Page last updated: 2024-10-28

lidocaine and Erythema

lidocaine has been researched along with Erythema in 48 studies

Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.

Erythema: Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of disease processes.

Research Excerpts

ExcerptRelevanceReference
"The aim of this study was to compare the efficacy of topical piroxicam and EMLA cream on pain control and subsequent inflammation in neodymium:yttrium-aluminum-garnet (Nd:YAG) 1,064 nm laser hair removal in female volunteers."9.14A clinical comparison of topical piroxicam and EMLA cream for pain relief and inflammation in laser hair removal. ( Akinturk, S; Eroglu, A, 2009)
"Pain scores with piroxicam gel were higher on cannulation and on advancement of the cannula (P < 0."9.10Piroxicam gel, compared to EMLA cream is associated with less pain after venous cannulation in volunteers. ( Dutta, A; Puri, GD; Wig, J, 2003)
"We found that ketoprofen (but not hydroxyzine or lidocaine) significantly attenuated tDCS-induced erythema regarding intensity and duration, with a medium effect compared with placebo."5.20Reducing transcranial direct current stimulation-induced erythema with skin pretreatment: considerations for sham-controlled clinical trials. ( Benseñor, IM; Bikson, M; Boggio, PS; Brunoni, AR; Caumo, W; Cordeiro, Q; Guarienti, F; Lotufo, PA; Shiozawa, P, 2015)
"The aim of this study was to compare the efficacy of topical piroxicam and EMLA cream on pain control and subsequent inflammation in neodymium:yttrium-aluminum-garnet (Nd:YAG) 1,064 nm laser hair removal in female volunteers."5.14A clinical comparison of topical piroxicam and EMLA cream for pain relief and inflammation in laser hair removal. ( Akinturk, S; Eroglu, A, 2009)
"To examine the efficacy and safety of a new topical anesthetic containing a disinfection ingredient (LidoDin cream) in reducing the pain associated with venipuncture by comparing it with the proven eutectic mixture of lidocaine 2."5.14Lidocaine-based topical anesthetic with disinfectant (LidoDin) versus EMLA for venipuncture: a randomized controlled trial. ( Hadash, A; Kassis, I; Knaani-Levinz, H; Shachor-Meyouhas, Y; Shavit, I, 2009)
"Twenty patients with localized neuropathic pain [postoperative neuropathic pain (n = 14); complex regional pain syndrome (n = 2); and postherpetic neuralgia (n = 4)], who had been successfully treated with 5% lidocaine medicated plaster, were followed up by telephone interview after 3 and 5 years."5.14Long-term treatment of neuropathic pain with a 5% lidocaine medicated plaster. ( Griessinger, N; Likar, R; Sittl, R; Tzabazis, A; Wilhelm, IR, 2010)
"To determine whether brief, focal pretreatment of children's skin with low-frequency ultrasound followed by a 5-minute application of a 4% lidocaine topical anesthetic decreases the pain of intravenous (IV) catheter placement."5.12Brief focal ultrasound with topical anesthetic decreases the pain of intravenous placement in children. ( Bates, A; Becker, BM; Lovgren, K; Minugh, PA; Skarbek-Borowska, S, 2006)
"Pain scores with piroxicam gel were higher on cannulation and on advancement of the cannula (P < 0."5.10Piroxicam gel, compared to EMLA cream is associated with less pain after venous cannulation in volunteers. ( Dutta, A; Puri, GD; Wig, J, 2003)
"A chart review was performed and patients who presented with erythema of face, neck, chest, and extremities pretreated with topical anesthesia (23% lidocaine/7% tetracaine ointment or 7% lidocaine/7% tetracaine ointment) undergoing PDL were reviewed and compared with another group without anesthesia."3.96The Efficacy of Pulsed Dye Laser Pretreated With or Without Local Anesthetic on Patients Presenting With Erythema of Face, Neck, Chest, and Extremities. ( Alhaddad, M; Boen, M; Chunharas, C; Wu, DC, 2020)
" The validity and utility of this in vivo system were demonstrated in a skin blanching/reddening experiment using epinephrine and lidocaine, and in a study measuring the severity of radiation-induced erythema during radiation therapy."3.80Inexpensive diffuse reflectance spectroscopy system for measuring changes in tissue optical properties. ( Farrell, TJ; Glennie, DL; Hayward, JE; McKee, DE, 2014)
"Pain and potential adverse events (AE) remain challenges for patients being treated with calcium hydroxylapatite (CaHA; Radiesse), especially CaHA not mixed with an anesthetic."2.79Safety and effectiveness of injection of calcium hydroxylapatite via blunt cannula compared to injection by needle for correction of nasolabial folds. ( Beer, KR, 2014)
"Flare, spontaneous pain, and primary and secondary hyperalgesia to punctate mechanical stimuli were assessed after the incision had been made."2.70Different mechanisms of development and maintenance of experimental incision-induced hyperalgesia in human skin. ( Kawamata, M; Kawamata, T; Kozuka, Y; Namiki, A; Nishikawa, K; Omote, K; Takahashi, T; Watanabe, H, 2002)
"Pain was evaluated on a visual analog scale (VAS, 0-10)."2.69[Efficacy of EMLA cream, effect of time and place of application]. ( Cano Serrano, ME; Martínez-Tellería, A; Rufino Ruiz, J, 1999)
" The most common adverse events generally involve mild skin reactions."2.42Safety and tolerability of the lidocaine patch 5%, a targeted peripheral analgesic: a review of the literature. ( Alvarez, NA; Galer, BS; Gammaitoni, AR, 2003)
"Localized neuropathic pain (LNP) is a subgroup of neuropathic pain characterized by consistent and circumscribed area(s) of maximum pain, associated with negative or positive sensory signs and/or spontaneous symptoms characteristic of NP."1.48Efficacy of lidocaine 5% medicated plaster (VERSATIS®) in patients with localized neuropathic pain poorly responsive to pharmacological therapy. ( Chinellato, E; Del Balzo, G; Martini, A; Parolini, M; Picelli, A; Polati, E; Schweiger, V; Tamburin, S; Zanzotti, M, 2018)
"The Safety of Microfocused Ultrasound with Visualization (MFU-V) has been well established in both controlled clinical studies and in clinical use, showing only mild and transient anticipated side effects and only rare unanticipated adverse events (AEs)."1.40Review of the safety profile for microfocused ultrasound with visualization. ( Dobke, MK; Hitchcock, TM, 2014)

