lidocaine has been researched along with Heart Disease, Ischemic in 67 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
| Excerpt | Relevance | Reference |
|---|---|---|
| "VGSC blockade with lidocaine rescues function of ischemic myocardium as a potential bridging to revascularisation in the setting of perioperative myocardial ischemia." | 7.83 | Lidocaine Enhances Contractile Function of Ischemic Myocardial Regions in Mouse Model of Sustained Myocardial Ischemia. ( Beck-Schimmer, B; Blyszczuk, P; Eriksson, U; Jakob, P; Kania, G; Krasniqi, N; Müller-Edenborn, B; Osto, E, 2016) |
| "To compare the early postarrest inflammatory cytokine response between animals administered amiodarone (AMIO) and lidocaine (LIDO) intra-arrest during resuscitation from ventricular fibrillation (VF)." | 7.79 | Administration of amiodarone during resuscitation is associated with higher tumor necrosis factor-α levels in the early postarrest period in the swine model of ischemic ventricular fibrillation. ( Niemann, JT; Rosborough, JP; Shah, AP; Thomas, JL; Youngquist, ST, 2013) |
| " Combinations of the action potential-widening drug tedisamil (Class III antiarrhythmic activity), and the inactivated state sodium channel blocker lidocaine (Class Ib antiarrhythmic activity) were assessed for antiarrhythmic actions in a rat model of ischaemia-induced arrhythmias and for electrophysiological actions in normal rat myocardial tissue." | 7.72 | Tedisamil and lidocaine enhance each other's antiarrhythmic activity against ischaemia-induced arrhythmias in rats. ( Barrett, TD; Sarraf, G; Walker, MJ, 2003) |
| "The purpose of this study was to investigate the effects of lidocaine and diltiazem on ventricular tachyarrhythmia and dispersion of conduction during severe myocardial ischemia in dogs." | 7.69 | Effects of lidocaine and diltiazem on ventricular tachyarrhythmia and dispersion of conduction during severe myocardial ischemia in canine hearts. ( Kuraoka, F; Kuroiwa, A; Murasato, Y; Nagamoto, Y; Nakashima, Y; Urabe, T, 1997) |
| "The effects of lidocaine and diltiazem on recovery of electrophysiologic activity during partial reperfusion following severe myocardial ischemia were investigated in 28 dogs." | 7.69 | Effects of lidocaine and diltiazem on recovery of electrophysiologic activity during partial reperfusion following severe myocardial ischemia in canine hearts. ( Kuraoka, F; Kuroiwa, A; Murasato, Y; Nagamoto, Y; Nakashima, Y; Urabe, T, 1997) |
| "We compared the ability of a new amiodarone-like agent, SR 33589, with that of amiodarone, D,L-sotalol, and lignocaine to reduce the incidence of ventricular fibrillation (VF) and associated arrhythmias caused by acute coronary artery occlusion in anesthetized pigs." | 7.69 | Effects of a new amiodarone-like agent, SR 33589, in comparison to amiodarone, D,L-sotalol, and lignocaine, on ischemia-induced ventricular arrhythmias in anesthetized pigs. ( Chatelain, P; Finance, O; Manning, A, 1995) |
| "No evidence of ischemic heart disease was detected." | 5.30 | Class IC antiarrhythmic drugs, flecainide and pilsicainide, produce ST segment elevation simulating inferior myocardial ischemia. ( Ito, H; Nakamura, W; Segawa, K; Tanaka, S; Yoshimoto, N, 1998) |
| "We report a patient with chronic renal failure and ischemic heart disease who developed clinically significant methemoglobinemia after an axillary block with bupivacaine and additional injection of lidocaine in the operative field." | 5.30 | Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field. ( Dieterich, HJ; Mühlbauer, B; Schroeder, TH, 1999) |
| "VGSC blockade with lidocaine rescues function of ischemic myocardium as a potential bridging to revascularisation in the setting of perioperative myocardial ischemia." | 3.83 | Lidocaine Enhances Contractile Function of Ischemic Myocardial Regions in Mouse Model of Sustained Myocardial Ischemia. ( Beck-Schimmer, B; Blyszczuk, P; Eriksson, U; Jakob, P; Kania, G; Krasniqi, N; Müller-Edenborn, B; Osto, E, 2016) |
