Page last updated: 2024-10-28

lidocaine and Epilepsy

lidocaine has been researched along with Epilepsy in 62 studies

Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.

Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Research Excerpts

ExcerptRelevanceReference
"Lidocaine is used to treat neonatal seizures refractory to other anticonvulsants."7.96Lidocaine as treatment for neonatal seizures: Evaluation of previously developed population pharmacokinetic models and dosing regimen. ( de Haan, TR; Egberts, TCG; Favié, LMA; Groenendaal, F; Huitema, ADR; Nuytemans, DHGM; Rademaker, CMA; Rijken, M; Simons, SHP; van den Broek, MPH; van Straaten, HLM, 2020)
"We report a patient with lidocaine-responsive neonatal epilepsy treated successfully with oral mexiletine."7.79Oral mexiletine for lidocaine-responsive neonatal epilepsy. ( Hirose, S; Nakazawa, M; Niijima, S; Okumura, A; Shimizu, T; Shimono, K; Yamashita, S, 2013)
" To quantify effects of a loading dose of midazolam and lidocaine on the EEG frequency spectrum of full-term neonates with perinatal arterial ischemic stroke (PAIS), 11 full-term infants underwent multi-channel amplitude-integrated EEG (aEEG) and EEG recordings."7.78Effects of midazolam and lidocaine on spectral properties of the EEG in full-term neonates with stroke. ( Andriessen, P; Dankers, F; de Vries, L; Janssen, F; Jennekens, W; Niemarkt, H; Toet, M; van der Aa, N; van Pul, C, 2012)
"Hypocapnia increases the toxic dose of lidocaine given IV without altering lidocaine concentrations in blood, brain, or cerebrospinal fluid."7.70Concentrations of lidocaine and monoethylglycine xylidide in brain, cerebrospinal fluid, and plasma during lidocaine-induced epileptiform electroencephalogram activity in rabbits: the effects of epinephrine and hypocapnia. ( Artru, AA; Mautz, DS; Momota, Y; Powers, KM; Ueda, Y, 2000)
"This article will review the different therapeutic options for status, from early treatment at home to the different first-line (benzodiazepines), second-line (phenobarbital, valproic acid, phenytoin, levetiracetam and lacosamide) or third-line treatments, which include both pharmacological (anaesthetics, propofol, ketamine, lidocaine, topiramate, brivaracetam or perampanel) and non-pharmacological (ketogenic diet, immunomodulatory treatments or epilepsy surgery) therapies."5.22[Paediatric status epilepticus]. ( García-Peñas, JJ; González-Alguacil, E; Soto-Insuga, V, 2022)
"Twenty-four patients with refractory epilepsy were treated with mexiletine as an additional antiepileptic drug."5.09[Clinical applications and the effect of mexiletine on refractory epilepsies]. ( Enoki, H; Hata, H; Kobayashi, K; Maniwa, S; Ohmori, I; Ohta, H, 2000)
"Literature searches were conducted utilizing PubMed and MEDLINE databases employing combinations of search terms including, but not limited to, "epilepsy", "refractory", "seizure", and the following medications: acetazolamide, amantadine, bumetanide, imipramine, lidocaine, verapamil, and various stimulants."4.95Outside the box: Medications worth considering when traditional antiepileptic drugs have failed. ( Perry, MS; Turner, AL, 2017)
