lidocaine has been researched along with Disease Models, Animal in 342 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Our aim was to examine the effect of two different analgesics, buprenorphine and carprofen, on adenosine, lidocaine, and magnesium (ALM) resuscitation in a rat model of laparotomy and non-compressible hemorrhage." | 8.02 | Buprenorphine Analgesia Reduces Survival With ALM Resuscitation in a Rat Model of Uncontrolled Hemorrhage: Concerns for Trauma-Related Research. ( Dobson, GP; Letson, HL, 2021) |
| "4T1 murine breast cancer cells were exposed to lidocaine and/or bosutinib." | 8.02 | The Effect of Lidocaine and Bosutinib on 4T1 Murine Breast Cancer Cell Behaviour ( Buggy, DJ; Crowley, PD; Wall, TP, 2021) |
| "Lidocaine has been shown to inhibit the invasion and metastasis of breast cancer, but the mechanism still remains unclear." | 8.02 | Lidocaine prevents breast cancer growth by targeting neuronatin to inhibit nerve fibers formation. ( He, C; Li, B; Tu, Y; Xu, H; Zou, W, 2021) |
| "Herein, it was investigated whether a complex of lidocaine with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) would present a better antinociceptive profile in vivo when compared with plain lidocaine in models of orofacial pain." | 7.91 | Comparison of antinociceptive effects of plain lidocaine versus lidocaine complexed with hydroxypropyl-β-cyclodextrin in animal models of acute and persistent orofacial pain. ( Araya, EI; Chichorro, JG; Claudino, RF; de Oliveira, SB; Ferreira, LEN; Franz-Montan, M; Gambeta, E, 2019) |
| "Adenosine, lidocaine, and magnesium, as administered in this study, are inferior to current Hextend-based resuscitation for survival from prolonged hemorrhagic shock in this model." | 7.91 | Prehospital adenosine, lidocaine, and magnesium has inferior survival compared with tactical combat casualty care resuscitation in a porcine model of prolonged hemorrhagic shock. ( Cardin, S; Fryer, DM; Glaser, JJ; How, RA; Morgan, CG; Ozuna, KM; Sams, VG; Schaub, LJ, 2019) |
| "Background This study assessed the effect of blockading neural transmission in the ganglionated plexi by injecting lidocaine into fat pads in the vagal nerve stimulation canine model and patients with persistent atrial fibrillation ( AF )." | 7.91 | Effect of Lidocaine Injection of Ganglionated Plexi in a Canine Model and Patients With Persistent and Long-Standing Persistent Atrial Fibrillation. ( Khrestian, A; Khrestian, CM; Lee, S; Markowitz, A; Sahadevan, J; Waldo, AL, 2019) |
| "To determine the neuroprotection mechanism of lidocaine on early brain injury resulted from subarachnoid hemorrhage." | 7.85 | [Neuroprotection Mechanism of Lidocaine in Rabbits with Early Brain Injury Resulted from Subarachnoid Hemorrhage]. ( Chen, J; Ding, H; Fu, YJ; Shi, XQ; Zheng, LR, 2017) |
| "To compare the neuroprotection effect of two methods of Lidocaine administration in rabbit model of subarachnoid hemorrhage." | 7.85 | [Comparison of Two Methods of Lidocaine Administrating for Neuroprotection in Rabbit Model of Subarachnoid Hemorrhage]. ( Fu, YJ; Shi, XQ; Zheng, LR, 2017) |
| " However, the function and underlying mechanisms of lidocaine in hepatocellular carcinoma both in vitro and in vivo have been poorly studied." | 7.85 | Lidocaine Induces Apoptosis and Suppresses Tumor Growth in Human Hepatocellular Carcinoma Cells In Vitro and in a Xenograft Model In Vivo. ( Chen, DT; Chen, YH; Li, Q; Pan, JH; Xing, W; Xue, RF; Yan, Y; Yuan, YF; Zeng, WA, 2017) |
| "Inhaled lidocaine antagonized bronchospasm in animal models and patients, but adverse effects limited its efficacy." | 7.83 | JM25-1, a Lidocaine Analog Combining Airway Relaxant and Antiinflammatory Properties: Implications for New Bronchospasm Therapy. ( Anjos-Valotta, EA; Cordeiro, RS; Costa, JC; Cotias, AC; Couto, GC; de Carvalho, KI; Faria, RX; Martins, MA; Neves, JS; Olsen, PC; Pão, CR; Serra, MF; Silva, PM, 2016) |
| " In this study, we investigated spontaneous pain and mechanical allodynia in a preclinical model of oral ulcerative mucositis after systemic administration of the chemotherapy drug 5-fluorouracil, using our proprietary pain assay system for conscious rats." | 7.83 | Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil. ( Goto, T; Harano, N; Hitomi, S; Inenaga, K; Inoue, H; Ito, M; Matoba, M; Miyano, K; Nodai, T; Ono, K; Uezono, Y; Watanabe, S; Yamaguchi, K, 2016) |
| "VGSC blockade with lidocaine rescues function of ischemic myocardium as a potential bridging to revascularisation in the setting of perioperative myocardial ischemia." | 7.83 | Lidocaine Enhances Contractile Function of Ischemic Myocardial Regions in Mouse Model of Sustained Myocardial Ischemia. ( Beck-Schimmer, B; Blyszczuk, P; Eriksson, U; Jakob, P; Kania, G; Krasniqi, N; Müller-Edenborn, B; Osto, E, 2016) |
| "To compare the early postarrest inflammatory cytokine response between animals administered amiodarone (AMIO) and lidocaine (LIDO) intra-arrest during resuscitation from ventricular fibrillation (VF)." | 7.79 | Administration of amiodarone during resuscitation is associated with higher tumor necrosis factor-α levels in the early postarrest period in the swine model of ischemic ventricular fibrillation. ( Niemann, JT; Rosborough, JP; Shah, AP; Thomas, JL; Youngquist, ST, 2013) |
| " The sheep were prophylactically treated with amiodarone plus lidocaine before ligation of the four to six coronary artery branches supplying the apex of the heart (arrhythmia prevention [AP] group, n = 45) and with epinephrine (shock prevention [SP] group, n = 49), respectively." | 7.79 | Prophylactic amiodarone and lidocaine improve survival in an ovine model of large size myocardial infarction. ( Griffith, BP; Li, T; Sanchez, PG; Watkins, AC; Wei, X; Wu, ZJ, 2013) |
| "Evidence suggests that nebulized lidocaine is beneficial in asthma therapy, but to what extent and the mechanisms underlying this effect remain poorly understood." | 7.78 | Nebulized lidocaine prevents airway inflammation, peribronchial fibrosis, and mucus production in a murine model of asthma. ( Anjos-Valotta, EA; Arantes, AC; Cordeiro, RS; Cotias, AC; Couto, GC; Ferreira, TP; Jurgilas, PB; Martins, MA; Olsen, PC; Pão, CR; Pires, AL; Serra, MF; Silva, PM, 2012) |
| "To study the protective effects of lidocaine and nerve growth factor (NGF) pretreatment on cerebral ischemia/reperfusion (I/R) injury." | 7.76 | [A study of the protective effects of lidocaine and nerve growth factor pretreatment on cerebral ischemia/reperfusion injury in gerbils]. ( Wang, DF; Xie, JD, 2010) |
| "These results indicate that pre-treatment with lidocaine attenuates referred hyperalgesia associated with cystitis." | 7.75 | Lidocaine prevents referred hyperalgesia associated with cystitis. ( Bjorling, DE; Boldon, K; Bushman, W; Guerios, SD; Wang, ZY, 2009) |
| "To study the protective effect of lidocaine against lung injury after hemorrhagic shock in rabbits." | 7.74 | [Protective effects of lidocaine against lung injury after hemorrhagic shock in rabbits]. ( Gu, MN; Lin, CS; Liu, YY; Ruan, LY, 2007) |
| " Combinations of the action potential-widening drug tedisamil (Class III antiarrhythmic activity), and the inactivated state sodium channel blocker lidocaine (Class Ib antiarrhythmic activity) were assessed for antiarrhythmic actions in a rat model of ischaemia-induced arrhythmias and for electrophysiological actions in normal rat myocardial tissue." | 7.72 | Tedisamil and lidocaine enhance each other's antiarrhythmic activity against ischaemia-induced arrhythmias in rats. ( Barrett, TD; Sarraf, G; Walker, MJ, 2003) |
| "The use of local anesthetics, such as lidocaine, has been proposed in the treatment of distal ulcerative colitis." | 7.72 | Beneficial effect of trimebutine and N-monodesmethyl trimebutine on trinitrobenzene sulfonic acid-induced colitis in rats. ( Chevalier, E; Chovet, M; Langlois, A; Pétoux, F, 2004) |
| "Liver cirrhosis was produced in rats by intra-abdominal injection of thioacetamide." | 7.71 | Reassessment of monoethylglycinexylidide as preoperative liver function test in a rat model of liver cirrhosis and man. ( Ishii, T; Kaneko, H; Katagiri, M; Maeda, T; Otsuka, Y; Shiba, T; Takagi, S; Tamura, A; Tsuchiya, M, 2001) |
| "Antiarrhythmic effects of bisaramil were examined by using new in vivo triggered arrhythmia models, and they were compared with those of other antiarrhythmic drugs." | 7.69 | Antiarrhythmic effects of bisaramil on triggered arrhythmias produced by intracoronary injection of digitalis and adrenaline in the dog. ( Haruno, A; Hashimoto, K, 1995) |
| "The aim of this study was to evaluate the efficacy of a single dose of intravenous amiodarone in facilitating defibrillation of ventricular fibrillation refractory to lidocaine and epinephrine plus direct current countershocks in experimental acute myocardial infarction." | 7.69 | Effects of amiodarone on refractory ventricular fibrillation in acute myocardial infarction: experimental study. ( Anastasiou-Nana, MI; Moulopoulos, SD; Nanas, JN; Nanas, SN; Poyadjis, A; Rapti, A; Stathaki, S, 1994) |
| "We compared the ability of a new amiodarone-like agent, SR 33589, with that of amiodarone, D,L-sotalol, and lignocaine to reduce the incidence of ventricular fibrillation (VF) and associated arrhythmias caused by acute coronary artery occlusion in anesthetized pigs." | 7.69 | Effects of a new amiodarone-like agent, SR 33589, in comparison to amiodarone, D,L-sotalol, and lignocaine, on ischemia-induced ventricular arrhythmias in anesthetized pigs. ( Chatelain, P; Finance, O; Manning, A, 1995) |
| "We have assessed the ability of the new amiodarone-like antiarrhythmic agent, SR 33589, to reduce the incidence of ischemia- and reperfusion-induced arrhythmias, in comparison to amiodarone, D-sotalol, and lignocaine." | 7.69 | SR 33589, a new amiodarone-like agent: effect on ischemia- and reperfusion-induced arrhythmias in anesthetized rats. ( Bruyninckx, C; Chatelain, P; Manning, AS; Ramboux, J, 1995) |
| "Our observations indicate that lidocaine reduces reperfusion injury and inhibits PMN adhesion and subsequent migration to the lung allograft." | 7.69 | Lidocaine reduces reperfusion injury and neutrophil migration in canine lung allografts. ( Ando, K; Cooper, JD; Patterson, GA; Schmid, RA; Tanaka, Y; Yamashita, M, 1996) |
| "The effects of lidocaine and diltiazem on recovery of electrophysiologic activity during partial reperfusion following severe myocardial ischemia were investigated in 28 dogs." | 7.69 | Effects of lidocaine and diltiazem on recovery of electrophysiologic activity during partial reperfusion following severe myocardial ischemia in canine hearts. ( Kuraoka, F; Kuroiwa, A; Murasato, Y; Nagamoto, Y; Nakashima, Y; Urabe, T, 1997) |
| "Dogs were treated with repeated doses of lidocaine or equivalent volumes of saline during hyperbaric therapy after internal carotid air embolism and transient hypertension." | 7.68 | Effect of lidocaine on somatosensory evoked response and cerebral blood flow after canine cerebral air embolism. ( Clark, JB; Dutka, AJ; Hallenbeck, JM; McDermott, J; Mink, R, 1992) |
| "Effects of flecainide, a class I antiarrhythmic drug, on ventricular arrhythmias, ventricular abnormal automaticity and ventricular activation were examined in a canine model of myocardial infarction, and compared with those of lidocaine." | 7.68 | Effects of flecainide on ventricular arrhythmias, abnormal automaticity and activation in a canine model of myocardial infarction. ( Hashimoto, H; Katoh, H; Nakashima, M, 1992) |
| "Ventricular fibrillation threshold was determined using a train of pulses, 4 ms in duration, delivered at 10 ms intervals, in 20 anaesthetised dogs receiving toxic doses of quinidine sulphate (30 mg X kg-1) injected intravenously over 5 min to prolong the QT interval." | 7.67 | Ventricular fibrillation threshold in canine hearts with quinidine induced prolonged QT interval: effects of atrial pacing, isoproterenol, and lignocaine. ( Inoue, H; Mashima, S; Matsuo, H; Murao, S; Sugimoto, T, 1986) |
| "This study was performed to investigate the prophylactic effect of disopyramide phosphate on ventricular fibrillation in acute myocardial infarction." | 7.66 | Studies on the preventive method of lowered ventricular fibrillation threshold during experimental acute myocardial infarctions. A comparison between disopyramide phosphate and lidocaine. ( Fukuzaki, H; Hatani, M; Hori, Y; Imai, N; Nadai, T; Okamoto, R; Takano, S; Toh, H, 1981) |
| "Methylene blue (MB) is a blue cationic thiazine dye and currently used in different medical settings." | 5.62 | Methylene blue induces an analgesic effect by significantly decreasing neural firing rates and improves pain behaviors in rats. ( Han, HC; Lee, SW; Moon, SW; Park, JS; Suh, HR, 2021) |
| "Severe arrhythmias-such as ventricular arrhythmias-can be fatal, but treatment options are limited." | 5.51 | Combination Formulation of Tetrodotoxin and Lidocaine as a Potential Therapy for Severe Arrhythmias. ( Bai, K; Chen, Y; He, J; Hong, B; Huang, W; Le, Q, 2019) |
| "Menthol inhibited phototoxicity-evoked APs and reduced pain behavior when applied topically to mice." | 5.48 | Menthol reduces phototoxicity pain in a mouse model of photodynamic therapy. ( Baptista-Hon, D; Bull, F; Dalgaty, F; Gallacher, M; Hales, TG; Ibbotson, SH; Wright, L, 2018) |
| "More than 90% of spinal cord injuries are caused by traumatic accidents and are often associated with other tissue damage (polytrauma) that can provide a source of continued pain input during recovery." | 5.46 | Pain Input Impairs Recovery after Spinal Cord Injury: Treatment with Lidocaine. ( Aceves, M; Grau, JW; Hook, MA; Huang, YJ; Reynolds, JA; Strain, MM; Turtle, JD, 2017) |
| "Lidocaine has proven anti-inflammatory activity in several tissues but its modulation of miRNAs has not been investigated." | 5.43 | Lidocaine Administration Controls MicroRNAs Alterations Observed After Lung Ischemia-Reperfusion Injury. ( Calvo, A; Casanova, J; García, C; Garutti, I; Marchal-Duval, E; Paredes, SD; Rancan, L; Rincón, D; Simón, C; Turrero, A; Vara, E, 2016) |
| "Adenosine-lidocaine-magnesium (ALM) mixture is a cardioplegic agent that improves survivability undisputedly in rodents, but not swine, models of hemorrhagic shock." | 5.41 | Mechanistic considerations for adenosine-lidocaine-magnesium (ALM) in controlling coagulopathy. ( Biros, E; Birosova, E; Moran, CS, 2023) |
| "Ventricular fibrillation was induced in 16 pigs, and circulatory arrest was maintained for 14 minutes." | 5.40 | Effects of potassium/lidocaine-induced cardiac standstill during cardiopulmonary resuscitation in a pig model of prolonged ventricular fibrillation. ( Heo, T; Hun Jung, Y; Il Min, Y; Jeong, IS; Joon Lee, S; Kook Lee, B; Lim, V; Woon Jeung, K; Youn Lee, H, 2014) |
| "Sepsis was induced by cecal ligation and puncture." | 5.40 | Adenosine, lidocaine and Mg2+ (ALM) induces a reversible hypotensive state, reduces lung edema and prevents coagulopathy in the rat model of polymicrobial sepsis. ( Dobson, GP; Griffin, MJ; Letson, HL, 2014) |
| "Diclofenac was highly effective in both tests on day 3, while on day 20 it induced a less pronounced decrease in the Knee-Bend score and was ineffective in the CatWalk test." | 5.38 | Analgesic effects of lidocaine, morphine and diclofenac on movement-induced nociception, as assessed by the Knee-Bend and CatWalk tests in a rat model of osteoarthritis. ( Adães, S; Castro-Lopes, JM; Ferreira-Gomes, J; Mendonça, M, 2012) |
| "A second spell of arrhythmia of similar intensity and pattern, which had the same latency to onset, was reproduced 60 min after the first spell of arrhythmia." | 5.28 | Isolated paced guinea pig left atrium: a new ouabain-induced arrhythmia model. ( Thomas, GP; Varma, RK, 1991) |
| "Lidocaine pretreatment (10 mg/kg i." | 5.26 | Acute coronary artery occlusion-reperfusion-induced arrhythmias in rats, dogs and pigs: antiarrhythmic evaluation of quinidine, procainamide and lidocaine. ( Bergey, JL; McCallum, JD; Nocella, K, 1982) |