| "To compare the early postarrest inflammatory cytokine response between animals administered amiodarone (AMIO) and lidocaine (LIDO) intra-arrest during resuscitation from ventricular fibrillation (VF)." | 3.79 | Administration of amiodarone during resuscitation is associated with higher tumor necrosis factor-α levels in the early postarrest period in the swine model of ischemic ventricular fibrillation. ( Niemann, JT; Rosborough, JP; Shah, AP; Thomas, JL; Youngquist, ST, 2013) |
| " Combinations of the action potential-widening drug tedisamil (Class III antiarrhythmic activity), and the inactivated state sodium channel blocker lidocaine (Class Ib antiarrhythmic activity) were assessed for antiarrhythmic actions in a rat model of ischaemia-induced arrhythmias and for electrophysiological actions in normal rat myocardial tissue." | 3.72 | Tedisamil and lidocaine enhance each other's antiarrhythmic activity against ischaemia-induced arrhythmias in rats. ( Barrett, TD; Sarraf, G; Walker, MJ, 2003) |
| ") reduced or completely abolished the ventricular fibrillation (VF) induced by reperfusion after 5 min of regional ischemia, while lidocaine, a class I antiarrhythmic agent, showed less effect against VF as compared with FR168888." | 3.70 | Protective effect of FR168888, a new Na+/H+ exchange inhibitor, on ischemia and reperfusion-induced arrhythmia and myocardial infarction in rats: in comparison with other cardioprotective compounds. ( Goto, T; Maeda, K; Ohara, F; Ohkubo, K; Ozaki, T; Seki, J; Sugimoto, T; Yamamoto, N, 1999) |
| "The purpose of this study was to investigate the effects of lidocaine and diltiazem on ventricular tachyarrhythmia and dispersion of conduction during severe myocardial ischemia in dogs." | 3.69 | Effects of lidocaine and diltiazem on ventricular tachyarrhythmia and dispersion of conduction during severe myocardial ischemia in canine hearts. ( Kuraoka, F; Kuroiwa, A; Murasato, Y; Nagamoto, Y; Nakashima, Y; Urabe, T, 1997) |
| "The effects of lidocaine and diltiazem on recovery of electrophysiologic activity during partial reperfusion following severe myocardial ischemia were investigated in 28 dogs." | 3.69 | Effects of lidocaine and diltiazem on recovery of electrophysiologic activity during partial reperfusion following severe myocardial ischemia in canine hearts. ( Kuraoka, F; Kuroiwa, A; Murasato, Y; Nagamoto, Y; Nakashima, Y; Urabe, T, 1997) |
| "During myocardial ischemia, lidocaine has favorable antiarrhythmic properties." | 3.69 | ATP-dependent potassium channel in rat cardiomyocytes is blocked by lidocaine. Possible impact on the antiarrhythmic action of lidocaine. ( Bräu, ME; Hempelmann, G; Olschewski, A; Olschewski, H; Vogel, W, 1996) |
| "We compared the ability of a new amiodarone-like agent, SR 33589, with that of amiodarone, D,L-sotalol, and lignocaine to reduce the incidence of ventricular fibrillation (VF) and associated arrhythmias caused by acute coronary artery occlusion in anesthetized pigs." | 3.69 | Effects of a new amiodarone-like agent, SR 33589, in comparison to amiodarone, D,L-sotalol, and lignocaine, on ischemia-induced ventricular arrhythmias in anesthetized pigs. ( Chatelain, P; Finance, O; Manning, A, 1995) |
| "Because recent clinical studies have failed to show evidence of the benefit of lidocaine in the arrhythmias occurring in the early stage of myocardial infarction and have even shown an increased mortality in patients thus treated, we investigated the value of lidocaine as a protective agent against ventricular fibrillation related to myocardial ischemia in the in situ heart of anesthetized open-chest pigs subjected to transient total occlusion of the proximal left anterior descending coronary artery (LAD) under ventricular pacing at a constant high rate." | 3.69 | Profibrillatory effects of lidocaine in the acutely ischemic porcine heart. ( Aupetit, JF; Barral-Cadière, L; Faucon, G; Freysz, M; Lopez, M; Loufoua-Moundanga, J; Timour, Q, 1995) |
| "The aim of this study was to elucidate whether the electrophysiologic properties of pilsicainide, a novel class IC drug with slow kinetic properties, could be altered in the presence of acute myocardial ischemia." | 3.69 | Ischemia enhances use-dependent sodium channel blockade by pilsicainide, a class IC antiarrhythmic agent. ( Ogawa, S; Sadanaga, T, 1994) |
| "Propranolol and lidocaine are effective antiarrhythmic drugs in myocardial ischemia and infarction." | 3.68 | Propranolol and lidocaine inhibit neural norepinephrine release in hearts with increased extracellular potassium and ischemia. ( Dart, AM; Du, XJ; Fox, KA; Riemersma, RA, 1993) |