"We describe a two-year-old boy with Dravet syndrome, a severe genetic epilepsy, who developed a generalized tonic-clonic seizure immediately following an intravenous bolus of lidocaine given for propofol pain amelioration during induction of anesthesia for emergency gastroscopy."4.12Anesthetic considerations in Dravet syndrome. ( Corlette, S; Davidson, A; Howell, KB; Macdonald-Laurs, E, 2022)
"Lidocaine is used to treat neonatal seizures refractory to other anticonvulsants."3.96Lidocaine as treatment for neonatal seizures: Evaluation of previously developed population pharmacokinetic models and dosing regimen. ( de Haan, TR; Egberts, TCG; Favié, LMA; Groenendaal, F; Huitema, ADR; Nuytemans, DHGM; Rademaker, CMA; Rijken, M; Simons, SHP; van den Broek, MPH; van Straaten, HLM, 2020)
"We report a patient with lidocaine-responsive neonatal epilepsy treated successfully with oral mexiletine."3.79Oral mexiletine for lidocaine-responsive neonatal epilepsy. ( Hirose, S; Nakazawa, M; Niijima, S; Okumura, A; Shimizu, T; Shimono, K; Yamashita, S, 2013)
" To quantify effects of a loading dose of midazolam and lidocaine on the EEG frequency spectrum of full-term neonates with perinatal arterial ischemic stroke (PAIS), 11 full-term infants underwent multi-channel amplitude-integrated EEG (aEEG) and EEG recordings."3.78Effects of midazolam and lidocaine on spectral properties of the EEG in full-term neonates with stroke. ( Andriessen, P; Dankers, F; de Vries, L; Janssen, F; Jennekens, W; Niemarkt, H; Toet, M; van der Aa, N; van Pul, C, 2012)
"Forty consecutive patients with neurological disorders (encephalopathy, autism, and epilepsy) were referred to dental treatment, and 45 sedations were performed; all were sedated with Midazolam (intramuscular 0."3.76Special care dentistry: Midazolam conscious sedation for patients with neurological diseases. ( Capp, PL; Cillo, MT; de Faria, ME; de Siqueira, JT; Prado, EG; Siqueira, SR, 2010)
"Hypocapnia increases the toxic dose of lidocaine given IV without altering lidocaine concentrations in blood, brain, or cerebrospinal fluid."3.70Concentrations of lidocaine and monoethylglycine xylidide in brain, cerebrospinal fluid, and plasma during lidocaine-induced epileptiform electroencephalogram activity in rabbits: the effects of epinephrine and hypocapnia. ( Artru, AA; Mautz, DS; Momota, Y; Powers, KM; Ueda, Y, 2000)
"Neonatal stroke is the second cause of acute symptomatic neonatal seizures after hypoxic-ischemic encephalopathy."2.82Efficacy of the anti-seizure medications in acute symptomatic neonatal seizures caused by stroke. A systematic review. ( Criscione, R; Falsaperla, R; Marino, S; Pisani, F; Praticò, A; Ruggieri, M; Sortino, V, 2022)
" Lignocaine bioavailability after oral administration was more than two-fold in the patients than in the normal subjects (0."2.65Reduction of oral bioavailability of lignocaine by induction of first pass metabolism in epileptic patients. ( Perucca, E; Richens, A, 1979)
"Current therapeutic options to treat neonatal seizures (i."2.49Treatment of neonatal seizures. ( de Vries, LS; Hellström-Westas, L; van Rooij, LG, 2013)
"Carbamazepine dosage gradually tapered until stop and epileptic pain attacks become less and less, eventually disappear."1.46A case report of stellate ganglion block in the treatment of epileptic pain. ( Wang, S; Zhu, Y, 2017)

