Page last updated: 2024-10-28

lidocaine and Edema

lidocaine has been researched along with Edema in 70 studies

Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.

Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.

Research Excerpts

ExcerptRelevanceReference
"In volunteers EMLA cream is associated with less pain on cannulation and cannula advancement compared to piroxicam gel."9.10Piroxicam gel, compared to EMLA cream is associated with less pain after venous cannulation in volunteers. ( Dutta, A; Puri, GD; Wig, J, 2003)
" When infected mice were treated with different amounts of lidocaine (a local anesthetic, chemically defined as a tertiary amide compound), reduction in intensity of the pancreatic necrosis and in the number of PMN were observed."7.69Protective effect of lidocaine in the experimental foot-and-mouth disease pancreatitis. ( González, PH; Portiansky, EL, 1995)
"Sepsis was induced by cecal ligation and puncture."5.40Adenosine, lidocaine and Mg2+ (ALM) induces a reversible hypotensive state, reduces lung edema and prevents coagulopathy in the rat model of polymicrobial sepsis. ( Dobson, GP; Griffin, MJ; Letson, HL, 2014)
"Lavage of nasal flaps with lidocaine-adrenaline mixture seems an effective and simple way in the control of early postoperative pain, edema, and ecchymosis in septorhinoplasty patients."5.34Lavage With Lidocaine and Adrenaline Mixture Reduces the Early Side Effects of Septorhinoplasty. ( Gümüş, N, 2020)
"To examine the efficacy and safety of a new topical anesthetic containing a disinfection ingredient (LidoDin cream) in reducing the pain associated with venipuncture by comparing it with the proven eutectic mixture of lidocaine 2."5.14Lidocaine-based topical anesthetic with disinfectant (LidoDin) versus EMLA for venipuncture: a randomized controlled trial. ( Hadash, A; Kassis, I; Knaani-Levinz, H; Shachor-Meyouhas, Y; Shavit, I, 2009)
"In volunteers EMLA cream is associated with less pain on cannulation and cannula advancement compared to piroxicam gel."5.10Piroxicam gel, compared to EMLA cream is associated with less pain after venous cannulation in volunteers. ( Dutta, A; Puri, GD; Wig, J, 2003)
"We present a case of a middle-aged woman with no prior history of deep venous thrombosis, with a blue swollen left leg in intractable severe pain unresponsive to 3 doses of hydromorphone."4.12Phlegmasia cerulea dolens causing compartment syndrome. ( Aydemir, B; Hakmeh, W; Hoyle, C, 2022)
" Lidocaine formulations significantly reduced the paw edema on day 6 after Walker 256 cells inoculation."3.96Effects of 2-Hydroxypropil-Β-Cyclodextrin-Lidocaine on Tumor Growth and Inflammatory Response. ( Abdalla, HB; Burga-Sánchez, J; da Costa, JP; de Freitas Domingues, JS; Ferreira, LEN; Groppo, FC; Volpato, MC, 2020)
" We evaluated the effect of lidocaine on tissue necrosis after electrical burn injuries."3.78Effect of lidocaine on reducing injury in a rat electrical burn model. ( Aygit, AC; Benlier, E; Eskiocak, S; Kandulu, H; Omurlu, IK; Puyan, FO; Sikar, EY; Top, H, 2012)
"The involvement of bradykinin and some other inflammatory mediators in formalin-induced oedema and plasma extravasation was examined."3.70The inflammatory reaction induced by formalin in the rat paw. ( Damas, J; Liégeois, JF, 1999)
" When infected mice were treated with different amounts of lidocaine (a local anesthetic, chemically defined as a tertiary amide compound), reduction in intensity of the pancreatic necrosis and in the number of PMN were observed."3.69Protective effect of lidocaine in the experimental foot-and-mouth disease pancreatitis. ( González, PH; Portiansky, EL, 1995)
"A 43-year-old woman suffered from recurrent localized swellings and an eczematous dermatitis starting 1 day after an injection of lidocaine."3.69Delayed-type hypersensitivity to subcutaneous lidocaine with tolerance to articaine: confirmation by in vivo and in vitro tests. ( Bircher, AJ; Messmer, SL; Rufli, T; Surber, C, 1996)
"We have assessed the effects of intraplantar local anaesthetics (bupivacaine and lignocaine) on carrageenan-induced oedema, mechanical allodynia and spinal c-fos protein expression."3.69Effects of local anaesthetics on carrageenan-evoked inflammatory nociceptive processing in the rat. ( Besson, JM; Buritova, J; Fletcher, D; Honoré, P, 1996)