| "In isolated hearts, OCT2013 and lidocaine prevented ischaemia-induced VF equi-effectively, but OCT2013 did not share lidocaine's adverse effects (PR widening, bradycardia and negative inotropy)." | 1.72 | OCT2013, an ischaemia-activated antiarrhythmic prodrug, devoid of the systemic side effects of lidocaine. ( Chowdhury, RA; Curtis, MJ; Firth, J; Hesketh, LM; MacLeod, KT; Mahoney-Sanchez, L; Mazzacuva, F; Ogrodzinski, S; Patterson, LH; Peters, NS; Sikkel, MB; Tzortzis, KN; Wilder, CDE; Winter, J, 2022) |
| "Lidocaine treatment abolished almost completely reperfusion arrhythmias in the FO group, but did not display anti-arrhythmic properties in the SSO group." | 1.39 | Mitochondrial basis of the anti-arrhythmic action of lidocaine and modulation by the n-6 to n-3 PUFA ratio of cardiac phospholipids. ( Clauw, F; Demaison, L; Moreau, D; Rochette, L; Vergely, C, 2013) |
| " The use of 10 ml 2% lidocaine with epinephrine 1:100,000 in patients with cardiac disease represent a safe anesthetic procedure." | 1.39 | The evaluation of perioperative safety of local anesthesia with lidocaine containing epinephrine in patients with ischemic heart disease. ( Esmaeili, N; Fathi, HR; Ghazizadeh, S; Naseri, MH; Sadeghi, M; Sadrossadat, H; Sanatkar, M; Shoroughi, M, 2013) |
| "Ranolazine is a drug that exerts antianginal and antiischemic effects and also acts as an antiarrhythmic in isolation and in combination with other class III medications." | 1.37 | Ranolazine reduces ventricular tachycardia burden and ICD shocks in patients with drug-refractory ICD shocks. ( Anderson, JL; Bair, TL; Bunch, TJ; Crandall, BG; Day, JD; Lappe, DL; Mader, KM; Mahapatra, S; May, HT; Molden, J; Muhlestein, JB; Murdock, D; Osborn, JS; Weiss, JP, 2011) |
| "Lidocaine is a class I antiarrhytmic drug that blocks Na(+) channels and exists in both neutral and charged forms at a physiological pH." | 1.36 | Exploring the role of pH in modulating the effects of lidocaine in virtual ischemic tissue. ( Cardona, K; Ferrero, JM; Martínez, M; Moltó, G; Saiz, J; Starmer, F; Trénor, B, 2010) |
| "Lidocaine has been demonstrated to exert antiinflammatory pleiotropic effects." | 1.35 | Lidocaine protects from myocardial damage due to ischemia and reperfusion in mice by its antiapoptotic effects. ( Echtermeyer, F; Gillmann, HJ; Hahnenkamp, K; Harendza, T; Herzog, C; Hildebrand, R; Kaczmarek, DJ; Larmann, J; Osthaus, AW; Schmitz, M; Theilmeier, G; Werdehausen, R; Westermann, A; Wollert, KC, 2009) |
| "Flecainide was equi-effective at low and high concentrations, with VF incidence reduced from 92% to 17% (p < 0." | 1.31 | Limited antifibrillatory effectiveness of clinically relevant concentrations of class I antiarrhythmics in isolated perfused rat hearts. ( Curtis, MJ; Farkas, A, 2002) |
| "No evidence of ischemic heart disease was detected." | 1.30 | Class IC antiarrhythmic drugs, flecainide and pilsicainide, produce ST segment elevation simulating inferior myocardial ischemia. ( Ito, H; Nakamura, W; Segawa, K; Tanaka, S; Yoshimoto, N, 1998) |
| "Lidocaine is a drug widely used to treat arrhythmias in patients with myocardial ischemia." | 1.30 | Effect of lidocaine on left ventricular pressure-volume curves during demand ischemia in pigs. ( Glantz, SA; Solomon, SB; Tayama, M, 1998) |
| "We report a patient with chronic renal failure and ischemic heart disease who developed clinically significant methemoglobinemia after an axillary block with bupivacaine and additional injection of lidocaine in the operative field." | 1.30 | Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field. ( Dieterich, HJ; Mühlbauer, B; Schroeder, TH, 1999) |
| " R56865 was given before ischemia and with the onset of reperfusion, applying different dosing schedules, including an initial loading dose." | 1.29 | R56865 is antifibrillatory in reperfused ischemic guinea-pig hearts, even when given only during reperfusion. ( Guttmann, I; Mozes, A; Scheufler, E; Wilffert, B, 1995) |
