Page last updated: 2024-10-28

lidocaine and Embryopathies

lidocaine has been researched along with Embryopathies in 22 studies

Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.

Research Excerpts

ExcerptRelevanceReference
"The effects of lidocaine on the fetal circulatory responses to asphyxia were evaluated in chronically instrumented pregnant sheep."7.67Effect of lidocaine on the asphyxial responses in the mature fetal lamb. ( Arthur, GR; Covino, BG; Finster, M; Hiraoka, H; Morishima, HO; Pedersen, H; Santos, AC; Tsuji, A, 1987)
"To investigate whether fetal acidosis increases the placental transfer of lidocaine, resulting in higher fetal blood levels of the drug, lidocaine was infused intravenously into ten pregnant ewes to maintain plasma levels of 2-4 microgram/ml."7.66Placental transfer of lidocaine: effects of fetal acidosis. ( Biehl, D; Callender, K; Levinson, G; Shnider, SM, 1978)
" Prenatal treatment with beta-adrenergic blocker (propranolol) and digitalis glycosides was prescribed because of suspicion of long QT syndrome occurring with fetal congestive heart failure."3.71Prenatal diagnosis and treatment of fetal long QT syndrome: a case report. ( Chang, IK; Chow, SN; Hsieh, FJ; Kau, ML; Ko, YH; Lee, CN; Shyu, MK, 2002)
"The effects of lidocaine on the fetal circulatory responses to asphyxia were evaluated in chronically instrumented pregnant sheep."3.67Effect of lidocaine on the asphyxial responses in the mature fetal lamb. ( Arthur, GR; Covino, BG; Finster, M; Hiraoka, H; Morishima, HO; Pedersen, H; Santos, AC; Tsuji, A, 1987)
"In order to define the causal relationship between the use of local anesthetics and fetal bradycardia, paracervical block anesthesia (PCB) with lidocaine of 2-chloroprocaine was induced on 52 occasions to 27 pregnant baboons."3.66Bradycardia in the fetal baboon following paracervical block anesthesia. ( Covino, BG; James, LS; Morishima, HO; Stark, RI; Yeh, MN, 1981)
"To investigate whether fetal acidosis increases the placental transfer of lidocaine, resulting in higher fetal blood levels of the drug, lidocaine was infused intravenously into ten pregnant ewes to maintain plasma levels of 2-4 microgram/ml."3.66Placental transfer of lidocaine: effects of fetal acidosis. ( Biehl, D; Callender, K; Levinson, G; Shnider, SM, 1978)
"Lidocaine was administered into a fetal femoral vein either as a continuous infusion or as a bolus injection."1.26Gestational differences in lidocaine toxicity in the fetal lamb. ( Benowitz, N; Heymann, MA; Rudolph, AM; Teramo, K, 1976)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-199014 (63.64)18.7374
1990's2 (9.09)18.2507
2000's3 (13.64)29.6817
2010's3 (13.64)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Clivatti, J1
Siddiqui, N1
Goel, A1
Shaw, M1
Crisan, I1
Carvalho, JC1
Cuneo, BF2
Strasburger, JF2
Yu, S1
Horigome, H1
Hosono, T1
Kandori, A1
Wakai, RT2
Komarlu, R1
Beerman, L1
Freeman, D1
Arora, G1
Chang, IK1
Shyu, MK1
Lee, CN1
Kau, ML1
Ko, YH1
Chow, SN1
Hsieh, FJ1
Moral Turiel, M1
Bermúdez Montón, JL1
Sahagún de la Lastra, J1
Aguirrebengoa Olarán, M1
Yuste Pascual, JA1
Ovadia, M1
Zhao, H1
Petropulos, T1
Schneider, J1
DAVIS, JE1
FRUDENFELD, JC1
FRUDENFELD, K1
FRUDENFELD, JH1
WEBB, AN1
Morishima, HO3
Covino, BG2
Yeh, MN1
Stark, RI1
James, LS2
Halpern, S1
Glanc, P1
Myhr, T1
Ryan, M1
Fong, K1
Amankwah, K1
Ohlsson, A1
Fulgencio, JP1
Hamza, J1
Biehl, D1
Shnider, SM1
Levinson, G1
Callender, K1
Guntheroth, W1
Stofer, AR1
Ulrich, L1
Steinsiepe, KF1
Egger, G1
Heymann, MA2
Rudolph, AM2
Barrett, CT1
Teramo, K1
Benowitz, N1
Santos, AC1
Pedersen, H1
Finster, M1
Tsuji, A1
Hiraoka, H1
Arthur, GR1
Moore, J1
Murnaghan, GA1
Lewis, MA1
Goodlin, RC1
Lowe, EW1
Hamilton, LA1
Gottschalk, W1
Vasicka, A1
Robertazzi, R1
Raji, M1
Scheffs, J1
Kosmowski, J1
Goei, T1
Boba, A1
Linkie, DM1
Plotz, EJ1
Bernier, G1
Turcot, MJ1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Fetal Electrophysiologic Abnormalities in High-risk Pregnancies Associated With Fetal Demise[NCT03775954]200 participants (Anticipated)Observational2018-07-01Recruiting
Maternal-Fetal Monitoring of Patients With Rheumatic Heart Disease During Dental Procedure Under Local Anesthesia[NCT00482573]Phase 131 participants (Actual)Interventional2004-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