| "We conducted a literature review between 1990 and 2006 in MEDLINE using the following MeSH headings: swine, dogs, resuscitation, heart arrest, EMS, EMT, ambulance, ventricular fibrillation, drug therapy, epinephrine, vasopressin, amiodarone, lidocaine, magnesium, and sodium bicarbonate." | 4.84 | Drug administration in animal studies of cardiac arrest does not reflect human clinical experience. ( Menegazzi, JJ; Reynolds, JC; Rittenberger, JC, 2007) |
| " Instead of using deep sedation and neuromuscular blockade, the authors hypothesized that perineural administration of lidocaine around the phrenic nerve would reduce tidal volume (VT) and peak transpulmonary pressure in spontaneously breathing patients with acute respiratory distress syndrome." | 4.12 | Phrenic Nerve Block and Respiratory Effort in Pigs and Critically Ill Patients with Acute Lung Injury. ( Adkson Sales Lima, C; Amato, MBP; Brochard, L; Costa, ELV; Goligher, EC; Ho, YL; Morais, CCA; Nakamura, MAM; Pereira, SM; Ranzani, OT; Sinedino, BE; Sklar, MC; Taniguchi, LU; Tucci, MR; Vieira, JE, 2022) |
| " Our aim was to examine the effect of two different analgesics, buprenorphine and carprofen, on adenosine, lidocaine, and magnesium (ALM) resuscitation in a rat model of laparotomy and non-compressible hemorrhage." | 4.02 | Buprenorphine Analgesia Reduces Survival With ALM Resuscitation in a Rat Model of Uncontrolled Hemorrhage: Concerns for Trauma-Related Research. ( Dobson, GP; Letson, HL, 2021) |
| "4T1 murine breast cancer cells were exposed to lidocaine and/or bosutinib." | 4.02 | The Effect of Lidocaine and Bosutinib on 4T1 Murine Breast Cancer Cell Behaviour ( Buggy, DJ; Crowley, PD; Wall, TP, 2021) |
| "Lidocaine has been shown to inhibit the invasion and metastasis of breast cancer, but the mechanism still remains unclear." | 4.02 | Lidocaine prevents breast cancer growth by targeting neuronatin to inhibit nerve fibers formation. ( He, C; Li, B; Tu, Y; Xu, H; Zou, W, 2021) |
| " Lidocaine formulations significantly reduced the paw edema on day 6 after Walker 256 cells inoculation." | 3.96 | Effects of 2-Hydroxypropil-Β-Cyclodextrin-Lidocaine on Tumor Growth and Inflammatory Response. ( Abdalla, HB; Burga-Sánchez, J; da Costa, JP; de Freitas Domingues, JS; Ferreira, LEN; Groppo, FC; Volpato, MC, 2020) |
| "Herein, it was investigated whether a complex of lidocaine with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) would present a better antinociceptive profile in vivo when compared with plain lidocaine in models of orofacial pain." | 3.91 | Comparison of antinociceptive effects of plain lidocaine versus lidocaine complexed with hydroxypropyl-β-cyclodextrin in animal models of acute and persistent orofacial pain. ( Araya, EI; Chichorro, JG; Claudino, RF; de Oliveira, SB; Ferreira, LEN; Franz-Montan, M; Gambeta, E, 2019) |
| "Adenosine, lidocaine, and magnesium, as administered in this study, are inferior to current Hextend-based resuscitation for survival from prolonged hemorrhagic shock in this model." | 3.91 | Prehospital adenosine, lidocaine, and magnesium has inferior survival compared with tactical combat casualty care resuscitation in a porcine model of prolonged hemorrhagic shock. ( Cardin, S; Fryer, DM; Glaser, JJ; How, RA; Morgan, CG; Ozuna, KM; Sams, VG; Schaub, LJ, 2019) |
| "Background This study assessed the effect of blockading neural transmission in the ganglionated plexi by injecting lidocaine into fat pads in the vagal nerve stimulation canine model and patients with persistent atrial fibrillation ( AF )." | 3.91 | Effect of Lidocaine Injection of Ganglionated Plexi in a Canine Model and Patients With Persistent and Long-Standing Persistent Atrial Fibrillation. ( Khrestian, A; Khrestian, CM; Lee, S; Markowitz, A; Sahadevan, J; Waldo, AL, 2019) |
| "The purpose of this work was to develop an effective carbomer hydrogel to be used to treat second-degree burns that combined ciprofloxacin and lidocaine (CbCipLid hydrogel)." | 3.88 | Ciprofloxacin-lidocaine-based hydrogel: development, characterization, and in vivo evaluation in a second-degree burn model. ( Breda, SA; Manzo, RH; Olivera, ME; Sanchez, MF; Soria, EA; Tártara, LI, 2018) |
| "To observe the expression of Rho/Rho-associated kinase (ROCK) signaling pathway in the basilar artery and the effect of lidocaine on this signaling pathway after subarachnoid hemorrhage (SAH) in rabbits." | 3.88 | [Effects of Lidocaine on the Rho/ROCK Signal Transduction of the Posterior Basilar Artery in Rabbit SAH]. ( Chen, J; Ding, H; Fu, YJ; Shi, XQ; Zhang, SS, 2018) |
| "To determine the neuroprotection mechanism of lidocaine on early brain injury resulted from subarachnoid hemorrhage." | 3.85 | [Neuroprotection Mechanism of Lidocaine in Rabbits with Early Brain Injury Resulted from Subarachnoid Hemorrhage]. ( Chen, J; Ding, H; Fu, YJ; Shi, XQ; Zheng, LR, 2017) |
| "To compare the neuroprotection effect of two methods of Lidocaine administration in rabbit model of subarachnoid hemorrhage." | 3.85 | [Comparison of Two Methods of Lidocaine Administrating for Neuroprotection in Rabbit Model of Subarachnoid Hemorrhage]. ( Fu, YJ; Shi, XQ; Zheng, LR, 2017) |
| " The aim of our research was to compare molsidomine, SIN-1, SIN-1A, and lidocaine influence on arrhythmias and hemodynamic parameters in 2 experimental models in rats." | 3.85 | New approach to molsidomine active metabolites coming from the results of 2 models of experimental cardiology. ( Krzemiński, TF; Mitręga, KA; Porc, M; Żorniak, M, 2017) |
| " However, the function and underlying mechanisms of lidocaine in hepatocellular carcinoma both in vitro and in vivo have been poorly studied." | 3.85 | Lidocaine Induces Apoptosis and Suppresses Tumor Growth in Human Hepatocellular Carcinoma Cells In Vitro and in a Xenograft Model In Vivo. ( Chen, DT; Chen, YH; Li, Q; Pan, JH; Xing, W; Xue, RF; Yan, Y; Yuan, YF; Zeng, WA, 2017) |
| "Inhaled lidocaine antagonized bronchospasm in animal models and patients, but adverse effects limited its efficacy." | 3.83 | JM25-1, a Lidocaine Analog Combining Airway Relaxant and Antiinflammatory Properties: Implications for New Bronchospasm Therapy. ( Anjos-Valotta, EA; Cordeiro, RS; Costa, JC; Cotias, AC; Couto, GC; de Carvalho, KI; Faria, RX; Martins, MA; Neves, JS; Olsen, PC; Pão, CR; Serra, MF; Silva, PM, 2016) |
| " In this study, we investigated spontaneous pain and mechanical allodynia in a preclinical model of oral ulcerative mucositis after systemic administration of the chemotherapy drug 5-fluorouracil, using our proprietary pain assay system for conscious rats." | 3.83 | Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil. ( Goto, T; Harano, N; Hitomi, S; Inenaga, K; Inoue, H; Ito, M; Matoba, M; Miyano, K; Nodai, T; Ono, K; Uezono, Y; Watanabe, S; Yamaguchi, K, 2016) |
| " Here, we examine the effects of experimental lidocaine-induced anosmia on anxiety-like behavior and whole-body cortisol levels in adult zebrafish (Danio rerio)." | 3.83 | The smell of "anxiety": Behavioral modulation by experimental anosmia in zebrafish. ( Abreu, MS; Barcellos, LJ; Giacomini, AC; Kalueff, AV, 2016) |
| "The analgesic effects on pain-related behaviors following the topical application of hangeshashinto were evaluated in an oral ulcer rat model treated with acetic acid using recently developed methods." | 3.83 | The traditional Japanese medicine hangeshashinto alleviates oral ulcer-induced pain in a rat model. ( Hattori, T; Hitomi, S; Imai, R; Inenaga, K; Kase, Y; Kubota, K; Omiya, Y; Ono, K; Terawaki, K; Yamaguchi, K, 2016) |
| "This study tested the hypothesis that the hypothalamus participates in the decompensatory phase of hemorrhage by measuring Fos immunoreactivity and by inhibiting neuronal activity in selected hypothalamic nuclei with lidocaine or cobalt chloride." | 3.83 | Hypovolemic hemorrhage induces Fos expression in the rat hypothalamus: Evidence for involvement of the lateral hypothalamus in the decompensatory phase of hemorrhage. ( Göktalay, G; Millington, WR, 2016) |
| "VGSC blockade with lidocaine rescues function of ischemic myocardium as a potential bridging to revascularisation in the setting of perioperative myocardial ischemia." | 3.83 | Lidocaine Enhances Contractile Function of Ischemic Myocardial Regions in Mouse Model of Sustained Myocardial Ischemia. ( Beck-Schimmer, B; Blyszczuk, P; Eriksson, U; Jakob, P; Kania, G; Krasniqi, N; Müller-Edenborn, B; Osto, E, 2016) |
| " Facilitation of pain behaviour induced by GAL in the DMH was reversed by lidocaine in the DRt and by ondansetron, a 5HT3R antagonist, in the spinal cord." | 3.81 | Galanin-Mediated Behavioural Hyperalgesia from the Dorsomedial Nucleus of the Hypothalamus Involves Two Independent Descending Pronociceptive Pathways. ( Almeida, A; Amorim, D; Pertovaara, A; Pinto-Ribeiro, F; Viisanen, H; Wei, H, 2015) |
| "5% NaCl + adenosine, lidocaine, and Mg/adenosine and lidocaine provided superior cardiovascular, acid-base, metabolic, and renal recoveries following severe hemorrhagic shock in the pig compared with 7." | 3.80 | Small-volume 7.5% NaCl adenosine, lidocaine, and Mg2+ has multiple benefits during hypotensive and blood resuscitation in the pig following severe blood loss: rat to pig translation. ( Dobson, GP; Granfeldt, A; Hyldebrandt, JA; Letson, HL; Nielsen, TK; Salcedo, PA; Tønnesen, E; Vinten-Johansen, J; Wang, ER, 2014) |
| " Using a rat model of acoustic trauma-induced tinnitus, the role of the cerebellum was further examined in a series of experiments:The PFL was surgically ablated in animals with established tinnitus; the PFL was surgically ablated in animals before induction of tinnitus; the PFL was reversibly inactivated by chronic lidocaine infusion into the subarcuate fossa of animals with established tinnitus." | 3.79 | The cerebellum as a novel tinnitus generator. ( Bauer, CA; Brozoski, TJ; Kurt, W; Sybert, LT, 2013) |
| "To compare the early postarrest inflammatory cytokine response between animals administered amiodarone (AMIO) and lidocaine (LIDO) intra-arrest during resuscitation from ventricular fibrillation (VF)." | 3.79 | Administration of amiodarone during resuscitation is associated with higher tumor necrosis factor-α levels in the early postarrest period in the swine model of ischemic ventricular fibrillation. ( Niemann, JT; Rosborough, JP; Shah, AP; Thomas, JL; Youngquist, ST, 2013) |
| " The sheep were prophylactically treated with amiodarone plus lidocaine before ligation of the four to six coronary artery branches supplying the apex of the heart (arrhythmia prevention [AP] group, n = 45) and with epinephrine (shock prevention [SP] group, n = 49), respectively." | 3.79 | Prophylactic amiodarone and lidocaine improve survival in an ovine model of large size myocardial infarction. ( Griffith, BP; Li, T; Sanchez, PG; Watkins, AC; Wei, X; Wu, ZJ, 2013) |
| " Joint pain relief from lidocaine administration could be reliably tracked over its brief acting time course." | 3.79 | Intra-articular anaesthesia mitigates established pain in experimental osteoarthritis: a preliminary study of gait impulse redistribution as a biomarker of analgesia pharmacodynamics. ( Bertram, JE; Gutmann, A; Hurtig, M; Matyas, JR; Randev, J, 2013) |
| " We concluded that only peripheral blockade of transient receptor potential vanilloid receptor 1-expressing nociceptive afferents by the QX-314/capsaicin combination was effective at reducing neuropathic allodynia and hyperalgesia." | 3.78 | Differential effects of peripheral versus central coadministration of QX-314 and capsaicin on neuropathic pain in rats. ( Cheng, J; Fox, LE; Shen, J, 2012) |
| "5% NaCl adenocaine (adenosine and lidocaine, adenocaine) and Mg on hypotensive resuscitation and coagulopathy in the rat model of severe hemorrhagic shock." | 3.78 | Reversal of acute coagulopathy during hypotensive resuscitation using small-volume 7.5% NaCl adenocaine and Mg2+ in the rat model of severe hemorrhagic shock. ( Dobson, GP; Letson, HL; Mhango, LP; Pecheniuk, NM, 2012) |
| "Evidence suggests that nebulized lidocaine is beneficial in asthma therapy, but to what extent and the mechanisms underlying this effect remain poorly understood." | 3.78 | Nebulized lidocaine prevents airway inflammation, peribronchial fibrosis, and mucus production in a murine model of asthma. ( Anjos-Valotta, EA; Arantes, AC; Cordeiro, RS; Cotias, AC; Couto, GC; Ferreira, TP; Jurgilas, PB; Martins, MA; Olsen, PC; Pão, CR; Pires, AL; Serra, MF; Silva, PM, 2012) |
| "To study the protective effects of lidocaine and nerve growth factor (NGF) pretreatment on cerebral ischemia/reperfusion (I/R) injury." | 3.76 | [A study of the protective effects of lidocaine and nerve growth factor pretreatment on cerebral ischemia/reperfusion injury in gerbils]. ( Wang, DF; Xie, JD, 2010) |
| "Lidocaine can alleviate acute as well as chronic neuropathic pain at very low plasma concentrations in humans and laboratory animals." | 3.75 | The effect of intravenous lidocaine on brain activation during non-noxious and acute noxious stimulation of the forepaw: a functional magnetic resonance imaging study in the rat. ( Benveniste, H; Du, C; Glass, PS; Kritzer, M; Luo, Z; Ma, Y; Smith, SD; Volkow, ND; Yu, M, 2009) |
| "These results indicate that pre-treatment with lidocaine attenuates referred hyperalgesia associated with cystitis." | 3.75 | Lidocaine prevents referred hyperalgesia associated with cystitis. ( Bjorling, DE; Boldon, K; Bushman, W; Guerios, SD; Wang, ZY, 2009) |
| "To study the protective effect of lidocaine against lung injury after hemorrhagic shock in rabbits." | 3.74 | [Protective effects of lidocaine against lung injury after hemorrhagic shock in rabbits]. ( Gu, MN; Lin, CS; Liu, YY; Ruan, LY, 2007) |
| "Antiarrhythmic properties of taurhythman were demonstrated on experimental models of ventricular (early occlusion and calcium chloride-induced) and atrioventricular (aconitine-induced) arrhythmias." | 3.73 | Antiarrhythmic activity of taurhythman. ( Evdokimova, NR; Gavrovskaya, LK; Krylova, IB; Sapronov, NS, 2005) |
| "Microinjection of lidocaine into either the NG or the RVM produced a time-related reversal of pancreatitis-induced pain." | 3.73 | Descending facilitation from the rostral ventromedial medulla maintains visceral pain in rats with experimental pancreatitis. ( King, T; Kowal, J; Ossipov, MH; Porreca, F; Vera-Portocarrero, LP; Xie, JY; Yie, JX, 2006) |
| " Lidocaine, which prevents neutrophil adhesion to endothelial cells, inhibited granulocyte colony-stimulating factor-related exacerbation of acute lung injury (bronchoalveolar lavage fluid cells and pulmonary edema) and pulmonary fibrosis (lung static compliance and morphologic changes)." | 3.72 | Effect of granulocyte colony-stimulating factor on bleomycin-induced acute lung injury and pulmonary fibrosis. ( Azoulay, E; Brochard, L; Delclaux, C; Harf, A; Herigault, S; Levame, M; Schlemmer, B, 2003) |
| " Combinations of the action potential-widening drug tedisamil (Class III antiarrhythmic activity), and the inactivated state sodium channel blocker lidocaine (Class Ib antiarrhythmic activity) were assessed for antiarrhythmic actions in a rat model of ischaemia-induced arrhythmias and for electrophysiological actions in normal rat myocardial tissue." | 3.72 | Tedisamil and lidocaine enhance each other's antiarrhythmic activity against ischaemia-induced arrhythmias in rats. ( Barrett, TD; Sarraf, G; Walker, MJ, 2003) |
| "The use of local anesthetics, such as lidocaine, has been proposed in the treatment of distal ulcerative colitis." | 3.72 | Beneficial effect of trimebutine and N-monodesmethyl trimebutine on trinitrobenzene sulfonic acid-induced colitis in rats. ( Chevalier, E; Chovet, M; Langlois, A; Pétoux, F, 2004) |
| "Liver cirrhosis was produced in rats by intra-abdominal injection of thioacetamide." | 3.71 | Reassessment of monoethylglycinexylidide as preoperative liver function test in a rat model of liver cirrhosis and man. ( Ishii, T; Kaneko, H; Katagiri, M; Maeda, T; Otsuka, Y; Shiba, T; Takagi, S; Tamura, A; Tsuchiya, M, 2001) |
| "Antiarrhythmic effects and cardiovascular effects of pilsicainide hydrochloride were compared with those of disopyramide in a canine model of coronary ligation-induced ventricular arrhythmias and anesthetized dogs." | 3.70 | [Antiarrhythmic effects of pilsicainide hydrochloride and effects on cardiac function and ECG in dogs: comparison with disopyramide]. ( Hayashi, Y; Hidaka, T; Inomata, N; Inoue, T; Komoriya, K, 2000) |
