lidocaine and Generalized Vulvodynia
lidocaine has been researched along with Generalized Vulvodynia in 16 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"Key messagesPeripheral lidocaine and oestradiol and centrally-targeted nortriptyline medications are used for the treatment of pain in women with VBD, but there is a lack of data from well-powered RCTs." | 5.51 | Rationale and design of a multicenter randomized clinical trial of vestibulodynia: understanding pathophysiology and determining appropriate treatments (vestibulodynia: UPDATe). ( Akaninwor, J; Bortsov, A; Carey, ET; Cutting, H; DeLaRosa, J; Farb, D; Geller, EJ; Luo, S; McNulty, S; Merrill, P; Nackley, AG; Rapkin, A; Stirling, C; Zakroysky, P, 2022) |
"Intent-to-treat multilevel analyses showed that for women, CBCT yielded significantly more improvements than lidocaine in pain unpleasantness at 6-month follow-up, pain anxiety and pain catastrophizing at post-treatment and 6-month follow-up, and sexual distress at post-treatment, and resulted in better treatment satisfaction and global sexuality improvements at both time points." | 5.41 | Cognitive-behavioral couple therapy versus lidocaine for provoked vestibulodynia: A randomized clinical trial. ( Bergeron, S; Corsini-Munt, S; Delisle, I; Mayrand, MH; Rosen, NO; Steben, M; Vaillancourt-Morel, MP, 2021) |
"The purpose of this study was to compare techniques and pain scales that assess tenderness in the vulvar vestibule in provoked vestibulodynia, using the cotton swab test and a vulvalgesiometer, and assess topical lidocaine solution with each." | 5.41 | Comparing Vestibule Examination Techniques: Light Touch, Serial Forces, and the Lidocaine Test. ( Goetsch, MF; Leclair, CM; Stenson, AL, 2021) |
"Severe unprovoked vestibulodynia can present as unprovoked generalized pain in late menopause, and topical lidocaine can aid the diagnosis." | 3.78 | Unprovoked vestibular burning in late estrogen-deprived menopause: a case series. ( Goetsch, MF, 2012) |
"Provoked vestibulodynia (PVD) is a chronic vulvovaginal pain condition affecting 8%-10% of women and is associated with negative sexual sequalae." | 3.11 | Sexual communication mediates cognitive-behavioral couple therapy outcomes: A randomized clinical trial for provoked vestibulodynia. ( Bergeron, S; Delisle, I; Lee-Baggley, D; Rancourt, KM; Rosen, NO; Vaillancourt-Morel, MP, 2022) |
"Provoked vestibulodynia is a vulvar pain condition causing sexual dysfunction, affecting 8% to 10% of women." | 3.01 | Predictors and Moderators of Provoked Vestibulodynia Treatment Outcome Following a Randomized Trial Comparing Cognitive-Behavioral Couple Therapy to Overnight Lidocaine. ( Baxter, ML; Bergeron, S; Corsini-Munt, S; Delisle, I; Rosen, NO; Steben, M; Vaillancourt-Morel, MP, 2021) |
"The etiology of vulvodynia remains unknown, making it difficult to identify or develop effective treatment methods." | 3.01 | Evaluation and Treatment of Vulvodynia: State of the Science. ( Glayzer, EJ; Glayzer, JE; He, Y; Kobak, WH; Li, H; McFarlin, BL; Schlaeger, JM; Takakura, N; Takayama, M; Villegas-Downs, M; Yajima, H, 2023) |
