lidocaine has been researched along with Endotoxin Shock in 34 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Contractility was examined in a randomized dose-response manner to both norepinephrine and the prostaglandin endoperoxide analog U-46619." | 5.26 | Vascular reactivity in endotoxin shock: effect of lidocaine or indomethacin pretreatment. ( Casey, L; Fletcher, JR; Pomerantz, K; Ramwell, PW, 1982) |
| " Subdiaphragmatic vagotomy and abdominal perivagal lidocaine administration, or lidocaine injection into the nucleus tractus solitarius (NTS) prevented LPS hypotension." | 3.74 | Lipopolysaccharide-induced hypotension is mediated by a neural pathway involving the vagus nerve, the nucleus tractus solitarius and alpha-adrenergic receptors in the preoptic anterior hypothalamic area. ( Cutrera, RA; Feleder, C; Goktalay, G; Millington, WR; Myer, BS; Yilmaz, MS, 2008) |
| "Patients with septic shock commonly require endotracheal intubation under general anaesthesia in the operating theatre, the emergency department, and the intensive care unit." | 3.01 | The benefit of adding lidocaine to ketamine during rapid sequence endotracheal intubation in patients with septic shock: A randomised controlled trial. ( Almenesey, T; Fathy, S; Gado, AA; Hamden, GA; Hasanin, A; Hosny, O; Mokhtar, A; Mostafa, M; Ramzy, E; Safina, AG; Sarhan, K, 2021) |
| " Within the first 10 hrs after baseline measurements, the dosage was increased until no further increase in the left ventricular stroke work index occurred." | 2.70 | Enoximone in contrast to dobutamine improves hepatosplanchnic function in fluid-optimized septic shock patients. ( Kaulfuss, M; Kern, H; Kox, WJ; Martin, M; Schröder, T; Spies, CD, 2001) |
| "We examined 60 septic shock patients within 24 hrs after onset of sepsis." | 2.69 | N-acetylcysteine increases liver blood flow and improves liver function in septic shock patients: results of a prospective, randomized, double-blind study. ( Haertel, C; Lenhart, A; Meier-Hellmann, A; Michel, C; Rank, N; Spies, C; Welte, M, 2000) |
| "Lidocaine was injected both prior to and following NAC administration in order to determine MEGX formation." | 1.32 | N-acetylcysteine decreases lactate signal intensities in liver tissue and improves liver function in septic shock patients, as shown by magnetic resonance spectroscopy: extended case report. ( Armstrong, VW; Hein, OV; Kox, WJ; Oellerich, M; Ohring, R; Schilling, A; Spies, C, 2004) |
| "LPS-induced hypotension has been attributed to nitric oxide (NO) activation of leukocytes, oxidants, cytokines, and other causes." | 1.31 | A role for abdominal vagal afferents in lipopolysaccharide-induced hypotension. ( Mailman, D, 2002) |
| "Captopril-treated pigs experienced a significant increase in %Rd at 60 min, which was followed in 20 min by a significant increase in pancreatic insulin secretion." | 1.27 | Hepatosplanchnic insulin kinetics in awake endotoxemic Yucatan minipigs: the "misinformed B-cell" hypothesis revisited. ( Chandrasena, LG; Cleek, JL; Fettman, MJ; Hand, MS; Mason, RA; Phillips, RW, 1984) |
| " Contractility was examined in a randomized dose-response manner to both norepinephrine and the prostaglandin endoperoxide analog U-46619." | 1.26 | Vascular reactivity in endotoxin shock: effect of lidocaine or indomethacin pretreatment. ( Casey, L; Fletcher, JR; Pomerantz, K; Ramwell, PW, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (64.71) | 18.7374 |
| 1990's | 1 (2.94) | 18.2507 |
