lidocaine has been researched along with Epilepsy, Tonic-Clonic in 29 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Epilepsy, Tonic-Clonic: A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report two female infants with early myoclonic encephalopathy (EME) whose intractable focal seizures were suppressed with lidocaine and carbamazepine (CBZ)." | 3.79 | Successful treatment of early myoclonic encephalopathy using lidocaine and carbamazepine. ( Kobayashi, K; Kodani, N; Maniwa, S; Nakano, K; Ohtsuka, Y, 2013) |
| "In newborn infants suffering from perinatal asphyxia seizures, lidocaine (LD) has proved to be an effective anticonvulsant." | 3.69 | Lidocaine pharmacokinetics and toxicity in newborn pigs. ( Haaland, K; Hoem, NO; Johannessen, SI; Satas, S; Sørensen, DR; Thoresen, M, 1997) |
| "Drug treatment of status epilepticus is reviewed." | 2.36 | Drug therapy reviews: drug therapy of status epilepticus. ( Browne, TR, 1978) |
| " The number of adverse reactions reported, particularly toxic reactions, are extraordinarily negligible." | 1.30 | Lidocaine toxicity. ( Caiazzo, A; Maloney, P; Mehra, P, 1998) |
| "Orphenadrine is an anticholinergic drug used mainly in the treatment of Parkinson's disease." | 1.30 | Orphenadrine poisoning in a child: clinical and analytical data. ( Maes, V; Mertens, K; Ramet, J; Van Herreweghe, I, 1999) |
| " This resulted in toxic serum lidocaine levels (8." | 1.29 | Seizures due to lidocaine toxicity in a child during cardiac catheterization. ( Coe, JY; Robertson, M; Ryan, CA, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (48.28) | 18.7374 |
| 1990's | 7 (24.14) | 18.2507 |
| 2000's | 5 (17.24) | 29.6817 |
| 2010's | 3 (10.34) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nakano, K | 1 |
| Kobayashi, K | 1 |
| Maniwa, S | 1 |
| Kodani, N | 1 |
| Ohtsuka, Y | 1 |
| Doye, E | 1 |
| Desgranges, FP | 1 |
| Stamm, D | 1 |
| de Queiroz, M | 1 |
| Valla, FV | 1 |
| Javouhey, E | 1 |
| Hsieh, XX | 1 |
| Hsu, YC | 1 |
| Cherng, CH | 1 |
| Lin, CC | 1 |
| Huang, GS | 1 |
| Lin, SL | 1 |
| Wu, ZF | 1 |
| Yeh, CC | 1 |
| Rosado Caracena, R | 1 |
| Uña Orejón, R | 1 |
| Garrido Ortega, P | 1 |
| Pérez Andujar, JA | 1 |
| Criado Jiménez, A | 1 |
| Berger, I | 1 |
| Steinberg, A | 1 |
| Schlesinger, Y | 1 |
| Seelenfreund, M | 1 |
| Schimmel, MS | 1 |
| OTTOSSON, JO | 1 |
| Mosovich, A | 1 |
| Etchepareborda, J | 1 |
| Martínez, MA | 1 |
| Ballesteros, S | 1 |
| Segura, LJ | 1 |
| García, M | 1 |
| Davis, NL | 1 |
| de Jong, RH | 2 |
| Ryan, CA | 1 |
| Robertson, M | 1 |
| Coe, JY | 1 |
| Satas, S | 1 |
| Johannessen, SI | 1 |
| Hoem, NO | 1 |
| Haaland, K | 1 |
| Sørensen, DR | 1 |
| Thoresen, M | 1 |
| Baraka, A | 2 |
| Aouad, M | 1 |
| Mehra, P | 1 |
| Caiazzo, A | 1 |
| Maloney, P | 1 |
| Lee, DL | 1 |
| Ayoub, C | 1 |
| Shaw, RK | 1 |
| Fontes, ML | 1 |
| Serizawa, M | 1 |
| Aihara, M | 1 |
| Takei, Y | 1 |
| Sata, Y | 1 |
| Nakazawa, S | 1 |
| Van Herreweghe, I | 1 |
| Mertens, K | 1 |
| Maes, V | 1 |
| Ramet, J | 1 |
| Boulinguez, S | 1 |
| Sparsa, A | 1 |
| Bouyssou-Gauthier, ML | 1 |
| Bedane, C | 1 |
| Bonnetblanc, JM | 1 |
| Mahli, A | 1 |
| Coskun, D | 1 |
| Akcali, DT | 1 |
| Browne, TR | 1 |
| Meyers, EF | 1 |
| Ramirez, RC | 1 |
| Boniuk, I | 1 |
| Klein, HO | 1 |
| Jutrin, I | 1 |
| Kaplinsky, E | 1 |
| Haroun, S | 1 |
| Hambert, O | 2 |
| Petersén, I | 2 |
| Mayer, PP | 1 |
| Singer, K | 1 |
| Lundberg, WB | 1 |
| Rump, S | 1 |
| Edelwejn, Z | 1 |
| Crampton, RS | 1 |
| Oriscello, RG | 1 |