| "When isoflurane was discontinued both the ECG and the cardiovascular changes returned to the previous condition." | 1.29 | Repeated episodes of myocardial ischaemia during combined thoracic epidural-isoflurane anaesthesia. ( Brouwer, RP; Sigurdsson, GH; Thomson, D, 1994) |
| "Severe hypertension, ventricular tachycardia and subendocardial ischaemia occurred during the manipulation of adrenal gland in a patient who underwent live related donor nephrectomy." | 1.29 | Hypertension and tachycardia during adrenal manipulation. ( Sikora, R; Tewari, P, 1995) |
| "Lidocaine was also found to inhibit the 1O2-dependent 2,2,6,6-tetramethylpiperidine N-oxyl (TEMPO) formation in a dose dependent manner." | 1.28 | Lidocaine: a hydroxyl radical scavenger and singlet oxygen quencher. ( Das, KC; Misra, HP, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 38 (56.72) | 18.2507 |
| 2000's | 16 (23.88) | 29.6817 |
| 2010's | 12 (17.91) | 24.3611 |
| 2020's | 1 (1.49) | 2.80 |
| Authors | Studies |
|---|---|
| Plouvier, B | 1 |
| Beatch, GN | 1 |
| Jung, GL | 1 |
| Zolotoy, A | 1 |
| Sheng, T | 1 |
| Clohs, L | 1 |
| Barrett, TD | 3 |
| Fedida, D | 1 |
| Wang, WQ | 1 |
| Zhu, JJ | 1 |
| Liu, Y | 1 |
| Abraham, S | 1 |
| Lynn, L | 1 |
| Dong, Y | 1 |
| Wall, RA | 1 |
| Walker, MJ | 3 |
| Hesketh, LM | 1 |
| Sikkel, MB | 1 |
| Mahoney-Sanchez, L | 1 |
| Mazzacuva, F | 1 |
| Chowdhury, RA | 1 |
| Tzortzis, KN | 1 |
| Firth, J | 1 |
| Winter, J | 1 |
| MacLeod, KT | 1 |
| Ogrodzinski, S | 1 |
| Wilder, CDE | 1 |
| Patterson, LH | 1 |
| Peters, NS | 1 |
| Curtis, MJ | 2 |
| Poffers, M | 1 |
| Bühne, N | 1 |
| Herzog, C | 2 |
| Thorenz, A | 1 |
| Chen, R | 1 |
| Güler, F | 1 |
| Hage, A | 1 |
| Leffler, A | 1 |
| Echtermeyer, F | 2 |
| Youngquist, ST | 1 |
| Niemann, JT | 1 |
| Shah, AP | 1 |
| Thomas, JL | 1 |
| Rosborough, JP | 1 |
| Sanatkar, M | 1 |
| Sadeghi, M | 1 |
| Esmaeili, N | 1 |
| Naseri, MH | 1 |
| Sadrossadat, H | 1 |
| Shoroughi, M | 1 |
| Fathi, HR | 1 |
| Ghazizadeh, S | 1 |
| Müller-Edenborn, B | 1 |
| Kania, G | 1 |
| Osto, E | 1 |
| Jakob, P | 1 |
| Krasniqi, N | 1 |
| Beck-Schimmer, B | 1 |
| Blyszczuk, P | 1 |
| Eriksson, U | 1 |
| Omichi, C | 1 |
| Fujimoto, N | 1 |
| Kawasaki, A | 1 |
| Kasai, A | 1 |
| Kaczmarek, DJ | 1 |
| Larmann, J | 1 |
| Gillmann, HJ | 1 |
| Hildebrand, R | 1 |
| Schmitz, M | 1 |
| Westermann, A | 1 |
| Harendza, T | 1 |
| Werdehausen, R | 1 |
| Osthaus, AW | 1 |
| Hahnenkamp, K | 1 |
| Wollert, KC | 1 |
| Theilmeier, G | 1 |
| Garneau, SY | 1 |
| Deschamps, A | 1 |
| Couture, P | 1 |
| Levesque, S | 1 |
| Babin, D | 1 |
| Lambert, J | 1 |
| Tardif, JC | 1 |
| Perrault, LP | 1 |
| Denault, AY | 1 |
| Cardona, K | 1 |
| Trénor, B | 1 |
| Moltó, G | 1 |
| Martínez, M | 1 |
| Ferrero, JM | 1 |
| Starmer, F | 1 |
| Saiz, J | 1 |
| Weiss, SM | 1 |
| Saint, DA | 1 |
| Bunch, TJ | 1 |
| Mahapatra, S | 1 |
| Murdock, D | 1 |
| Molden, J | 1 |
| Weiss, JP | 1 |
| May, HT | 1 |
| Bair, TL | 1 |
| Mader, KM | 1 |
| Crandall, BG | 1 |
| Day, JD | 1 |
| Osborn, JS | 1 |
| Muhlestein, JB | 1 |
| Lappe, DL | 1 |
| Anderson, JL | 1 |
| Farid, TA | 1 |
| Nair, K | 1 |
| Massé, S | 1 |
| Azam, MA | 1 |
| Maguy, A | 1 |
| Lai, PF | 1 |
| Umapathy, K | 1 |
| Dorian, P | 1 |
| Chauhan, V | 1 |
| Varró, A | 1 |
| Al-Hesayen, A | 1 |
| Waxman, M | 1 |
| Nattel, S | 1 |
| Nanthakumar, K | 1 |
| Demaison, L | 1 |
| Moreau, D | 1 |
| Clauw, F | 1 |
| Vergely, C | 1 |
| Rochette, L | 1 |
| Tsuchiya, H | 1 |
| Mizogami, M | 1 |
| Shigemi, K | 1 |
| Sarraf, G | 1 |
| Camara, AK | 1 |
| Chen, Q | 1 |
| Rhodes, SS | 1 |
| Riess, ML | 1 |
| Stowe, DF | 1 |
| Canyon, SJ | 1 |
| Dobson, GP | 1 |
| Niwano, S | 1 |
| Inuo, K | 1 |
| Morohoshi, Y | 1 |
| Nakayama, S | 1 |
| Yuge, M | 1 |
| Imaki, R | 1 |
| Izumi, T | 1 |
| Kanchi, M | 1 |
| Prasad, N | 1 |
| Garg, D | 1 |
| Banakal, SK | 1 |
| Dias, RR | 1 |
| Stolf, NA | 1 |
| Dalva, M | 1 |
| Dias, AR | 1 |
| Moreira, LF | 1 |
| Oliveira, SA | 1 |
| You, B | 1 |
| Pu, J | 1 |
| Liu, N | 1 |
| Yu, R | 1 |
| Ruan, Y | 1 |
| Li, Y | 1 |
| Wang, L | 1 |
| ten Hove, M | 1 |
| Jansen, MA | 1 |
| Nederhoff, MG | 2 |
| Van Echteld, CJ | 2 |
| Elad, S | 1 |
| Admon, D | 1 |
| Kedmi, M | 1 |
| Naveh, E | 1 |
| Benzki, E | 1 |
| Ayalon, S | 1 |
| Tuchband, A | 1 |
| Lutan, H | 1 |
| Kaufman, E | 1 |
| Buffington, CW | 1 |
| Strum, DP | 1 |
| Watanabe, S | 1 |
| Tewari, P | 1 |