| 2000's | 7 (20.59) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 4 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Cong, N | 1 |
| Tian, T | 1 |
| Hu, B | 1 |
| Xue, FS | 1 |
| Hasanin, A | 2 |
| Fathy, S | 2 |
| Mostafa, M | 1 |
| Ramzy, E | 1 |
| Sarhan, K | 1 |
| Almenesey, T | 1 |
| Safina, AG | 1 |
| Hosny, O | 1 |
| Hamden, GA | 1 |
| Gado, AA | 1 |
| Mokhtar, A | 1 |
| Cardinale, M | 1 |
| Mathais, Q | 1 |
| Nguyen, C | 1 |
| Bordes, J | 1 |
| Meaudre, E | 1 |
| Yilmaz, MS | 1 |
| Goktalay, G | 1 |
| Millington, WR | 1 |
| Myer, BS | 1 |
| Cutrera, RA | 1 |
| Feleder, C | 1 |
| Mailman, D | 1 |
| NAGOSHI, Y | 1 |
| KANEKO, Z | 1 |
| UMEZAWA, S | 1 |
| MICHINOSHITA, K | 1 |
| YAMAMOTO, K | 1 |
| NAKAI, Y | 1 |
| FUKUDA, S | 1 |
| AOKI, S | 1 |
| MIYABE, I | 1 |
| SUGIYAMA, S | 1 |
| HONJO, S | 1 |
| YAMADA, T | 1 |
| KIMURA, S | 1 |
| NAKAZAWA, A | 1 |
| FURUYA, M | 1 |
| HOSOGAWA, A | 1 |
| KOBAYASHI, Y | 1 |
| Del Sorbo, L | 1 |
| Zhang, H | 1 |
| Hein, OV | 1 |
| Ohring, R | 1 |
| Schilling, A | 1 |
| Oellerich, M | 1 |
| Armstrong, VW | 1 |
| Kox, WJ | 2 |
| Spies, C | 2 |
| Fettman, MJ | 1 |
| Hand, MS | 1 |
| Chandrasena, LG | 1 |
| Cleek, JL | 1 |
| Mason, RA | 1 |
| Phillips, RW | 1 |
| Arai, Y | 1 |
| Miyao, J | 1 |
| Sameshima, T | 1 |
| Oda, T | 1 |
| Pomerantz, K | 1 |
| Casey, L | 1 |
| Fletcher, JR | 8 |
| Ramwell, PW | 6 |
| Short, BL | 1 |
| Gardiner, M | 1 |
| Walker, RI | 1 |
| Jones, SR | 1 |
| Harris, RH | 1 |
| Zmudka, M | 1 |
| Maddox, Y | 1 |
| Casey, LC | 1 |
| Ramwell, PC | 1 |
| McKindley, DS | 2 |
| Chichester, C | 2 |
| Raymond, R | 1 |
| Rank, N | 1 |
| Michel, C | 1 |
| Haertel, C | 1 |
| Lenhart, A | 1 |
| Welte, M | 1 |
| Meier-Hellmann, A | 1 |
| Kern, H | 1 |
| Schröder, T | 1 |
| Kaulfuss, M | 1 |
| Martin, M | 1 |
| Spies, CD | 1 |
| Boulet, J | 1 |
| Sachdeva, K | 1 |
| Wang, P | 1 |
| Tanaka, K | 1 |
| Anderson, CT | 1 |
| Berde, CB | 1 |
| Sethna, NF | 1 |
| Pribaz, JJ | 1 |
| Anderson, ST | 1 |
| Pitt, A | 1 |
| Vacek, V | 1 |
| Puzanová, L | 1 |
| Noble, J | 1 |
| Jornod, J | 1 |
| Buhler, JC | 1 |
| Hauman, RL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Lidocaine-Ketamine Versus Ketamine for Induction of Anesthesia in Septic Shock Patients: a Randomized Controlled Trial[NCT03844984] | Phase 3 | 43 participants (Actual) | Interventional | 2019-02-20 | Completed | ||
| Effectiveness of N-acetylcysteine on Preservation Solution During Liver Transplantation[NCT01866644] | Phase 3 | 214 participants (Actual) | Interventional | 2011-09-30 | Completed | ||
| Prognostic Value of Indocyanine Clearance Rate for Sepsis Patients in ICU[NCT01447836] | 100 participants (Anticipated) | Observational | 2011-07-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for lidocaine and Endotoxin Shock
| Article | Year |
|---|---|
The benefit of adding lidocaine to ketamine during rapid sequence endotracheal intubation in patients with septic shock: A randomised controlled trial.
Topics: Adult; Anesthesia, General; Humans; Intubation, Intratracheal; Ketamine; Lidocaine; Shock, Septic | 2021 |
N-acetylcysteine increases liver blood flow and improves liver function in septic shock patients: results of a prospective, randomized, double-blind study.
Topics: Acetylcysteine; Adult; Aged; Blood Flow Velocity; Coloring Agents; Double-Blind Method; Female; Free | 2000 |
N-acetylcysteine increases liver blood flow and improves liver function in septic shock patients: results of a prospective, randomized, double-blind study.