Research

Studies (48)

TimeframeStudies, this research(%)All Research%
pre-19905 (10.42)18.7374
1990's12 (25.00)18.2507
2000's16 (33.33)29.6817
2010's13 (27.08)24.3611
2020's2 (4.17)2.80

Authors

AuthorsStudies
Li, L1
Cai, B1
Li, H1
Wei, J1
Tao, L1
Ma, P1
Chunharas, C1
Boen, M1
Alhaddad, M1
Wu, DC1
Kwon, HJ1
Lee, SJ1
Kim, JM1
Park, KY1
Martini, A1
Del Balzo, G1
Schweiger, V1
Zanzotti, M1
Picelli, A1
Parolini, M1
Chinellato, E1
Tamburin, S1
Polati, E1
Dickison, P1
Smith, SD1
Zhu, X1
Li, F1
Peng, X1
Zeng, K1
Sanaei-Zadeh, H1
Guarienti, F1
Caumo, W1
Shiozawa, P1
Cordeiro, Q1
Boggio, PS1
Benseñor, IM1
Lotufo, PA1
Bikson, M1
Brunoni, AR1
Glennie, DL1
Hayward, JE1
McKee, DE1
Farrell, TJ1
Beer, KR1
Hitchcock, TM1
Dobke, MK1
Akinturk, S1
Eroglu, A1
Shavit, I1
Hadash, A1
Knaani-Levinz, H1
Shachor-Meyouhas, Y1
Kassis, I1
Wilhelm, IR1
Tzabazis, A1
Likar, R1
Sittl, R1
Griessinger, N1
Cilurzo, F1
Minghetti, P1
Gennari, CG1
Casiraghi, A1
Montanari, L1
Lupo, MP1
Swetman, G1
Waller, W1
Glück, J1
Rymarczyk, B1
Rogala, B1
Kawamata, M1
Watanabe, H1
Nishikawa, K1
Takahashi, T1
Kozuka, Y1
Kawamata, T1
Omote, K1
Namiki, A1
Gammaitoni, AR2
Alvarez, NA1
Galer, BS1
Haderer, A1
Gerner, P1
Kao, G1
Srinivasa, V1
Wang, GK1
Fasting, S1
Gisvold, SE1
Dutta, A1
Puri, GD1
Wig, J1
Moppett, IK1
Szypula, K1
Yeoman, PM1
Koppert, W1
Brueckl, V1
Weidner, C1
Schmelz, M1
Migdal, M1
Chudzynska-Pomianowska, E1
Vause, E1
Henry, E1
Lazar, J1
Skarbek-Borowska, S1
Becker, BM1
Lovgren, K1
Bates, A1
Minugh, PA1
Ogden, L1
Love, G1
Basta, S1
Lederman, DA1
Freedman, PD1
Kerpel, SM1
Lumerman, H1
Lawson, RA1
Smart, NG1
Gudgeon, AC1
Morton, NS1
Jackson, D1
Chen, AH1
Bennett, CR1
Rowbotham, MC1
Davies, PS1
Fields, HL1
Oshima, T1
Kashiki, K1
Toyooka, H1
Masuda, A1
Amaha, K1
Sharara, AM1
Higham, MA1
Iredale, MJ1
Ind, PW1
Groth, L1
Serup, J1
Hewitt, T1
Scales, K1
Martínez-Tellería, A1
Cano Serrano, ME1
Rufino Ruiz, J1
Mattsson, U2
Cassuto, J2
Jontell, M2
Jönsson, A2
Sinclair, R1
Tarnow, P2
Khatri, KA1
Machado, A1
Magro, C1
Davenport, S1
Davis, MW1
Dong, H1
Kerl, H1
Cerroni, L1
Nakai, S1
Iikura, Y1
Akimoto, K1
Shiraki, K1
Monteiro-Riviere, NA1
Villada, G1
Zetlaoui, J1
Revuz, J1
Bjerring, P1
Andersen, PH1
Arendt-Nielsen, L1
Soschin, D1
Leyden, JJ1
Wuepper, KD1
Bokisch, VA1
Müller-Eberhard, HJ1
Stoughton, RB1
Greaves, MW1
Birkett, D1
Johnson, C1

