Page last updated: 2024-10-28

lidocaine and Generalized Vulvodynia

lidocaine has been researched along with Generalized Vulvodynia in 16 studies

Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.

Research Excerpts

ExcerptRelevanceReference
"Key messagesPeripheral lidocaine and oestradiol and centrally-targeted nortriptyline medications are used for the treatment of pain in women with VBD, but there is a lack of data from well-powered RCTs."5.51Rationale and design of a multicenter randomized clinical trial of vestibulodynia: understanding pathophysiology and determining appropriate treatments (vestibulodynia: UPDATe). ( Akaninwor, J; Bortsov, A; Carey, ET; Cutting, H; DeLaRosa, J; Farb, D; Geller, EJ; Luo, S; McNulty, S; Merrill, P; Nackley, AG; Rapkin, A; Stirling, C; Zakroysky, P, 2022)
"Intent-to-treat multilevel analyses showed that for women, CBCT yielded significantly more improvements than lidocaine in pain unpleasantness at 6-month follow-up, pain anxiety and pain catastrophizing at post-treatment and 6-month follow-up, and sexual distress at post-treatment, and resulted in better treatment satisfaction and global sexuality improvements at both time points."5.41Cognitive-behavioral couple therapy versus lidocaine for provoked vestibulodynia: A randomized clinical trial. ( Bergeron, S; Corsini-Munt, S; Delisle, I; Mayrand, MH; Rosen, NO; Steben, M; Vaillancourt-Morel, MP, 2021)
"The purpose of this study was to compare techniques and pain scales that assess tenderness in the vulvar vestibule in provoked vestibulodynia, using the cotton swab test and a vulvalgesiometer, and assess topical lidocaine solution with each."5.41Comparing Vestibule Examination Techniques: Light Touch, Serial Forces, and the Lidocaine Test. ( Goetsch, MF; Leclair, CM; Stenson, AL, 2021)
"Severe unprovoked vestibulodynia can present as unprovoked generalized pain in late menopause, and topical lidocaine can aid the diagnosis."3.78Unprovoked vestibular burning in late estrogen-deprived menopause: a case series. ( Goetsch, MF, 2012)
"Provoked vestibulodynia (PVD) is a chronic vulvovaginal pain condition affecting 8%-10% of women and is associated with negative sexual sequalae."3.11Sexual communication mediates cognitive-behavioral couple therapy outcomes: A randomized clinical trial for provoked vestibulodynia. ( Bergeron, S; Delisle, I; Lee-Baggley, D; Rancourt, KM; Rosen, NO; Vaillancourt-Morel, MP, 2022)
"Provoked vestibulodynia is a vulvar pain condition causing sexual dysfunction, affecting 8% to 10% of women."3.01Predictors and Moderators of Provoked Vestibulodynia Treatment Outcome Following a Randomized Trial Comparing Cognitive-Behavioral Couple Therapy to Overnight Lidocaine. ( Baxter, ML; Bergeron, S; Corsini-Munt, S; Delisle, I; Rosen, NO; Steben, M; Vaillancourt-Morel, MP, 2021)
"The etiology of vulvodynia remains unknown, making it difficult to identify or develop effective treatment methods."3.01Evaluation and Treatment of Vulvodynia: State of the Science. ( Glayzer, EJ; Glayzer, JE; He, Y; Kobak, WH; Li, H; McFarlin, BL; Schlaeger, JM; Takakura, N; Takayama, M; Villegas-Downs, M; Yajima, H, 2023)
"Provoked vestibulodynia is the most common subtype of chronic vulvar pain."3.01Multimodal physical therapy versus topical lidocaine for provoked vestibulodynia: a multicenter, randomized trial. ( Bergeron, S; Dubois, MF; Dumoulin, C; Khalifé, S; Mayrand, MH; Morin, M; Waddell, G, 2021)
"Provoked vestibulodynia (PVD) is a highly prevalent and debilitating condition yet its management relies mainly on non-empirically validated interventions."2.82Randomized clinical trial of multimodal physiotherapy treatment compared to overnight lidocaine ointment in women with provoked vestibulodynia: Design and methods. ( Bergeron, S; Dubois, MF; Dumoulin, C; Khalifé, S; Mayrand, MH; Morin, M; Waddell, G, 2016)
"Provoked vestibulodynia (PVD), a frequent form of chronic genital pain, is associated with decreased sexual function for afflicted women, as well as impoverished sexual satisfaction for women and their partners."2.79A comparison of cognitive-behavioral couple therapy and lidocaine in the treatment of provoked vestibulodynia: study protocol for a randomized clinical trial. ( Aerts, L; Bergeron, S; Corsini-Munt, S; Delisle, I; Mayrand, MH; McDuff, P; Rosen, NO; Santerre-Baillargeon, M; Steben, M, 2014)
"Lidocaine release was based on a diffusion mechanism rather than through film dissolution and faster release (∼5 min) was observed for HEC films compared HPC films (∼120 min)."1.72A mucoadhesive biodissolvable thin film for localized and rapid delivery of lidocaine for the treatment of vestibulodynia. ( Ban, J; Button, B; Carey, ET; Dahl, DK; Fox, RJ; Janusziewicz, R; Loznev, HT; Maturavongsadit, P; Montgomery, SA; Rahima Benhabbour, S; Schorzman, AN; Sharma-Huynh, P; Whitesell, AN; Zamboni, W, 2022)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's7 (43.75)24.3611
2020's9 (56.25)2.80