| "Antiarrhythmic effects of bisaramil were examined by using new in vivo triggered arrhythmia models, and they were compared with those of other antiarrhythmic drugs." | 3.69 | Antiarrhythmic effects of bisaramil on triggered arrhythmias produced by intracoronary injection of digitalis and adrenaline in the dog. ( Haruno, A; Hashimoto, K, 1995) |
| "Because recent clinical studies have failed to show evidence of the benefit of lidocaine in the arrhythmias occurring in the early stage of myocardial infarction and have even shown an increased mortality in patients thus treated, we investigated the value of lidocaine as a protective agent against ventricular fibrillation related to myocardial ischemia in the in situ heart of anesthetized open-chest pigs subjected to transient total occlusion of the proximal left anterior descending coronary artery (LAD) under ventricular pacing at a constant high rate." | 3.69 | Profibrillatory effects of lidocaine in the acutely ischemic porcine heart. ( Aupetit, JF; Barral-Cadière, L; Faucon, G; Freysz, M; Lopez, M; Loufoua-Moundanga, J; Timour, Q, 1995) |
| "Epidural lidocaine compared to epidural saline hastens the recovery of gastrointestinal motility in rats after a 30-min period of bowel ischemia." | 3.69 | Epidural anesthesia accelerates the recovery of postischemic bowel motility in the rat. ( Eimerl, D; Haskel, Y; Schiffman, J; Udassin, R, 1994) |
| "The aim of this study was to evaluate the efficacy of a single dose of intravenous amiodarone in facilitating defibrillation of ventricular fibrillation refractory to lidocaine and epinephrine plus direct current countershocks in experimental acute myocardial infarction." | 3.69 | Effects of amiodarone on refractory ventricular fibrillation in acute myocardial infarction: experimental study. ( Anastasiou-Nana, MI; Moulopoulos, SD; Nanas, JN; Nanas, SN; Poyadjis, A; Rapti, A; Stathaki, S, 1994) |
| "We compared the ability of a new amiodarone-like agent, SR 33589, with that of amiodarone, D,L-sotalol, and lignocaine to reduce the incidence of ventricular fibrillation (VF) and associated arrhythmias caused by acute coronary artery occlusion in anesthetized pigs." | 3.69 | Effects of a new amiodarone-like agent, SR 33589, in comparison to amiodarone, D,L-sotalol, and lignocaine, on ischemia-induced ventricular arrhythmias in anesthetized pigs. ( Chatelain, P; Finance, O; Manning, A, 1995) |
| "We have assessed the ability of the new amiodarone-like antiarrhythmic agent, SR 33589, to reduce the incidence of ischemia- and reperfusion-induced arrhythmias, in comparison to amiodarone, D-sotalol, and lignocaine." | 3.69 | SR 33589, a new amiodarone-like agent: effect on ischemia- and reperfusion-induced arrhythmias in anesthetized rats. ( Bruyninckx, C; Chatelain, P; Manning, AS; Ramboux, J, 1995) |
| "Our observations indicate that lidocaine reduces reperfusion injury and inhibits PMN adhesion and subsequent migration to the lung allograft." | 3.69 | Lidocaine reduces reperfusion injury and neutrophil migration in canine lung allografts. ( Ando, K; Cooper, JD; Patterson, GA; Schmid, RA; Tanaka, Y; Yamashita, M, 1996) |
| "Using the extracellular recording method, the effects of lidocaine (a local anesthetic known to relieve tinnitus) on discharge of inferior colliculus (IC) neurons of the guinea pig were studied before and after salicylate (200 mg/kg) administration." | 3.69 | Effects of lidocaine on salicylate-induced discharge of neurons in the inferior colliculus of the guinea pig. ( Manabe, Y; Oka, H; Saito, H; Yoshida, S, 1997) |
| "The effects of lidocaine and diltiazem on recovery of electrophysiologic activity during partial reperfusion following severe myocardial ischemia were investigated in 28 dogs." | 3.69 | Effects of lidocaine and diltiazem on recovery of electrophysiologic activity during partial reperfusion following severe myocardial ischemia in canine hearts. ( Kuraoka, F; Kuroiwa, A; Murasato, Y; Nagamoto, Y; Nakashima, Y; Urabe, T, 1997) |
| "Effects of SUN-1165, a class I antiarrhythmic drug, on ventricular arrhythmias, intraventricular conduction, and the effective refractory period (ERP) were examined in a canine model of myocardial infarction and compared with those of lidocaine." | 3.68 | Effects of SUN-1165, N-(2,6-dimethylphenyl)-8-pyrrolizidine acetamide hydrochloride hemihydrate, a new class I antiarrhythmic drug, on ventricular arrhythmias, intraventricular conduction, and the refractory period in canine myocardial infarction. ( Hashimoto, H; Nakashima, M; Satoh, N, 1992) |
| "Dogs were treated with repeated doses of lidocaine or equivalent volumes of saline during hyperbaric therapy after internal carotid air embolism and transient hypertension." | 3.68 | Effect of lidocaine on somatosensory evoked response and cerebral blood flow after canine cerebral air embolism. ( Clark, JB; Dutka, AJ; Hallenbeck, JM; McDermott, J; Mink, R, 1992) |
| "Effects of flecainide, a class I antiarrhythmic drug, on ventricular arrhythmias, ventricular abnormal automaticity and ventricular activation were examined in a canine model of myocardial infarction, and compared with those of lidocaine." | 3.68 | Effects of flecainide on ventricular arrhythmias, abnormal automaticity and activation in a canine model of myocardial infarction. ( Hashimoto, H; Katoh, H; Nakashima, M, 1992) |
| "Bretylium tosylate has been shown effective in the treatment of ventricular fibrillation and in the prevention of its recurrence." | 3.68 | Bretylium tosylate versus lidocaine in experimental cardiac arrest. ( Blecic, S; Contempré, B; Reuse, C; Vachiery, JL; Vincent, JL, 1990) |
| " In these models it is more potent than lidocaine, procainamide and quinidine, as well as a number of investigational agents, and is active against both ventricular and supraventricular arrhythmias from a number of causes." | 3.67 | Antiarrhythmic and electrophysiologic actions of flecainide in animal models. ( Banitt, EH; Kvam, DC; Schmid, JR, 1984) |
| "Thrombophlebitis is a common complication associated with infusion of intravenous sedatives, especially diazepam." | 3.67 | Development of an in vivo model for assessment of drug-induced vascular injury. ( Herrera, GQ; Jeske, AH; Johnson, JV; McDaniel, HK, 1989) |
| "5 V, 750 ms) or programmed ventricular stimulation, creation of a small myocardial infarction, and application of antiarrhythmic drugs (ajmalin, lidocaine, sotalol)." | 3.67 | Acute induction of sustained ventricular tachycardia: a new porcine model. ( Lüderitz, B; Nitsch, J; Schmid, C, 1989) |
| "Ventricular fibrillation threshold was determined using a train of pulses, 4 ms in duration, delivered at 10 ms intervals, in 20 anaesthetised dogs receiving toxic doses of quinidine sulphate (30 mg X kg-1) injected intravenously over 5 min to prolong the QT interval." | 3.67 | Ventricular fibrillation threshold in canine hearts with quinidine induced prolonged QT interval: effects of atrial pacing, isoproterenol, and lignocaine. ( Inoue, H; Mashima, S; Matsuo, H; Murao, S; Sugimoto, T, 1986) |
| " However, in vitro experiments are not satisfactory to predict antiarrhythmic activity "in vivo", because: 1) they are mostly performed in preparations made from the normal myocardium; 2) "in vitro" the autonomic and hormonal effects are absent; 3) some drugs as nitroglycerin or strophanthin do not produce antiarrhythmic electrophysiological changes in "vitro" but under appropriate conditions they may have a clear-cut antiarrhythmic action "in vivo"; 4) arrhythmias mostly arise from the interaction of changes in several fundamental electrophysiological parameters which could be best studied "in vivo"." | 3.66 | [Pharmacologic evaluation of electrical processes in the myocardium]. ( Sekeresh, L, 1982) |
| " Lidocaine and pindolol pretreatment increased the survival rate and attenuated the life-threatening arrhythmias during the first 20 min, but did not influence the infarct size 16 hrs later." | 3.66 | Coronary artery ligation, early arrhythmias, and determination of the ischemic area in conscious rats. ( Koltai, M; Leprán, I; Siegmund, W; Szekeres, L, 1983) |
| "This study was performed to investigate the prophylactic effect of disopyramide phosphate on ventricular fibrillation in acute myocardial infarction." | 3.66 | Studies on the preventive method of lowered ventricular fibrillation threshold during experimental acute myocardial infarctions. A comparison between disopyramide phosphate and lidocaine. ( Fukuzaki, H; Hatani, M; Hori, Y; Imai, N; Nadai, T; Okamoto, R; Takano, S; Toh, H, 1981) |
| "Ventricular arrhythmias due to myocardial infarct were produced in 14 dogs, and the antiarrhytmic effects of quinidine (Qd), lidocaine (Lid), aprindine (Apr), and dl-propranolol (dl-Prop) were investigated." | 3.66 | [Effects of antiarrhythmic agents on ventricular arrhythmias following myocardial infarct induced with glass beads in dogs (author's transl)]. ( Haruna, M; Kimoto, S; Nakao, T; Ueda, M, 1981) |
| "Lidocaine has analgesics and anti-inflammatory properties, and poloxamer/alginate/CaCl2 (PACM) is a known antiadhesive agent." | 2.84 | Effects of a Lidocaine-Loaded Poloxamer/Alginate/CaCl2 Mixture on Postoperative Pain and Adhesion in a Rat Model of Incisional Pain. ( Baek, CW; Cho, WJ; Choi, GJ; Hong, ME; Jung, YH; Kang, H; Kim, JW; Lee, Y; Park, ILK; Shin, HY, 2017) |
| "Methylene blue (MB) is a blue cationic thiazine dye and currently used in different medical settings." | 1.62 | Methylene blue induces an analgesic effect by significantly decreasing neural firing rates and improves pain behaviors in rats. ( Han, HC; Lee, SW; Moon, SW; Park, JS; Suh, HR, 2021) |
| "Amitriptyline-induced lower post-TBI HR and improved functional outcomes without affecting inflammatory response." | 1.62 | Postinjury treatments to make early tactical aeromedical evacuation practical for the brain after TBI. ( Earnest, R; Goodman, MD; McGlone, E; Morris, MC; Singer, KE; Stevens-Topie, S; Wallen, TE, 2021) |
| "Lidocaine is a common local anesthetic and antiarrhythmic drug that acts via the local anesthetic effect of blocking voltage-gated sodium channels in peripheral neurons." | 1.56 | Effects of 1% Lidocaine Instillation on Overactive Bladder Induced by Bladder Outlet Obstruction in Rats. ( Han, SW; Kang, HJ; Kim, JH; Kim, SW; Lee, YS, 2020) |
| "Severe arrhythmias-such as ventricular arrhythmias-can be fatal, but treatment options are limited." | 1.51 | Combination Formulation of Tetrodotoxin and Lidocaine as a Potential Therapy for Severe Arrhythmias. ( Bai, K; Chen, Y; He, J; Hong, B; Huang, W; Le, Q, 2019) |
| "Menthol inhibited phototoxicity-evoked APs and reduced pain behavior when applied topically to mice." | 1.48 | Menthol reduces phototoxicity pain in a mouse model of photodynamic therapy. ( Baptista-Hon, D; Bull, F; Dalgaty, F; Gallacher, M; Hales, TG; Ibbotson, SH; Wright, L, 2018) |
| " To investigate the pharmacokinetic hypothesis, we determined concentrations of radiolabeled (C) lidocaine up to 90 min after administration." | 1.48 | Pharmacodynamics and Pharmacokinetics of Lidocaine in a Rodent Model of Diabetic Neuropathy. ( de Bruin, K; Hollmann, MW; Horn, J; Lirk, P; Picardi, S; Rigaud, M; Tan, HL; Ten Hoope, W; Verberne, HJ; Verhamme, C; Verkerk, AO, 2018) |
| "Diarrhea is a severe complication in HIV-1-infected patients with Trans-activator of transcription (HIV-1 Tat) protein being recognized as a major underlying cause." | 1.48 | HIV-1 Tat-induced diarrhea is improved by the PPARalpha agonist, palmitoylethanolamide, by suppressing the activation of enteric glia. ( Bruzzese, E; Cuomo, R; D'Alessandro, A; Esposito, G; Gigli, S; Lattanzi, R; Lu, J; Pesce, M; Sarnelli, G; Seguella, L; Steardo, L, 2018) |
| "Latent sensitization is a model of chronic pain in which an injury triggers a period of hyperalgesia followed by an apparent recovery, but in which pain sensitization persists but is suppressed by opioid and adrenergic receptors." | 1.48 | Corticotropin-Releasing Factor in the Brain and Blocking Spinal Descending Signals Induce Hyperalgesia in the Latent Sensitization Model of Chronic Pain. ( Chen, W; Marvizón, JC; Taché, Y, 2018) |
| "Myocardial infarction is the leading cause of death worldwide." | 1.46 | Cardioprotection induced in a mouse model of neuropathic pain via anterior nucleus of paraventricular thalamus. ( Chang, YT; Chen, CC; Chen, WH; Chen, YH; Cheng, YF; Shih, HC; Shyu, BC, 2017) |
| "More than 90% of spinal cord injuries are caused by traumatic accidents and are often associated with other tissue damage (polytrauma) that can provide a source of continued pain input during recovery." | 1.46 | Pain Input Impairs Recovery after Spinal Cord Injury: Treatment with Lidocaine. ( Aceves, M; Grau, JW; Hook, MA; Huang, YJ; Reynolds, JA; Strain, MM; Turtle, JD, 2017) |
| "Pain is one of the most challenging and stressful conditions to patients with sickle cell disease (SCD) and their clinicians." | 1.43 | CaMKIIα underlies spontaneous and evoked pain behaviors in Berkeley sickle cell transgenic mice. ( Chen, Y; DeSimone, J; He, Y; Lu, J; Molokie, RE; Tian, X; Wang, ZJ; Wilkie, DJ; Xiao, C; Yang, C, 2016) |
| "Lidocaine has proven anti-inflammatory activity in several tissues but its modulation of miRNAs has not been investigated." | 1.43 | Lidocaine Administration Controls MicroRNAs Alterations Observed After Lung Ischemia-Reperfusion Injury. ( Calvo, A; Casanova, J; García, C; Garutti, I; Marchal-Duval, E; Paredes, SD; Rancan, L; Rincón, D; Simón, C; Turrero, A; Vara, E, 2016) |
| "Due to the complex nature of Alzheimer's disease, multi-target-directed ligand approaches are one of the most promising strategies in the search for effective treatments." | 1.42 | Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo. ( Bajda, M; Brus, B; Czerwińska, P; Filipek, B; Gobec, S; Malawska, B; Sałat, K; Więckowska, A; Więckowski, K, 2015) |
| "NaV1." | 1.42 | Genetic background modulates impaired excitability of inhibitory neurons in a mouse model of Dravet syndrome. ( Catterall, WA; Jones, CJ; Rubinstein, M; Scheuer, T; Westenbroek, RE; Yu, FH, 2015) |
| "We tested the hypothesis that ulcerative colitis-like inflammation induced by dextran sodium sulfate (DSS) exacerbates the ongoing spontaneous activity in colon-projecting afferent neurons that induces abdominal discomfort and anxiety, and depressive-like behaviors in rats." | 1.42 | Genesis of anxiety, depression, and ongoing abdominal discomfort in ulcerative colitis-like colon inflammation. ( Chen, J; Fu, Y; Green, TA; Guptarak, J; Jensen, KL; Sarna, SK; Shi, XZ; Winston, JH, 2015) |
| "Cardiac arrest was induced for 10 min in 120 rats." | 1.42 | Effect of a pharmacologically induced decrease in core temperature in rats resuscitated from cardiac arrest. ( Frank, JE; Glickman, LT; Gordon, CJ; Katz, LM; Lambert, BH; McGwin, G, 2015) |
| "Cancer-induced bone pain is described as dull, aching ongoing pain." | 1.42 | Behavioral and neurochemical analysis of ongoing bone cancer pain in rats. ( King, T; Navratilova, E; Okun, A; Porreca, F; Remeniuk, B; Sukhtankar, D; Xie, JY, 2015) |
| "Ventricular fibrillation was induced in 16 pigs, and circulatory arrest was maintained for 14 minutes." | 1.40 | Effects of potassium/lidocaine-induced cardiac standstill during cardiopulmonary resuscitation in a pig model of prolonged ventricular fibrillation. ( Heo, T; Hun Jung, Y; Il Min, Y; Jeong, IS; Joon Lee, S; Kook Lee, B; Lim, V; Woon Jeung, K; Youn Lee, H, 2014) |
| "Sepsis was induced by cecal ligation and puncture." | 1.40 | Adenosine, lidocaine and Mg2+ (ALM) induces a reversible hypotensive state, reduces lung edema and prevents coagulopathy in the rat model of polymicrobial sepsis. ( Dobson, GP; Griffin, MJ; Letson, HL, 2014) |
| "Mechanisms underlying the chronicity of neuropathic pain are not well understood." | 1.39 | Descending facilitation maintains long-term spontaneous neuropathic pain. ( De Felice, M; Guo, W; King, T; Ossipov, MH; Porreca, F; Wang, R, 2013) |
| "Levobupivacaine was more potent than lidocaine in all tests employed on diabetic rats." | 1.39 | Comparison of actions of systemically and locally administrated local anaesthetics in diabetic rats with painful neuropathy. ( Gunay, I; Gunes, Y; Mert, T, 2013) |