Research

Studies (62)

TimeframeStudies, this research(%)All Research%
pre-199033 (53.23)18.7374
1990's5 (8.06)18.2507
2000's12 (19.35)29.6817
2010's8 (12.90)24.3611
2020's4 (6.45)2.80

Authors

AuthorsStudies
Anger, T1
Madge, DJ1
Mulla, M1
Riddall, D1
Vivier, D1
Bennis, K1
Lesage, F1
Ducki, S1
Macdonald-Laurs, E1
Corlette, S1
Davidson, A1
Howell, KB1
Soto-Insuga, V1
González-Alguacil, E1
García-Peñas, JJ1
Sortino, V1
Praticò, A1
Marino, S1
Criscione, R1
Ruggieri, M1
Pisani, F1
Falsaperla, R1
Favié, LMA1
Huitema, ADR1
van den Broek, MPH1
Rademaker, CMA1
de Haan, TR1
van Straaten, HLM1
Simons, SHP1
Rijken, M1
Nuytemans, DHGM1
Egberts, TCG1
Groenendaal, F1
Turner, AL1
Perry, MS1
van Rooij, LG1
Hellström-Westas, L1
de Vries, LS1
Wang, S1
Zhu, Y1
Capp, PL1
de Faria, ME1
Siqueira, SR1
Cillo, MT1
Prado, EG1
de Siqueira, JT1
van der Heide, MJ1
Roze, E1
van der Veere, CN1
Ter Horst, HJ1
Brouwer, OF1
Bos, AF1
Jennekens, W1
Dankers, F1
Janssen, F1
Toet, M1
van der Aa, N1
Niemarkt, H1
van Pul, C1
de Vries, L1
Andriessen, P1
Nakazawa, M1
Okumura, A1
Niijima, S1
Yamashita, S1
Shimono, K1
Hirose, S1
Shimizu, T1
DeToledo, JC1
Minagar, A1
Lowe, MR1
Kempen, PM1
HALLDIN, T1
LATTINEN, L1
TAVERNER, D1
BAIN, WA1
BOHM, E3
FLODMARK, S1
PETERSEN, I1
BERNHARD, CG2
DI PIAZZA, P1
GORI, E1
OTTOSSON, JO1
GEJROT, T1
FENG, YK1
YANG, SL1
FEI, YH1
YANG, PH1
LI, SW1
Mosovich, A1
Etchepareborda, J1
LEHTINEN, LO1
HOJEBERG, S1
Boylan, GB1
Rennie, JM1
Chorley, G1
Pressler, RM1
Fox, GF1
Farrer, K1
Morton, M1
Binnie, CD1
Haanpää, M1
Wedlund, PJ1
Wilkinson, GR1
Colburn, WA1
Routledge, PA1
Stargel, WW1
Finn, AL1
Barchowsky, A1
Shand, DG1
Campos, CJ1
Cavalheiro, EA1
Sotaniemi, EA1
Rautio, A1
Bäckstrom, M1
Arvela, P1
Pelkonen, O1
Momota, Y2
Artru, AA2
Powers, KM2
Mautz, DS2
Ueda, Y2
Stoneham, MD1
Bree, SE1
Enoki, H1
Hata, H1
Ohmori, I1
Maniwa, S1
Ohta, H1
Kobayashi, K1
Nagaki, S1
Fukamauchi, F1
Sakamoto, Y1
Higuchi, H1
Miki, N2
Ono, M1
Sadamatsu, M1
Kato, N1
Osawa, M1
Al-Noori, S1
Swann, JW1
Ando, M1
Wu, J1
Javedan, SP1
Ellsworth, K1
Smith, K1
Fisher, RS1
Yano, T1
Sawaishi, Y1
Takada, G1
Perucca, E1
Richens, A1
Raskin, NH1
Fishman, RA1
Cobcroft, MD1
Witkin, JM1
Goldberg, SR1
Marley, RJ1
Mesulam, MM1
Miyata, H1
Tsubota, T1
Kuroda, E1
Takemoto, H1
Kanazawa, Y1
Ogino, H1
Julien, RM1
Depaepe, A1
Bohyn, P1
De Maertelaere, M1
Dernier, J1
Cloetens, W1
De Mey, D1
Dereymaeker, A1
Martens, C1
Sorel, L1
Hariga, M1
Ectors, L1
Westphal, P1
Raisfeld, IH1
Teramo, K1
Benowitz, N1
Heymann, MA1
Kahanpää, K1
Siimes, A1
Rudolph, AM1
Westreich, G1
Kneller, AW1
Steinhaus, JE1
Suranyi, LA1
Heinonen, J1
Takki, S1
Jarho, L1
Gonzalez Toledo, EC1
Christensen, JC1

Reviews

9 reviews available for lidocaine and Epilepsy

ArticleYear
Medicinal chemistry of neuronal voltage-gated sodium channel blockers.
    Journal of medicinal chemistry, 2001, Jan-18, Volume: 44, Issue:2

    Topics: Amyotrophic Lateral Sclerosis; Analgesics; Anticonvulsants; Epilepsy; Humans; Ion Channel Gating; Mo

2001
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
    Journal of medicinal chemistry, 2016, 06-09, Volume: 59, Issue:11

    Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Struc

2016
[Paediatric status epilepticus].
    Revista de neurologia, 2022, 10-16, Volume: 75, Issue:8

    Topics: Adult; Anesthetics; Anticonvulsants; Benzodiazepines; Child; Epilepsy; Humans; Ketamine; Lacosamide;

2022
Efficacy of the anti-seizure medications in acute symptomatic neonatal seizures caused by stroke. A systematic review.
    Acta bio-medica : Atenei Parmensis, 2022, 12-16, Volume: 93, Issue:6