"Provoked vestibulodynia is the most common subtype of chronic vulvar pain." | 3.01 | Multimodal physical therapy versus topical lidocaine for provoked vestibulodynia: a multicenter, randomized trial. ( Bergeron, S; Dubois, MF; Dumoulin, C; Khalifé, S; Mayrand, MH; Morin, M; Waddell, G, 2021) |
"Provoked vestibulodynia (PVD) is a highly prevalent and debilitating condition yet its management relies mainly on non-empirically validated interventions." | 2.82 | Randomized clinical trial of multimodal physiotherapy treatment compared to overnight lidocaine ointment in women with provoked vestibulodynia: Design and methods. ( Bergeron, S; Dubois, MF; Dumoulin, C; Khalifé, S; Mayrand, MH; Morin, M; Waddell, G, 2016) |
"Provoked vestibulodynia (PVD), a frequent form of chronic genital pain, is associated with decreased sexual function for afflicted women, as well as impoverished sexual satisfaction for women and their partners." | 2.79 | A comparison of cognitive-behavioral couple therapy and lidocaine in the treatment of provoked vestibulodynia: study protocol for a randomized clinical trial. ( Aerts, L; Bergeron, S; Corsini-Munt, S; Delisle, I; Mayrand, MH; McDuff, P; Rosen, NO; Santerre-Baillargeon, M; Steben, M, 2014) |
"Lidocaine release was based on a diffusion mechanism rather than through film dissolution and faster release (∼5 min) was observed for HEC films compared HPC films (∼120 min)." | 1.72 | A mucoadhesive biodissolvable thin film for localized and rapid delivery of lidocaine for the treatment of vestibulodynia. ( Ban, J; Button, B; Carey, ET; Dahl, DK; Fox, RJ; Janusziewicz, R; Loznev, HT; Maturavongsadit, P; Montgomery, SA; Rahima Benhabbour, S; Schorzman, AN; Sharma-Huynh, P; Whitesell, AN; Zamboni, W, 2022) |
Research
Studies (16)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 7 (43.75) | 24.3611 |
2020's | 9 (56.25) | 2.80 |
Authors
Authors | Studies |
---|---|
Rosen, NO | 4 |
Vaillancourt-Morel, MP | 3 |
Corsini-Munt, S | 3 |
Steben, M | 3 |
Delisle, I | 4 |
Baxter, ML | 1 |
Bergeron, S | 6 |
Dahl, DK | 1 |
Whitesell, AN | 1 |
Sharma-Huynh, P | 1 |
Maturavongsadit, P | 1 |
Janusziewicz, R | 1 |
Fox, RJ | 1 |
Loznev, HT | 1 |
Button, B | 1 |
Schorzman, AN | 1 |
Zamboni, W | 1 |
Ban, J | 1 |
Montgomery, SA | 1 |
Carey, ET | 2 |
Rahima Benhabbour, S | 1 |
Rancourt, KM | 1 |
Lee-Baggley, D | 1 |
Close, A | 1 |
Culha, MG | 1 |
Albert, V | 1 |
Valancogne, G | 1 |
Geller, EJ | 1 |
Rapkin, A | 1 |
Farb, D | 1 |
Cutting, H | 1 |
Akaninwor, J | 1 |
Stirling, C | 1 |
Bortsov, A | 1 |
McNulty, S | 1 |
Merrill, P | 1 |
Zakroysky, P | 1 |
DeLaRosa, J | 1 |
Luo, S | 1 |
Nackley, AG | 1 |
Schlaeger, JM | 1 |
Glayzer, JE | 1 |
Villegas-Downs, M | 1 |
Li, H | 1 |
Glayzer, EJ | 1 |
He, Y | 1 |
Takayama, M | 1 |
Yajima, H | 1 |
Takakura, N | 1 |
Kobak, WH | 1 |
McFarlin, BL | 1 |
Hullender Rubin, LE | 1 |
Mist, SD | 1 |
Schnyer, RN | 1 |
Chao, MT | 1 |
Leclair, CM | 2 |
Morin, M | 2 |
Dumoulin, C | 2 |
Mayrand, MH | 4 |
Khalifé, S | 2 |
Waddell, G | 2 |
Dubois, MF | 2 |
Stenson, AL | 1 |
Goetsch, MF | 2 |
Pérez-López, FR | 1 |
Bueno-Notivol, J | 1 |
Hernandez, AV | 1 |
Vieira-Baptista, P | 1 |
Preti, M | 1 |
Bornstein, J | 1 |
Corbett, SH | 1 |
Cuddeback, G | 1 |
Lewis, J | 1 |
As-Sanie, S | 1 |
Zolnoun, D | 1 |
McDuff, P | 1 |
Aerts, L | 1 |
Santerre-Baillargeon, M | 1 |
Foster, DC | 1 |
Kotok, MB | 1 |
Huang, LS | 1 |