" Quinidine, procainamide, lidocaine, and propranolol are used to treat a variety of supraventricular and ventricular arrhythmias."3.67Pharmacology and pharmacokinetics of drugs used to treat cardiac disease in horses. ( McGuirk, SM; Muir, WW, 1985)
" Most common treatment-emergent adverse events (AEs) included lip bruising, swelling, and pain and were mostly mild and transient in nature, without anticipated device AEs."2.80A randomized, evaluator-blinded, controlled study of effectiveness and safety of small particle hyaluronic acid plus lidocaine for lip augmentation and perioral rhytides. ( Beer, K; Bulley, B; Dover, JS; Glogau, RG; Handiwala, L; Olin, JT; Shamban, A, 2015)
"Association of trismus was found less with the steroid treatment groups when compared to the control group."2.79Effects of intra-space injection of Twin mix versus intraoral-submucosal, intramuscular, intravenous and per-oral administration of dexamethasone on post-operative sequelae after mandibular impacted third molar surgery: a preliminary clinical comparative ( Bhargava, D; Deshpande, A; Sreekumar, K, 2014)
"Pain and potential adverse events (AE) remain challenges for patients being treated with calcium hydroxylapatite (CaHA; Radiesse), especially CaHA not mixed with an anesthetic."2.79Safety and effectiveness of injection of calcium hydroxylapatite via blunt cannula compared to injection by needle for correction of nasolabial folds. ( Beer, KR, 2014)
"Pain, swelling, and trismus are the most common complications associated with third molar surgery."2.76Comparative study of effect of single and multiple suture techniques on inflammatory complications after third molar surgery. ( Adebola, RA; Osunde, OD; Saheeb, BD, 2011)
" The overall incidence of adverse events in the combined studies was 22 percent for the articaine group and 20 percent for the lidocaine group."2.70Articaine hydrochloride: a study of the safety of a new amide local anesthetic. ( Gagnon, S; Leblanc, D; Malamed, SF, 2001)
"Sub-Tenon's anaesthesia is an efficient and safe anaesthetic technique."2.68Sub-Tenon's anaesthesia: an efficient and safe technique. ( Auclin, FX; Boureau, CM; Chong Sit, DA; Roman, SJ; Ullern, MM, 1997)
"Sepsis was induced by cecal ligation and puncture."1.40Adenosine, lidocaine and Mg2+ (ALM) induces a reversible hypotensive state, reduces lung edema and prevents coagulopathy in the rat model of polymicrobial sepsis. ( Dobson, GP; Griffin, MJ; Letson, HL, 2014)
"The Safety of Microfocused Ultrasound with Visualization (MFU-V) has been well established in both controlled clinical studies and in clinical use, showing only mild and transient anticipated side effects and only rare unanticipated adverse events (AEs)."1.40Review of the safety profile for microfocused ultrasound with visualization. ( Dobke, MK; Hitchcock, TM, 2014)
"In episodic cluster headache, the effect lasted for most of the bout."1.38Efficacy and safety of 121 injections of the greater occipital nerve in episodic and chronic cluster headache. ( Gantenbein, AR; Lutz, NJ; Riederer, F; Sándor, PS, 2012)
"Tumescent liposuction under local anesthesia is a safe method, providing it is performed by an experienced surgeon and the guidelines of care for liposuction are strictly followed."1.37Safety of tumescent liposuction under local anesthesia in a series of 4,380 patients. ( Boeni, R, 2011)
"Inflammation found in temporomandibular disorders and rheumatoid arthritis may result from mediators released by pain-sensing neurons."1.31Local anesthesia does not block mustard-oil-induced temporomandibular inflammation. ( Haas, DA; Hu, JW; Wong, JK, 2001)
"A case of progressive anaphylactoid reaction complicating a local anaesthetic agent administered to a dental patient is described."1.30Anaphylactic reaction following administration of lignocaine hydrochloride infiltration. Case report. ( Ogunsalu, CO, 1998)
"In the present study we investigated the antiinflammatory effect of pentosanpolysulfate (SP 54) in combination with metamizol using different forms of rat paw edema (induced by dextrane, hyaluronidase, trypsin, formaldehyde, carragenine or kaolin)."1.26[Pharmacological studies on the antiphlogistic effect of pentosanpolysulfate in combination with metamizol]. ( Kalbhen, DA; Smalla, HD, 1977)