| Sikora, R | 1 |
| Aupetit, JF | 2 |
| Timour, Q | 2 |
| Loufoua-Moundanga, J | 2 |
| Barral-Cadière, L | 1 |
| Lopez, M | 1 |
| Freysz, M | 1 |
| Faucon, G | 2 |
| Ye, VZ | 1 |
| Wyse, KR | 1 |
| Campbell, TJ | 1 |
| Patterson, E | 1 |
| Scherlag, BJ | 1 |
| Berlin, KD | 1 |
| Lazzara, R | 1 |
| Kamiyama, T | 1 |
| Tanonaka, K | 2 |
| Harada, H | 1 |
| Nakai, K | 1 |
| Takeo, S | 2 |
| Hélie, F | 1 |
| Cossette, J | 1 |
| Vermeulen, M | 1 |
| Cardinal, R | 1 |
| Cave, AC | 1 |
| Horowitz, GL | 1 |
| Apstein, CS | 1 |
| Sigurdsson, GH | 1 |
| Brouwer, RP | 1 |
| Thomson, D | 1 |
| Van Winkle, DM | 1 |
| Chien, GL | 1 |
| Wolff, RA | 1 |
| Soifer, BE | 1 |
| Kuzume, K | 1 |
| Davis, RF | 1 |
| Sadanaga, T | 1 |
| Ogawa, S | 2 |
| Bellemin-Baurreau, J | 1 |
| Poizot, A | 1 |
| Hicks, PE | 1 |
| Armstrong, JM | 1 |
| Wendland, MF | 1 |
| Saeed, M | 1 |
| Kondo, C | 1 |
| Derugin, N | 1 |
| Higgins, CB | 1 |
| Liu, JX | 1 |
| Ohtsuka, Y | 1 |
| Sakai, Y | 1 |
| Du, XJ | 1 |
| Riemersma, RA | 1 |
| Fox, KA | 1 |
| Dart, AM | 1 |
| Coetzee, A | 1 |
| Moolman, J | 1 |
| Scheufler, E | 1 |
| Mozes, A | 1 |
| Guttmann, I | 1 |
| Wilffert, B | 1 |
| Finance, O | 1 |
| Manning, A | 1 |
| Chatelain, P | 1 |
| Hayes, ES | 1 |
| Olschewski, A | 1 |
| Bräu, ME | 1 |
| Olschewski, H | 1 |
| Hempelmann, G | 1 |
| Vogel, W | 1 |
| Vander Heide, RS | 1 |
| Reimer, KA | 1 |
| Yin, H | 1 |
| el-Sherif, N | 1 |
| Caref, EB | 1 |
| Ndrepepa, G | 1 |
| Levin, R | 1 |
| Isber, N | 1 |
| Stergiopolus, K | 1 |
| Assadi, MA | 1 |
| Gough, WB | 1 |
| Restivo, M | 1 |
| van Emous, JG | 1 |
| Ruigrok, TJ | 1 |
| Murasato, Y | 2 |
| Nagamoto, Y | 2 |
| Urabe, T | 2 |
| Kuraoka, F | 2 |
| Nakashima, Y | 2 |
| Kuroiwa, A | 2 |
| Wolk, R | 1 |
| Cobbe, SM | 1 |
| Hicks, MN | 1 |
| Kane, KA | 2 |
| Lee, R | 1 |
| Nitta, T | 1 |
| Schmid, RA | 1 |
| Schuessler, RB | 1 |
| Harris, KM | 1 |
| Gay, WA | 1 |
| Nakamura, W | 1 |
| Segawa, K | 1 |
| Ito, H | 1 |
| Tanaka, S | 1 |
| Yoshimoto, N | 1 |
| Tayama, M | 1 |
| Solomon, SB | 1 |
| Glantz, SA | 1 |
| Blinder, D | 1 |
| Manor, Y | 1 |
| Shemesh, J | 1 |
| Taicher, S | 1 |
| Schroeder, TH | 1 |
| Dieterich, HJ | 1 |
| Mühlbauer, B | 1 |
| Alsabrook, G | 1 |
| Lazio, L | 1 |
| Lasater, M | 1 |
| Shimada, M | 1 |
| Nakamura, Y | 1 |
| Iwanaga, S | 1 |
| Asakura, K | 1 |
| Hori, S | 1 |
| Hattori, S | 1 |
| Takahashi, M | 1 |
| Ohara, F | 1 |
| Sugimoto, T | 1 |
| Yamamoto, N | 1 |
| Ohkubo, K | 1 |
| Ozaki, T | 1 |
| Maeda, K | 1 |
| Seki, J | 1 |
| Goto, T | 1 |
| Benito Bartolomé, F | 1 |
| Funes Moñux, R | 1 |
| Ebel, D | 1 |
| Lipfert, P | 1 |
| Frässdorf, J | 1 |
| Preckel, B | 1 |
| Müllenheim, J | 1 |
| Thämer, V | 1 |
| Schlack, W | 1 |
| Middlehurst, RJ | 1 |
| Gibbs, A | 1 |
| Walton, G | 1 |
| Crockett, TR | 1 |
| Scott, GA | 1 |
| McGowan, NW | 1 |
| Wainwright, CL | 1 |
| Bazzani, C | 1 |
| Mioni, C | 1 |
| Ferrazza, G | 1 |
| Cainazzo, MM | 1 |
| Bertolini, A | 1 |
| Guarini, S | 1 |
| Farkas, A | 1 |
| Zhang, L | 1 |
| Li, S | 1 |
| Liu, Q | 1 |
| Luo, H | 1 |
| Xiao, J | 1 |
| Xue, Z | 1 |
| Das, KC | 1 |
| Misra, HP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Study for the Evaluation of the Effectiveness of Stellate Ganglion Blockade in Preventing Postoperative Atrial Fibrillation[NCT03269383] | Phase 4 | 0 participants (Actual) | Interventional | 2019-12-31 | Withdrawn (stopped due to Lack of funding and other logistical issues) | ||
| Occurrence of Heart Arrhythmia During Restorative Dental Procedure Under Local Anesthesia , in Heart Failure Pacients. A Double-blind Study[NCT02228083] | 70 participants (Anticipated) | Interventional | 2014-09-30 | Recruiting | |||
| Maternal-Fetal Monitoring of Patients With Rheumatic Heart Disease During Dental Procedure Under Local Anesthesia[NCT00482573] | Phase 1 | 31 participants (Actual) | Interventional | 2004-04-30 | Completed | ||
| Safety of Local Dental Anesthesia in Patients With Cardiac Channelopathies[NCT03182777] | 31 participants (Actual) | Interventional | 2015-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for lidocaine and Heart Disease, Ischemic
| Article | Year |
|---|---|
Prophylactic magnesium sulphate vs. lidocaine during off-pump coronary artery bypass grafting.