    Topics: Anticonvulsants; Bumetanide; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetirac

2022
Outside the box: Medications worth considering when traditional antiepileptic drugs have failed.
    Seizure, 2017, Volume: 50

    Topics: Amantadine; Anticonvulsants; Bumetanide; Central Nervous System Stimulants; Epilepsy; Humans; Imipra

2017
Treatment of neonatal seizures.
    Seminars in fetal & neonatal medicine, 2013, Volume: 18, Issue:4

    Topics: Animals; Anticonvulsants; Brain; Child Development; Drug Resistance; Epilepsy; Humans; Infant, Newbo

2013
[Recognition and treatment of neuropathic pain].
    Duodecim; laaketieteellinen aikakauskirja, 2004, Volume: 120, Issue:2

    Topics: Analgesics, Opioid; Chronic Disease; Depressive Disorder; Drug Therapy, Combination; Epilepsy; Femal

2004
Neurologic disorders in renal failure (first of two parts).
    The New England journal of medicine, 1976, Jan-15, Volume: 294, Issue:3

    Topics: Blood-Brain Barrier; Brain Diseases; Cerebrospinal Fluid Proteins; Diazepam; Epilepsy; Humans; Lidoc

1976
Clinical pharmacology of drug interactions.
    Annual review of medicine, 1973, Volume: 24

    Topics: Antihypertensive Agents; Blood Coagulation Disorders; Cardiovascular Diseases; Coumarins; Drug Inter

1973

Trials

3 trials available for lidocaine and Epilepsy

ArticleYear
Second-line anticonvulsant treatment of neonatal seizures: a video-EEG monitoring study.
    Neurology, 2004, Feb-10, Volume: 62, Issue:3

    Topics: Anticonvulsants; Clonazepam; Drug Resistance; Electroencephalography; Epilepsy; Female; Humans; Infa

2004
[Clinical applications and the effect of mexiletine on refractory epilepsies].
    No to hattatsu = Brain and development, 2000, Volume: 32, Issue:1

    Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Child; Child, Preschool; Drug Therapy, Combination; Elect

2000
Reduction of oral bioavailability of lignocaine by induction of first pass metabolism in epileptic patients.
    British journal of clinical pharmacology, 1979, Volume: 8, Issue:1

    Topics: Administration, Oral; Adult; Biological Availability; Enzyme Induction; Epilepsy; Female; Humans; In

1979

Other Studies

50 other studies available for lidocaine and Epilepsy

ArticleYear
Anesthetic considerations in Dravet syndrome.
    Paediatric anaesthesia, 2022, Volume: 32, Issue:10

    Topics: Anesthetics; Anticonvulsants; Child, Preschool; Epilepsies, Myoclonic; Epilepsy; Epileptic Syndromes

2022
Lidocaine as treatment for neonatal seizures: Evaluation of previously developed population pharmacokinetic models and dosing regimen.
    British journal of clinical pharmacology, 2020, Volume: 86, Issue:1

    Topics: Anticonvulsants; Epilepsy; Humans; Hypothermia, Induced; Infant, Newborn; Lidocaine; Seizures

2020
A case report of stellate ganglion block in the treatment of epileptic pain.
    Medicine, 2017, Volume: 96, Issue:6

    Topics: Anesthetics, Local; Autonomic Nerve Block; Child; Epilepsy; Female; Humans; Lidocaine; Pain Manageme

2017
Special care dentistry: Midazolam conscious sedation for patients with neurological diseases.
    European journal of paediatric dentistry, 2010, Volume: 11, Issue:4

    Topics: Adolescent; Adult; Anesthesia, Dental; Anesthetics, Local; Autistic Disorder; Brain Damage, Chronic;

2010
Long-term neurological outcome of term-born children treated with two or more anti-epileptic drugs during the neonatal period.
    Early human development, 2012, Volume: 88, Issue:1

    Topics: Anticonvulsants; Apgar Score; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Fol

2012
Effects of midazolam and lidocaine on spectral properties of the EEG in full-term neonates with stroke.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2012, Volume: 16, Issue:6

    Topics: Anticonvulsants; Brain Ischemia; Data Interpretation, Statistical; Electroencephalography; Epilepsy;