Research

Studies (70)

TimeframeStudies, this research(%)All Research%
pre-199015 (21.43)18.7374
1990's14 (20.00)18.2507
2000's14 (20.00)29.6817
2010's23 (32.86)24.3611
2020's4 (5.71)2.80

Authors

AuthorsStudies
Aydemir, B1
Hoyle, C1
Hakmeh, W1
Gümüş, N1
Ferreira, LEN1
Abdalla, HB1
da Costa, JP1
de Freitas Domingues, JS1
Burga-Sánchez, J1
Groppo, FC1
Volpato, MC1
Kara, YS1
Hapa, O1
Işın, Y1
Kılıç, Aİ1
Havitçioğlu, H1
Kim, J1
Chopra, R1
Graivier, M1
Fabi, S1
Nestor, M1
Meuse, P1
Mashburn, J1
Tasman, AJ1
Bhargava, D1
Sreekumar, K1
Deshpande, A1
Zhu, X1
Li, F1
Peng, X1
Zeng, K1
Christensen, J1
Matzen, LH1
Vaeth, M1
Wenzel, A1
Schou, S1
Sanaei-Zadeh, H1
Griffin, MJ2
Letson, HL2
Dobson, GP2
Beer, KR1
Hitchcock, TM1
Dobke, MK1
Beer, K1
Glogau, RG1
Dover, JS1
Shamban, A1
Handiwala, L1
Olin, JT1
Bulley, B1
Rajalakshmi, AR1
Kumar, MA1
Ong, AA1
Farhood, Z1
Kyle, AR1
Patel, KG1
Lee, U1
Choi, YJ1
Choi, GJ1
Kang, H1
Dionyssiou, D1
Fry, R1
Ring, P1
Shavit, I1
Hadash, A1
Knaani-Levinz, H1
Shachor-Meyouhas, Y1
Kassis, I1
Osunde, OD1
Saheeb, BD1
Adebola, RA1
Gun, R1
Yorgancılar, E1
Yıldırım, M1
Bakır, S1
Topcu, I1
Akkus, Z1
Boeni, R1
Watanabe, K1
Nakaya, M1
Glück, J1
Rymarczyk, B1
Rogala, B1
Gantenbein, AR1
Lutz, NJ1
Riederer, F1
Sándor, PS1
Benlier, E1
Eskiocak, S1
Puyan, FO1
Sikar, EY1
Kandulu, H1
Omurlu, IK1
Top, H1
Aygit, AC1
Plank, RM1
Kubiak, DW1
Abdullahi, RB1
Ndubuka, N1
Nkgau, MM1
Dapaah-Siakwan, F1
Powis, KM1
Lockman, S1
Evans, LA1
Pointing, J1
Wills, EJ1
Michalopoulos, J1
Adelstein, S1
Fasting, S1
Gisvold, SE1
Dutta, A1
Puri, GD1
Wig, J1
Kumar, CM1
Dodds, C1
McLure, H1
Chabria, R1
Kohase, H1
Umino, M1
Kimura, S1
Hirai, A1
Shimizu, H1
Portiansky, EL1
González, PH1
Sharara, AM1
Higham, MA1
Iredale, MJ1
Ind, PW1
Condés-Lara, M1
Sánchez-Moreno, RM1
Omaña-Zapata, I1
Bircher, AJ1
Messmer, SL1
Surber, C1
Rufli, T1
Buritova, J1
Fletcher, D1
Honoré, P1
Besson, JM1
Hefer, T1
Joachims, HZ1
Roman, SJ1
Chong Sit, DA1
Boureau, CM1
Auclin, FX1
Ullern, MM1
Kayser, V1
Idänpään-Heikkilä, JJ1
Guilbaud, G1
Jönsson, A1
Mattsson, U1
Tarnow, P1
Nellgård, P1
Cassuto, J1
Ogunsalu, CO1
Yaman, Z1
Kişnişci, RS1
Walters, G1
Georgiou, T1
Hayward, JM1
Damas, J1
Liégeois, JF1
Gautam, PL1
Kathuria, S1
Kaul, TK1
Greenberg, MF1
Cogen, MS1
Pollard, ZF1
Malamed, SF1
Gagnon, S1
Leblanc, D1
Field, LM1
Wong, JK1
Haas, DA1
Hu, JW1
Campbell, JR1
Maestrello, CL1
Campbell, RL1
Gammaitoni, AR1
Davis, MW1
Kalbhen, DA1
Smalla, HD1
Ravindranathan, N1
Poraszka, J1
Szeluga, J1
Keskitalo, E1
Persson, G1
Kalichman, MW1
Powell, HC1
Myers, RR1
Schmidt, SH1
Hellström, S1
Anniko, M1
Racle, JP1
Jourdren, L1
Benkhadra, A1
Poy, JY1
Fockenier, F1
Muir, WW1
McGuirk, SM1
Soschin, D1
Leyden, JJ1
Burn, JM1
Shehadi, SI1
Shields, PW1
Eichbaum, FW1
Yasaka, WJ1
Kerstein, MD1
Bergentz, SE1
Lewis, DH1