Topics: Analysis of Variance; Anesthetics, Local; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Art | 2004 |
The cardiovascular effect of local anesthesia with articaine plus 1:200,000 adrenalin versus lidocaine plus 1:100,000 adrenalin in medically compromised cardiac patients: a prospective, randomized, double blinded study.
Topics: Analysis of Variance; Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Blood Pressure; Car | 2008 |
Cardiovascular risk: the safety of local anesthesia, vasoconstrictors, and sedation in heart disease.
Topics: Anesthesia, Dental; Anesthetics, Local; Arrhythmias, Cardiac; Blood Pressure; Conscious Sedation; El | 1999 |
64 other studies available for lidocaine and Heart Disease, Ischemic
| Article | Year |
|---|---|
Synthesis and biological studies of novel 2-aminoalkylethers as potential antiarrhythmic agents for the conversion of atrial fibrillation.
Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Biological Availability; | 2007 |
OCT2013, an ischaemia-activated antiarrhythmic prodrug, devoid of the systemic side effects of lidocaine.
Topics: Animals; Anti-Arrhythmia Agents; Ischemia; Lidocaine; Myocardial Ischemia; Prodrugs; Rats; Rats, Wis | 2022 |
Sodium Channel Nav1.3 Is Expressed by Polymorphonuclear Neutrophils during Mouse Heart and Kidney Ischemia In Vivo and Regulates Adhesion, Transmigration, and Chemotaxis of Human and Mouse Neutrophils In Vitro.
Topics: Animals; Cell Adhesion; Chemotaxis; Gene Expression; Humans; Kidney; Lidocaine; Male; Mice; Mice, In | 2018 |
Administration of amiodarone during resuscitation is associated with higher tumor necrosis factor-α levels in the early postarrest period in the swine model of ischemic ventricular fibrillation.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Cardiopulmonary Resuscitation; Coronary Vessels; Diseas | 2013 |
The evaluation of perioperative safety of local anesthesia with lidocaine containing epinephrine in patients with ischemic heart disease.
Topics: Aged; Anesthetics, Local; Coronary Angiography; Electrocardiography; Epinephrine; Female; Humans; Li | 2013 |
Lidocaine Enhances Contractile Function of Ischemic Myocardial Regions in Mouse Model of Sustained Myocardial Ischemia.
Topics: Animals; Diastole; Disease Models, Animal; Electrocardiography; Lidocaine; Mice; Mice, Inbred BALB C | 2016 |
Ischemia-induced Brugada-type ST-segment alternans and Brugada syndrome.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Brugada Syndrome; Bundle-Branch Block; Coronary Artery | 2010 |
Lidocaine protects from myocardial damage due to ischemia and reperfusion in mice by its antiapoptotic effects.
Topics: Animals; Apoptosis; Cardiotonic Agents; Lidocaine; Mice; Myocardial Ischemia; Myocardial Reperfusion | 2009 |
Preliminary experience in the use of preoperative echo-guided left stellate ganglion block in patients undergoing cardiac surgery.
Topics: Aged; Anesthesia, General; Anesthetics, Local; Arrhythmias, Cardiac; Autonomic Nerve Block; Blood Pr | 2011 |
Exploring the role of pH in modulating the effects of lidocaine in virtual ischemic tissue.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Guinea Pigs; Heart Ventricles; Hydrogen-Ion Conc | 2010 |
The persistent sodium current blocker riluzole is antiarrhythmic and anti-ischaemic in a pig model of acute myocardial infarction.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Female; Heart; Lidocaine | 2010 |
Ranolazine reduces ventricular tachycardia burden and ICD shocks in patients with drug-refractory ICD shocks.
Topics: Acetanilides; Aged; Amiodarone; Anti-Arrhythmia Agents; Cardiomyopathy, Dilated; Cohort Studies; Def | 2011 |
Role of KATP channels in the maintenance of ventricular fibrillation in cardiomyopathic human hearts.
Topics: Action Potentials; Animals; Cardiomyopathy, Dilated; Endocardium; Glyburide; Humans; In Vitro Techni | 2011 |
Mitochondrial basis of the anti-arrhythmic action of lidocaine and modulation by the n-6 to n-3 PUFA ratio of cardiac phospholipids.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Diet; Dietary Fats; Fatty Acids, Ome | 2013 |
Increasing membrane interactions of local anaesthetics as hypothetic mechanism for their cardiotoxicity enhanced by myocardial ischaemia.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Anesthetics, Local; Animals; Bupivacaine; Cardiolipins; Chemical | 2012 |
Tedisamil and lidocaine enhance each other's antiarrhythmic activity against ischaemia-induced arrhythmias in rats.
Topics: Animals; Anti-Asthmatic Agents; Arrhythmias, Cardiac; Blood Pressure; Bridged Bicyclo Compounds, Het | 2003 |
Negative inotropic drugs alter indexes of cytosolic [Ca(2+)]-left ventricular pressure relationships after ischemia.
Topics: Animals; Benzopyrans; Calcium; Calcium Channel Blockers; Cardiotonic Agents; Cytosol; Diacetyl; Dihy | 2004 |
Protection against ventricular arrhythmias and cardiac death using adenosine and lidocaine during regional ischemia in the in vivo rat.
Topics: Adenosine; Animals; Anti-Arrhythmia Agents; Drug Combinations; Hemodynamics; Lidocaine; Male; Myocar | 2004 |
Mexiletine protects myocardium during acute ischemia by opening sarcolemmal K-ATP channel: studies in closed-chest acute ischemia model in rabbits.