| "Whether ongoing pain is present in this model is unknown." | 1.38 | Afferent drive elicits ongoing pain in a model of advanced osteoarthritis. ( Brion, T; Davis, P; Dussor, GO; King, T; Liu, P; Okun, A; Ossipov, MH; Porreca, F; Remeniuk, B; Ren, J; Xie, J, 2012) |
| "Diclofenac was highly effective in both tests on day 3, while on day 20 it induced a less pronounced decrease in the Knee-Bend score and was ineffective in the CatWalk test." | 1.38 | Analgesic effects of lidocaine, morphine and diclofenac on movement-induced nociception, as assessed by the Knee-Bend and CatWalk tests in a rat model of osteoarthritis. ( Adães, S; Castro-Lopes, JM; Ferreira-Gomes, J; Mendonça, M, 2012) |
| "Surgical site infections are common, with an incidence of 1." | 1.38 | Effect of local anesthetic on microorganisms in a murine model of surgical site infection. ( Barlow, P; Bemis, D; Coan, P; Daley, BJ; Goldman, MH; Karlstad, M; Lawson, CM; Newkirk, K; Norwood, J; Sams, VG, 2012) |
| "Catecholaminergic polymorphic ventricular tachycardia (CPVT) is caused by mutations in the cardiac ryanodine receptor (RyR2) or calsequestrin (Casq2) and can be difficult to treat." | 1.37 | Inhibition of cardiac Ca2+ release channels (RyR2) determines efficacy of class I antiarrhythmic drugs in catecholaminergic polymorphic ventricular tachycardia. ( Faggioni, M; Hasdemir, C; Hwang, HS; Knollmann, BC; Laver, D; Mehra, D; Turhan, K; Yin, H, 2011) |
| "Lidocaine was either applied to the nerve at or distal to the injury site in concentrations of 1 to 1000 μg/mL or injected i." | 1.37 | Effect of local and intravenous lidocaine on ongoing activity in injured afferent nerve fibers. ( Baron, R; Bartsch, F; Gorodetskaya, N; Grossmann, L; Jänig, W; Kirillova, I; Rausch, VH; Struck, M; Teliban, A; Tode, J, 2011) |
| "Deep mechanical hyperalgesia observed after RCS at -3 degrees C lasted longer ( approximately 6 weeks) and was severer than RCS at 4 degrees C." | 1.36 | Persistent deep mechanical hyperalgesia induced by repeated cold stress in rats. ( Mizumura, K; Nasu, T; Taguchi, T, 2010) |
| "In male Sprague-Dawley rats (postoperative pain model), the authors applied the SRLS, lidocaine alone, or polylactic-coglycolic acid (control) near the ipsilateral sciatic nerve just before making the paw incision." | 1.36 | Long-term effect of sciatic nerve block with slow-release lidocaine in a rat model of postoperative pain. ( Nakazato, Y; Obata, H; Saito, S; Suto, T; Tabata, Y; Tobe, M; Yokoo, H, 2010) |
| "Lidocaine action was modeled with the Hondeghem-Katzung modulated-receptor theory and maximum affinity for activated Na(+) channels." | 1.35 | Mechanisms of atrial fibrillation termination by rapidly unbinding Na+ channel blockers: insights from mathematical models and experimental correlates. ( Comtois, P; Munoz, M; Nattel, S; Sakabe, M; Shiroshita-Takeshita, A; Texier, A; Vigmond, EJ, 2008) |
| " Local administration of lidocaine was shown to ablate all stimulation-induced fMRI signals by the total blockage of peripheral nerve transmission, while the analgesic effect of systemically administered lidocaine was robustly detected after intravenous infusion of approximately 3mg/kg, which is similar to clinical dosage for human." | 1.35 | fMRI investigation of the effect of local and systemic lidocaine on noxious electrical stimulation-induced activation in spinal cord. ( Abbadie, C; Cook, JJ; Hargreaves, R; Meng, X; Reicin, AS; Ritter, A; Welsh, DC; Williams, DS; Williams, M; Zhao, F, 2009) |
| "To analyze the effect of lidocaine on postoperative pain relief, we performed compression of the right sciatic nerve in Wistar rats and observed the differences on behavior between the group that received lidocaine and the group that was not treated with the local anesthetics pre-operatively." | 1.35 | Preemptive analgesic effect of lidocaine in a chronic neuropathic pain model. ( Almeida, JP; Batista, IM; Batista, LM; Carvalho, CH; Castro-Costa, CM; Castro-Costa, SB, 2009) |
| "Alternans and arrhythmia occurred in hypokalaemic, but not normokalaemic (5." | 1.35 | Restitution analysis of alternans and its relationship to arrhythmogenicity in hypokalaemic Langendorff-perfused murine hearts. ( Grace, AA; Huang, CL; Li, LM; Sabir, IN, 2008) |
| "Lidocaine has been reported to attenuate the inflammatory response in addition to its anesthetic activity, but the mechanisms are poorly understood." | 1.35 | Lidocaine attenuates lipopolysaccharide-induced acute lung injury through inhibiting NF-kappaB activation. ( Feng, G; Liu, GJ; Liu, S; Wang, GL, 2008) |
| " The protection of mitochondrial functions was almost complete at a dosage of 10 mg/kg/day during normothermic ischemia and 10 microg/ml in the preservation liquid during hypothermic ischemia." | 1.35 | Protection of cellular and mitochondrial functions against liver ischemia by N-benzyl-N'-(2-hydroxy-3,4-dimethoxybenzyl)-piperazine (BHDP), a sigma1 ligand. ( Ferchichi, H; Klouz, A; Kourda, N; Lakhal, M; Morin, D; Ouanes, L; Saïd, DB; Tillement, JP, 2008) |
| "Pelvic pain was detected 5 days after antigen instillation and was sustained beyond 30 days, indicating the development of chronic pain." | 1.35 | Experimental autoimmune prostatitis induces chronic pelvic pain. ( Rudick, CN; Schaeffer, AJ; Thumbikat, P, 2008) |
| "Lidocaine was soaked on spinal nerves or intrathecally injected 10 min before SNT to block neuronal discharges caused by the injury, and L703,606 (NK1 receptor antagonist) and CGRP8-37 (CGRP receptor antagonist) were intrathecally injected into the rats to block actions of substance P and CGRP released from central nerve terminals in the spinal cord by injury discharges." | 1.34 | Involvement of substance P and calcitonin gene-related peptide in development and maintenance of neuropathic pain from spinal nerve injury model of rat. ( Kim, JH; Lee, SE, 2007) |
| "Measuring primary hyperalgesia from deep somatic tissue (ie, muscle and joint) is difficult in laboratory animals but clinically important." | 1.33 | Characterization of a method for measuring primary hyperalgesia of deep somatic tissue. ( Radhakrishnan, R; Skyba, DA; Sluka, KA, 2005) |
| "Pretreatment with lidocaine (10 microM), but not procaine (50 microM), restored the membrane potential after the reintroduction of oxygen and glucose." | 1.33 | Neuroprotective mechanisms of lidocaine against in vitro ischemic insult of the rat hippocampal CA1 pyramidal neurons. ( Higashi, H; Kuroiwa, M; Murai, Y; Niiyama, S; Noguchi, M; Sakamoto, H; Satani, M; Takahashi, K; Tanaka, E; Tsuji, S; Yamada, A, 2005) |
| "We evaluated mechanical allodynia in sham-operated animals and a disc herniation model." | 1.33 | Up-regulation of acid-sensing ion channel 3 in dorsal root ganglion neurons following application of nucleus pulposus on nerve root in rats. ( Doya, H; Inoue, G; Ito, T; Koshi, T; Moriya, H; Ohtori, S; Saito, T; Takahashi, K, 2006) |
| "The incisional allodynia and the carrageenan-induced hyperalgesia were intensified by the microinjection of 2% lidocaine into the contralateral, but not ipsilateral APtN, the effect being significantly stronger when a large incision or a higher carrageenan concentration was utilized." | 1.32 | Involvement of the anterior pretectal nucleus in the control of persistent pain: a behavioral and c-Fos expression study in the rat. ( Del Bel, EA; Prado, WA; Villarreal, CF, 2003) |
| "Lidocaine and phenol were injected into the sciatic nerves of the rats in Groups 1 and 2, respectively." | 1.32 | Free radical-induced damage in experimental peripheral nerve injection injury. ( Apan, A; Kisa, U; Saray, A, 2003) |
| "Biliary acute pancreatitis or postendoscopic iatrogenia acute pancreatitis (AP) are likely triggered by autonomous arc reflexes (AAR) initiated in the peri-Vaterian duodenum (PV-D)." | 1.32 | Acute pancreatitis possible initial triggering mechanism and prophylaxis. ( Binker, MG; Cosen-Binker, LI; Negri, G; Tiscornia, O, 2003) |
| "Lidocaine treatment improved early electrophysiological recovery and reduced the size of the cortical infarct at 24 h, but had no significant effect on cerebral blood flow in either the penumbra or core during ischemia." | 1.32 | Lidocaine attenuates apoptosis in the ischemic penumbra and reduces infarct size after transient focal cerebral ischemia in rats. ( Capuano-Waters, C; Cottrell, JE; Kass, IS; Lei, B; Popp, S, 2004) |
| "Both morphine and lidocaine were active topically in the tail formalin assay, although their time-course of action appeared to be shorter than that of the formalin." | 1.32 | Evaluation of the tail formalin test in mice as a new model to assess local analgesic effects. ( Cristea, M; Kolesnikov, Y; Oksman, G; Torosjan, A; Wilson, R, 2004) |
| "LPS-induced hypotension has been attributed to nitric oxide (NO) activation of leukocytes, oxidants, cytokines, and other causes." | 1.31 | A role for abdominal vagal afferents in lipopolysaccharide-induced hypotension. ( Mailman, D, 2002) |
| "Lidocaine treatment attenuated these changes." | 1.31 | Lidocaine attenuates acute lung injury induced by a combination of phospholipase A2 and trypsin. ( Kiyonari, Y; Maekawa, N; Mikawa, K; Nishina, K; Obara, H, 2000) |
| "Cocaine addiction is a chronically relapsing brain disease, but its neural basis is not yet well understood." | 1.31 | Dissociable effects of lidocaine inactivation of the rostral and caudal basolateral amygdala on the maintenance and reinstatement of cocaine-seeking behavior in rats. ( Black, Y; Eichenbaum, HB; Green-Jordan, K; Kantak, KM; Valencia, E, 2002) |
| "The effect of lidocaine pretreatment on thermal hyperalgesia and thermal skin asymmetries provoked by experimental mononeuropathy was investigated in rats." | 1.29 | Pre-injury lidocaine treatment prevents thermal hyperalgesia and cutaneous thermal abnormalities in a rat model of peripheral neuropathy. ( Castagna, A; Lacerenza, M; Marchettini, P; Sotgiu, ML, 1995) |
| " Such procedures are undertaken using single infiltration dosage recommendations for lignocaine, both with and without adrenaline." | 1.29 | The relationship between regional blood flow and absorption of lignocaine. ( Karatassas, A; Morris, RG; Slavotinek, AH, 1993) |
| " Thus the objective of this investigation was to evaluate the antifibrillatory properties of moricizine (a new antiarrhythmic agent) alone and in combination with lidocaine (an established antifibrillatory agent)." | 1.29 | Antifibrillatory and electrophysiologic actions of moricizine alone and in combination with lidocaine: a prospective, randomized trial. ( Chow, MS; Fan, C; Kluger, J; O'Rangers, EA; Ujhelyi, MR, 1993) |
| "Lidocaine was microinjected in the RVM or PAG and allodynia was quantitatively determined by measuring the hindlimb withdrawal thresholds to mechanical stimulation of the paw." | 1.29 | Lidocaine in the rostroventromedial medulla and the periaqueductal gray attenuates allodynia in neuropathic rats. ( Hämäläinen, MM; Pertovaara, A; Wei, H, 1996) |
| "Monoethylglycinexylidide (MEGX) is a hepatic metabolite of lidocaine, used clinically to determine graft function following hepatic transplantation." | 1.28 | Monoethylglycinexylidide production parallels changes in hepatic blood flow and oxygen delivery in lung injury managed with positive end-expiratory pressure. ( Branson, RD; Davis, K; Johnson, DJ; Purcell, PN; Schroeder, TJ, 1992) |
| "In this study, the canine model of laryngospasm previously described by Aviv, et al." | 1.28 | A canine model for studying laryngospasm and its prevention. ( Cohen, JI; Henderson, PS; Jarnberg, PO; Smith, JD; Stevens, W, 1992) |
| "A second spell of arrhythmia of similar intensity and pattern, which had the same latency to onset, was reproduced 60 min after the first spell of arrhythmia." | 1.28 | Isolated paced guinea pig left atrium: a new ouabain-induced arrhythmia model. ( Thomas, GP; Varma, RK, 1991) |
| "When lidocaine (2 mg/kg) was substituted for cocaine-base, responding decreased to approximately half of that maintained by cocaine, and when cocaine was reinstated, higher response rates returned." | 1.28 | Cocaine-base smoking in rhesus monkeys: reinforcing and physiological effects. ( Carroll, ME; Gieske, D; Krattiger, KL; Sadoff, DA, 1990) |
| "In 15 rabbits with severe changes, arrhythmia was followed by ST depression (in 30." | 1.28 | Model of electrocardiographic changes seen with subarachnoid hemorrhage in rabbits. ( Niitsu, T; Okuda, H; Saito, K; Uchida, M, 1989) |
| "The onset of ventricular arrhythmias was associated with continuous electrical activity in epicardial and intramural electrograms recorded from the reperfused zone." | 1.27 | Ventricular arrhythmias following one-stage and two-stage coronary reperfusion: evidence for both reentry and enhanced automaticity. ( Brachmann, J; Harrison, L; Kabell, G; Lazzara, R; Scherlag, BJ, 1985) |
| " Suppression of wound healing was found with a dosage of DFV lower than those of PS, HC and H." | 1.27 | [Neriproct: its anti-inflammatory effect on an experimentally induced hemorrhoid model in the rat]. ( Iwai, K; Kudoh, D; Nakagawa, H; Nishiki, K; Nishinaga, K, 1988) |
| "Protection from arrhythmias seems to be related to the combined presence of a noncompetitive adrenergic blockade associated with salutary effects on coronary circulation." | 1.27 | The effect of antiarrhythmic drugs on life-threatening arrhythmias induced by the interaction between acute myocardial ischemia and sympathetic hyperactivity. ( Schwartz, PJ; Vanoli, E; Zaza, A; Zuanetti, G, 1985) |
| "Lidocaine pretreatment (10 mg/kg i." | 1.26 | Acute coronary artery occlusion-reperfusion-induced arrhythmias in rats, dogs and pigs: antiarrhythmic evaluation of quinidine, procainamide and lidocaine. ( Bergey, JL; McCallum, JD; Nocella, K, 1982) |
| "Lidocaine was given as a 2-mg/kg loading dose 10 minutes prior to ischemic arrest and a 2-mg/min continuous infusion during the entire experimental period." | 1.26 | Reduction of ischemic myocardial damage in the dog by lidocaine infusion. ( Lemoie, G; Ruotolo, R; Schaub, RG; Stewart, G; Strong, M, 1977) |
| "Of particular importance are the arrhythmias observed immediately after experimentally induced acute myocardial infarction (AMI)." | 1.25 | Pharmacological modification of arrhythmias after experimentally induced acute myocardial infarction. Drugs acting on the nervous system. ( Kniffen, FJ; Lucchesi, BR, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 56 (16.37) | 18.7374 |
| 1990's | 49 (14.33) | 18.2507 |
| 2000's | 84 (24.56) | 29.6817 |
| 2010's | 133 (38.89) | 24.3611 |
| 2020's | 20 (5.85) | 2.80 |
| Authors | Studies |
|---|---|
| Johnson, RE | 1 |
| Baizman, ER | 1 |
| Becker, C | 1 |
| Bohnet, EA | 1 |
| Bell, RH | 1 |
| Birsner, NC | 1 |
| Busacca, CA | 1 |
| Carabateas, PM | 1 |
| Chadwick, CC | 1 |
| Gruett, MD | 1 |
| Więckowska, A | 1 |
| Więckowski, K | 1 |
| Bajda, M | 1 |
| Brus, B | 1 |
| Sałat, K | 1 |
| Czerwińska, P | 1 |
| Gobec, S | 1 |
| Filipek, B | 1 |
| Malawska, B | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Letson, HL | 12 |
| Biros, E | 3 |
| Morris, JL | 2 |
| Dobson, GP | 14 |
| Franko, JJ | 1 |
| Vu, MM | 1 |
| Parsons, ME | 1 |
| Conner, JR | 1 |
| Lammers, DT | 1 |
| Ieronimakis, N | 1 |
| Reynolds, GD | 1 |
| Eckert, MJ | 1 |
| Bingham, JR | 1 |
| Pereira, SM | 1 |
| Sinedino, BE | 1 |
| Costa, ELV | 1 |
| Morais, CCA | 1 |
| Sklar, MC | 1 |
| Adkson Sales Lima, C | 1 |
| Nakamura, MAM | 1 |
| Ranzani, OT | 1 |
| Goligher, EC | 1 |
| Tucci, MR | 1 |
| Ho, YL | 1 |
| Taniguchi, LU | 1 |
| Vieira, JE | 1 |
| Brochard, L | 2 |
| Amato, MBP | 1 |
| Wang, YC | 1 |
| Chen, YS | 1 |
| Hsieh, ST | 1 |
| Birosova, E | 1 |
| Moran, CS | 1 |
| Biben, JA | 1 |
| Prasetyono, TOH | 1 |
| Tantri, AR | 1 |
| Chim, H | 1 |
| Salgado, CJ | 1 |
| Miller, NL | 1 |
| Wolfe, EM | 1 |
| Rao, S | 1 |
| Pearse, DD | 1 |
| González-López, A | 1 |
| López-Alonso, I | 1 |
| Pickerodt, PA | 1 |
| von Haefen, C | 1 |
| Amado-Rodríguez, L | 1 |
| Reimann, H | 1 |
| Niendorf, T | 1 |
| Kuebler, W | 1 |
| Albaiceta, GM | 1 |
| Francis, RCE | 1 |
| Spies, CD | 1 |
| Kang, HJ | 1 |
| Kim, SW | 1 |
| Lee, YS | 1 |
| Han, SW | 1 |
| Kim, JH | 2 |
| Lee, S | 3 |
| Jo, S | 1 |
| Talbot, S | 2 |
| Zhang, HB | 1 |