2012
Oral mexiletine for lidocaine-responsive neonatal epilepsy.
    Brain & development, 2013, Volume: 35, Issue:7

    Topics: Administration, Oral; Anti-Arrhythmia Agents; Electroencephalography; Epilepsy; Humans; Infant, Newb

2013
Lidocaine-induced seizures in patients with history of epilepsy: effect of antiepileptic drugs.
    Anesthesiology, 2002, Volume: 97, Issue:3

    Topics: Adult; Anesthetics, Local; Anticonvulsants; Diabetes Complications; Electroencephalography; Epilepsi

2002
Lidocaine administration, seizures, and causality.
    Anesthesiology, 2003, Volume: 98, Issue:5

    Topics: Adult; Anesthetics, Local; Anticonvulsants; Epilepsy; Female; Humans; Lidocaine; Seizures

2003
[Beneficial effect of xylocaine in a case of epilepsy].
    Svenska lakartidningen, 1954, Aug-20, Volume: 51, Issue:34

    Topics: Anesthetics; Anesthetics, Local; Epilepsy; Humans; Lidocaine

1954
[Xylocaine in the treatment of status epilepticus].
    Duodecim; laaketieteellinen aikakauskirja, 1957, Volume: 73, Issue:10

    Topics: Epilepsy; Humans; Lidocaine; Status Epilepticus

1957
Intravenous lignocaine as an anticonvulsant in status epilepticus and serial epilepsy.
    Lancet (London, England), 1958, Nov-29, Volume: 2, Issue:7057

    Topics: Anticonvulsants; Epilepsy; Humans; Lidocaine; Status Epilepticus

1958
Effect of lidocaine (xylocaine) on seizure and interseizure electroencephalograms in epileptics.
    A.M.A. archives of neurology and psychiatry, 1959, Volume: 81, Issue:5

    Topics: Electroencephalography; Epilepsy; Humans; Lidocaine; Seizures

1959
[Effect of local anesthetics on epileptic manifestations].
    Nordisk medicin, 1959, Jun-11, Volume: 61, Issue:24

    Topics: Anesthetics, Local; Cerebral Cortex; Epilepsy; Humans; Lidocaine

1959
[Effect of intravenous lidocaine on epileptic seizures].
    Nordisk medicin, 1959, Jun-11, Volume: 61, Issue:24

    Topics: Administration, Intravenous; Epilepsy; Humans; Lidocaine

1959
[The use of lidocaine (xylocaine) in the treatment of epilepsy].
    Giornale di psichiatria e di neuropatologia, 1961, Volume: 89

    Topics: Epilepsy; Lidocaine

1961
Seizure characteristics and therapeutic efficiency in electroconvulsive therapy: an analysis of the antidepressive efficiency of grand mal and lidocaine-modified seizures.
    The Journal of nervous and mental disease, 1962, Volume: 135

    Topics: Antidepressive Agents; Electroconvulsive Therapy; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Lidocain

1962
THE INFLUENCE OF XYLOCAINE ON INDUCED AND SPONTANEOUS NYSTAGMUS. A PRELIMINARY REPORT.
    Practica oto-rhino-laryngologica, 1963, Volume: 25

    Topics: Alcoholism; Amyotrophic Lateral Sclerosis; Brain Neoplasms; Dimenhydrinate; Epilepsy; Lidocaine; Men

1963
THE THERAPEUTIC EFFECT OF INTRAVENOUS XYLOCAINE ON STATUS EPILEPTICUS.
    Chinese medical journal (Peking, China : 1932), 1963, Volume: 82

    Topics: Adolescent; Child; Epilepsy; Geriatrics; Humans; Lidocaine; Status Epilepticus

1963
THE EFFECT OF XYLOCAINE UPON THE BURSTS OF PAROXYSMAL ACTIVITY IN THE E.E.G. OF EPILEPTICS.
    Acta neurologica Scandinavica, 1964, Volume: 40, Issue:1

    Topics: Electroencephalography; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Humans; Lidocaine; Phar

1964
[STATUS EPILEPTICUS].
    Suomen laakarilehti. Finlands lakartidning, 1964, Feb-01, Volume: 19

    Topics: Epilepsy; Geriatrics; Humans; Lidocaine; Paraldehyde; Pathology; Physiology; Posture; Status Epilept