Watts, A | 1 |
Oakes, D | 1 |
Howard, FM | 1 |
Poleshuck, EL | 1 |
Stodgell, CJ | 1 |
Dworkin, RH | 1 |
Clinical Trials (6)
Trial Overview
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Acupuncture Augmentation of Lidocaine for the Treatment of Provoked, Localized vulvodynia-a Feasibility and Acceptability Pilot Study[NCT01996384] | Phase 1 | 19 participants (Actual) | Interventional | 2013-11-30 | Completed | ||
Telerehabilitation in Chronic Pelvic Pain[NCT05698355] | 43 participants (Anticipated) | Interventional | 2023-01-16 | Recruiting | |||
Efficacy of Treatments for Provoked Vestivulodynia : a Randomised Clinical Trial Comparing Multimodal Physiotherapy Treatments to Topical Lidocaine[NCT01455350] | 212 participants (Actual) | Interventional | 2011-10-31 | Completed | |||
A Comparison of Cognitive-behavioral Couple Therapy and Lidocaine in the Treatment of Provoked Vestibulodynia: A Randomized Clinical Trial[NCT01935063] | 108 participants (Actual) | Interventional | 2014-03-06 | Completed | |||
Vulvar Vestibulitis Trial: Desipramine-Lidocaine[NCT00276068] | 128 participants (Anticipated) | Interventional | 2002-08-31 | Completed | |||
Randomized Controlled Trial of Fractional CO2 Laser vs Sham Laser for Women With Provoked Vestibulodynia Who Have Failed Conservative Management[NCT03390049] | 0 participants (Actual) | Interventional | 2018-08-31 | Withdrawn (stopped due to No funding) | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Reviews
2 reviews available for lidocaine and Generalized Vulvodynia
Article | Year |
---|---|
Evaluation and Treatment of Vulvodynia: State of the Science.
Topics: Amitriptyline; Female; Humans; Lidocaine; Transcutaneous Electric Nerve Stimulation; Treatment Outco | 2023 |
Systematic review and meta-analysis of the effects of treatment modalities for vestibulodynia in women.
Topics: Administration, Intravaginal; Administration, Oral; Adult; Anesthetics, Local; Desipramine; Dyspareu | 2019 |
Trials
10 trials available for lidocaine and Generalized Vulvodynia
Article | Year |
---|---|
Predictors and Moderators of Provoked Vestibulodynia Treatment Outcome Following a Randomized Trial Comparing Cognitive-Behavioral Couple Therapy to Overnight Lidocaine.
Topics: Cognition; Couples Therapy; Female; Humans; Lidocaine; Sexual Behavior; Sexual Partners; Surveys and | 2021 |
Sexual communication mediates cognitive-behavioral couple therapy outcomes: A randomized clinical trial for provoked vestibulodynia.
Topics: Cognition; Communication; Couples Therapy; Female; Humans; Lidocaine; Pain; Personal Satisfaction; S | 2022 |
Rationale and design of a multicenter randomized clinical trial of vestibulodynia: understanding pathophysiology and determining appropriate treatments (vestibulodynia: UPDATe).
Topics: Antidepressive Agents, Tricyclic; Cytokines; Estradiol; Female; Humans; Lidocaine; MicroRNAs; Multic | 2022 |
Acupuncture Augmentation of Lidocaine for Provoked, Localized Vulvodynia: A Feasibility and Acceptability Study.
Topics: Acupuncture; Adolescent; Adult; Anesthetics, Local; Female; Humans; Lidocaine; Middle Aged; Patient | 2019 |
Multimodal physical therapy versus topical lidocaine for provoked vestibulodynia: a multicenter, randomized trial.