| Walts, LF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Double-blind Randomized Clinical Trial to Evaluate the Reduction of Pain in the Wounds Treatment Previously Applying Lidocaine Topical Solution vs Placebo, in the Outpatients Area.[NCT03676556] | Phase 3 | 46 participants (Anticipated) | Interventional | 2021-06-16 | Recruiting | ||
| Randomised, Double-blind Clinical Trial to Evaluate the Reduction of Pain in the Wounds Treatment Previously Applying Lidocaine Topical Solution vs Placebo[NCT02584335] | Phase 4 | 7 participants (Actual) | Interventional | 2015-07-31 | Terminated (stopped due to Difficulties with the recruitment) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for lidocaine and Epilepsy, Tonic-Clonic
| Article | Year |
|---|---|
Aetiology of convulsions due to stellate ganglion block: a review and report of two cases.
Topics: Adult; Anesthetics, Local; Autonomic Nerve Block; Epilepsy, Tonic-Clonic; Female; Humans; Lidocaine; | 2002 |
Drug therapy reviews: drug therapy of status epilepticus.
Topics: Anesthesia, General; Diazepam; Epilepsies, Partial; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epil | 1978 |
27 other studies available for lidocaine and Epilepsy, Tonic-Clonic
| Article | Year |
|---|---|
Successful treatment of early myoclonic encephalopathy using lidocaine and carbamazepine.
Topics: Anesthetics, Local; Anticonvulsants; Brain; Carbamazepine; Electroencephalography; Epilepsy, Tonic-C | 2013 |
[Severe local anesthetic intoxication in an infant undergoing circumcision].
Topics: Anesthesia, Local; Anesthetics, Local; Child, Preschool; Circumcision, Male; Epilepsy, Tonic-Clonic; | 2015 |
Grand mal seizure induced by low-dose fentanyl and lidocaine in a young child.
Topics: Analgesics, Opioid; Anesthetics, Local; Child; Epilepsy, Tonic-Clonic; Female; Fentanyl; Humans; Lid | 2015 |
[Convulsions in the operating room in a man with AIDS].
Topics: Acquired Immunodeficiency Syndrome; Acute Disease; AIDS-Related Opportunistic Infections; Anti-HIV A | 2009 |
Neonatal mydriasis: intravenous lidocaine adverse reaction.
Topics: Anti-Arrhythmia Agents; Anticonvulsants; Diagnosis, Differential; Drug Overdose; Drug Therapy, Combi | 2002 |
Seizure characteristics and therapeutic efficiency in electroconvulsive therapy: an analysis of the antidepressive efficiency of grand mal and lidocaine-modified seizures.
Topics: Antidepressive Agents; Electroconvulsive Therapy; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Lidocain | 1962 |
THE EFFECT OF XYLOCAINE UPON THE BURSTS OF PAROXYSMAL ACTIVITY IN THE E.E.G. OF EPILEPTICS.
Topics: Electroencephalography; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Humans; Lidocaine; Phar | 1964 |
Reporting a fatality during tumescent liposuction.
Topics: Adult; Ambulatory Care; Anesthetics, Local; Drug Overdose; Epilepsy, Tonic-Clonic; Epinephrine; Fata | 2008 |
Successful resuscitation following massive bupivacaine overdose.
Topics: Adult; Bupivacaine; Epilepsy, Tonic-Clonic; Female; Humans; Lidocaine; Resuscitation; Tachycardia | 1982 |
Seizures due to lidocaine toxicity in a child during cardiac catheterization.
Topics: Anesthesia, Local; Cardiac Catheterization; Catheterization; Dose-Response Relationship, Drug; Epile | 1993 |
Lidocaine pharmacokinetics and toxicity in newborn pigs.
Topics: Age Factors; Anesthetics, Local; Animals; Animals, Newborn; Anticonvulsants; Awareness; Brain; Dose- | 1997 |
Is propofol anticonvulsant or proconvulsant?