Topics: Acetylcysteine; Adult; Aged; Blood Flow Velocity; Coloring Agents; Double-Blind Method; Female; Free | 2000 |
N-acetylcysteine increases liver blood flow and improves liver function in septic shock patients: results of a prospective, randomized, double-blind study.
Topics: Acetylcysteine; Adult; Aged; Blood Flow Velocity; Coloring Agents; Double-Blind Method; Female; Free | 2000 |
N-acetylcysteine increases liver blood flow and improves liver function in septic shock patients: results of a prospective, randomized, double-blind study.
Topics: Acetylcysteine; Adult; Aged; Blood Flow Velocity; Coloring Agents; Double-Blind Method; Female; Free | 2000 |
Enoximone in contrast to dobutamine improves hepatosplanchnic function in fluid-optimized septic shock patients.
Topics: Aged; APACHE; Cardiotonic Agents; Dobutamine; Double-Blind Method; Enoximone; Hemodynamics; Humans; | 2001 |
Endotoxic shock alters the pharmacokinetics of lidocaine and monoethylglycinexylidide.
Topics: Animals; Blood Pressure; Carboxylesterase; Carboxylic Ester Hydrolases; Cytochrome P-450 CYP3A; Cyto | 2002 |
30 other studies available for lidocaine and Endotoxin Shock
| Article | Year |
|---|---|
Is addition of lidocaine to ketamine beneficial for rapid sequence endotracheal intubation in patients with septic shock?
Topics: Humans; Intubation, Intratracheal; Ketamine; Lidocaine; Rapid Sequence Induction and Intubation; Sho | 2022 |
In response: Was ketamine-lidocaine an adequate hypnotic agent in patients with septic shock?
Topics: Anesthetics, Local; Humans; Hypnotics and Sedatives; Ketamine; Lidocaine; Shock, Septic | 2022 |
Reply to: The benefit of adding lidocaine to ketamine during rapid sequence endotracheal intubation in patients with septic shock: A randomised controlled trial.
Topics: Humans; Intubation, Intratracheal; Ketamine; Lidocaine; Rapid Sequence Induction and Intubation; Sho | 2021 |
Lipopolysaccharide-induced hypotension is mediated by a neural pathway involving the vagus nerve, the nucleus tractus solitarius and alpha-adrenergic receptors in the preoptic anterior hypothalamic area.
Topics: Acute Disease; Adrenergic alpha-Antagonists; Anesthetics, Local; Animals; Hypotension; Lidocaine; Li | 2008 |
A role for abdominal vagal afferents in lipopolysaccharide-induced hypotension.
Topics: Animals; Blood Pressure Determination; Capsaicin; Disease Models, Animal; Drug Interactions; Female; | 2002 |
[CASES OF SHOCK-LIKE CONDITIONS. (3) CLINICAL CASES OF SHOCK-LIKE CONDITIONS CAUSED BY DRUGS].
Topics: Adolescent; Child; Drug Hypersensitivity; Lidocaine; Otolaryngology; Penicillins; Procaine; Shock; S | 1963 |
[CASES OF SHOCK-LIKE CONDITIONS. (6)].
Topics: Adenoidectomy; Child; Cocaine; Drug Hypersensitivity; Lidocaine; Otolaryngology; Shock; Shock, Septi | 1963 |
[CASES OF SHOCK-LIKE CONDITIONS. (8)].
Topics: Drug Hypersensitivity; Heart Massage; Infant; Lidocaine; Otolaryngology; Resuscitation; Shock; Shock | 1963 |
[CASE OF SUCCESSFUL TREATMENT OF SHOCK IN TONSILLECTOMY AND MEASURES FOR PREVENTING IT].
Topics: Blood Sedimentation; Blood Transfusion; Caffeine; Cyanosis; Drug Hypersensitivity; Electrocardiograp | 1963 |
[CASE OF SHOCK CAUSED BY LOCAL ANESTHESIA].
Topics: Anesthesia, Local; Blood Transfusion; Cocaine; Drug Hypersensitivity; Lidocaine; Oxygen Inhalation T | 1963 |
[5 RECENT CASES OF LOCAL ANESTHETIC TOXICITY IN TONSILLECTOMY].
Topics: Anesthesia, Local; Anesthetics, Local; Child; Cocaine; Drug Hypersensitivity; Lidocaine; Pharmacolog | 1963 |
Is there a place for N-acetylcysteine in the treatment of septic shock?