Topics: Administration, Topical; Adult; Anesthetics, Local; Biofeedback, Psychology; Coitus; Dilatation; Fem | 2021 |
Multimodal physical therapy versus topical lidocaine for provoked vestibulodynia: a multicenter, randomized trial.
Topics: Administration, Topical; Adult; Anesthetics, Local; Biofeedback, Psychology; Coitus; Dilatation; Fem | 2021 |
Multimodal physical therapy versus topical lidocaine for provoked vestibulodynia: a multicenter, randomized trial.
Topics: Administration, Topical; Adult; Anesthetics, Local; Biofeedback, Psychology; Coitus; Dilatation; Fem | 2021 |
Multimodal physical therapy versus topical lidocaine for provoked vestibulodynia: a multicenter, randomized trial.
Topics: Administration, Topical; Adult; Anesthetics, Local; Biofeedback, Psychology; Coitus; Dilatation; Fem | 2021 |
Cognitive-behavioral couple therapy versus lidocaine for provoked vestibulodynia: A randomized clinical trial.
Topics: Adult; Anxiety; Catastrophization; Cognitive Behavioral Therapy; Couples Therapy; Female; Humans; In | 2021 |
Comparing Vestibule Examination Techniques: Light Touch, Serial Forces, and the Lidocaine Test.
Topics: Adult; Anesthetics, Local; Female; Humans; Lidocaine; Oregon; Pain; Pain Measurement; Touch; Vulva; | 2021 |
A comparison of cognitive-behavioral couple therapy and lidocaine in the treatment of provoked vestibulodynia: study protocol for a randomized clinical trial.
Topics: Administration, Intravaginal; Adolescent; Adult; Anesthetics, Local; Chronic Pain; Clinical Protocol | 2014 |
Randomized clinical trial of multimodal physiotherapy treatment compared to overnight lidocaine ointment in women with provoked vestibulodynia: Design and methods.
Topics: Academic Medical Centers; Administration, Topical; Adult; Anesthetics, Local; Anxiety; Catastrophiza | 2016 |
Oral desipramine and topical lidocaine for vulvodynia: a randomized controlled trial.
Topics: Administration, Intravaginal; Administration, Oral; Adult; Anesthetics, Local; Antidepressive Agents | 2010 |
Oral desipramine and topical lidocaine for vulvodynia: a randomized controlled trial.
Topics: Administration, Intravaginal; Administration, Oral; Adult; Anesthetics, Local; Antidepressive Agents | 2010 |
Oral desipramine and topical lidocaine for vulvodynia: a randomized controlled trial.
Topics: Administration, Intravaginal; Administration, Oral; Adult; Anesthetics, Local; Antidepressive Agents | 2010 |
Oral desipramine and topical lidocaine for vulvodynia: a randomized controlled trial.
Topics: Administration, Intravaginal; Administration, Oral; Adult; Anesthetics, Local; Antidepressive Agents | 2010 |
Other Studies
4 other studies available for lidocaine and Generalized Vulvodynia
Article | Year |
---|---|
A mucoadhesive biodissolvable thin film for localized and rapid delivery of lidocaine for the treatment of vestibulodynia.
Topics: Anesthetics, Local; Animals; Drug Compounding; Drug Liberation; Female; Lidocaine; Mice; Vulvodynia | 2022 |
Exclusive manual perineal rehabilitation with lidocaine 2% gel in the treatment of provoked vestibulodynia: results from a single-arm interventional study.
Topics: Adult; Female; Humans; Lidocaine; Pain; Quality of Life; Surveys and Questionnaires; Treatment Outco | 2023 |
Trends in pharmacy compounding for women's health in North Carolina: focus on vulvodynia.
Topics: Androgens; Anesthetics, Local; Drug Combinations; Drug Compounding; Estradiol; Estriol; Estrogens; F | 2014 |
Unprovoked vestibular burning in late estrogen-deprived menopause: a case series.
Topics: Aged; Anesthetics, Local; Estrogens; Female; Humans; Lidocaine; Menopause; Middle Aged; Vulvodynia | 2012 |