Topics: Acute Disease; Animals; Anti-Arrhythmia Agents; ATP-Binding Cassette Transporters; Disease Models, A | 2004 |
Inclusion of lidocaine in cardioplegic solutions provides additional myocardial protection.
Topics: Animals; Anti-Arrhythmia Agents; Cardiac Surgical Procedures; Cardioplegic Solutions; Creatine Kinas | 2004 |
Effect of lidocaine and amiodarone on transmural heterogeneity of ventricular repolarization in isolated rabbit hearts model of sustained global ischemia.
Topics: Action Potentials; Amiodarone; Animals; Anti-Arrhythmia Agents; Electrocardiography; Female; Heart V | 2005 |
Combined blockade of the Na+ channel and the Na+/H+ exchanger virtually prevents ischemic Na+ overload in rat hearts.
Topics: Animals; Blood Pressure; Guanidines; Heart; Heart Rate; Hydrogen-Ion Concentration; Lidocaine; Magne | 2007 |
Regional oxygen consumption persists in dyskinetic canine myocardium.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Citrates; Coronary Circulation; Diacetyl; Dogs; H | 1994 |
Hypertension and tachycardia during adrenal manipulation.
Topics: Adrenal Glands; Follow-Up Studies; Humans; Hypertension; Intraoperative Complications; Kidney Transp | 1995 |
Profibrillatory effects of lidocaine in the acutely ischemic porcine heart.
Topics: Action Potentials; Animals; Cardiac Pacing, Artificial; Coronary Disease; Disease Models, Animal; El | 1995 |
Lidocaine shows greater selective depression of depolarized and acidotic myocardium than propafenone: possible implications for proarrhythmia.
Topics: Action Potentials; Analysis of Variance; Animals; Arrhythmias, Cardiac; Female; Guinea Pigs; Heart; | 1993 |
Electrophysiologic actions of BRB-I-28 in ischemically injured canine myocardium.
Topics: Animals; Anti-Arrhythmia Agents; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; | 1993 |
Mexiletine and lidocaine reduce post-ischemic functional and biochemical dysfunction of perfused hearts.
Topics: Adenosine Triphosphate; Animals; Calcium; Creatine Kinase; Lidocaine; Mexiletine; Myocardial Contrac | 1995 |
Differential effects of lignocaine and hypercalcaemia on anisotropic conduction and reentry in the ischaemically damaged canine ventricle.
Topics: Animals; Anisotropy; Dogs; Electrophysiology; Female; Heart Conduction System; Hypercalcemia; Lidoca | 1995 |
Can ischemic preconditioning protect against hypoxia-induced damage? Studies of contractile function in isolated perfused rat hearts.
Topics: Animals; Arrhythmias, Cardiac; Coronary Circulation; Energy Metabolism; Heart; Hypoxia; Lidocaine; M | 1994 |
Repeated episodes of myocardial ischaemia during combined thoracic epidural-isoflurane anaesthesia.
Topics: Anesthesia, Epidural; Anesthesia, Inhalation; Aortic Aneurysm, Abdominal; Blood Pressure; Cardiac Ou | 1994 |
Cardioprotection provided by adenosine receptor activation is abolished by blockade of the KATP channel.
Topics: Adenosine; Adenosine Triphosphate; Animals; Blood Pressure; Cardiotonic Agents; Coronary Vessels; He | 1994 |
Ischemia enhances use-dependent sodium channel blockade by pilsicainide, a class IC antiarrhythmic agent.
Topics: Acute Disease; Aged; Analysis of Variance; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chi-Square | 1994 |
An in vitro method for the evaluation of antiarrhythmic and antiischemic agents by using programmed electrical stimulation of rabbit heart.
Topics: Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Electric Stimulation; Glycine; Heart; | 1994 |
Effect of lidocaine on acute regional myocardial ischemia and reperfusion in the cat. An in-vivo 31P magnetic resonance spectroscopy study.
Topics: Animals; Cats; Female; Hemodynamics; Lidocaine; Magnetic Resonance Spectroscopy; Male; Myocardial Is | 1993 |
Improvement of ischemia/reperfusion-induced contractile dysfunction of perfused hearts by class Ic antiarrhythmic agents.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Creatine Kinase; Flecainide; Heart; Lidocai | 1993 |
Propranolol and lidocaine inhibit neural norepinephrine release in hearts with increased extracellular potassium and ischemia.
Topics: Animals; Extracellular Space; Heart; Lidocaine; Male; Myocardial Ischemia; Norepinephrine; Perfusion | 1993 |
Halothane and the reperfusion injury in the intact animal model.
Topics: Animals; Arrhythmias, Cardiac; Disease Models, Animal; Dose-Response Relationship, Drug; Halothane; | 1993 |
R56865 is antifibrillatory in reperfused ischemic guinea-pig hearts, even when given only during reperfusion.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Benzothiazoles; Calcium; Calcium Channel Block | 1995 |
Effects of a new amiodarone-like agent, SR 33589, in comparison to amiodarone, D,L-sotalol, and lignocaine, on ischemia-induced ventricular arrhythmias in anesthetized pigs.
Topics: Amiodarone; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzofurans | 1995 |
Lack of selectivity for ventricular and ischaemic tissue limits the antiarrhythmic actions of lidocaine, quinidine and flecainide against ischaemia-induced arrhythmias.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Dose-Response Relationship, Drug; Electrocardiograp | 1995 |
ATP-dependent potassium channel in rat cardiomyocytes is blocked by lidocaine. Possible impact on the antiarrhythmic action of lidocaine.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Humans; In Vitro Tech | 1996 |
Effect of adenosine therapy at reperfusion on myocardial infarct size in dogs.