Topics: Acetylcysteine; Antioxidants; Hemodynamics; Humans; Lidocaine; Liver; Liver Circulation; Shock, Sept | 2004 |
N-acetylcysteine decreases lactate signal intensities in liver tissue and improves liver function in septic shock patients, as shown by magnetic resonance spectroscopy: extended case report.
Topics: Acetylcysteine; Adult; Aged; Antioxidants; Female; Hemodynamics; Humans; Lactates; Lidocaine; Liver; | 2004 |
Hepatosplanchnic insulin kinetics in awake endotoxemic Yucatan minipigs: the "misinformed B-cell" hypothesis revisited.
Topics: Animals; Blood Glucose; Captopril; Endotoxins; Insulin; Islets of Langerhans; Kinetics; Lidocaine; L | 1984 |
[Antishock effect of lidocaine].
Topics: Animals; Glucan 1,4-alpha-Glucosidase; Lidocaine; Male; Mice; Shock, Septic | 1983 |
Vascular reactivity in endotoxin shock: effect of lidocaine or indomethacin pretreatment.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aorta, Thoracic; Dose-R | 1982 |
Indomethacin improves survival in gram-negative sepsis.
Topics: Animals; Blood Pressure; Disease Models, Animal; Escherichia coli Infections; Indomethacin; Leukocyt | 1981 |
Relationship of TXB2 and 6-keto PGF1 alpha to the hemodynamic changes during baboon endotoxic shock.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arteries; Blood Pressure; Haplorhini; Indomethacin; Lidocaine | 1980 |
The protective effect of lidocaine on arachidonate metabolism in septic shock.
Topics: Animals; Arachidonic Acids; Dogs; Humans; Indomethacin; Lidocaine; Papio; Prostaglandins; Rats; Shoc | 1981 |
Effect of endotoxin shock on the clearance of lidocaine and indocyanine green in the perfused rat liver.
Topics: Anesthetics, Local; Animals; Cimetidine; Coloring Agents; Cytochrome P-450 Enzyme Inhibitors; Cytoch | 1999 |
Lidocaine treatment following baboon endotoxin shock improves survival.
Topics: Animals; Blood Pressure; Cardiac Output; Dinoprost; Endotoxins; Heart Rate; Lidocaine; Male; Papio; | 1979 |
E. coli endotoxin shock in the dog; treatment with lidocaine or indomethacin.
Topics: Animals; Blood Cell Count; Blood Coagulation; Dogs; Endotoxins; Escherichia coli; Hemodynamics; Indo | 1978 |
Lidocaine or indomethacin improves survival in baboon endotoxin shock.
Topics: Animals; Dogs; Haplorhini; Hemodynamics; Indomethacin; Lidocaine; Male; Papio; Prostaglandins F; Sho | 1978 |
E. coli endotoxin shock in the baboon: treatment with lidocaine or indomethacin.
Topics: Animals; Blood Pressure; Cardiac Output; Escherichia coli; Haplorhini; Heart Rate; Indomethacin; Lid | 1978 |
[The anti-shock effects of several drugs, with special reference to the effect of lidocaine].
Topics: Animals; Aprotinin; Fibrin; Gabexate; Guanidines; Lidocaine; Methylprednisolone; Rabbits; Shock, Sep | 1985 |
Meningococcal purpura fulminans: treatment of vascular insufficiency in a 2-yr-old child with lumbar epidural sympathetic blockade.
Topics: Anesthesia, Epidural; Autonomic Nerve Block; Bupivacaine; Child, Preschool; Disseminated Intravascul | 1989 |
Lignocaine in the management of ventricular arrhythmias.
Topics: Adult; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Coronary Disease; Digitalis Glycosides; H | 1969 |
[Injecting around the celiac plexus in septic shock].
Topics: Adolescent; Anesthesia, Conduction; Celiac Plexus; Female; Ganglionic Blockers; Humans; Lidocaine; S | 1966 |
[Suicide attempt using ajmaline].
Topics: Adult; Ajmaline; Anuria; Bicarbonates; Bundle-Branch Block; Electrocardiography; Female; Humans; Iso | 1971 |
Effect of celiac blockade fn intestinal arteriolar resistance and critical closing pressure during endotoxin shock.
Topics: Animals; Blood Pressure; Celiac Plexus; Dogs; Hemodynamics; Intestinal Mucosa; Intestine, Small; Lid | 1968 |