Clinical Trials (10)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparison Between the Effects of Lidocaine Prilocaine Cream and Lidocaine Injection on Reduction of Perineal Pain During Episiotomy and Perineum Repair in Vaginal Delivery: Randomized Control Trial[NCT05891132]60 participants (Anticipated)Interventional2023-09-01Not yet recruiting
Randomized Double Blind Clinical Trial on the Effect of Levobupivacaine Infiltration Versus Placebo on the Post Partum Perineal Pain in Episiotomy in Primiparous Women After Instrumental Delivery[NCT02796547]Phase 20 participants (Actual)Interventional2016-07-14Withdrawn (stopped due to Lack of human ressources)
A Randomized Controlled Trial of Lidocaine Patch for Lower Limb Amputation Pain[NCT02696720]Phase 20 participants (Actual)Interventional2016-05-13Withdrawn (stopped due to Lack of recruitment)
Diode Laser as a Biomarker for Neuropathic Pain of Peripheral Origin.[NCT06030297]301 participants (Anticipated)Interventional2022-11-01Recruiting
Lidocaine Patches Prior to Percutaneous Nerve Evaluation[NCT05783219]Phase 234 participants (Anticipated)Interventional2023-05-01Recruiting
Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444]Phase 213 participants (Actual)Interventional2017-05-23Terminated (stopped due to Efficacy was not seen after interim analysis)
The PATCH Trial: Effectiveness and Safety of 5% Lidocaine-medicated Plaster for the Treatment of Trigeminal Neuralgia[NCT04570293]Phase 4226 participants (Actual)Interventional2021-05-01Completed
A Comparison of Amethocaine Creams Versus Liposomal Lidocaine Cream as Pain Reliever Prior to Venipuncture in Children at the Paediatric Emergency Department.[NCT00353002]0 participants (Actual)Interventional2006-07-31Withdrawn
The Efficacy of the Eutectic Mixture of Local Anesthetics (EMLA) Cream Versus the Synera Patch for Pain Reduction During Venipuncture in Children[NCT00530803]Phase 2100 participants (Actual)Interventional2007-06-30Completed
Maternal-Fetal Monitoring of Patients With Rheumatic Heart Disease During Dental Procedure Under Local Anesthesia[NCT00482573]Phase 131 participants (Actual)Interventional2004-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Peak Itch Intensity Between the Vehicle and Active Treatments (Individual and KeAmLi-combo).

"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes

InterventionIntensity score (Mean)
Topical KeAmLi Combo62.7
Topical Ketamine63.1
Topical Amitriptyline69.2
Topical Lidocaine65.8
Topical Vehicle61.9

Mechanical Thresholds (Mechanical Detection and Pain).

Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes

,,,,
InterventionmN (Mean)
Mechanical Detection ThresholdMechanical Pain Threshold
Topical Amitriptyline3.573423965152.4768146
Topical KeAmLi Combo3.519376956152.3293608
Topical Ketamine3.464204768135.9
Topical Lidocaine3.546037659126.9
Topical Vehicle3.525692637148.7138273

Thermal Threshold Detection (Warmth and Heat Pain)

Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes

,,,,
InterventionDegrees celsius (Mean)
Warm Detection ThresholdHeat Pain Threshold
Topical Amitriptyline33.940.0
Topical KeAmLi Combo33.639.8
Topical Ketamine34.040.0
Topical Lidocaine33.739.4
Topical Vehicle33.839.7

Blinded Observer's Subjective Ratings of Participants' Pain Level at Tourniquet Placement, Using a 6-point NRS

The NRS (Numerical Rating Scale) is a 6-point rating scale where 0= no pain and 5 = worst pain. Blinded observers reported their own subjective evaluation of the level of pain experienced by the participants at tourniquet placement. Total number of participants subjectively evaluated as experiencing each pain level is reported. (NCT00530803)
Timeframe: before venipuncture

,
InterventionParticipants (Count of Participants)
Participants evaluated at NRS = 0 (No pain)Participants evaluated at NRS = 1Participants evaluated at NRS = 2Participants evaluated at NRS = 3Participants evaluated at NRS = 4Participants evaluated at NRS = 5
EMLA Cream4162100
Synera Patch3765110

Blinded Observer's Subjective Ratings of the Participant's Pain Level at 5 Minutes Post Venipuncture Procedure, Using a 6-point NRS

The NRS (Numerical Rating Scale) is a 6-point rating scale where 0= no pain and 5 = worst pain. Blinded observers reported their own subjective evaluation of the level of pain participants were experiencing 5 minutes after the venipuncture was completed. Total number of participants subjectively evaluated as experiencing each pain level is reported. (NCT00530803)
Timeframe: 5 minutes post venipuncture