Topics: Adenosine; Animals; Dogs; Female; Lidocaine; Male; Myocardial Infarction; Myocardial Ischemia; Myoca | 1996 |
Ischaemia-induced loss or reversal of the effects of the class I antiarrhythmic drugs on vulnerability to fibrillation.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Coronary Vessels; Disopyramide; Electric Stimulatio | 1997 |
Actions of lidocaine on reentrant ventricular rhythms in the subacute myocardial infarction period in dogs.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Heart Conduction System; Heart Rate; Li | 1997 |
The role of the Na+ channel in the accumulation of intracellular Na+ during myocardial ischemia: consequences for post-ischemic recovery.
Topics: Animals; Anti-Arrhythmia Agents; Combined Modality Therapy; Drug Evaluation, Preclinical; In Vitro T | 1997 |
Effects of lidocaine and diltiazem on recovery of electrophysiologic activity during partial reperfusion following severe myocardial ischemia in canine hearts.
Topics: Animals; Anti-Arrhythmia Agents; Blood Flow Velocity; Coronary Vessels; Diltiazem; Disease Models, A | 1997 |
Effects of lidocaine and diltiazem on ventricular tachyarrhythmia and dispersion of conduction during severe myocardial ischemia in canine hearts.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Dogs; Heart Conduction System; Lidocaine; Myocardial I | 1997 |
Effects of lignocaine on dispersion of repolarisation and refractoriness in a working rabbit heart model of regional myocardial ischaemia.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrophysiology; Heart C | 1998 |
Retrograde infusion of lidocaine or L-arginine before reperfusion reduces myocardial infarct size.
Topics: Anesthetics, Local; Animals; Arginine; Cardiovascular Agents; Coloring Agents; Coronary Vessels; Ech | 1998 |
Class IC antiarrhythmic drugs, flecainide and pilsicainide, produce ST segment elevation simulating inferior myocardial ischemia.
Topics: Anti-Arrhythmia Agents; Diagnosis, Differential; Drug Therapy, Combination; Electrocardiography; Fle | 1998 |
Effect of lidocaine on left ventricular pressure-volume curves during demand ischemia in pigs.
Topics: Animals; Blood Pressure; Cardiotonic Agents; Diastole; Female; Lidocaine; Myocardial Ischemia; Strok | 1998 |
Electrocardiographic changes in cardiac patients having dental extractions under a local anesthetic containing a vasopressor.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Dental; Anesthetics, Local; Arrhythmias, Cardiac; Contra | 1998 |
Electrocardiographic changes in cardiac patients having dental extractions under a local anesthetic containing a vasopressor.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Dental; Anesthetics, Local; Arrhythmias, Cardiac; Contra | 1998 |
Electrocardiographic changes in cardiac patients having dental extractions under a local anesthetic containing a vasopressor.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Dental; Anesthetics, Local; Arrhythmias, Cardiac; Contra | 1998 |
Electrocardiographic changes in cardiac patients having dental extractions under a local anesthetic containing a vasopressor.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Dental; Anesthetics, Local; Arrhythmias, Cardiac; Contra | 1998 |
Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field.
Topics: Acidosis; Alkalies; Anesthetics, Local; Antidotes; Axilla; Bupivacaine; Drug Interactions; Female; H | 1999 |
Noninvasive assessment of hemodynamic characteristics in an episode of sustained narrow-complex tachycardia.
Topics: Adenosine; Anti-Arrhythmia Agents; Cardiac Catheterization; Drug Monitoring; Electric Impedance; Hem | 1999 |
Nonischemic ST-segment elevation induced by negative inotropic agents.
Topics: Adenosine; Animals; Depression, Chemical; Dogs; Dyskinesia, Drug-Induced; Electrocardiography; Femal | 1999 |
Protective effect of FR168888, a new Na+/H+ exchange inhibitor, on ischemia and reperfusion-induced arrhythmia and myocardial infarction in rats: in comparison with other cardioprotective compounds.
Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Benzyl Alcohol; Benzyl Alcohols; Diltiazem; Dose-Response | 1999 |
[Efficacy of lidocaine in neonatal ischemic ventricular tachycardia].
Topics: Anti-Arrhythmia Agents; Humans; Infant, Newborn; Lidocaine; Male; Myocardial Ischemia; Postoperative | 2001 |
Lidocaine reduces ischaemic but not reperfusion injury in isolated rat heart.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Creatine Kinase; Lidocaine; Male; Metabolic Clear | 2001 |
Anti-arrhythmic and electrophysiological effects of the endothelin receptor antagonists, BQ-123 and PD161721.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Function; Dioxins; Dose-Response Relat | 2001 |
Involvement of the central nervous system in the protective effect of melanocortins in myocardial ischaemia/reperfusion injury.
Topics: Adrenocorticotropic Hormone; Animals; Central Nervous System; Disease Models, Animal; Dose-Response | 2002 |
Limited antifibrillatory effectiveness of clinically relevant concentrations of class I antiarrhythmics in isolated perfused rat hearts.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Circulation; Electrocardiography; Fl | 2002 |
[Relation between the occurrence of malignant arrhythmia during acute myocardial ischemia and the weight of ischemic myocardium in goats].
Topics: Animals; Goats; Lidocaine; Male; Myocardial Ischemia; Myocardium; Tachycardia, Ventricular; Ventricu | 1992 |
Lidocaine: a hydroxyl radical scavenger and singlet oxygen quencher.
Topics: Cyclic N-Oxides; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Free Radica | 1992 |