Clinical Trials (8)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized Controlled Trial on Assessment of Preoperative Versus Postoperative Submucosal Dexamethasone On Postoperative Complications Following Surgical Extraction Of Mandibular Third Molar.[NCT06160180]Phase 460 participants (Anticipated)Interventional2023-12-31Not yet recruiting
Comparing the Efficacy of Local Anesthetics in Mohs Surgery[NCT03871478]105 participants (Anticipated)Interventional2019-10-01Recruiting
Comparison Between the Effects of Lidocaine Prilocaine Cream and Lidocaine Injection on Reduction of Perineal Pain During Episiotomy and Perineum Repair in Vaginal Delivery: Randomized Control Trial[NCT05891132]60 participants (Anticipated)Interventional2023-09-01Not yet recruiting
Intra-operative Nasal Compression After Lateral Osteotomy to Minimize Post-operative Peri-orbital Ecchymosis and Edema[NCT02319954]16 participants (Actual)Interventional2015-01-31Completed
Maternal-Fetal Monitoring of Patients With Rheumatic Heart Disease During Dental Procedure Under Local Anesthesia[NCT00482573]Phase 131 participants (Actual)Interventional2004-04-30Completed
A Single Center, Randomized, Double-Blind Controlled Study of Topical Endoluminal Pancreatic Duct Lidocaine for Prevention of Post-ERCP Pancreatitis[NCT00953199]506 participants (Actual)Interventional2010-03-31Completed
Pain During Pars Plana Vitrectomy Comparing Peribulbar Anesthesia Versus Sub-tenon Injection Plus Topical Jelly Anesthesia[NCT03902925]Phase 1/Phase 256 participants (Actual)Interventional2019-01-01Completed
Is the Direct Inferior Alveolar Nerve Block Required for Third Lower Molar Extraction?[NCT03443726]120 participants (Actual)Interventional2017-06-10Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Post ERCP Pancreatitis is the Primary Outcome.

The primary outcome of interest will be development of acute pancreatitis defined as new or worsening abdominal pain post-ERCP associated with an increase in serum amylase at least 3 times the upper limit of normal. (NCT00953199)
Timeframe: 24-48 hours post-procedure

Interventionparticipants (Number)
Lidocaine26
Normal Saline20

Serum Amylase Levels

serum amylase levels are measure by a blood draw (NCT00953199)
Timeframe: measurement is taken 2 hrs after ERCP

Interventionunits/liter (Mean)
Lidocaine130
Normal Saline128

Reviews

2 reviews available for lidocaine and Edema

ArticleYear
Reducing Periorbital Edema and Ecchymosis after Rhinoplasty: Literature Review and Personal Approach.
    Facial plastic surgery : FPS, 2018, Volume: 34, Issue:1

    Topics: Adrenal Cortex Hormones; Anticoagulants; Ecchymosis; Edema; Eye Pain; Female; Humans; Hypothermia, I

2018
Interventions to Decrease Postoperative Edema and Ecchymosis after Rhinoplasty: A Systematic Review of the Literature.
    Plastic and reconstructive surgery, 2016, Volume: 137, Issue:5

    Topics: Adrenal Cortex Hormones; Blood Loss, Surgical; Ecchymosis; Edema; Fibrin Tissue Adhesive; Humans; Hy

2016

Trials

17 trials available for lidocaine and Edema

ArticleYear
Lavage With Lidocaine and Adrenaline Mixture Reduces the Early Side Effects of Septorhinoplasty.
    Annals of plastic surgery, 2020, Volume: 84, Issue:6

    Topics: Adult; Ecchymosis; Edema; Epinephrine; Female; Humans; Lidocaine; Male; Pain, Postoperative; Postope

2020
A comparison of ice wrap and subacromial injection for postoperative pain and edema control following arthroscopic rotator cuff repair.
    Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology, 2020, Sep-02, Volume: 21, Issue:1

    Topics: Adult; Aged; Anesthetics, Local; Arthroscopy; Bupivacaine; Cryotherapy; Edema; Female; Humans; Ice;

2020
Effects of intra-space injection of Twin mix versus intraoral-submucosal, intramuscular, intravenous and per-oral administration of dexamethasone on post-operative sequelae after mandibular impacted third molar surgery: a preliminary clinical comparative
    Oral and maxillofacial surgery, 2014, Volume: 18, Issue:3

    Topics: Administration, Oral; Adult; Anesthetics, Local; Anti-Inflammatory Agents; Dexamethasone; Double-Bli

2014
Efficiency of bupivacaine versus lidocaine and methylprednisolone versus placebo to reduce postoperative pain and swelling after surgical removal of mandibular third molars: a randomized, double-blinded, crossover clinical trial.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2013, Volume: 71, Issue:9

    Topics: Adult; Analgesics; Anesthetics, Local; Anti-Inflammatory Agents; Bupivacaine; Cross-Over Studies; Do

2013
Safety and effectiveness of injection of calcium hydroxylapatite via blunt cannula compared to injection by needle for correction of nasolabial folds.
    Journal of cosmetic dermatology, 2014, Volume: 13, Issue:4