| Kotoda, M | 1 |
| Andrews, NA | 1 |
| Puopolo, M | 2 |
| Liu, PW | 1 |
| Jacquemont, T | 1 |
| Pascal, M | 1 |
| Heckman, LM | 1 |
| Jain, A | 1 |
| Lee, J | 1 |
| Woolf, CJ | 3 |
| Bean, BP | 3 |
| Hong, B | 1 |
| He, J | 1 |
| Le, Q | 1 |
| Bai, K | 1 |
| Chen, Y | 2 |
| Huang, W | 1 |
| Leon-Constantin, MM | 1 |
| Alexa-Stratulat, T | 1 |
| Luca, A | 1 |
| Tamba, BI | 1 |
| Trandafir, LM | 1 |
| Harabagiu, V | 1 |
| Cojocaru, E | 1 |
| Chen, JM | 1 |
| Liu, KC | 1 |
| Yeh, WL | 1 |
| Chen, JC | 1 |
| Liu, SJ | 1 |
| Granfeldt, A | 5 |
| Jensen, TH | 1 |
| Mattson, TH | 1 |
| Ferreira, LEN | 2 |
| Abdalla, HB | 1 |
| da Costa, JP | 1 |
| de Freitas Domingues, JS | 1 |
| Burga-Sánchez, J | 1 |
| Groppo, FC | 1 |
| Volpato, MC | 1 |
| Zhang, Z | 1 |
| Wang, J | 1 |
| Song, Z | 2 |
| Wang, Y | 1 |
| Cheng, Z | 1 |
| Guo, Q | 1 |
| Wang, E | 1 |
| Jian, Y | 1 |
| Wu, L | 1 |
| Lee, SW | 1 |
| Moon, SW | 1 |
| Park, JS | 1 |
| Suh, HR | 1 |
| Han, HC | 1 |
| Stigall, KS | 1 |
| Neidert, LE | 1 |
| Morgan, CG | 2 |
| Hemond, PJ | 1 |
| Brown, DR | 1 |
| Salas, M | 1 |
| Hathaway, EN | 1 |
| Tiller, MM | 1 |
| Cardin, S | 2 |
| Glaser, JJ | 2 |
| Singer, KE | 1 |
| Wallen, TE | 1 |
| Morris, MC | 1 |
| McGlone, E | 1 |
| Stevens-Topie, S | 1 |
| Earnest, R | 1 |
| Goodman, MD | 1 |
| Wall, TP | 1 |
| Crowley, PD | 1 |
| Buggy, DJ | 1 |
| Li, B | 1 |
| Xu, H | 1 |
| He, C | 1 |
| Zou, W | 1 |
| Tu, Y | 1 |
| Kirschner, A | 1 |
| Koch, SE | 1 |
| Robbins, N | 1 |
| Karthik, F | 1 |
| Mudigonda, P | 1 |
| Ramasubramanian, R | 1 |
| Nieman, ML | 1 |
| Lorenz, JN | 1 |
| Rubinstein, J | 1 |
| Conner, J | 1 |
| Lammers, D | 1 |
| Holtestaul, T | 1 |
| Jones, I | 1 |
| Kuckelman, J | 1 |
| Letson, H | 1 |
| Dobson, G | 1 |
| Eckert, M | 1 |
| Bingham, J | 1 |
| Choi, GJ | 1 |
| Kang, H | 1 |
| Hong, ME | 1 |
| Shin, HY | 1 |
| Baek, CW | 1 |
| Jung, YH | 1 |
| Lee, Y | 1 |
| Kim, JW | 1 |
| Park, ILK | 1 |
| Cho, WJ | 1 |
| Allen, J | 2 |
| Imbert, I | 2 |
| Havelin, J | 2 |
| Henderson, T | 1 |
| Stevenson, G | 1 |
| Liaw, L | 1 |
| King, T | 7 |
| Saito, T | 2 |
| Yamamoto, Y | 1 |
| Feng, GG | 1 |
| Kazaoka, Y | 1 |
| Fujiwara, Y | 1 |
| Kinoshita, H | 1 |
| Ding, H | 2 |
| Fu, YJ | 3 |
| Zheng, LR | 2 |
| Chen, J | 3 |
| Shi, XQ | 3 |
| Davenport, L | 1 |
| Asiri, YI | 1 |
| Fung, T | 1 |
| Schwarz, SKW | 1 |
| Asseri, KA | 1 |
| Welch, ID | 1 |
| Schuppli, CA | 1 |
| Barr, AM | 1 |
| Wall, RA | 1 |
| Puil, E | 1 |
| MacLeod, BA | 2 |
| Cheng, YF | 1 |
| Chang, YT | 1 |
| Chen, WH | 1 |
| Shih, HC | 1 |
| Chen, YH | 2 |
| Shyu, BC | 1 |
| Chen, CC | 1 |
| Luh, JJ | 1 |
| Huang, WT | 1 |
| Lin, KH | 1 |
| Huang, YY | 1 |
| Kuo, PL | 1 |
| Chen, WS | 1 |
| Wright, L | 1 |
| Baptista-Hon, D | 1 |
| Bull, F | 1 |
| Dalgaty, F | 1 |
| Gallacher, M | 1 |
| Ibbotson, SH | 1 |
| Hales, TG | 1 |
| Tsutsui, Y | 1 |
| Sunada, K | 1 |
| Ten Hoope, W | 1 |
| Hollmann, MW | 1 |
| de Bruin, K | 1 |
| Verberne, HJ | 1 |
| Verkerk, AO | 1 |
| Tan, HL | 1 |
| Verhamme, C | 1 |
| Horn, J | 1 |
| Rigaud, M | 1 |
| Picardi, S | 1 |
| Lirk, P | 1 |
| Remeniuk, B | 3 |
| Sukhtankar, D | 2 |
| Nippert, A | 1 |
| Li, N | 1 |
| Li, F | 1 |
| Cheng, K | 1 |
| Rice, KC | 1 |
| Porreca, F | 7 |
| Makdisi, JR | 1 |
| Kim, DP | 1 |
| Klein, PA | 1 |
| Klein, JA | 1 |
| Sarnelli, G | 1 |
| Seguella, L | 1 |
| Pesce, M | 1 |
| Lu, J | 2 |
| Gigli, S | 1 |
| Bruzzese, E | 1 |
| Lattanzi, R | 1 |
| D'Alessandro, A | 1 |
| Cuomo, R | 1 |
| Steardo, L | 1 |
| Esposito, G | 1 |
| Wang, L | 1 |
| Wang, M | 1 |
| Li, S | 1 |
| Wu, H | 1 |
| Shen, Q | 1 |
| Zhang, S | 1 |
| Fang, L | 1 |
| Liu, R | 1 |
| Ji, NN | 1 |
| Kang, J | 1 |
| Hua, R | 1 |
| Zhang, YM | 1 |
| Sanchez, MF | 1 |
| Breda, SA | 1 |
| Soria, EA | 1 |
| Tártara, LI | 1 |
| Manzo, RH | 1 |
| Olivera, ME | 1 |
| Chen, W | 1 |
| Taché, Y | 1 |
| Marvizón, JC | 1 |
| Yang, L | 1 |
| Broomhead, M | 1 |
| Nuutila, K | 1 |
| Proppe, K | 1 |
| Eriksson, E | 1 |
| Sarchahi, AA | 1 |
| Eskandari, M | 1 |
| Tripathi, SJ | 1 |
| Chakraborty, S | 1 |
| Srikumar, BN | 1 |
| Raju, TR | 1 |
| Shankaranarayana Rao, BS | 1 |
| Sisti, MS | 2 |
| Zanuzzi, CN | 2 |
| Nishida, F | 2 |
| Cantet, RJC | 2 |
| Portiansky, EL | 2 |
| Sezgin, Y | 1 |
| Bilgin Çetin, M | 1 |
| Bulut, Ş | 1 |
| Alptekin, NÖ | 1 |
| Börçek, P | 1 |
| Zhang, SS | 1 |
| de Oliveira, SB | 1 |
| Araya, EI | 1 |
| Gambeta, E | 1 |
| Franz-Montan, M | 1 |
| Claudino, RF | 1 |
| Chichorro, JG | 1 |
| Laurella, SL | 1 |
| Kim, JM | 1 |
| Choi, SH | 1 |
| How, RA | 1 |
| Schaub, LJ | 1 |
| Fryer, DM | 1 |
| Ozuna, KM | 1 |
| Sams, VG | 2 |
| Khrestian, A | 1 |
| Waldo, AL | 1 |
| Khrestian, CM | 1 |
| Markowitz, A | 1 |
| Sahadevan, J | 1 |
| Ura, K | 1 |
| Sudo, H | 1 |
| Iwasaki, K | 1 |
| Tsujimoto, T | 1 |
| Ukeba, D | 1 |
| Iwasaki, N | 1 |
| Bauer, CA | 1 |
| Kurt, W | 1 |
| Sybert, LT | 1 |
| Brozoski, TJ | 1 |
| Rogers, TD | 1 |
| Dickson, PE | 1 |
| McKimm, E | 1 |
| Heck, DH | 1 |
| Goldowitz, D | 1 |
| Blaha, CD | 1 |
| Mittleman, G | 1 |
| López-Huerta, VG | 1 |
| Carrillo-Reid, L | 1 |
| Galarraga, E | 1 |
| Tapia, D | 1 |
| Fiordelisio, T | 1 |
| Drucker-Colin, R | 1 |
| Bargas, J | 1 |
| Wang, Z | 1 |
| Shen, L | 1 |
| Li, X | 1 |
| Shu, X | 1 |
| Shan, B | 1 |
| Zhang, L | 1 |
| Gong, Y | 1 |
| Dong, Z | 1 |
| Wang, R | 1 |
| De Felice, M | 2 |
| Guo, W | 1 |
| Ossipov, MH | 3 |
| Youngquist, ST | 1 |
| Niemann, JT | 1 |
| Shah, AP | 1 |
| Thomas, JL | 1 |
| Rosborough, JP | 1 |
| Li, T | 1 |
| Wei, X | 1 |
| Watkins, AC | 1 |
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| Wu, ZJ | 1 |
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| Schmarkey, SL | 1 |
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| Bone, CC | 1 |
| Cline, JM | 1 |
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| Tønnesen, E | 4 |
| Vinten-Johansen, J | 4 |
| Matyas, JR | 1 |
| Gutmann, A | 1 |
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| Suzuki, T | 3 |
| Mori, K | 1 |
| Inoue, K | 1 |
| Seki, H | 2 |
| Yamada, T | 1 |
| Kosugi, S | 1 |
| Minamishima, S | 1 |
| Katori, N | 1 |
| Sano, F | 1 |
| Abe, T | 1 |
| Morisaki, H | 1 |
| Cui, W | 1 |
| Wang, S | 2 |
| Han, R | 1 |
| Wang, Q | 1 |
| Li, J | 1 |
| Katz, LM | 1 |
| Frank, JE | 1 |
| Glickman, LT | 1 |
| McGwin, G | 1 |
| Lambert, BH | 1 |
| Gordon, CJ | 1 |
| Okun, A | 2 |
| Navratilova, E | 1 |
| Xie, JY | 2 |
| Green, PG | 1 |
| Alvarez, P | 1 |
| Levine, JD | 1 |
| Abdulnour, RE | 1 |
| Burkett, PR | 1 |
| Cronin, SJ | 1 |
| Pascal, MA | 1 |
| Laedermann, C | 1 |
| Foster, SL | 1 |
| Tran, JV | 1 |
| Lai, N | 1 |
| Chiu, IM | 1 |
| Ghasemlou, N | 2 |
| DiBiase, M | 1 |
| Roberson, D | 2 |
| Von Hehn, C | 1 |
| Agac, B | 1 |
| Haworth, O | 1 |
| Penninger, JM | 1 |
| Kuchroo, VK | 1 |
| Levy, BD | 1 |
| Kharatmal, SB | 1 |
| Singh, JN | 1 |
| Sharma, SS | 1 |
| Cheng, KI | 1 |
| Wang, HC | 1 |
| Wu, YC | 1 |
| Tseng, KY | 1 |
| Chuang, YT | 1 |
| Chou, CW | 1 |
| Chen, PL | 1 |
| Chang, LL | 1 |
| Lai, CS | 1 |
| Amorim, D | 1 |
| Viisanen, H | 1 |
| Wei, H | 2 |
| Almeida, A | 1 |
| Pinto-Ribeiro, F | 1 |
| Serra, MF | 2 |
| Neves, JS | 1 |
| Couto, GC | 2 |
| Cotias, AC | 2 |
| Pão, CR | 2 |
| Olsen, PC | 2 |
| de Carvalho, KI | 1 |
| Anjos-Valotta, EA | 2 |
| Faria, RX | 1 |
| Costa, JC | 1 |
| Cordeiro, RS | 2 |
| Silva, PM | 2 |
| Martins, MA | 2 |
| Cormier, J | 1 |
| Yamaguchi, K | 2 |
| Ono, K | 2 |
| Hitomi, S | 2 |
| Ito, M | 1 |
| Nodai, T | 1 |
| Goto, T | 1 |
| Harano, N | 1 |
| Watanabe, S | 1 |
| Inoue, H | 4 |
| Miyano, K | 1 |
| Uezono, Y | 1 |
| Matoba, M | 1 |
| Inenaga, K | 2 |
| Abreu, MS | 1 |
| Giacomini, AC | 1 |
| Kalueff, AV | 1 |
| Barcellos, LJ | 1 |
| Terawaki, K | 1 |
| Imai, R | 1 |
| Kubota, K | 1 |
| Omiya, Y | 1 |
| Hattori, T | 1 |
| Kase, Y | 1 |
| Onoglu, R | 1 |
| Narin, C | 1 |
| Kiyici, A | 1 |
| Sarkilar, G | 1 |
| Hacibeyoglu, G | 1 |
| Baba, F | 1 |
| Sarigul, A | 1 |
| Göktalay, G | 1 |
| Millington, WR | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Subcutaneous Injection of Large Volumes of Tumescent Lidocaine and Epinephrine (TLE) by Laypersons: a Double-blind, Non-inferiority, Randomized Clinical Trial[NCT04733781] | Phase 2/Phase 3 | 36 participants (Anticipated) | Interventional | 2021-02-22 | Not yet recruiting | ||
| Transcranial Modulation of Oscillatory Brain Activity in People With Tinnitus: A Concurrent Transcranial Direct Current Stimulation (tDCS) - Magnetoencephalography (MEG) Study[NCT04978142] | 40 participants (Actual) | Interventional | 2020-12-07 | Completed | |||
| Effectiveness of the Addition of Lidocaine to a Hemostatic, Bioresorbable Putty in the Treatment of Iliac Crest Donor Site Pain[NCT01504035] | Phase 2/Phase 3 | 14 participants (Actual) | Interventional | 2008-05-31 | Completed | ||
| Diode Laser as a Biomarker for Neuropathic Pain of Peripheral Origin.[NCT06030297] | 301 participants (Anticipated) | Interventional | 2022-11-01 | Recruiting | |||
| Fractional Carbon Dioxide Laser Assisted Delivery of Topical Anesthetics: a Randomized Controlled Pilot Study[NCT02246179] | Phase 4 | 10 participants (Actual) | Interventional | 2014-09-30 | Completed | ||
| Parameters in Fractional Laser Assisted Delivery of Topical Anesthetics: Role of Anesthetic and Application Time[NCT03279757] | Phase 4 | 15 participants (Actual) | Interventional | 2016-10-01 | Completed | ||
| Parameters in Fractional Laser Assisted Delivery of Topical Anesthetics: Role of Laser Type and Laser Settings[NCT02938286] | Phase 4 | 15 participants (Actual) | Interventional | 2016-03-31 | Completed | ||
| Fractional CO2 Laser Assisted Topical Articaine Anesthesia vs. Topical EMLA Administration: a Randomized Controlled Study[NCT02548533] | Phase 4 | 3 participants (Actual) | Interventional | 2015-06-30 | Terminated (stopped due to Not enough patients eligible for recruitment.) | ||
| Prospective Randomized Trial of Penile Nerve Block With Liposomal Bupivacaine for Hypospadias Repair vs Standard Penile Block With Bupivacaine[NCT04479371] | Phase 1 | 0 participants (Actual) | Interventional | 2021-07-31 | Withdrawn (stopped due to Limited funding and resources to complete FDA requirements for enrollment) | ||
| Use of Preemptive Pudendal Nerve Block Prior to Hydrodistension for the Treatment of Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS): a Prospective, Double-blinded, Randomized Control Trial[NCT02517996] | 18 participants (Actual) | Interventional | 2015-02-28 | Terminated (stopped due to Preliminary results were promising when interim analysis performed but terminated due to primary investigators left recruitment site.) | |||
| A Single Center, Randomized, Double-Blind Controlled Study of Topical Endoluminal Pancreatic Duct Lidocaine for Prevention of Post-ERCP Pancreatitis[NCT00953199] | 506 participants (Actual) | Interventional | 2010-03-31 | Completed | |||
| Lidocaine For Neuroprotection During Cardiac Surgery[NCT00938964] | 550 participants (Actual) | Interventional | 2009-07-31 | Completed | |||
| The Study of Perioperative Intravenous Infusion of Lidocaine on Postoperative Analgesia in Patients Undergoing Single-port Thoracoscopic[NCT04043624] | Phase 4 | 80 participants (Anticipated) | Interventional | 2019-08-01 | Recruiting | ||
| Short Term Topical Tetracaine is Safe and Highly Efficacious for the Treatment of Pain Caused by Corneal Abrasions: a Double-blind Randomized Clinical Trial[NCT04187417] | 118 participants (Actual) | Interventional | 2015-01-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"To determine the change in interstitial cystitis symptom index at baseline, 2 hours, 2 weeks, 6 weeks and 3 months after hydrodistention with preemptive pudendal nerve block (1% Lidocaine) compared to hydrodistention with placebo (saline).~The IC symptom index questionnaire consists of 4 questions on IC symptoms. 2 of the questions have 6 answer choices ranging from 0-never, to 5-almost always. 1 question has 6 answer choices ranging from 0-never to 5-usually. 1 question has 7 answer choices ranging from 0-never to 6-5 or more times. The numerical score for each question are added together, with a minimum score of 0 and a maximum score of 21. A higher score indicates greater severity of IC symptoms." (NCT02517996)
Timeframe: Baseline, 2 weeks, 6 weeks, 3 months (Up to 3 months)
| Intervention | score on a scale (Mean) | |||
|---|---|---|---|---|
| Baseline | 2 weeks | 6 weeks | 12 weeks | |
| 1% Lidocaine | 12.5 | 11.43 | 11.8 | 10 |
| Normal Saline | 10 | 9 | 8.67 | 5 |
"To determine the change in pain at 2 hours, 2 weeks, 6 weeks, and 3 months postoperatively in patients undergoing hydrodistention with preemptive pudendal nerve block (1% Lidocaine) compared to hydrodistention with placebo (saline) using the visual analog scale (VAS).~VAS consists of a 10cm horizontal line with the minimum endpoint labeled no pain (0) and maximum labeled worst pain ever (10). Patients placed a mark on the point that corresponds to the level of pain severity they felt. The cm distance from the low end of the VAS to the patient's mark is used as the numerical index of the intensity of pain. Pain scores of 3.0-5.4 cm are moderate, over 5.4 indicates severe pain." (NCT02517996)
Timeframe: Baseline, 2 hours, 2 weeks, 6 weeks, 3 months (Up to 3 months)
| Intervention | score on a scale (Mean) | ||||
|---|---|---|---|---|---|
| Pre operative VAS score | Post operative VAS score | 2 week post operative VAS scores | 6 week post operative VAS score | 12 weeks post operative VAS score | |
| 1% Lidocaine | 3.125 | 3.75 | 2.7 | 3 | 2.6 |
| Normal Saline | 4.5 | 5 | 4.8 | 4.33 | 2 |
"To determine the change in pelvic urgency, pain and frequency (PUF) questionnaire at baseline, 2 hours, 2 weeks, 6 weeks and 3 months after hydrodistention with preemptive pudendal nerve block (1% Lidocaine) compared to hydrodistention with placebo (saline).~The Pelvic Urgency, Pain, and Frequency Patient Symptom Scale asks 11 questions, 7 on PUF symptoms, 4 on how bothersome PUF symptoms are. Symptom questions include 3, 4, or 5 ranked answers, with higher answers indicating more voids, or greater frequency of pain. The bother questions each of 4 ranked answers from 0-never, to 3-always. The symptom score is added, the bother score is added, and then the total score is added. The total PUF score is then reported. The minimum score is 0 and the maximum score is 35, and a higher score indicates greater symptoms and higher bother from pelvic pain and frequency." (NCT02517996)
Timeframe: Baseline, 2 hours, 2 weeks, 6 weeks, 3 months (Up to 3 months)
| Intervention | score on a scale (Mean) | |||
|---|---|---|---|---|
| Baseline | 2 weeks | 6 weeks | 12 weeks | |
| 1% Lidocaine | 22.63 | 18.83 | 18.2 | 17.2 |
| Normal Saline | 19 | 17.4 | 16.7 | 14 |
"To determine the change in problem index (O'Leary Sant) at baseline, 2 hours, 2 weeks, 6 weeks and 3 months after hydrodistention with preemptive pudendal nerve block (1% Lidocaine) compared to hydrodistention with placebo (saline).~The IC problem index questionnaire consists of 4 questions on how much of a problem a patient's IC symptoms cause them. Each question has 5 answer choices ranging from 0-no problem, to 4-big problem. The numerical score for each question are added together, with a minimum score of 0 and a maximum score of 16. A higher score indicates that IC symptoms cause more problems for the patient." (NCT02517996)
Timeframe: Baseline, 2 hours, 2 weeks, 6 weeks, 3 months (Up to 3 months)
| Intervention | score on a scale (Mean) | |||
|---|---|---|---|---|
| Baseline | 2 weeks | 6 weeks | 12 weeks | |
| 1% Lidocaine | 11.75 | 9.71 | 10 | 9.6 |
| Normal Saline | 9.43 | 8.6 | 7.33 | 6 |
The primary outcome of interest will be development of acute pancreatitis defined as new or worsening abdominal pain post-ERCP associated with an increase in serum amylase at least 3 times the upper limit of normal. (NCT00953199)
Timeframe: 24-48 hours post-procedure
| Intervention | participants (Number) |
|---|---|
| Lidocaine | 26 |
| Normal Saline | 20 |
serum amylase levels are measure by a blood draw (NCT00953199)
Timeframe: measurement is taken 2 hrs after ERCP
| Intervention | units/liter (Mean) |
|---|---|
| Lidocaine | 130 |
| Normal Saline | 128 |