,
InterventionParticipants (Count of Participants)
Participants evaluated at NRS = 0 (No pain)Participants evaluated at NRS = 1Participants evaluated at NRS = 2Participants evaluated at NRS = 3Participants evaluated at NRS = 4Participants evaluated at NRS = 5
EMLA Cream4531100
Synera Patch4541000

Blinded Observer's Subjective Ratings of the Participant's Pain Level at Needle Insertion, Using a 6-point NRS

The NRS (Numerical Rating Scale) is a 6-point rating scale where 0= no pain and 5 = worst pain. Blinded observers reported their own subjective evaluation of the level of pain experienced by the participants at needle insertion. Total number of participants subjectively evaluated as experiencing each pain level is reported. (NCT00530803)
Timeframe: during needle insertion

,
InterventionParticipants (Count of Participants)
Participants evaluated at NRS = 0 (No pain)Participants evaluated at NRS = 1Participants evaluated at NRS = 2Participants evaluated at NRS = 3Participants evaluated at NRS = 4Participants evaluated at NRS = 5
EMLA Cream32142200
Synera Patch25129220

Parent Rating of Child's Pain Using a 6-point NRS

The Numerical Rating Scale (NRS) is a 6-point rating scale where 0= no pain and 5 = worst pain. Parents reported their own subjective evaluation of participants pain level. Each participant had only one parental assessment. Total number of parental assessment for each pain level on the 6-point NRS is reported as total number of participants experiencing that pain level. (NCT00530803)
Timeframe: immediately after venipuncture is completed

,
InterventionParticipants (Count of Participants)
number of participants with NRS=0 (no pain)number of participants with NRS=1number of participants with NRS=2number of participants with NRS=3number of participants with NRS=4number of participants with NRS=5
EMLA Cream4261100
Synera Patch4151201

Participants Self-rating of Pain Using the Wong-Baker FACES Pain Rating Scale.

"Participants were asked to report their level of pain using a 6-point Wong-Baker FACES Pain Rating Scale ranging from 0, no pain, to 5, the most pain you can have. The Wong-Baker FACES Pain Rating Scale is a validated tool for measuring pain in patients as young as 3 years old. A FACES pain score less than or equal to 2 is considered no pain to mild pain, and is clinically acceptable. Studies have shown average FACES pain scores for children receiving vascular access with placebo to be 2.2 to 3.5." (NCT00530803)
Timeframe: immediately after completion of venipuncture

,
InterventionParticipants (Count of Participants)
Participants with FACES Score = 0 (No pain)Participants with FACES Score = 1Participants with FACES Score = 2Participants with FACES Score = 3Participants with FACES Score = 4Participants with FACES Score = 5
EMLA Cream4262000
Synera Patch3883100

Reviews

1 review available for lidocaine and Erythema

ArticleYear
Safety and tolerability of the lidocaine patch 5%, a targeted peripheral analgesic: a review of the literature.
    Journal of clinical pharmacology, 2003, Volume: 43, Issue:2

    Topics: Administration, Cutaneous; Aged; Analgesia; Area Under Curve; Biological Availability; Clinical Tria

2003
Safety and tolerability of the lidocaine patch 5%, a targeted peripheral analgesic: a review of the literature.
    Journal of clinical pharmacology, 2003, Volume: 43, Issue:2

    Topics: Administration, Cutaneous; Aged; Analgesia; Area Under Curve; Biological Availability; Clinical Tria

2003
Safety and tolerability of the lidocaine patch 5%, a targeted peripheral analgesic: a review of the literature.
    Journal of clinical pharmacology, 2003, Volume: 43, Issue:2

    Topics: Administration, Cutaneous; Aged; Analgesia; Area Under Curve; Biological Availability; Clinical Tria

2003
Safety and tolerability of the lidocaine patch 5%, a targeted peripheral analgesic: a review of the literature.
    Journal of clinical pharmacology, 2003, Volume: 43, Issue:2

    Topics: Administration, Cutaneous; Aged; Analgesia; Area Under Curve; Biological Availability; Clinical Tria

2003
Safety and tolerability of the lidocaine patch 5%, a targeted peripheral analgesic: a review of the literature.
    Journal of clinical pharmacology, 2003, Volume: 43, Issue:2

    Topics: Administration, Cutaneous; Aged; Analgesia; Area Under Curve; Biological Availability; Clinical Tria

2003
Safety and tolerability of the lidocaine patch 5%, a targeted peripheral analgesic: a review of the literature.
    Journal of clinical pharmacology, 2003, Volume: 43, Issue:2

    Topics: Administration, Cutaneous; Aged; Analgesia; Area Under Curve; Biological Availability; Clinical Tria

2003
Safety and tolerability of the lidocaine patch 5%, a targeted peripheral analgesic: a review of the literature.
    Journal of clinical pharmacology, 2003, Volume: 43, Issue:2

    Topics: Administration, Cutaneous; Aged; Analgesia; Area Under Curve; Biological Availability; Clinical Tria

2003
Safety and tolerability of the lidocaine patch 5%, a targeted peripheral analgesic: a review of the literature.
    Journal of clinical pharmacology, 2003, Volume: 43, Issue:2

    Topics: Administration, Cutaneous; Aged; Analgesia; Area Under Curve; Biological Availability; Clinical Tria