Authors

AuthorsStudies
Rosen, NO4
Vaillancourt-Morel, MP3
Corsini-Munt, S3
Steben, M3
Delisle, I4
Baxter, ML1
Bergeron, S6
Dahl, DK1
Whitesell, AN1
Sharma-Huynh, P1
Maturavongsadit, P1
Janusziewicz, R1
Fox, RJ1
Loznev, HT1
Button, B1
Schorzman, AN1
Zamboni, W1
Ban, J1
Montgomery, SA1
Carey, ET2
Rahima Benhabbour, S1
Rancourt, KM1
Lee-Baggley, D1
Close, A1
Culha, MG1
Albert, V1
Valancogne, G1
Geller, EJ1
Rapkin, A1
Farb, D1
Cutting, H1
Akaninwor, J1
Stirling, C1
Bortsov, A1
McNulty, S1
Merrill, P1
Zakroysky, P1
DeLaRosa, J1
Luo, S1
Nackley, AG1
Schlaeger, JM1
Glayzer, JE1
Villegas-Downs, M1
Li, H1
Glayzer, EJ1
He, Y1
Takayama, M1
Yajima, H1
Takakura, N1
Kobak, WH1
McFarlin, BL1
Hullender Rubin, LE1
Mist, SD1
Schnyer, RN1
Chao, MT1
Leclair, CM2
Morin, M2
Dumoulin, C2
Mayrand, MH4
Khalifé, S2
Waddell, G2
Dubois, MF2
Stenson, AL1
Goetsch, MF2
Pérez-López, FR1
Bueno-Notivol, J1
Hernandez, AV1
Vieira-Baptista, P1
Preti, M1
Bornstein, J1
Corbett, SH1
Cuddeback, G1
Lewis, J1
As-Sanie, S1
Zolnoun, D1
McDuff, P1
Aerts, L1
Santerre-Baillargeon, M1
Foster, DC1
Kotok, MB1
Huang, LS1
Watts, A1
Oakes, D1
Howard, FM1
Poleshuck, EL1
Stodgell, CJ1
Dworkin, RH1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Acupuncture Augmentation of Lidocaine for the Treatment of Provoked, Localized vulvodynia-a Feasibility and Acceptability Pilot Study[NCT01996384]Phase 119 participants (Actual)Interventional2013-11-30Completed
Telerehabilitation in Chronic Pelvic Pain[NCT05698355]43 participants (Anticipated)Interventional2023-01-16Recruiting
Efficacy of Treatments for Provoked Vestivulodynia : a Randomised Clinical Trial Comparing Multimodal Physiotherapy Treatments to Topical Lidocaine[NCT01455350]212 participants (Actual)Interventional2011-10-31Completed
A Comparison of Cognitive-behavioral Couple Therapy and Lidocaine in the Treatment of Provoked Vestibulodynia: A Randomized Clinical Trial[NCT01935063]108 participants (Actual)Interventional2014-03-06Completed
Vulvar Vestibulitis Trial: Desipramine-Lidocaine[NCT00276068]128 participants (Anticipated)Interventional2002-08-31Completed
Randomized Controlled Trial of Fractional CO2 Laser vs Sham Laser for Women With Provoked Vestibulodynia Who Have Failed Conservative Management[NCT03390049]0 participants (Actual)Interventional2018-08-31Withdrawn (stopped due to No funding)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for lidocaine and Generalized Vulvodynia