    Topics: Aged; Anesthetics, Local; Catheters; Contusions; Cosmetic Techniques; Durapatite; Edema; Erythema; F

2014
A randomized, evaluator-blinded, controlled study of effectiveness and safety of small particle hyaluronic acid plus lidocaine for lip augmentation and perioral rhytides.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2015, Volume: 41 Suppl 1

    Topics: Adolescent; Aged; Anesthetics, Local; Contusions; Cosmetic Techniques; Edema; Female; Gels; Humans;

2015
Intravenous lidocaine for effective pain relief after bimaxillary surgery.
    Clinical oral investigations, 2017, Volume: 21, Issue:9

    Topics: Adolescent; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Cone-Beam Computed T

2017
Lidocaine-based topical anesthetic with disinfectant (LidoDin) versus EMLA for venipuncture: a randomized controlled trial.
    The Clinical journal of pain, 2009, Volume: 25, Issue:8

    Topics: Adolescent; Adult; Anesthetics, Combined; Anesthetics, Local; Child; Disinfectants; Edema; Erythema;

2009
Comparative study of effect of single and multiple suture techniques on inflammatory complications after third molar surgery.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2011, Volume: 69, Issue:4

    Topics: Adolescent; Adult; Ambulatory Surgical Procedures; Anesthetics, Local; Cephalometry; Double-Blind Me

2011
Statistical process control methods allow the analysis and improvement of anesthesia care.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2003, Volume: 50, Issue:8

    Topics: Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Catheterization, Peripheral

2003
Piroxicam gel, compared to EMLA cream is associated with less pain after venous cannulation in volunteers.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2003, Volume: 50, Issue:8

    Topics: Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Catheterization, Peripheral

2003
A comparison of three sub-Tenon's cannulae.
    Eye (London, England), 2004, Volume: 18, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Local; Anesthetics, Local; Cataract Extraction; Catheter

2004
Intradermal actions of hypertonic saline involve neural and vascular mechanisms.
    British journal of clinical pharmacology, 1995, Volume: 40, Issue:1

    Topics: Anesthetics, Local; Double-Blind Method; Drug Interactions; Edema; Erythema; Forearm; Histamine; Hum

1995
Sub-Tenon's anaesthesia: an efficient and safe technique.
    The British journal of ophthalmology, 1997, Volume: 81, Issue:8

    Topics: Adult; Aged; Anesthesia, Local; Anesthetics, Local; Conjunctival Diseases; Edema; Eye Hemorrhage; Fe

1997
Articaine hydrochloride: a study of the safety of a new amide local anesthetic.
    Journal of the American Dental Association (1939), 2001, Volume: 132, Issue:2

    Topics: Adolescent; Adult; Aged; Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Carticaine; Chil

2001
Pharmacokinetics and tolerability of lidocaine patch 5% with extended dosing.
    The Annals of pharmacotherapy, 2002, Volume: 36, Issue:2

    Topics: Administration, Topical; Anesthetics, Local; Delayed-Action Preparations; Edema; Erythema; Female; H

2002
Complications after removal of mandibular third molars with special reference to local anaesthetics with different vasoactive properties.
    Odontologisk revy, 1975, Volume: 26, Issue:2

    Topics: Adolescent; Adult; Alveolar Process; Analgesics; Anesthesia, Dental; Clinical Trials as Topic; Deglu

1975

Other Studies

51 other studies available for lidocaine and Edema

ArticleYear
Phlegmasia cerulea dolens causing compartment syndrome.
    The American journal of emergency medicine, 2022, Volume: 61

    Topics: Compartment Syndromes; Edema; Female; Humans; Hydromorphone; Lidocaine; Middle Aged; Pain; Thromboph

2022
Effects of 2-Hydroxypropil-Β-Cyclodextrin-Lidocaine on Tumor Growth and Inflammatory Response.
    Current drug delivery, 2020, Volume: 17, Issue:7

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Che

2020
Tumescent anesthesia for reducing pain, swelling, and ecchymosis during polycaprolactone filler injections in the face.
    Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology, 2017, Volume: 19, Issue:7

    Topics: Adult; Anesthesia, Local; Anesthetics, Local; Cicatrix; Cosmetic Techniques; Dermal Fillers; Ecchymo

2017
A Multi-Center, Open-Label, Prospective Study of Cannula Injection of Small-Particle Hyaluronic Acid Plus Lidocaine (SPHAL) for Lip Augmentation.
    Journal of drugs in dermatology : JDD, 2018, Jan-01, Volume: 17, Issue:1

    Topics: Adult; Aged; Anesthetics, Local; Cannula; Contusions; Dermal Fillers; Edema; Esthetics; Female; Huma