22 other studies available for lidocaine and Embryopathies

ArticleYear
Quality of labour neuraxial analgesia and maternal satisfaction at a tertiary care teaching hospital: a prospective observational study.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2013, Volume: 60, Issue:8

    Topics: Adjuvants, Anesthesia; Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesia, Patient-Contro

2013
In utero diagnosis of long QT syndrome by magnetocardiography.
    Circulation, 2013, Nov-12, Volume: 128, Issue:20

    Topics: Anti-Arrhythmia Agents; Cohort Studies; Electrocardiography; Female; Fetal Diseases; Genetic Associa

2013
Fetal and neonatal presentation of long QT syndrome.
    Pacing and clinical electrophysiology : PACE, 2012, Volume: 35, Issue:4

    Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Electrocardiography; ERG1 Potassium Channel; Et

2012
Prenatal diagnosis and treatment of fetal long QT syndrome: a case report.
    Prenatal diagnosis, 2002, Volume: 22, Issue:13

    Topics: Adult; Bradycardia; Bundle-Branch Block; Electrocardiography; Female; Fetal Diseases; Heart Block; H

2002
[Remifentanil as a buffer for the stress response in cesarean section under general anesthesia].
    Revista espanola de anestesiologia y reanimacion, 2003, Volume: 50, Issue:2

    Topics: Adult; Analgesics, Opioid; Anesthesia, General; Anesthesia, Obstetrical; Anesthetics, Local; Cesarea

2003
Prenatal diagnosis and in utero treatment of torsades de pointes associated with congenital long QT syndrome.
    The American journal of cardiology, 2003, Jun-01, Volume: 91, Issue:11

    Topics: Adult; Anti-Arrhythmia Agents; Echocardiography; Electrocardiography; Female; Fetal Diseases; Gestat

2003
THE COMBINED PARACERVICAL-PUDENDAL BLOCK ANESTHESIA FOR LABOR AND DELIVERY. A REVIEW OF 2,100 PRIVATE CASES.
    American journal of obstetrics and gynecology, 1964, Jun-01, Volume: 89

    Topics: Anesthesia, Obstetrical; Bradycardia; Cervix Uteri; Epinephrine; Female; Fetal Diseases; Humans; Inf

1964
Bradycardia in the fetal baboon following paracervical block anesthesia.
    American journal of obstetrics and gynecology, 1981, Aug-01, Volume: 140, Issue:7

    Topics: Anesthesia, Local; Anesthesia, Obstetrical; Animals; Bradycardia; Female; Fetal Diseases; Fetus; Hem

1981
Uterine and umbilical blood flow velocity during epidural anaesthesia for caesarean section.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1994, Volume: 41, Issue:11

    Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Arteries; Blood Flow Velocity; Cesarean Sectio

1994
Anaesthesia for caesarean section in a patient receiving high dose amiodarone for fetal supraventricular tachycardia.
    Anaesthesia, 1994, Volume: 49, Issue:5

    Topics: Adult; Amiodarone; Anesthesia, Epidural; Anesthesia, Obstetrical; Cesarean Section; Drug Interaction

1994
Placental transfer of lidocaine: effects of fetal acidosis.
    Anesthesiology, 1978, Volume: 48, Issue:6

    Topics: Acidosis; Animals; Bicarbonates; Blood Pressure; Female; Fetal Diseases; Heart Rate; Hydrogen-Ion Co

1978
Neonatal and pediatric cardiovascular crises.
    JAMA, 1975, Apr-14, Volume: 232, Issue:2

    Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Bradycardia; Cardiovascular Diseases; Digoxin; Emerge

1975
[Clinical and experimental contribution to the pathogenesis of acute life-threatening incidents following neck anesthesia].
    Schweizerische medizinische Wochenschrift, 1975, Jan-11, Volume: 105, Issue:2

    Topics: Acute Disease; Anaphylaxis; Anesthesia, Epidural; Anesthesia, Local; Anesthetics; Drug Hypersensitiv

1975
Transfer of lidocaine across the sheep placenta to the fetus. Hemodynamic and acid-base responses of the fetal lamb.
    American journal of obstetrics and gynecology, 1975, Jul-01, Volume: 122, Issue:5

    Topics: Acid-Base Equilibrium; Animals; Asphyxia; Blood; Blood Circulation; Female; Fetal Blood; Fetal Disea

1975
Gestational differences in lidocaine toxicity in the fetal lamb.
    Anesthesiology, 1976, Volume: 44, Issue:2

    Topics: Animals; Blood Pressure; Cerebellar Cortex; Female; Femoral Artery; Fetal Diseases; Fetus; Gestation

1976
Effect of lidocaine on the asphyxial responses in the mature fetal lamb.
    Anesthesiology, 1987, Volume: 66, Issue:4

    Topics: Anesthesia, Epidural; Animals; Asphyxia; Blood Gas Analysis; Blood Pressure; Cardiac Output; Female;

1987
A clinical evaluation of the maternal effects of lumbar extradural analgesia for labour.
    Anaesthesia, 1974, Volume: 29, Issue:5

    Topics: Anesthesia, Epidural; Anesthesia, Obstetrical; Bupivacaine; Cesarean Section; Epinephrine; Extractio

1974
Multiphasic fetal monitoring. A preliminary evaluation.
    American journal of obstetrics and gynecology, 1974, Jun-01, Volume: 119, Issue:3

    Topics: Acoustic Stimulation; Anesthesia, Conduction; Anesthesia, Obstetrical; Atropine; Ballistocardiograph

1974
Paracervical block: advantages and disadvantages.
    Clinical obstetrics and gynecology, 1974, Volume: 17, Issue:2

    Topics: Acidosis; Anesthesia, Obstetrical; Anesthetics, Local; Bradycardia; Cervix Uteri; Female; Fetal Dise

1974
Fetal bradycardia after paracervical block.
    Obstetrics and gynecology, 1971, Volume: 38, Issue:4

    Topics: Anesthesia, Conduction; Anesthesia, Obstetrical; Bradycardia; Catheterization; Cervix Uteri; Epineph

1971
Fetal effects of spinal hypotension. Observations in the dog at term of pregnancy.
    Obstetrics and gynecology, 1971, Volume: 37, Issue:2

    Topics: Anesthesia, Spinal; Animals; Blood Pressure; Bradycardia; Dogs; Female; Fetal Diseases; Fetal Heart;

1971
[Paracervical block in obstetrics].
    L'union medicale du Canada, 1971, Volume: 100, Issue:8

    Topics: Anesthesia, Local; Anesthesia, Obstetrical; Bradycardia; Cervix Uteri; Female; Fetal Diseases; Human

1971