ArticleYear
Evaluation and Treatment of Vulvodynia: State of the Science.
    Journal of midwifery & women's health, 2023, Volume: 68, Issue:1

    Topics: Amitriptyline; Female; Humans; Lidocaine; Transcutaneous Electric Nerve Stimulation; Treatment Outco

2023
Systematic review and meta-analysis of the effects of treatment modalities for vestibulodynia in women.
    The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception, 2019, Volume: 24, Issue:5

    Topics: Administration, Intravaginal; Administration, Oral; Adult; Anesthetics, Local; Desipramine; Dyspareu

2019

Trials

10 trials available for lidocaine and Generalized Vulvodynia

ArticleYear
Predictors and Moderators of Provoked Vestibulodynia Treatment Outcome Following a Randomized Trial Comparing Cognitive-Behavioral Couple Therapy to Overnight Lidocaine.
    Behavior therapy, 2021, Volume: 52, Issue:6

    Topics: Cognition; Couples Therapy; Female; Humans; Lidocaine; Sexual Behavior; Sexual Partners; Surveys and

2021
Sexual communication mediates cognitive-behavioral couple therapy outcomes: A randomized clinical trial for provoked vestibulodynia.
    Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43), 2022, Volume: 36, Issue:7

    Topics: Cognition; Communication; Couples Therapy; Female; Humans; Lidocaine; Pain; Personal Satisfaction; S

2022
Rationale and design of a multicenter randomized clinical trial of vestibulodynia: understanding pathophysiology and determining appropriate treatments (vestibulodynia: UPDATe).
    Annals of medicine, 2022, Volume: 54, Issue:1

    Topics: Antidepressive Agents, Tricyclic; Cytokines; Estradiol; Female; Humans; Lidocaine; MicroRNAs; Multic

2022
Acupuncture Augmentation of Lidocaine for Provoked, Localized Vulvodynia: A Feasibility and Acceptability Study.
    Journal of lower genital tract disease, 2019, Volume: 23, Issue:4

    Topics: Acupuncture; Adolescent; Adult; Anesthetics, Local; Female; Humans; Lidocaine; Middle Aged; Patient

2019
Multimodal physical therapy versus topical lidocaine for provoked vestibulodynia: a multicenter, randomized trial.
    American journal of obstetrics and gynecology, 2021, Volume: 224, Issue:2

    Topics: Administration, Topical; Adult; Anesthetics, Local; Biofeedback, Psychology; Coitus; Dilatation; Fem

2021
Multimodal physical therapy versus topical lidocaine for provoked vestibulodynia: a multicenter, randomized trial.
    American journal of obstetrics and gynecology, 2021, Volume: 224, Issue:2

    Topics: Administration, Topical; Adult; Anesthetics, Local; Biofeedback, Psychology; Coitus; Dilatation; Fem

2021
Multimodal physical therapy versus topical lidocaine for provoked vestibulodynia: a multicenter, randomized trial.
    American journal of obstetrics and gynecology, 2021, Volume: 224, Issue:2

    Topics: Administration, Topical; Adult; Anesthetics, Local; Biofeedback, Psychology; Coitus; Dilatation; Fem

2021
Multimodal physical therapy versus topical lidocaine for provoked vestibulodynia: a multicenter, randomized trial.
    American journal of obstetrics and gynecology, 2021, Volume: 224, Issue:2