"Center for Epidemiological Studies Depression Scale (CES-D). The CES-D is a 20-item self-report examination designed to measure symptoms of depression. Subjects rate the degree to which they have experienced a range of symptoms of depression, such as I had crying spells and I felt lonely. Scores range from 0 to 60, with higher scores indicating greater depressive symptoms. Scores greater than 16 are typically considered indicative of clinically significant depression." (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | -1.27 |
| Placebo | -0.89 |
"Center for Epidemiological Studies Depression Scale (CES-D). The CES-D is a 20-item self-report examination designed to measure symptoms of depression. Subjects rate the degree to which they have experienced a range of symptoms of depression, such as I had crying spells and I felt lonely. Scores range from 0 to 60, with higher scores indicating greater depressive symptoms. Scores greater than 16 are typically considered indicative of clinically significant depression." (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 0.57 |
| Placebo | 0.16 |
To characterize cognitive function over time, while minimizing potential redundancy in the cognitive measures, a factor analysis was performed on the 14 cognitive test scores from baseline. We chose a five-factor solution, which represents 5 cognitive domains: structured verbal memory, unstructured verbal memory, executive function, visual memory and attention/concentration. To quantify overall cognitive function, a baseline cognitive index was first calculated as the mean of the 5 preoperative domain scores. The cognitive index score has a mean of zero, thus any positive score is above the mean, any negative score is below the mean. A continuous change score was then calculated by subtracting the baseline from the 1 year cognitive index. The resulting outcome measure is unbounded with standard deviation of 0.35. A negative change score indicating decline and a positive score indicating improvement (NCT00938964)
Timeframe: 1 year after surgery
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 0.09 |
| Placebo | 0.07 |
To characterize cognitive function over time, while minimizing potential redundancy in the cognitive measures, a factor analysis was performed on the 14 cognitive test scores from baseline. We chose a five-factor solution, which represents 5 cognitive domains: structured verbal memory, unstructured verbal memory, executive function, visual memory and attention/concentration. To quantify overall cognitive function, a baseline cognitive index was first calculated as the mean of the 5 preoperative domain scores. The cognitive index score has a mean of zero, thus any positive score is above the mean, any negative score is below the mean. A continuous change score was then calculated by subtracting the baseline from the 6-week cognitive index. The resulting outcome measure is unbounded with standard deviation of 0.35. A negative change score indicating decline and a positive score indicating improvement. (NCT00938964)
Timeframe: Preoperative to 6 weeks after surgery
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 0.07 |
| Placebo | 0.07 |
"The DASI is a 12-item scale of functional capacity that has been found to correlate well with objective measures of maximal exercise capacity. Items reflect activities of personal care, ambulation, household tasks, sexual function, and recreational activities. Activities done with no difficulty receive scores, which are weighted and summed, for a quantitative measure of functional status. Scores range from 0 to 60; a higher-weighted score indicates better function." (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 6.3 |
| Placebo | 6.96 |
"The DASI is a 12-item scale of functional capacity that has been found to correlate well with objective measures of maximal exercise capacity. Items reflect activities of personal care, ambulation, household tasks, sexual function, and recreational activities. Activities done with no difficulty receive scores, which are weighted and summed, for a quantitative measure of functional status. Scores range from 0 to 60; a higher-weighted score indicates better function." (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | -10.98 |
| Placebo | -11.67 |
The National Institutes of Health Stroke Scale (NIHSS) is a 15-item neurologic examination stroke scale used to evaluate the effect of acute cerebral infarction on the levels of consciousness, language, neglect, visual-field loss, extraocular movement, motor strength, ataxia, dysarthria, and sensory loss. A trained observer rates the patent's ability to answer questions and perform activities. Ratings for each item are scored with 3 to 5 grades with 0 as normal, and there is an allowance for untestable items. The range of scores is from 0 (normal) to 42 (profound effect of stroke on patient). (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 0.05 |
| Placebo | 0.07 |
The National Institutes of Health Stroke Scale (NIHSS) is a 15-item neurologic examination stroke scale used to evaluate the effect of acute cerebral infarction on the levels of consciousness, language, neglect, visual-field loss, extraocular movement, motor strength, ataxia, dysarthria, and sensory loss. A trained observer rates the patent's ability to answer questions and perform activities. Ratings for each item are scored with 3 to 5 grades with 0 as normal, and there is an allowance for untestable items. The range of scores is from 0 (normal) to 42 (profound effect of stroke on patient). (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 0.05 |
| Placebo | 0.04 |
The Western perioperative neurologic scale was designed to detect neurologic deficits after cardiac surgery. It includes 14 items classified into eight domains (mentation, speech, cranial nerve function, motor weakness, sensation and cerebellum, reflexes, and gait). Each item is scored from 0 (severe deficit) to3 (normal), and a maximum score of 42 indicates normal neurological function. (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 0.02 |
| Placebo | -0.02 |
The Western perioperative neurologic scale was designed to detect neurologic deficits after cardiac surgery. It includes 14 items classified into eight domains (mentation, speech, cranial nerve function, motor weakness, sensation and cerebellum, reflexes, and gait). Each item is scored from 0 (severe deficit) to3 (normal), and a maximum score of 42 indicates normal neurological function. (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 0.04 |
| Placebo | -0.01 |
"Perceived Social Support Scale: Twelve items indicate how strongly subjects agree that there is a special person who is around when I am in need and my family really tries to help me. Choices range from very strongly disagree to very strongly agree. Items are summed for a range of 12 to 84, with a high score meaning more social support." (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 0.71 |
| Placebo | -1.16 |
"Perceived Social Support Scale: Twelve items indicate how strongly subjects agree that there is a special person who is around when I am in need and my family really tries to help me. Choices range from very strongly disagree to very strongly agree. Items are summed for a range of 12 to 84, with a high score meaning more social support." (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 1.23 |
| Placebo | -0.49 |
"Social Activity: This measure consisted of eight items that indicate the degree of social interaction. Sample items are How often do you talk on the telephone with friends and relatives? and How often do you attend meetings of social groups, clubs, or civic organizations? Scores range from 8 to 32. A lower score indicates more social activity." (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | -0.20 |
| Placebo | 0.03 |
"Social Activity: This measure consisted of eight items that indicate the degree of social interaction. Sample items are How often do you talk on the telephone with friends and relatives? and How often do you attend meetings of social groups, clubs, or civic organizations? Scores range from 8 to 32. A lower score indicates more social activity." (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 0.95 |
| Placebo | 1.59 |
"Spielberger State Anxiety Inventory (STAI): The STAI consists of two 20-item scales that measure anxiety. Representative items include statements such as I feel nervous and I feel worried. These items are rated on a 4-point scale, based on how well they describe the patient's current or typical mood, from not at all to very much so. Scores range from 20 to 80, with higher scores indicating greater anxiety." (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | -6.70 |
| Placebo | -6.39 |
"Spielberger State Anxiety Inventory (STAI): The STAI consists of two 20-item scales that measure anxiety. Representative items include statements such as I feel nervous and I feel worried. These items are rated on a 4-point scale, based on how well they describe the patient's current or typical mood, from not at all to very much so. Scores range from 20 to 80, with higher scores indicating greater anxiety." (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | -7.12 |
| Placebo | -6.31 |
Symptom limitations: Patients were given a list of eight symptoms and asked to rate the degree to which the symptom limited daily activities. The symptoms were angina, shortness of breath, arthritis, back trouble, leg pains, headaches, fatigue, and other. Scores range from 8 to 32, with higher scores indicating greater limitations. (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | -1.39 |
| Placebo | -1.48 |
Symptom limitations: Patients were given a list of eight symptoms and asked to rate the degree to which the symptom limited daily activities. The symptoms were angina, shortness of breath, arthritis, back trouble, leg pains, headaches, fatigue, and other. Scores range from 8 to 32, with higher scores indicating greater limitations. (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | -0.67 |
| Placebo | -0.8 |
"Cognitive Difficulties Scale: a 39-item scale, is a self-report assessment of perceived problems in long- and short-term memory, concentration, attention, and psycho-motor coordination. Sample items are I forget errands I planned to do and I fail to recognize people I know. Scores range from 39 to 164, with higher scores indicating greater cognitive difficulty." (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | -0.46 |
| Placebo | -1.02 |
"Cognitive Difficulties Scale: a 39-item scale, is a self-report assessment of perceived problems in long- and short-term memory, concentration, attention, and psycho-motor coordination. Sample items are I forget errands I planned to do and I fail to recognize people I know. Scores range from 39 to 164, with higher scores indicating greater cognitive difficulty." (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | -3 |
| Placebo | -3.21 |
"Duke Older Americans Resources and Services Procedures- Instrumental Activities of Daily Living (OARS-IADL): This measure contains six items that assess the ability to perform important tasks for daily living (e.g., Could you prepare your own meals? Could you drive a car?). Scores range from 6 to 24. Higher scores indicate increasing difficulty in engaging in daily activities." (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | -0.15 |
| Placebo | -0.31 |
"Duke Older Americans Resources and Services Procedures- Instrumental Activities of Daily Living (OARS-IADL): This measure contains six items that assess the ability to perform important tasks for daily living (e.g., Could you prepare your own meals? Could you drive a car?). Scores range from 6 to 24. Higher scores indicate increasing difficulty in engaging in daily activities." (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 2.46 |
| Placebo | 2.1 |
To characterize cognitive function over time, while minimizing potential redundancy in the cognitive measures, a factor analysis was performed on the 14 cognitive test scores from baseline. We chose a five-factor solution, which represents 5 cognitive domains: structured verbal memory, unstructured verbal memory, executive function, visual memory and attention/concentration. Each domain score is normally distributed with a mean of zero. A change score was calculated for each domain by subtracting the baseline from the 6-week score. A dichotomous outcome variable of post-operative cognitive deficit was defined as a decline of ≥1 standard deviation in 1 or more of the 5 domains. (NCT00938964)
Timeframe: Preoperative to 6 weeks after surgery
| Intervention | Participants (Count of Participants) |
|---|---|
| Lidocaine | 87 |
| Placebo | 83 |
The Medical Outcomes Study 36-Item Short Form Health Survey (SF-36): The SF-36 was designed to measure general health status. Two scales were used: Work Activities (four items) and General Health (one item). For the work activities scale, the reported score was the sum of four questions, each with values ranging from 1 to 4, the total score could range from 4 to 16. A higher score on Work Activities indicates more health-related problems For the general health question, the patients ranked their health from Excellent (1) to poor (5), the scale ranged from 1 to 5 with 1 being best health and 5 being worst. A high score in General Health indicates poorer health state. (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) | |
|---|---|---|
| 1 year Change Work Activities | 1 year Change General health perception | |
| Lidocaine | -1.37 | -0.28 |
| Placebo | -1.42 | -0.43 |
The Medical Outcomes Study 36-Item Short Form Health Survey (SF-36): The SF-36 was designed to measure general health status. Two scales were used: Work Activities (four items) and General Health (one item). For the work activities scale, the reported score was the sum of four questions, each with values ranging from 1 to 4, the total score could range from 4 to 16. A higher score on Work Activities indicates more health-related problems For the general health question, the patients ranked their health from Excellent (1) to poor (5), the scale ranged from 1 to 5 with 1 being best health and 5 being worst. A high score in General Health indicates poorer health state. (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) | |
|---|---|---|
| 6-Week Change Work activities | 6-Week Change General health perception | |
| Lidocaine | 2.71 | -0.004 |
| Placebo | 3 | -0.03 |
Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removalime points and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal
| Intervention | Mean linear fluorescence intensity-MLFI (Mean) | |||
|---|---|---|---|---|
| Baseline | Cross-clamp removal | End of Bypass | 6 hours post cross-clamp removal | |
| Lidocaine | -0.15 | 0.02 | -0.73 | -0.10 |
| Placebo | -0.43 | -0.73 | -0.40 | 0.19 |
Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removalime points and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal
| Intervention | Mean linear fluorescence intensity-MLFI (Mean) | |||
|---|---|---|---|---|
| Baseline | Cross-clamp removal | End of Bypass | 6 hours post cross-clamp removal | |
| Lidocaine | -4.22 | -2.46 | -0.34 | 1.21 |
| Placebo | -0.04 | 1.83 | 2.64 | 0.54 |
Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removal and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal
| Intervention | Mean linear fluorescence intensity-MLFI (Mean) | |||
|---|---|---|---|---|
| Baseline | Cross-clamp removal | End of Bypass | 6 hours post cross-clamp removal | |
| Lidocaine | -2.02 | 0.56 | 0.58 | 1.04 |
| Placebo | -0.08 | 0.17 | 1.19 | -0.68 |
Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removalime points and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal
| Intervention | Mean linear fluorescence intensity-MLFI (Mean) | |||
|---|---|---|---|---|
| Baseline | Cross-clamp removal | End of Bypass | 6 hours post cross-clamp removal | |
| Lidocaine | -0.03 | 0.03 | 0.33 | 0.37 |
| Placebo | 0.35 | 0.43 | 0.05 | 0.27 |
12 reviews available for lidocaine and Disease Models, Animal
| Article | Year |
|---|---|
Mechanistic considerations for adenosine-lidocaine-magnesium (ALM) in controlling coagulopathy.