1964
A new treatment of status epilepticus; intravenous injections of a local anesthetic (lidocaine).
    A.M.A. archives of neurology and psychiatry, 1955, Volume: 74, Issue:2

    Topics: Anesthesia, Local; Anesthetics; Anesthetics, Local; Epilepsy; Humans; Injections, Intravenous; Lidoc

1955
Hepatic tissue binding and the oral first-pass effect.
    Journal of pharmaceutical sciences, 1984, Volume: 73, Issue:3

    Topics: Administration, Oral; Anticonvulsants; Epilepsy; Humans; Kinetics; Lidocaine; Liver; Liver Circulati

1984
First-pass clearance of lidocaine in healthy volunteers and epileptic patients: influence of effective liver volume.
    Journal of pharmaceutical sciences, 1981, Volume: 70, Issue:8

    Topics: Epilepsy; Humans; Lidocaine; Liver; Metabolic Clearance Rate

1981
Lignocaine disposition in blood in epilepsy.
    British journal of clinical pharmacology, 1981, Volume: 12, Issue:5

    Topics: Adult; Aged; Blood Proteins; Epilepsy; Female; Glycoproteins; Humans; Lidocaine; Male; Middle Aged;

1981
The paradoxical effect of lidocaine on an experimental model of epilepsy.
    Archives internationales de pharmacodynamie et de therapie, 1980, Volume: 243, Issue:1

    Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electric Stimulation; Electroencephal

1980
CYP3A4 and CYP2A6 activities marked by the metabolism of lignocaine and coumarin in patients with liver and kidney diseases and epileptic patients.
    British journal of clinical pharmacology, 1995, Volume: 39, Issue:1

    Topics: Administration, Oral; Adult; Aged; Aryl Hydrocarbon Hydroxylases; Capsules; Coumarins; Cytochrome P-

1995
Posttreatment with propofol terminates lidocaine-induced epileptiform electroencephalogram activity in rabbits: effects on cerebrospinal fluid dynamics.
    Anesthesia and analgesia, 1998, Volume: 87, Issue:4

    Topics: Anesthetics, Intravenous; Anesthetics, Local; Animals; Cerebrospinal Fluid; Electroencephalography;

1998
Epileptic seizure during awake carotid endarterectomy.
    Anesthesia and analgesia, 1999, Volume: 89, Issue:4

    Topics: Aged; Anesthetics, Local; Bupivacaine; Carotid Artery, Internal; Carotid Stenosis; Cervical Plexus;

1999
Upregulation of brain somatostatin and neuropeptide Y following lidocaine-induced kindling in the rat.
    Brain research, 2000, Jan-10, Volume: 852, Issue:2

    Topics: Amygdala; Animals; Anti-Arrhythmia Agents; Cerebral Cortex; Corpus Striatum; Epilepsy; Gene Expressi

2000
Concentrations of lidocaine and monoethylglycine xylidide in brain, cerebrospinal fluid, and plasma during lidocaine-induced epileptiform electroencephalogram activity in rabbits: the effects of epinephrine and hypocapnia.
    Anesthesia and analgesia, 2000, Volume: 91, Issue:2

    Topics: Anesthetics, Local; Animals; Brain; Cerebrospinal Fluid Pressure; Electroencephalography; Epilepsy;

2000
A role for sodium and chloride in kainic acid-induced beading of inhibitory interneuron dendrites.
    Neuroscience, 2000, Volume: 101, Issue:2

    Topics: Animals; Calcium; Chloride Channels; Chlorides; Dendrites; Dose-Response Relationship, Drug; Epileps

2000
[Efficacy of lidocaine tapes for a school boy with intractable epilepsy].
    No to hattatsu = Brain and development, 2001, Volume: 33, Issue:2

    Topics: Anticonvulsants; Bandages; Body Temperature; Child; Circadian Rhythm; Epilepsy; Humans; Infusions, I

2001
Gamma oscillation underlies hyperthermia-induced epileptiform-like spikes in immature rat hippocampal slices.
    BMC neuroscience, 2001, Volume: 2

    Topics: Action Potentials; Anesthetics, Local; Animals; Biological Clocks; Cortical Spreading Depression; El

2001
[Oral administration of lidocaine jelly to a patient with lidocaine-dependent].
    No to hattatsu = Brain and development, 2002, Volume: 34, Issue:3

