with local anesthesia.
    Surgery, gynecology & obstetrics, 1972, Volume: 135, Issue:6

    Topics: Abscess; Anesthesia, Local; Hemorrhage; Hemorrhoids; Humans; Injections, Subcutaneous; Lidocaine; Me

1972
Post-tonsillectomy morbidity: a clinical trial of a local penicillin-steroid-anesthetic mixture.
    The Annals of otology, rhinology, and laryngology, 1967, Volume: 76, Issue:5

    Topics: Child, Preschool; Feeding and Eating Disorders; Hemorrhage; Humans; Lidocaine; Methylprednisolone; P

1967
[Blood loss in tonsillectomy under local anesthesia and intubation anesthesia].
    HNO, 1970, Volume: 18, Issue:11

    Topics: Adolescent; Adult; Anesthesia, Endotracheal; Anesthesia, Local; Child; Child, Preschool; Female; Hem

1970
Fetal effects of spinal hypotension. Observations in the dog at term of pregnancy.
    Obstetrics and gynecology, 1971, Volume: 37, Issue:2

    Topics: Anesthesia, Spinal; Animals; Blood Pressure; Bradycardia; Dogs; Female; Fetal Diseases; Fetal Heart;

1971
Blind nasotracheal intubation. A review and a new guided technique.
    Acta anaesthesiologica Scandinavica, 1971, Volume: 15, Issue:2

    Topics: Adolescent; Adult; Aged; Analgesia; Anesthesia, General; Anesthesia, Local; Arteries; Blood Pressure

1971
Tonsillectomy by the new combined method.
    International surgery, 1968, Volume: 49, Issue:4

    Topics: Adolescent; Adult; Anesthesia, General; Anesthesia, Local; Epinephrine; Hemorrhage; Hemostasis; Huma

1968