Topics: Adenosine; Animals; Disease Models, Animal; Humans; Lidocaine; Magnesium; Shock, Hemorrhagic; Swine | 2023 |
The mechanisms of tinnitus: perspectives from human functional neuroimaging.
Topics: Action Potentials; Animals; Auditory Cortex; Disease Models, Animal; Electroencephalography; Electro | 2009 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Local anesthetic systemic toxicity: update on mechanisms and treatment.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models | 2011 |
Drug administration in animal studies of cardiac arrest does not reflect human clinical experience.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Clinical Trials as Topic; Disease Models, Animal; Drug | 2007 |
Animal models of tinnitus.
Topics: Acoustic Stimulation; Action Potentials; Aged; Animals; Cats; Cochlear Nerve; Disease Models, Animal | 1981 |
Lidocaine for acute lung injury: questions still to answer.
Topics: Animals; Critical Illness; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Inflammatio | 2000 |
Potential neurotoxicity of spinal anesthesia with lidocaine.
Topics: Adverse Drug Reaction Reporting Systems; Anesthesia, Spinal; Anesthetics, Local; Animals; Bupivacain | 2000 |
Advanced cardiac life support antiarrhythmic drugs.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Bretylium Compounds; Cardiopulmonary Resuscitation; Cli | 2002 |
Clinical relevance of experimentally obtained electrophysiologic data on antiarrhythmic drugs.
Topics: Animals; Anti-Arrhythmia Agents; Coronary Disease; Disease Models, Animal; Dogs; Drug Evaluation, Pr | 1979 |
Endotracheal drug delivery.
Topics: Animals; Atropine; Cardiopulmonary Resuscitation; Disease Models, Animal; Epinephrine; Humans; Intub | 1992 |
[Compounds with antiarrhythmic effects].
Topics: Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Animals, Laboratory; Anti-Arrhythmia Agent | 1973 |
Cerebral arterial spasm: current concepts.
Topics: Anesthesia, General; Animals; Blood Coagulation; Blood Platelets; Brain; Catecholamines; Cerebral Ar | 1974 |
2 trials available for lidocaine and Disease Models, Animal
| Article | Year |
|---|---|
Effects of a Lidocaine-Loaded Poloxamer/Alginate/CaCl2 Mixture on Postoperative Pain and Adhesion in a Rat Model of Incisional Pain.
Topics: Alginates; Anesthetics, Local; Animals; Anti-Inflammatory Agents; Behavior, Animal; Calcium Chloride | 2017 |
Effects of small-particle aerosols of local anaesthetic on dyspnoea in patients with respiratory disease.
Topics: Aerosols; Aged; Animals; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation, Preclini | 1985 |
328 other studies available for lidocaine and Disease Models, Animal
| Article | Year |
|---|---|
4,5-Dihydro-1-phenyl-1H-2,4-benzodiazepines: novel antiarrhythmic agents.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzodiazepines; Cats; Disease Models, Animal | 1993 |
Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo.
Topics: Acetylcholinesterase; Alzheimer Disease; Amnesia; Amyloid beta-Peptides; Animals; Blood-Brain Barrie | 2015 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
ALM Fluid Therapy Shifts Sympathetic Hyperactivity to Parasympathetic Dominance in the Rat Model of Non-Compressible Hemorrhagic Shock.
Topics: Adenosine; Animals; Disease Models, Animal; Drug Combinations; Fluid Therapy; Lidocaine; Magnesium; | 2022 |
Adenosine, lidocaine, and magnesium for attenuating ischemia reperfusion injury from resuscitative endovascular balloon occlusion of the aorta in a porcine model.
Topics: Adenosine; Animals; Aorta; Balloon Occlusion; Disease Models, Animal; Endovascular Procedures; Hemor | 2022 |
Phrenic Nerve Block and Respiratory Effort in Pigs and Critically Ill Patients with Acute Lung Injury.
Topics: Acute Lung Injury; Animals; Critical Illness; Disease Models, Animal; Female; Humans; Lidocaine; Phr | 2022 |
Neuroprotective Effects of a Cardioplegic Combination (Adenosine, Lidocaine, and Magnesium) in an Ischemic Stroke Model.
Topics: Adenosine; Animals; Cardioplegic Solutions; Cobalt; Disease Models, Animal; Glucose; Humans; Ischemi | 2022 |
Experimental Study of Tumescence Injection to Provide Anesthesia Without Local Anesthetics.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Disease Models, Animal; Dose-Response Relationship, | 2020 |
Analysis of Epineurial Lidocaine Injection for Nerve Transfers in a Rat Sciatic Nerve Model.
Topics: Animals; Calcium Gluconate; Disease Models, Animal; Injections; Lidocaine; Nerve Transfer; Neuroprot | 2019 |
Lung Purinoceptor Activation Triggers Ventilator-Induced Brain Injury.
Topics: Anesthetics, Local; Animals; Brain Injuries; Cell Line; Disease Models, Animal; Hippocampus; Humans; | 2019 |
Effects of 1% Lidocaine Instillation on Overactive Bladder Induced by Bladder Outlet Obstruction in Rats.
Topics: Administration, Intravesical; Anesthetics, Local; Animals; Disease Models, Animal; Female; Lidocaine | 2020 |
Novel charged sodium and calcium channel inhibitor active against neurogenic inflammation.
Topics: Animals; Bupivacaine; Calcium; Calcium Channel Blockers; Calcium Channels, N-Type; Calcium Signaling | 2019 |
Combination Formulation of Tetrodotoxin and Lidocaine as a Potential Therapy for Severe Arrhythmias.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Drug Combinations; Dr | 2019 |
The morphofunctional impact of topical Lidocaine formulation in inflammatory pain - experimental study.
Topics: Administration, Topical; Anesthetics, Local; Animal Experimentation; Animals; Disease Models, Animal | 2019 |
Sustained Release of Levobupivacaine, Lidocaine, and Acemetacin from Electrosprayed Microparticles: In Vitro and In Vivo Studies.
Topics: 3T3 Cells; Analgesics; Animals; Delayed-Action Preparations; Disease Models, Animal; Drug Compoundin | 2020 |
Adenosine, Lidocaine, and Magnesium Support a High Flow, Hypotensive, Vasodilatory State With Improved Oxygen Delivery and Cerebral Protection in a Pig Model of Noncompressible Hemorrhage.
Topics: Adenosine; Animals; Brain; Brain Chemistry; Disease Models, Animal; Drug Administration Schedule; Dr | 2020 |
Effects of 2-Hydroxypropil-Β-Cyclodextrin-Lidocaine on Tumor Growth and Inflammatory Response.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Che | 2020 |
Buprenorphine Analgesia Reduces Survival With ALM Resuscitation in a Rat Model of Uncontrolled Hemorrhage: Concerns for Trauma-Related Research.
Topics: Adenosine; Analgesia; Analgesics, Opioid; Animals; Biomedical Research; Buprenorphine; Disease Model | 2021 |
Downregulation of microRNA-199a-5p alleviated lidocaine-induced sensory dysfunction and spinal cord myelin lesions in a rat model.
Topics: Animals; Antagomirs; Disease Models, Animal; Down-Regulation; Lidocaine; Male; MicroRNAs; Myelin She | 2021 |
Methylene blue induces an analgesic effect by significantly decreasing neural firing rates and improves pain behaviors in rats.
Topics: Action Potentials; Analgesics; Animals; Coloring Agents; Disease Models, Animal; Dose-Response Relat | 2021 |
Therapeutic cardiac arrest as an adjunct to resuscitative endovascular balloon occlusion of the aorta: Bridging the gap from fatal hemorrhage to definitive surgical control in swine.
Topics: Adenosine; Animals; Aorta; Balloon Occlusion; Cardioplegic Solutions; Cardiovascular Agents; Disease | 2021 |
Postinjury treatments to make early tactical aeromedical evacuation practical for the brain after TBI.
Topics: Adenosine; Air Ambulances; Allopurinol; Amitriptyline; Animals; Brain; Brain Chemistry; Brain Injuri | 2021 |
The Effect of Lidocaine and Bosutinib on 4T1 Murine Breast Cancer Cell Behaviour
Topics: Aniline Compounds; Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Survival; Diseas | 2021 |
Lidocaine prevents breast cancer growth by targeting neuronatin to inhibit nerve fibers formation.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Female; Humans; Lidocaine; Male | 2021 |
Pharmacologic Inhibition of Pain Response to Incomplete Vascular Occlusion Blunts Cardiovascular Preconditioning Response.
Topics: Anesthetics, Local; Animals; Cytokines; Disease Models, Animal; Echocardiography; Forelimb; Ischemic | 2021 |
Combatting ischemia reperfusion injury from resuscitative endovascular balloon occlusion of the aorta using adenosine, lidocaine and magnesium: A pilot study.
Topics: Adenosine; Animals; Anti-Inflammatory Agents; Aorta; Balloon Occlusion; Disease Models, Animal; Drug | 2021 |
Effects of Treadmill Exercise on Advanced Osteoarthritis Pain in Rats.
Topics: Anesthetics, Local; Animals; Arthralgia; Arthritis, Experimental; Behavior, Animal; Disease Models, | 2017 |
Lidocaine Prevents Oxidative Stress-Induced Endothelial Dysfunction of the Systemic Artery in Rats With Intermittent Periodontal Inflammation.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Aorta; Disease Models, Animal; Dose-Response Relati | 2017 |
[Neuroprotection Mechanism of Lidocaine in Rabbits with Early Brain Injury Resulted from Subarachnoid Hemorrhage].
Topics: Animals; Caspase 3; Disease Models, Animal; Electron Transport Complex IV; Lidocaine; Neuroprotectiv | 2017 |
[Comparison of Two Methods of Lidocaine Administrating for Neuroprotection in Rabbit Model of Subarachnoid Hemorrhage].
Topics: Administration, Intravenous; Animals; Basilar Artery; Cisterna Magna; Disease Models, Animal; Inject | 2017 |
Immune-inflammatory activation after a single laparotomy in a rat model: effect of adenosine, lidocaine and Mg
Topics: Adenosine; Alkalosis, Respiratory; Animals; Blood Coagulation; Blood Platelets; Complex Mixtures; Di | 2017 |
An Intraplantar Hypertonic Saline Assay in Mice for Rapid Screening of Analgesics.
Topics: Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; F | 2018 |
Cardioprotection induced in a mouse model of neuropathic pain via anterior nucleus of paraventricular thalamus.
Topics: Animals; Butadienes; Chronic Pain; Disease Models, Animal; Enzyme Inhibitors; Ganglionic Blockers; H | 2017 |
Effects of Extracorporeal Shock Wave-Mediated Transdermal Local Anesthetic Drug Delivery on Rat Caudal Nerves.
Topics: Administration, Cutaneous; Anesthetics, Local; Animals; Disease Models, Animal; Extracorporeal Shock | 2018 |
Menthol reduces phototoxicity pain in a mouse model of photodynamic therapy.
Topics: Acrylamides; Animals; Animals, Newborn; Antipruritics; Bridged Bicyclo Compounds, Heterocyclic; Derm | 2018 |
Dexmedetomidine Increases the Latency of Thermal Antinociception in Rats.
Topics: Acute Pain; Adrenergic alpha-2 Receptor Agonists; Anesthetics, Local; Animals; Dexmedetomidine; Dise | 2017 |
Pharmacodynamics and Pharmacokinetics of Lidocaine in a Rodent Model of Diabetic Neuropathy.
Topics: Anesthetics, Local; Animals; Diabetic Neuropathies; Disease Models, Animal; Lidocaine; Male; Nerve B | 2018 |
Disease modifying actions of interleukin-6 blockade in a rat model of bone cancer pain.
Topics: Adenocarcinoma; Analgesics; Analysis of Variance; Anesthetics, Local; Animals; Bone Neoplasms; Bufan | 2018 |
Tumescent contravenom: murine model for prehospital treatment of Naja naja neurotoxic snake envenomation.
Topics: Animals; Antivenins; Disease Models, Animal; Epinephrine; Female; Humans; Injections, Subcutaneous; | 2018 |
Adenosine, lidocaine, and Mg2+ (ALM) resuscitation fluid protects against experimental traumatic brain injury.
Topics: Adenosine; Animals; Brain Injuries, Traumatic; Disease Models, Animal; Disease Progression; Fluid Th | 2018 |
HIV-1 Tat-induced diarrhea is improved by the PPARalpha agonist, palmitoylethanolamide, by suppressing the activation of enteric glia.
Topics: Amides; Anesthetics, Local; Animals; Antiviral Agents; Diarrhea; Disease Models, Animal; Ethanolamin | 2018 |
Nebulized lidocaine ameliorates allergic airway inflammation via downregulation of TLR2.
Topics: Administration, Inhalation; Animals; Disease Models, Animal; Down-Regulation; Female; Inflammation; | 2018 |
Involvement of dopamine system in the regulation of the brain corticotropin-releasing hormone in paraventricular nucleus in a rat model of chronic visceral pain.
Topics: Animals; Animals, Newborn; Central Nervous System Agents; Chronic Pain; Corticotropin-Releasing Horm | 2018 |
Ciprofloxacin-lidocaine-based hydrogel: development, characterization, and in vivo evaluation in a second-degree burn model.
Topics: Administration, Topical; Animals; Burns; Ciprofloxacin; Disease Models, Animal; Hydrogels; Lidocaine | 2018 |
Corticotropin-Releasing Factor in the Brain and Blocking Spinal Descending Signals Induce Hyperalgesia in the Latent Sensitization Model of Chronic Pain.
Topics: Analgesics, Opioid; Animals; Brain; Central Nervous System Sensitization; Chronic Pain; Corticotropi | 2018 |
Topically Delivered Minocycline Penetrates a Full-Thickness Burn Eschar and Reduces Tissue Bacterial Counts.
Topics: Administration, Topical; Anesthetics, Local; Animals; Anti-Bacterial Agents; Bacterial Load; Burns; | 2018 |
Effect of four local anesthetics (tetracaine, proparacaine, lidocaine, and bupivacaine) on intraocular pressure in dogs.
Topics: Administration, Topical; Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Disease Models | 2019 |
Basolateral amygdalar inactivation blocks chronic stress-induced lamina-specific reduction in prefrontal cortex volume and associated anxiety-like behavior.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Anxiety; Avoidance Learning; Basolateral Nuclear | 2019 |
Effects of an Intraparenchymal Injection of Lidocaine in the Rat Cervical Spinal Cord.