    Topics: Administration, Topical; Adult; Anesthetics, Local; Biofeedback, Psychology; Coitus; Dilatation; Fem

2021
Cognitive-behavioral couple therapy versus lidocaine for provoked vestibulodynia: A randomized clinical trial.
    Journal of consulting and clinical psychology, 2021, Volume: 89, Issue:4

    Topics: Adult; Anxiety; Catastrophization; Cognitive Behavioral Therapy; Couples Therapy; Female; Humans; In

2021
Comparing Vestibule Examination Techniques: Light Touch, Serial Forces, and the Lidocaine Test.
    Journal of lower genital tract disease, 2021, Jul-01, Volume: 25, Issue:3

    Topics: Adult; Anesthetics, Local; Female; Humans; Lidocaine; Oregon; Pain; Pain Measurement; Touch; Vulva;

2021
A comparison of cognitive-behavioral couple therapy and lidocaine in the treatment of provoked vestibulodynia: study protocol for a randomized clinical trial.
    Trials, 2014, Dec-23, Volume: 15

    Topics: Administration, Intravaginal; Adolescent; Adult; Anesthetics, Local; Chronic Pain; Clinical Protocol

2014
Randomized clinical trial of multimodal physiotherapy treatment compared to overnight lidocaine ointment in women with provoked vestibulodynia: Design and methods.
    Contemporary clinical trials, 2016, Volume: 46

    Topics: Academic Medical Centers; Administration, Topical; Adult; Anesthetics, Local; Anxiety; Catastrophiza

2016
Oral desipramine and topical lidocaine for vulvodynia: a randomized controlled trial.
    Obstetrics and gynecology, 2010, Volume: 116, Issue:3

    Topics: Administration, Intravaginal; Administration, Oral; Adult; Anesthetics, Local; Antidepressive Agents

2010
Oral desipramine and topical lidocaine for vulvodynia: a randomized controlled trial.
    Obstetrics and gynecology, 2010, Volume: 116, Issue:3

    Topics: Administration, Intravaginal; Administration, Oral; Adult; Anesthetics, Local; Antidepressive Agents

2010
Oral desipramine and topical lidocaine for vulvodynia: a randomized controlled trial.
    Obstetrics and gynecology, 2010, Volume: 116, Issue:3

    Topics: Administration, Intravaginal; Administration, Oral; Adult; Anesthetics, Local; Antidepressive Agents

2010
Oral desipramine and topical lidocaine for vulvodynia: a randomized controlled trial.
    Obstetrics and gynecology, 2010, Volume: 116, Issue:3

    Topics: Administration, Intravaginal; Administration, Oral; Adult; Anesthetics, Local; Antidepressive Agents

2010

Other Studies

4 other studies available for lidocaine and Generalized Vulvodynia

ArticleYear
A mucoadhesive biodissolvable thin film for localized and rapid delivery of lidocaine for the treatment of vestibulodynia.
    International journal of pharmaceutics, 2022, Jan-25, Volume: 612

    Topics: Anesthetics, Local; Animals; Drug Compounding; Drug Liberation; Female; Lidocaine; Mice; Vulvodynia

2022
Exclusive manual perineal rehabilitation with lidocaine 2% gel in the treatment of provoked vestibulodynia: results from a single-arm interventional study.
    International journal of impotence research, 2023, Volume: 35, Issue:2

    Topics: Adult; Female; Humans; Lidocaine; Pain; Quality of Life; Surveys and Questionnaires; Treatment Outco

2023
Trends in pharmacy compounding for women's health in North Carolina: focus on vulvodynia.
    Southern medical journal, 2014, Volume: 107, Issue:7

    Topics: Androgens; Anesthetics, Local; Drug Combinations; Drug Compounding; Estradiol; Estriol; Estrogens; F

2014
Unprovoked vestibular burning in late estrogen-deprived menopause: a case series.
    Journal of lower genital tract disease, 2012, Volume: 16, Issue:4

    Topics: Aged; Anesthetics, Local; Estrogens; Female; Humans; Lidocaine; Menopause; Middle Aged; Vulvodynia

2012
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