2003
Safety and tolerability of the lidocaine patch 5%, a targeted peripheral analgesic: a review of the literature.
    Journal of clinical pharmacology, 2003, Volume: 43, Issue:2

    Topics: Administration, Cutaneous; Aged; Analgesia; Area Under Curve; Biological Availability; Clinical Tria

2003
Safety and tolerability of the lidocaine patch 5%, a targeted peripheral analgesic: a review of the literature.
    Journal of clinical pharmacology, 2003, Volume: 43, Issue:2

    Topics: Administration, Cutaneous; Aged; Analgesia; Area Under Curve; Biological Availability; Clinical Tria

2003
Safety and tolerability of the lidocaine patch 5%, a targeted peripheral analgesic: a review of the literature.
    Journal of clinical pharmacology, 2003, Volume: 43, Issue:2

    Topics: Administration, Cutaneous; Aged; Analgesia; Area Under Curve; Biological Availability; Clinical Tria

2003
Safety and tolerability of the lidocaine patch 5%, a targeted peripheral analgesic: a review of the literature.
    Journal of clinical pharmacology, 2003, Volume: 43, Issue:2

    Topics: Administration, Cutaneous; Aged; Analgesia; Area Under Curve; Biological Availability; Clinical Tria

2003
Safety and tolerability of the lidocaine patch 5%, a targeted peripheral analgesic: a review of the literature.
    Journal of clinical pharmacology, 2003, Volume: 43, Issue:2

    Topics: Administration, Cutaneous; Aged; Analgesia; Area Under Curve; Biological Availability; Clinical Tria

2003
Safety and tolerability of the lidocaine patch 5%, a targeted peripheral analgesic: a review of the literature.
    Journal of clinical pharmacology, 2003, Volume: 43, Issue:2

    Topics: Administration, Cutaneous; Aged; Analgesia; Area Under Curve; Biological Availability; Clinical Tria

2003
Safety and tolerability of the lidocaine patch 5%, a targeted peripheral analgesic: a review of the literature.
    Journal of clinical pharmacology, 2003, Volume: 43, Issue:2

    Topics: Administration, Cutaneous; Aged; Analgesia; Area Under Curve; Biological Availability; Clinical Tria

2003
Safety and tolerability of the lidocaine patch 5%, a targeted peripheral analgesic: a review of the literature.
    Journal of clinical pharmacology, 2003, Volume: 43, Issue:2

    Topics: Administration, Cutaneous; Aged; Analgesia; Area Under Curve; Biological Availability; Clinical Tria

2003
Safety and tolerability of the lidocaine patch 5%, a targeted peripheral analgesic: a review of the literature.
    Journal of clinical pharmacology, 2003, Volume: 43, Issue:2

    Topics: Administration, Cutaneous; Aged; Analgesia; Area Under Curve; Biological Availability; Clinical Tria

2003
Safety and tolerability of the lidocaine patch 5%, a targeted peripheral analgesic: a review of the literature.
    Journal of clinical pharmacology, 2003, Volume: 43, Issue:2

    Topics: Administration, Cutaneous; Aged; Analgesia; Area Under Curve; Biological Availability; Clinical Tria

2003
Safety and tolerability of the lidocaine patch 5%, a targeted peripheral analgesic: a review of the literature.
    Journal of clinical pharmacology, 2003, Volume: 43, Issue:2

    Topics: Administration, Cutaneous; Aged; Analgesia; Area Under Curve; Biological Availability; Clinical Tria

2003
Safety and tolerability of the lidocaine patch 5%, a targeted peripheral analgesic: a review of the literature.
    Journal of clinical pharmacology, 2003, Volume: 43, Issue:2

    Topics: Administration, Cutaneous; Aged; Analgesia; Area Under Curve; Biological Availability; Clinical Tria

2003
Safety and tolerability of the lidocaine patch 5%, a targeted peripheral analgesic: a review of the literature.
    Journal of clinical pharmacology, 2003, Volume: 43, Issue:2

    Topics: Administration, Cutaneous; Aged; Analgesia; Area Under Curve; Biological Availability; Clinical Tria

2003
Safety and tolerability of the lidocaine patch 5%, a targeted peripheral analgesic: a review of the literature.
    Journal of clinical pharmacology, 2003, Volume: 43, Issue:2

    Topics: Administration, Cutaneous; Aged; Analgesia; Area Under Curve; Biological Availability; Clinical Tria

2003
Safety and tolerability of the lidocaine patch 5%, a targeted peripheral analgesic: a review of the literature.
    Journal of clinical pharmacology, 2003, Volume: 43, Issue:2

    Topics: Administration, Cutaneous; Aged; Analgesia; Area Under Curve; Biological Availability; Clinical Tria

2003
Safety and tolerability of the lidocaine patch 5%, a targeted peripheral analgesic: a review of the literature.
    Journal of clinical pharmacology, 2003, Volume: 43, Issue:2

    Topics: Administration, Cutaneous; Aged; Analgesia; Area Under Curve; Biological Availability; Clinical Tria

2003
Safety and tolerability of the lidocaine patch 5%, a targeted peripheral analgesic: a review of the literature.
    Journal of clinical pharmacology, 2003, Volume: 43, Issue:2