Topics: Adult; Anesthetics, Intravenous; Anesthetics, Local; Anticonvulsants; Cerebral Cortex; Convulsants; | 1997 |
Lidocaine toxicity.
Topics: Administration, Topical; Adult; Anesthesia, Dental; Anesthetics, Local; Dose-Response Relationship, | 1998 |
Grand mal seizure during cardiopulmonary bypass: probable lidocaine toxicity.
Topics: Anesthetics, Local; Aortic Valve; Aortic Valve Stenosis; Cardiopulmonary Bypass; Epilepsy, Tonic-Clo | 1999 |
[Lidocaine induced seizure following topical application of local anesthetics: case report].
Topics: Administration, Topical; Anesthetics, Local; Child, Preschool; Epilepsy, Tonic-Clonic; Female; Human | 1999 |
Orphenadrine poisoning in a child: clinical and analytical data.
Topics: Akathisia, Drug-Induced; Anti-Arrhythmia Agents; Anticonvulsants; Antiparkinson Agents; Ataxia; Chil | 1999 |
Adverse effects associated with EMLA cream used as topical anesthetic for the mechanical debridement of leg ulcers.
Topics: Aged; Aged, 80 and over; Anesthetics, Local; Debridement; Epilepsy, Tonic-Clonic; Female; Humans; Le | 2000 |
Adverse effects associated with EMLA cream used as topical anesthetic for the mechanical debridement of leg ulcers.
Topics: Aged; Aged, 80 and over; Anesthetics, Local; Debridement; Epilepsy, Tonic-Clonic; Female; Humans; Le | 2000 |
Adverse effects associated with EMLA cream used as topical anesthetic for the mechanical debridement of leg ulcers.
Topics: Aged; Aged, 80 and over; Anesthetics, Local; Debridement; Epilepsy, Tonic-Clonic; Female; Humans; Le | 2000 |
Adverse effects associated with EMLA cream used as topical anesthetic for the mechanical debridement of leg ulcers.
Topics: Aged; Aged, 80 and over; Anesthetics, Local; Debridement; Epilepsy, Tonic-Clonic; Female; Humans; Le | 2000 |
Grand mal seizures after retrobulbar block.
Topics: Aged; Anesthesia, Local; Bupivacaine; Epilepsy, Tonic-Clonic; Epinephrine; Eye; Humans; Injections, | 1978 |
Cerebral and cardiac toxicity of a small dose of lignocaine.
Topics: Arrhythmias, Cardiac; Bradycardia; Electrocardiography; Epilepsy, Tonic-Clonic; Humans; Injections, | 1975 |
Grand mal seizures following fentanyl-lidocaine.
Topics: Adult; Anesthesia; Epilepsy, Tonic-Clonic; Female; Fentanyl; Humans; Lidocaine | 1985 |
Clinical, electroencephalographical and neuropharmacological studies in syndromes of progressive myoclonus epilepsy.
Topics: Administration, Oral; Adrenocorticotropic Hormone; Adult; Amobarbital; Benzazepines; Chloral Hydrate | 1970 |
Lignocaine overdose and ampoule labelling.
Topics: Aged; Diazepam; Drug Labeling; Epilepsy, Tonic-Clonic; Humans; Lidocaine; Male; Myocardial Infarctio | 1972 |
Ventricular arrhythmias associated with the ingestion of alcohol.
Topics: Adult; Alcohol Drinking; Arrhythmias, Cardiac; Electrocardiography; Epilepsy, Tonic-Clonic; Ethanol; | 1972 |
Clinical and electroencephalographic studies of responses to lidocaine and chlormethiazole in progressive myoclonus epilepsy.
Topics: Adolescent; Adult; Chlormethiazole; Electroencephalography; Epilepsy, Tonic-Clonic; Female; Humans; | 1966 |
Effects of lignocaine on epileptiform patterns of bioelectrical activity of the rabbit's brain due to diisopropyl phosphorofluoridate (DFP).
Topics: Animals; Cerebral Cortex; Electroencephalography; Epilepsy, Tonic-Clonic; Isoflurophate; Lidocaine; | 1966 |
Petit and grand mal convulsions during lidocaine hydrochloride treatment of ventricular tachycardia.
Topics: Apnea; Electrocardiography; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Euphoria; Heart Ventricles; H | 1968 |
Lidocaine-induced psychomotor seizures in man.
Topics: Adolescent; Adult; Electroencephalography; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Humans; | 1966 |