    Topics: Administration, Oral; Epilepsy; Female; Humans; Infant; Lidocaine; Substance-Related Disorders

2002
Fit with finger block.
    Anaesthesia and intensive care, 1992, Volume: 20, Issue:4

    Topics: Anxiety; Epilepsy; Female; Fingers; Humans; Hyperventilation; Lidocaine; Male; Nerve Block

1992
Lack of a genetic correlation between the convulsant and epileptogenic effects of cocaine and lidocaine.
    NIDA research monograph, 1990, Volume: 105

    Topics: Animals; Cocaine; Convulsants; Epilepsy; Lidocaine; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; M

1990
Lidocaine toxicity and the limbic system.
    The American journal of psychiatry, 1987, Volume: 144, Issue:12

    Topics: Animals; Epilepsy; Hallucinations; Humans; Lidocaine; Limbic System; Procaine; Rats

1987
[Intravenous lidocaine in the treatment of convulsions in infancy].
    No to hattatsu = Brain and development, 1985, Volume: 17, Issue:3

    Topics: Anticonvulsants; Epilepsy; Female; Humans; Infant; Infant, Newborn; Injections, Intravenous; Lidocai

1985
Lidocaine in experimental epilepsy: correlation of anticonvulsant effect with blood concentrations.
    Electroencephalography and clinical neurophysiology, 1973, Volume: 34, Issue:6

    Topics: Animals; Anticonvulsants; Cats; Disease Models, Animal; Electroencephalography; Epilepsy; Female; In

1973
[Comparison of aprindine (AC 1802) and lidocaine by intravenous route during the acute phase of myocardial infarct].
    Acta cardiologica, 1974, Volume: Suppl 18

    Topics: Aniline Compounds; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bradycardia; Cardiac Complexes, Pre

1974
A new method of isolating the cerebral cortex. Study of the normal and epileptic evoked activity.
    European neurology, 1971, Volume: 5, Issue:6

    Topics: Anesthetics, Local; Animals; Blood-Brain Barrier; Central Nervous System Stimulants; Cerebral Cortex

1971
[Lidocaine in the treatment of epilepsy (author's transl)].
    Acta paediatrica Belgica, 1974, Volume: 28, Issue:5-6

    Topics: Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Humans; Lidocaine; Male

1974
Dental care of epileptics.
    Epilepsia, 1972, Volume: 13, Issue:1

    Topics: Anesthesia, Dental; Dental Caries; Dentistry; Dentures; Epilepsy; Gingival Hyperplasia; Humans; Hyda

1972
Effects of lidocaine on heart rate, blood pressure, and electrocorticogram in fetal sheep.
    American journal of obstetrics and gynecology, 1974, Apr-01, Volume: 118, Issue:7

    Topics: Acid-Base Equilibrium; Acidosis; Amniotic Fluid; Animals; Animals, Newborn; Blood; Blood Pressure; C

1974
Intravenous lidocaine for status epilepticus.
    Minnesota medicine, 1972, Volume: 55, Issue:9

    Topics: Epilepsy; Humans; Injections, Intravenous; Lidocaine; Male; Middle Aged

1972
Pharmacology of intravenous local anesthetics.
    Acta anaesthesiologica Scandinavica. Supplementum, 1969, Volume: 36

    Topics: Anesthetics, Local; Autonomic Nervous System; Cardiovascular System; Central Nervous System; Electro

1969
[Antiepileptics].
    Mitteilungen. Deutsche Pharmazeutische Gesellschaft, 1969, Volume: 39, Issue:4

    Topics: Barbiturates; Epilepsy; Humans; Hydantoins; Lidocaine; Oxyphenbutazone; Pyrrolidinones

1969
Plasma lidocaine levels in patients treated with potential inducers of microsomal enzymes.
    Acta anaesthesiologica Scandinavica, 1970, Volume: 14, Issue:2

    Topics: Adult; Anticonvulsants; Enzyme Induction; Epilepsy; Humans; Injections, Intravenous; Lidocaine; Male

1970
[Treatment of status epilepticus in neurosurgery].
    Prensa medica argentina, 1970, Jul-10, Volume: 57, Issue:19

    Topics: Adult; Epilepsy; Humans; Lidocaine; Middle Aged; Neurosurgery

1970