    Topics: Administration, Cutaneous; Aged; Analgesia; Area Under Curve; Biological Availability; Clinical Tria

2003

Trials

23 trials available for lidocaine and Erythema

ArticleYear
Reducing transcranial direct current stimulation-induced erythema with skin pretreatment: considerations for sham-controlled clinical trials.
    Neuromodulation : journal of the International Neuromodulation Society, 2015, Volume: 18, Issue:4

    Topics: Administration, Cutaneous; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Antip

2015
Safety and effectiveness of injection of calcium hydroxylapatite via blunt cannula compared to injection by needle for correction of nasolabial folds.
    Journal of cosmetic dermatology, 2014, Volume: 13, Issue:4

    Topics: Aged; Anesthetics, Local; Catheters; Contusions; Cosmetic Techniques; Durapatite; Edema; Erythema; F

2014
A clinical comparison of topical piroxicam and EMLA cream for pain relief and inflammation in laser hair removal.
    Lasers in medical science, 2009, Volume: 24, Issue:4

    Topics: Administration, Topical; Adolescent; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroi

2009
Lidocaine-based topical anesthetic with disinfectant (LidoDin) versus EMLA for venipuncture: a randomized controlled trial.
    The Clinical journal of pain, 2009, Volume: 25, Issue:8

    Topics: Adolescent; Adult; Anesthetics, Combined; Anesthetics, Local; Child; Disinfectants; Edema; Erythema;

2009
Long-term treatment of neuropathic pain with a 5% lidocaine medicated plaster.
    European journal of anaesthesiology, 2010, Volume: 27, Issue:2

    Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Data Collection; Eryt

2010
The effect of lidocaine when mixed with large gel particle hyaluronic acid filler tolerability and longevity: a six-month trial.
    Journal of drugs in dermatology : JDD, 2010, Volume: 9, Issue:9

    Topics: Adult; Aged; Anesthetics, Local; Biocompatible Materials; Contusions; Cosmetic Techniques; Double-Bl

2010
Different mechanisms of development and maintenance of experimental incision-induced hyperalgesia in human skin.
    Anesthesiology, 2002, Volume: 97, Issue:3

    Topics: Adult; Anesthetics, Local; Double-Blind Method; Erythema; Female; Forearm; Humans; Hyperalgesia; Lid

2002
Statistical process control methods allow the analysis and improvement of anesthesia care.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2003, Volume: 50, Issue:8

    Topics: Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Catheterization, Peripheral

2003
Piroxicam gel, compared to EMLA cream is associated with less pain after venous cannulation in volunteers.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2003, Volume: 50, Issue:8

    Topics: Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Catheterization, Peripheral

2003
Comparison of EMLA and lidocaine iontophoresis for cannulation analgesia.
    European journal of anaesthesiology, 2004, Volume: 21, Issue:3

    Topics: Adult; Aged; Analgesia; Anesthetics, Combined; Anesthetics, Local; Catheterization, Peripheral; Doub

2004
Mechanically induced axon reflex and hyperalgesia in human UV-B burn are reduced by systemic lidocaine.
    European journal of pain (London, England), 2004, Volume: 8, Issue:3

    Topics: Adult; Axons; Burns; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug

2004
Rapid, needle-free delivery of lidocaine for reducing the pain of venipuncture among pediatric subjects.
    Pediatrics, 2005, Volume: 115, Issue:4

    Topics: Adolescent; Anesthetics, Local; Child; Child, Preschool; Double-Blind Method; Erythema; Female; Huma

2005
Brief focal ultrasound with topical anesthetic decreases the pain of intravenous placement in children.
    Pediatric emergency care, 2006, Volume: 22, Issue:5

    Topics: Administration, Topical; Adolescent; Anesthetics, Local; Attitude of Health Personnel; Catheterizati

2006
Systemic exposure to lidocaine and tetracaine is low after an application of a lidocaine 7%-tetracaine 7% peel in adults.
    International journal of dermatology, 2008, Volume: 47, Issue:1

    Topics: Administration, Topical; Adult; Anesthetics, Local; Area Under Curve; Drug Combinations; Erythema; F

2008
Evaluation of an amethocaine gel preparation for percutaneous analgesia before venous cannulation in children.
    British journal of anaesthesia, 1995, Volume: 75, Issue:3

    Topics: Administration, Cutaneous; Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool;

1995
Evaluation of an amethocaine gel preparation for percutaneous analgesia before venous cannulation in children.
    British journal of anaesthesia, 1995, Volume: 75, Issue:3

    Topics: Administration, Cutaneous; Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool;

1995
Evaluation of an amethocaine gel preparation for percutaneous analgesia before venous cannulation in children.
    British journal of anaesthesia, 1995, Volume: 75, Issue:3

    Topics: Administration, Cutaneous; Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool;

1995
Evaluation of an amethocaine gel preparation for percutaneous analgesia before venous cannulation in children.
    British journal of anaesthesia, 1995, Volume: 75, Issue:3

    Topics: Administration, Cutaneous; Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool;