2018
Formulation and evaluation of lidocaine base ethosomes for transdermal delivery.
    Anesthesia and analgesia, 2013, Volume: 117, Issue:2

    Topics: Administration, Cutaneous; Anesthetics, Local; Animals; Chemistry, Pharmaceutical; Cholesterol; Chro

2013
Centipede bite.
    European review for medical and pharmacological sciences, 2014, Volume: 18, Issue:7

    Topics: Aged; Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Allergic Agents; Anti-Inflammatory Agent

2014
Adenosine, lidocaine and Mg2+ (ALM) induces a reversible hypotensive state, reduces lung edema and prevents coagulopathy in the rat model of polymicrobial sepsis.
    The journal of trauma and acute care surgery, 2014, Volume: 77, Issue:3

    Topics: Adenosine; Animals; Blood Coagulation Disorders; Disease Models, Animal; Drug Therapy, Combination;

2014
Review of the safety profile for microfocused ultrasound with visualization.
    Journal of cosmetic dermatology, 2014, Volume: 13, Issue:4

    Topics: Anesthetics, Local; Clinical Trials as Topic; Contusions; Edema; Erythema; Humans; Lidocaine; Produc

2014
Hyaluronidase hypersensitivity: A rare complication of peribulbar block.
    Indian journal of ophthalmology, 2016, Volume: 64, Issue:2

    Topics: Anesthetics, Combined; Anesthetics, Local; Bupivacaine; Cataract Extraction; Drug Hypersensitivity;

2016
Small-Volume Adenosine, Lidocaine, and Mg2+ 4-Hour Infusion Leads to 88% Survival after 6 Days of Experimental Sepsis in the Rat without Antibiotics.
    Clinical and vaccine immunology : CVI, 2016, Volume: 23, Issue:11

    Topics: Acidosis; Adenosine; Animals; Anti-Bacterial Agents; C-Reactive Protein; Cytokines; Disease Models,

2016
A simple and effective combined method for the management of postrhinoplasty ecchymosis and edema.
    Plastic and reconstructive surgery, 2008, Volume: 121, Issue:6

    Topics: Drug Administration Schedule; Drug Therapy, Combination; Ecchymosis; Edema; Epinephrine; Follow-Up S

2008
Delayed retrobulbar haemorrhage associated with a repeat sub-Tenon's block.
    Anaesthesia and intensive care, 2008, Volume: 36, Issue:5

    Topics: Acetaminophen; Acetazolamide; Analgesics, Non-Narcotic; Anesthetics, Local; Anti-Inflammatory Agents

2008
Effects of lidocaine and adrenaline combination on postoperative edema and ecchymosis in rhinoplasty.
    International journal of oral and maxillofacial surgery, 2011, Volume: 40, Issue:7

    Topics: Adult; Anesthetics, Local; Blood Loss, Surgical; Blood Pressure; Ecchymosis; Edema; Epinephrine; Eye

2011
Safety of tumescent liposuction under local anesthesia in a series of 4,380 patients.
    Dermatology (Basel, Switzerland), 2011, Volume: 222, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Local; Anesthetics, Local; Doxycycline; Drug

2011
Images in clinical medicine. Laryngopharyngeal edema.
    The New England journal of medicine, 2011, Jun-23, Volume: 364, Issue:25

    Topics: Aged; Anesthetics, Local; Edema; Epinephrine; Female; Humans; Hypopharynx; Lidocaine; Pharyngeal Dis

2011
An immediate hypersensitivity reaction caused by tolperisone hydrochloride.
    Journal of investigational allergology & clinical immunology, 2011, Volume: 21, Issue:5

    Topics: Drug Hypersensitivity; Edema; Erythema; Humans; Lidocaine; Male; Middle Aged; Muscle Relaxants, Cent

2011
Efficacy and safety of 121 injections of the greater occipital nerve in episodic and chronic cluster headache.
    Cephalalgia : an international journal of headache, 2012, Volume: 32, Issue:8

    Topics: Adrenal Cortex Hormones; Adult; Anesthetics, Local; Cluster Headache; Edema; Female; Follow-Up Studi

2012
Effect of lidocaine on reducing injury in a rat electrical burn model.
    Annals of plastic surgery, 2012, Volume: 69, Issue:2

    Topics: Anesthetics, Local; Animals; Burns, Electric; Drug Administration Schedule; Edema; Infusions, Intrav

2012
Loss of anatomical landmarks with eutectic mixture of local anesthetic cream for neonatal male circumcision.
    Journal of pediatric urology, 2013, Volume: 9, Issue:1

    Topics: Administration, Topical; Anatomic Landmarks; Circumcision, Male; Edema; Foreskin; Humans; Infant, Ne

2013
Recurrent facial swelling following dental procedures.
    The Medical journal of Australia, 2002, Nov-04, Volume: 177, Issue:9

    Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Drug Hypersensitivity; Edema; Face; Humans; Hypersens

2002
Allergic reaction to epinephrine preparation in 2% lidocaine: two case reports.
    Anesthesia progress, 2004, Volume: 51, Issue:4

    Topics: Adolescent; Anesthetics, Local; Arrhythmias, Cardiac; Drug Hypersensitivity; Edema; Epinephrine; Fem

2004
Epidermal vacuolation: an artifact due to injection of local anesthetics.
    Archives of dermatological research, 1981, Volume: 270, Issue:4

    Topics: Animals; Edema; Epidermis; Injections, Intradermal; Injections, Subcutaneous; Lidocaine; Male; Proca

1981
Protective effect of lidocaine in the experimental foot-and-mouth disease pancreatitis.
    Experientia, 1995, Nov-15, Volume: 51, Issue:11

    Topics: Animals; Aphthovirus; Edema; Foot-and-Mouth Disease; Lidocaine; Male; Mice; Necrosis; Neutrophils; P

1995
Cortical facilitatory action on centralis lateralis thalamic activity during the development of carrageenin-produced inflammation.
    Archives of medical research, 1996,Autumn, Volume: 27, Issue:3

    Topics: Acute Disease; Afferent Pathways; Anesthetics, Local; Animals; Carrageenan; Chronic Disease; Edema;

1996
Delayed-type hypersensitivity to subcutaneous lidocaine with tolerance to articaine: confirmation by in vivo and in vitro tests.
    Contact dermatitis, 1996, Volume: 34, Issue:6

    Topics: Adult; Anesthetics, Local; Benzocaine; Bupivacaine; Carticaine; Cross Reactions; Dermatitis, Allergi

1996
Effects of local anaesthetics on carrageenan-evoked inflammatory nociceptive processing in the rat.
    British journal of anaesthesia, 1996, Volume: 77, Issue:5

    Topics: Anesthetics, Local; Animals; Bupivacaine; Carrageenan; Edema; Inflammation; Lidocaine; Male; Nocicep

1996
CO2 laser repair of permanent tracheostomy stricture.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1997, Volume: 117, Issue:3 Pt 1

    Topics: Aged; Airway Obstruction; Anesthesia, Local; Anesthetics, Local; Carbon Dioxide; Carcinoma; Cicatrix

1997
Sensitization of the nervous system, induced by two successive hindpaw inflammations, is suppressed by a local anesthetic.
    Brain research, 1998, May-25, Volume: 794, Issue:1

    Topics: Analysis of Variance; Anesthetics, Local; Animals; Carrageenan; Edema; Hindlimb; Inflammation; Injec

1998
Topical local anaesthetics (EMLA) inhibit burn-induced plasma extravasation as measured by digital image colour analysis.
    Burns : journal of the International Society for Burn Injuries, 1998, Volume: 24, Issue:4

    Topics: Administration, Topical; Anesthetics, Local; Animals; Burns; Capillary Permeability; Coloring Agents

1998
Anaphylactic reaction following administration of lignocaine hydrochloride infiltration. Case report.
    Australian dental journal, 1998, Volume: 43, Issue:3

    Topics: Adolescent; Anaphylaxis; Anesthesia, Dental; Anesthetics, Local; Edema; Exanthema; Facial Dermatoses

1998
Idiopathic swelling of the lower lip associated with topical anaesthesia. Report of three cases.
    Australian dental journal, 1998, Volume: 43, Issue:5

    Topics: Anesthesia, Local; Anesthetics, Local; Angioedema; Child; Diagnosis, Differential; Edema; Female; Hu

1998
Sight-threatening acute orbital swelling from peribulbar local anesthesia.
    Journal of cataract and refractive surgery, 1999, Volume: 25, Issue:3

    Topics: Acute Disease; Aged; Anesthetics, Local; Drug Hypersensitivity; Edema; Female; Follow-Up Studies; Gl

1999
The inflammatory reaction induced by formalin in the rat paw.
    Naunyn-Schmiedeberg's archives of pharmacology, 1999, Volume: 359, Issue:3

    Topics: Anesthetics, Local; Animals; Blood Pressure; Bradykinin; Capillary Permeability; Capsaicin; Dose-Res

1999
Infiltration block for caesarean section in a morbidly obese parturient.
    Acta anaesthesiologica Scandinavica, 1999, Volume: 43, Issue:5

    Topics: Adult; Anesthesia, Obstetrical; Anesthetics, Local; Cesarean Section; Edema; Female; Fetal Death; Hu

1999
Treatment of chemotic conjunctival prolapse after pediatric craniofacial surgery: report of a technique.
    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2000, Volume: 4, Issue:3

    Topics: Child, Preschool; Conjunctival Diseases; Craniofacial Abnormalities; Drug Therapy, Combination; Edem