1995
Topical lidocaine gel relieves postherpetic neuralgia.
    Annals of neurology, 1995, Volume: 37, Issue:2

    Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Blood Pressure; Double-Blind Method; Erythema; F

1995
Cutaneous iontophoretic application of condensed lidocaine.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1994, Volume: 41, Issue:8

    Topics: Administration, Cutaneous; Adult; Anesthesia, Local; Erythema; Female; Forearm; Humans; Iontophoresi

1994
Intradermal actions of hypertonic saline involve neural and vascular mechanisms.
    British journal of clinical pharmacology, 1995, Volume: 40, Issue:1

    Topics: Anesthetics, Local; Double-Blind Method; Drug Interactions; Edema; Erythema; Forearm; Histamine; Hum

1995
[Efficacy of EMLA cream, effect of time and place of application].
    Revista espanola de anestesiologia y reanimacion, 1999, Volume: 46, Issue:3

    Topics: Adult; Anesthetics, Combined; Anesthetics, Local; Double-Blind Method; Elbow; Emulsions; Erythema; F

1999
Digital image analysis of erythema development after experimental thermal injury to human skin: effect of postburn topical local anesthetics (EMLA).
    Anesthesia and analgesia, 1999, Volume: 88, Issue:5

    Topics: Administration, Topical; Adult; Anesthetics, Combined; Anesthetics, Local; Burns; Erythema; Humans;

1999
Intravenous lidocaine infusion in the treatment of experimental human skin burns - digital colour image analysis of erythema development.
    Burns : journal of the International Society for Burn Injuries, 2000, Volume: 26, Issue:8

    Topics: Adult; Anesthetics, Local; Burns; Cross-Sectional Studies; Dose-Response Relationship, Drug; Double-

2000
Pharmacokinetics and tolerability of lidocaine patch 5% with extended dosing.
    The Annals of pharmacotherapy, 2002, Volume: 36, Issue:2

    Topics: Administration, Topical; Anesthetics, Local; Delayed-Action Preparations; Edema; Erythema; Female; H

2002
Local blanching after epicutaneous application of EMLA cream. A double-blind randomized study among 50 healthy volunteers.
    Dermatologica, 1990, Volume: 181, Issue:1

    Topics: Administration, Cutaneous; Anesthetics, Local; Double-Blind Method; Drug Combinations; Erythema; Hum

1990

Other Studies

24 other studies available for lidocaine and Erythema

ArticleYear
Dermal effects and pharmacokinetic evaluation of the lidocaine/prilocaine cream in healthy Chinese volunteers.
    BMC pharmacology & toxicology, 2023, 10-12, Volume: 24, Issue:1

    Topics: Anesthetics, Local; Drug Combinations; East Asian People; Erythema; Healthy Volunteers; Humans; Lido

2023
The Efficacy of Pulsed Dye Laser Pretreated With or Without Local Anesthetic on Patients Presenting With Erythema of Face, Neck, Chest, and Extremities.
    Lasers in surgery and medicine, 2020, Volume: 52, Issue:4

    Topics: Adult; Anesthetics, Local; Erythema; Female; Humans; Lasers, Dye; Lidocaine; Low-Level Light Therapy

2020
Topical brimonidine gel for extended-duration local anaesthesia.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2018, Volume: 32, Issue:1

    Topics: Adrenergic alpha-2 Receptor Agonists; Anesthesia, Local; Anesthetics, Local; Brimonidine Tartrate; E

2018
Efficacy of lidocaine 5% medicated plaster (VERSATIS®) in patients with localized neuropathic pain poorly responsive to pharmacological therapy.
    Minerva medica, 2018, Volume: 109, Issue:5

    Topics: Aged; Analgesics; Anesthetics, Local; Drug Evaluation; Drug Resistance; Drug Therapy, Combination; E

2018
Biting down on the truth: A case of a delayed hypersensitivity reaction to lidocaine.
    The Australasian journal of dermatology, 2019, Volume: 60, Issue:1

    Topics: Aged; Anesthetics, Local; Drug Eruptions; Erythema; Humans; Hypersensitivity, Delayed; Lidocaine; Ma

2019
Formulation and evaluation of lidocaine base ethosomes for transdermal delivery.
    Anesthesia and analgesia, 2013, Volume: 117, Issue:2

    Topics: Administration, Cutaneous; Anesthetics, Local; Animals; Chemistry, Pharmaceutical; Cholesterol; Chro

2013
Centipede bite.
    European review for medical and pharmacological sciences, 2014, Volume: 18, Issue:7

    Topics: Aged; Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Allergic Agents; Anti-Inflammatory Agent

2014
Inexpensive diffuse reflectance spectroscopy system for measuring changes in tissue optical properties.
    Journal of biomedical optics, 2014, Volume: 19, Issue:10

    Topics: Epinephrine; Erythema; Humans; Lidocaine; Optical Imaging; Skin; Spectrum Analysis

2014
Review of the safety profile for microfocused ultrasound with visualization.
    Journal of cosmetic dermatology, 2014, Volume: 13, Issue:4

    Topics: Anesthetics, Local; Clinical Trials as Topic; Contusions; Edema; Erythema; Humans; Lidocaine; Produc