2000
Facial tumescent solution for cryosurgery: subtract the epinephrine, add a steroid, and avoid spinal needles.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2001, Volume: 27, Issue:1

    Topics: Anesthetics, Local; Cryosurgery; Dermatologic Surgical Procedures; Edema; Epinephrine; Face; Glucoco

2001
Local anesthesia does not block mustard-oil-induced temporomandibular inflammation.
    Anesthesia and analgesia, 2001, Volume: 92, Issue:4

    Topics: Anesthetics, Local; Animals; Arthritis; Bupivacaine; Dose-Response Relationship, Drug; Edema; Electr

2001
Allergic response to metabisulfite in lidocaine anesthetic solution.
    Anesthesia progress, 2001,Winter, Volume: 48, Issue:1

    Topics: Adult; Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Antioxidants; Drug Hypersensitivit

2001
[Pharmacological studies on the antiphlogistic effect of pentosanpolysulfate in combination with metamizol].
    Arzneimittel-Forschung, 1977, Volume: 27, Issue:5

    Topics: Aminopyrine; Animals; Arthritis, Rheumatoid; Dipyrone; Drug Combinations; Drug Evaluation, Preclinic

1977
Allergic reaction to lignocaine. A case report.
    British dental journal, 1975, Feb-04, Volume: 138, Issue:3

    Topics: Anesthesia, Dental; Anesthesia, Local; Child; Drug Hypersensitivity; Edema; Eyelid Diseases; Female;

1975
[A case of early-type hypersesitivity to lignocaine].
    Czasopismo stomatologiczne, 1976, Volume: 29, Issue:6

    Topics: Adult; Anesthesia, Dental; Drug Hypersensitivity; Edema; Female; Humans; Lidocaine

1976
Quantitative histologic analysis of local anesthetic-induced injury to rat sciatic nerve.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 250, Issue:1

    Topics: Anesthetics, Local; Animals; Edema; Etidocaine; Female; Lidocaine; Nerve Fibers; Procaine; Rats; Rat

1989
Structural effects of the topical lidocaine-prilocaine anesthetic Emla on the tympanic membrane.
    Archives of oto-rhino-laryngology, 1988, Volume: 245, Issue:3

    Topics: Anesthetics, Local; Animals; Collagen; Drug Combinations; Edema; Epithelium; Guinea Pigs; Lidocaine;

1988
[Failure of an intravenous locoregional anesthesia in a hypertensive patient].
    Annales francaises d'anesthesie et de reanimation, 1987, Volume: 6, Issue:5

    Topics: Aged; Anesthesia, Intravenous; Arm; Edema; Female; Humans; Hypertension; Lidocaine; Tourniquets

1987
Pharmacology and pharmacokinetics of drugs used to treat cardiac disease in horses.
    The Veterinary clinics of North America. Equine practice, 1985, Volume: 1, Issue:2

    Topics: Administration, Oral; Animals; Arrhythmias, Cardiac; Cardiovascular Agents; Digoxin; Diuretics; Dobu

1985
Sorbic acid-induced erythema and edema.
    Journal of the American Academy of Dermatology, 1986, Volume: 14, Issue:2 Pt 1

    Topics: Administration, Topical; Anti-Inflammatory Agents; Aspirin; Betamethasone Valerate; Capsaicin; Cosme

1986
Treatment of chronic lumbosciatic pain.
    Proceedings of the Royal Society of Medicine, 1973, Volume: 66, Issue:6

    Topics: Anesthesia, Epidural; Back Pain; Edema; Follow-Up Studies; Humans; Hyaluronoglucosaminidase; Hydroco

1973
Reducing the eyelid edema and ecchymosis that occur after corrective rhinoplasty.
    Plastic and reconstructive surgery, 1972, Volume: 49, Issue:5

    Topics: Bromelains; Ecchymosis; Edema; Eyelids; Histamine H1 Antagonists; Humans; Hypothermia, Induced; Lido

1972
Local anaesthetic sensitivity. Case report.
    Australian dental journal, 1972, Volume: 17, Issue:1

    Topics: Antigen-Antibody Reactions; Asthma; Drug Hypersensitivity; Edema; Epinephrine; Female; Humans; Hyper

1972
Local anaesthetic effect of oxyfedrin in animals.
    British journal of anaesthesia, 1973, Volume: 45, Issue:10

    Topics: Administration, Topical; Anesthesia, Conduction; Anesthesia, Local; Anesthetics, Local; Animals; Con

1973
The clearance of red blood cells from the cadaver kidney.
    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1970, Volume: 2, Issue:4

    Topics: Animals; Body Weight; Cadaver; Chromium Radioisotopes; Dextrans; Edema; Erythrocytes; Female; Hepari

1970