2014
A novel polymethylmethacrylate hydrophilic adhesive matrix intended for transdermal patch formulations.
    Drug delivery, 2010, Volume: 17, Issue:3

    Topics: Adhesiveness; Adhesives; Administration, Cutaneous; Adult; Anesthetics, Local; Biopharmaceutics; Che

2010
An immediate hypersensitivity reaction caused by tolperisone hydrochloride.
    Journal of investigational allergology & clinical immunology, 2011, Volume: 21, Issue:5

    Topics: Drug Hypersensitivity; Edema; Erythema; Humans; Lidocaine; Male; Middle Aged; Muscle Relaxants, Cent

2011
Cutaneous analgesia after transdermal application of amitriptyline versus lidocaine in rats.
    Anesthesia and analgesia, 2003, Volume: 96, Issue:6

    Topics: Administration, Cutaneous; Amitriptyline; Analgesics; Anesthetics, Local; Animals; Antidepressive Ag

2003
An unusual skin reaction following local anesthetic injection. Review of the literature and report of four cases.
    Oral surgery, oral medicine, and oral pathology, 1980, Volume: 49, Issue:1

    Topics: Arthus Reaction; Child; Drug Eruptions; Drug Hypersensitivity; Drug Tolerance; Erythema; Female; Hum

1980
Identifying true lidocaine allergy.
    Journal of the American Dental Association (1939), 1994, Volume: 125, Issue:10

    Topics: Anesthesia, Dental; Anesthesia, Local; Dental Anxiety; Diagnosis, Differential; Drug Hypersensitivit

1994
Identifying true lidocaine allergy.
    Journal of the American Dental Association (1939), 1994, Volume: 125, Issue:10

    Topics: Anesthesia, Dental; Anesthesia, Local; Dental Anxiety; Diagnosis, Differential; Drug Hypersensitivit

1994
Identifying true lidocaine allergy.
    Journal of the American Dental Association (1939), 1994, Volume: 125, Issue:10

    Topics: Anesthesia, Dental; Anesthesia, Local; Dental Anxiety; Diagnosis, Differential; Drug Hypersensitivit

1994
Identifying true lidocaine allergy.
    Journal of the American Dental Association (1939), 1994, Volume: 125, Issue:10

    Topics: Anesthesia, Dental; Anesthesia, Local; Dental Anxiety; Diagnosis, Differential; Drug Hypersensitivit

1994
Cutaneous microdialysis in man: effects of needle insertion trauma and anaesthesia on skin perfusion, erythema and skin thickness.
    Acta dermato-venereologica, 1998, Volume: 78, Issue:1

    Topics: Administration, Cutaneous; Anesthetics, Local; Erythema; Female; Humans; Lidocaine; Male; Microdialy

1998
Prolonged contact with topical anaesthetic cream: a case report.
    Paediatric nursing, 1998, Volume: 10, Issue:2

    Topics: Administration, Topical; Anesthetics, Local; Erythema; Humans; Infant; Lidocaine; Lidocaine, Priloca

1998
Laser peel: facial rejuvenation with a superficial erbium:YAG laser treatment.
    Journal of cutaneous laser therapy, 2000, Volume: 2, Issue:3

    Topics: Adult; Aged; Anesthetics, Local; Erbium; Erythema; Female; Humans; Laser Therapy; Lidocaine; Lidocai

2000
EMLA cream-induced irritant contact dermatitis.
    Journal of cutaneous pathology, 2002, Volume: 29, Issue:3

    Topics: Acrodermatitis; Administration, Topical; Anesthetics, Local; Child; Dermatitis, Contact; Diagnosis,

2002
Substance p-induced cutaneous and bronchial reactions in children with bronchial asthma.
    Annals of allergy, 1991, Volume: 66, Issue:2

    Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Child; Child, Preschool; Erythema; Female; F

1991
Altered epidermal morphology secondary to lidocaine iontophoresis: in vivo and in vitro studies in porcine skin.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1990, Volume: 15, Issue:1

    Topics: Administration, Cutaneous; Animals; Erythema; Female; In Vitro Techniques; Iontophoresis; Lidocaine;

1990
Vascular response of human skin after analgesia with EMLA cream.
    British journal of anaesthesia, 1989, Volume: 63, Issue:6

    Topics: Adult; Analgesia; Anesthetics, Local; Drug Combinations; Drug Eruptions; Erythema; Female; Humans; L

1989
Sorbic acid-induced erythema and edema.
    Journal of the American Academy of Dermatology, 1986, Volume: 14, Issue:2 Pt 1

    Topics: Administration, Topical; Anti-Inflammatory Agents; Aspirin; Betamethasone Valerate; Capsaicin; Cosme

1986
Cutaneous responses to human C 3 anaphylatoxin in man.
    Clinical and experimental immunology, 1972, Volume: 11, Issue:1

    Topics: Biopsy; Cell Movement; Complement System Proteins; Erythema; Histamine; Histamine H1 Antagonists; Hi

1972
Nevus anemicus: a unique catecholamine-dependent nevus.
    Archives of dermatology, 1970, Volume: 102, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Anemia; Angiokeratoma; Blood Vessels; Bradykinin; Capillari

1970