Topics: Anesthetics, Local; Animals; Cervical Vertebrae; Disease Models, Animal; Injections, Spinal; Lidocai | 2018 |
Evaluating the Effects of a Topical Preparation with Dexpanthenol, Silbiol, Undecylenic Acid, and Lidocaine on Palatal Mucosa Wound Healing in a Rat Model
Topics: Administration, Topical; Animals; Disease Models, Animal; Drug Combinations; Lidocaine; Palate; Pant | 2019 |
[Effects of Lidocaine on the Rho/ROCK Signal Transduction of the Posterior Basilar Artery in Rabbit SAH].
Topics: Animals; Basilar Artery; Calmodulin; Disease Models, Animal; Lidocaine; Myosin Light Chains; Rabbits | 2018 |
Comparison of antinociceptive effects of plain lidocaine versus lidocaine complexed with hydroxypropyl-β-cyclodextrin in animal models of acute and persistent orofacial pain.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Analgesics; Animals; Capsaicin; Carrageenan; Disease Models, Anim | 2019 |
Lidocaine protects neurons of the spinal cord in an excitotoxicity model.
Topics: Animals; Disease Models, Animal; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Lidocai | 2019 |
Reversing Effect of Insulin on Local Anesthetics-Induced Sciatic Nerve Block in Rats.
Topics: Anesthesia, Local; Animals; Bupivacaine; Disease Models, Animal; Drug Combinations; Humans; Insulin; | 2019 |
Prehospital adenosine, lidocaine, and magnesium has inferior survival compared with tactical combat casualty care resuscitation in a porcine model of prolonged hemorrhagic shock.
Topics: Adenosine; Animals; Cardioplegic Solutions; Disease Models, Animal; Emergency Medical Services; Lido | 2019 |
Effect of Lidocaine Injection of Ganglionated Plexi in a Canine Model and Patients With Persistent and Long-Standing Persistent Atrial Fibrillation.
Topics: Action Potentials; Aged; Aged, 80 and over; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; At | 2019 |
Effects of Intradiscal Injection of Local Anesthetics on Intervertebral Disc Degeneration in Rabbit Degenerated Intervertebral Disc.
Topics: Anesthetics, Local; Animals; Bupivacaine; Disease Models, Animal; Intervertebral Disc; Intervertebra | 2019 |
Adenosine, lidocaine, and Mg2+ fluid therapy leads to 72-hour survival after hemorrhagic shock: A model for studying differential gene expression and extending biological time.
Topics: Adenosine; Animals; Disease Models, Animal; Fluid Therapy; Gene Expression; Gene Expression Profilin | 2019 |
The cerebellum as a novel tinnitus generator.
Topics: Animals; Auditory Perception; Auditory Threshold; Cerebellum; Disease Models, Animal; Hearing Loss, | 2013 |
Reorganization of circuits underlying cerebellar modulation of prefrontal cortical dopamine in mouse models of autism spectrum disorder.
Topics: Animals; Cerebellum; Child Development Disorders, Pervasive; Disease Models, Animal; Dopamine; Infus | 2013 |
The balance of striatal feedback transmission is disrupted in a model of parkinsonism.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adrenergic Agents; Anesthetics, Local; Anim | 2013 |
Pain‑relieving effect of a compound isolated from white peony root oral liquid on acute radiation‑induced esophagitis.
Topics: Administration, Oral; Anesthetics, Local; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; | 2013 |
Descending facilitation maintains long-term spontaneous neuropathic pain.
Topics: Afferent Pathways; Anesthetics, Local; Animals; Benzodiazepines; Conditioning, Operant; Disease Mode | 2013 |
Administration of amiodarone during resuscitation is associated with higher tumor necrosis factor-α levels in the early postarrest period in the swine model of ischemic ventricular fibrillation.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Cardiopulmonary Resuscitation; Coronary Vessels; Diseas | 2013 |
Prophylactic amiodarone and lidocaine improve survival in an ovine model of large size myocardial infarction.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Disease Mode | 2013 |
The effects of adenocaine (adenosine and lidocaine) on early post-resuscitation cardiac and neurological dysfunction in a porcine model of cardiac arrest.
Topics: Adenosine; Animals; Brain Death; Cardiopulmonary Resuscitation; Cardiovascular Agents; Coronary Angi | 2013 |
Intra-articular anaesthesia mitigates established pain in experimental osteoarthritis: a preliminary study of gait impulse redistribution as a biomarker of analgesia pharmacodynamics.
Topics: Anesthetics, Local; Animals; Anterior Cruciate Ligament Injuries; Anti-Inflammatory Agents, Non-Ster | 2013 |
Exploration of supraspinal mechanisms in effects of spinal cord stimulation: role of the locus coeruleus.
Topics: Action Potentials; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; | 2013 |
Lidocaine protects against renal and hepatic dysfunction in septic rats via downregulation of Toll‑like receptor 4.
Topics: Animals; Disease Models, Animal; Down-Regulation; Interleukin-6; Kidney; Lidocaine; Lipopolysacchari | 2014 |
Nociceptor-selective peripheral nerve block induces delayed mechanical hypersensitivity and neurotoxicity in rats.
Topics: Anesthetics, Combined; Anesthetics, Local; Animals; Behavior, Animal; Capsaicin; Disease Models, Ani | 2014 |
Recovery of motor neuron excitability after facial nerve impairment in rats.
Topics: Anesthetics, Local; Animals; Disease Models, Animal; Electric Stimulation; Electromyography; Evoked | 2014 |
Small-volume 7.5% NaCl adenosine, lidocaine, and Mg2+ has multiple benefits during hypotensive and blood resuscitation in the pig following severe blood loss: rat to pig translation.
Topics: Adenosine; Animals; Blood Volume; Disease Models, Animal; Drug Therapy, Combination; Female; Fluid T | 2014 |
Effects of potassium/lidocaine-induced cardiac standstill during cardiopulmonary resuscitation in a pig model of prolonged ventricular fibrillation.
Topics: Animals; Biomarkers; Cardioplegic Solutions; Cardiopulmonary Resuscitation; Disease Models, Animal; | 2014 |
Critical role of inflammatory cytokines in impairing biochemical processes for learning and memory after surgery in rats.
Topics: Animals; Carotid Arteries; Cytokines; Disease Models, Animal; Gene Expression Regulation; Hippocampu | 2014 |
Synergistic effect of lidocaine with pingyangmycin for treatment of venous malformation using a mouse spleen model.
Topics: Anesthetics, Local; Animals; Apoptosis; Bleomycin; Disease Models, Animal; Dose-Response Relationshi | 2014 |
Adenosine, lidocaine and Mg2+ (ALM) induces a reversible hypotensive state, reduces lung edema and prevents coagulopathy in the rat model of polymicrobial sepsis.
Topics: Adenosine; Animals; Blood Coagulation Disorders; Disease Models, Animal; Drug Therapy, Combination; | 2014 |
Effects of Static Magnetic Fields on the Visual Cortex: reversible Visual Deficits and Reduction of Neuronal Activity.
Topics: Action Potentials; Analysis of Variance; Anesthetics, Local; Animals; Cats; Disease Models, Animal; | 2016 |
Genetic background modulates impaired excitability of inhibitory neurons in a mouse model of Dravet syndrome.
Topics: Action Potentials; Animals; Animals, Newborn; Biophysical Phenomena; Conditioning, Psychological; Di | 2015 |
Haloperidol treatment at pre-exposure phase reduces the disturbance of latent inhibition in rats with neonatal ventral hippocampus lesions.
Topics: Animals; Animals, Newborn; Antipsychotic Agents; Behavior, Animal; Conditioning, Psychological; Dise | 2014 |
Genesis of anxiety, depression, and ongoing abdominal discomfort in ulcerative colitis-like colon inflammation.
Topics: Abdominal Pain; Action Potentials; Anesthetics, Local; Animals; Anxiety; Behavior, Animal; Colitis, | 2015 |
Nucleus incertus inactivation impairs spatial learning and memory in rats.
Topics: Anesthetics, Local; Animals; Avoidance Learning; Disease Models, Animal; Gene Expression Regulation; | 2015 |
Adenosine, lidocaine and Mg2+ improves cardiac and pulmonary function, induces reversible hypotension and exerts anti-inflammatory effects in an endotoxemic porcine model.
Topics: Adenosine; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Drug Therapy, Combination; End | 2014 |
The effects of epidural anesthesia on growth of Escherichia coli at pseudosurgical site: the roles of the lipocalin-2 pathway.
Topics: Anesthesia, Epidural; Anesthetics, Local; Animals; Cytokines; Disease Models, Animal; DNA, Bacterial | 2015 |
Correction of acute traumatic coagulopathy with small-volume 7.5% NaCl adenosine, lidocaine, and Mg2+ occurs within 5 minutes: a ROTEM analysis.
Topics: Adenosine; Animals; Blood Coagulation Disorders; Disease Models, Animal; Hemodynamics; Lidocaine; Ma | 2015 |
CaMKII Phosphorylation in Primary Somatosensory Cortical Neurons is Involved in the Inhibition of Remifentanil-induced Hyperalgesia by Lidocaine in Male Sprague-Dawley Rats.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; | 2016 |
Effect of a pharmacologically induced decrease in core temperature in rats resuscitated from cardiac arrest.
Topics: Anesthetics, Local; Animals; Body Temperature; Cardiopulmonary Resuscitation; Disease Models, Animal | 2015 |
Behavioral and neurochemical analysis of ongoing bone cancer pain in rats.
Topics: Adenocarcinoma; Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Stero | 2015 |
Topical Tetrodotoxin Attenuates Photophobia Induced by Corneal Injury in the Rat.
Topics: Administration, Topical; Analysis of Variance; Anesthetics, Local; Animals; Corneal Injuries; Diseas | 2015 |
Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation.
Topics: Airway Remodeling; Anesthetics, Local; Animals; Animals, Newborn; Capsaicin; Cytokines; Disease Mode | 2015 |
Comparative evaluation of in vitro and in vivo high glucose-induced alterations in voltage-gated tetrodotoxin-resistant sodium channel: Effects attenuated by sodium channel blockers.
Topics: Animals; Antibiotics, Antineoplastic; Cells, Cultured; Diabetes Mellitus, Experimental; Disease Mode | 2015 |
Sciatic Nerve Intrafascicular Lidocaine Injection-induced Peripheral Neuropathic Pain: Alleviation by Systemic Minocycline Administration.
Topics: Activating Transcription Factor 3; Analysis of Variance; Anesthetics, Local; Animals; Anti-Bacterial | 2016 |
Galanin-Mediated Behavioural Hyperalgesia from the Dorsomedial Nucleus of the Hypothalamus Involves Two Independent Descending Pronociceptive Pathways.
Topics: Animals; Arthritis; Behavior, Animal; Disease Models, Animal; Electrophysiology; Galanin; Glutamic A | 2015 |
JM25-1, a Lidocaine Analog Combining Airway Relaxant and Antiinflammatory Properties: Implications for New Bronchospasm Therapy.
Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents; Bronchial Spasm; Disease Models, Animal; Infl | 2016 |
Central Sensitization and Neuropathic Features of Ongoing Pain in a Rat Model of Advanced Osteoarthritis.
Topics: Analgesics; Animals; Arthralgia; Central Nervous System Sensitization; Disease Models, Animal; Dose- | 2016 |
Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil.
Topics: Acetanilides; Anesthetics, Local; Animals; Anti-Bacterial Agents; Antimetabolites; Carcinosarcoma; C | 2016 |
The smell of "anxiety": Behavioral modulation by experimental anosmia in zebrafish.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Antidepressive Agents, Second-Generation; Anxiety | 2016 |
The traditional Japanese medicine hangeshashinto alleviates oral ulcer-induced pain in a rat model.
Topics: Acetic Acid; Administration, Topical; Analgesics; Animals; Disease Models, Animal; Drugs, Chinese He | 2016 |
The Potential Effect of Epidural Anesthesia on Mesenteric Injury after Supraceliac Aortic Clamping in a Rabbit Model.
Topics: Anesthesia, Epidural; Anesthetics, Local; Animals; Aorta, Abdominal; Biomarkers; Constriction; Disea | 2016 |
Hypovolemic hemorrhage induces Fos expression in the rat hypothalamus: Evidence for involvement of the lateral hypothalamus in the decompensatory phase of hemorrhage.
Topics: Animals; Bradycardia; Cobalt; Disease Models, Animal; Hemorrhage; Hemostatics; Hypothalamus; Hypovol | 2016 |
Functional characterization of a mouse model for central post-stroke pain.
Topics: Animals; Collagenases; Disease Models, Animal; Hyperalgesia; Kainic Acid; Lidocaine; Mice, Inbred C5 | 2016 |
Lidocaine Enhances Contractile Function of Ischemic Myocardial Regions in Mouse Model of Sustained Myocardial Ischemia.
Topics: Animals; Diastole; Disease Models, Animal; Electrocardiography; Lidocaine; Mice; Mice, Inbred BALB C | 2016 |
Localized Sympathectomy Reduces Mechanical Hypersensitivity by Restoring Normal Immune Homeostasis in Rat Models of Inflammatory Pain.
Topics: Anesthetics, Local; Animals; Cytokines; Disease Models, Animal; Female; Ganglia, Spinal; Homeostasis | 2016 |
ATP-sensitive muscle afferents activate spinal trigeminal neurons with meningeal afferent input in rat - pathophysiological implications for tension-type headache.
Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Dura Mater; Lidocaine; Male; Muscle, Skelet | 2016 |
Small-Volume Adenosine, Lidocaine, and Mg2+ 4-Hour Infusion Leads to 88% Survival after 6 Days of Experimental Sepsis in the Rat without Antibiotics.
Topics: Acidosis; Adenosine; Animals; Anti-Bacterial Agents; C-Reactive Protein; Cytokines; Disease Models, | 2016 |
Effect of dexmedetomidine priming on convulsion reaction induced by lidocaine.
Topics: Administration, Topical; Adrenergic alpha-2 Receptor Agonists; Anesthetics, Local; Animals; Dexmedet | 2016 |
CaMKIIα underlies spontaneous and evoked pain behaviors in Berkeley sickle cell transgenic mice.
Topics: Anemia, Sickle Cell; Anesthetics, Local; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein | 2016 |
Lidocaine Administration Controls MicroRNAs Alterations Observed After Lung Ischemia-Reperfusion Injury.
Topics: Animals; Apoptosis Regulatory Proteins; Disease Models, Animal; Gene Expression Regulation; Inflamma | 2016 |
Pain Input Impairs Recovery after Spinal Cord Injury: Treatment with Lidocaine.
Topics: Anesthetics, Local; Animals; Disease Models, Animal; Lidocaine; Male; Pain; Rats; Rats, Sprague-Dawl | 2017 |
New approach to molsidomine active metabolites coming from the results of 2 models of experimental cardiology.
Topics: Animals; Anti-Asthmatic Agents; Arrhythmias, Cardiac; Creatine Kinase; Disease Models, Animal; Hemod | 2017 |
Bupivacaine increases the rate of motoneuron death following peripheral nerve injury.
Topics: Animals; Axotomy; Bupivacaine; Cell Death; Disease Models, Animal; Lidocaine; Male; Mice; Mice, Inbr | 2017 |
pH-sensitive niosomes: Effects on cytotoxicity and on inflammation and pain in murine models.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; BALB 3T3 Cells; Cells, Cultured; Disease Models, A | 2017 |
Lidocaine Induces Apoptosis and Suppresses Tumor Growth in Human Hepatocellular Carcinoma Cells In Vitro and in a Xenograft Model In Vivo.
Topics: Anesthetics, Local; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferat | 2017 |
Comparative antiallodynic activity of morphine, pregabalin and lidocaine in a rat model of neuropathic pain produced by one oxaliplatin injection.
Topics: Analgesics; Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response R | 2008 |
Mechanisms of atrial fibrillation termination by rapidly unbinding Na+ channel blockers: insights from mathematical models and experimental correlates.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Body Surface Potential Mapp | 2008 |
Electroanatomic mapping of the left ventricle in a porcine model of chronic myocardial infarction with magnetic resonance-based catheter tracking.
Topics: Animals; Catheter Ablation; Catheterization; Disease Models, Animal; Electrophysiologic Techniques, | 2008 |
Governing role of primary afferent drive in increased excitation of spinal nociceptive neurons in a model of sciatic neuropathy.
Topics: Anesthetics, Local; Animals; Disease Models, Animal; Lidocaine; Male; Membrane Potentials; Nerve Blo | 2008 |
The effect of intravenous lidocaine on brain activation during non-noxious and acute noxious stimulation of the forepaw: a functional magnetic resonance imaging study in the rat.
Topics: Anesthetics, Local; Animals; Brain; Brain Mapping; Disease Models, Animal; Electric Stimulation; Fem | 2009 |
Spinal NK-1 receptor-expressing neurons and descending pathways support fentanyl-induced pain hypersensitivity in a rat model of postoperative pain.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Disease Models, Animal; Dynorphins; Fentanyl; Immun | 2009 |
Lidocaine prevents referred hyperalgesia associated with cystitis.
Topics: Administration, Intravesical; Anesthetics, Local; Animals; Cystitis; Disease Models, Animal; Female; | 2009 |
Early termination of spiral wave reentry by combined blockade of Na+ and L-type Ca2+ currents in a perfused two-dimensional epicardial layer of rabbit ventricular myocardium.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Disease Models, Animal; Electrophysiolo | 2009 |
Mapping ventricular fibrillation: a simplified experimental model leads to a complicated result.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Disease Models, Animal; Electrophysiolo | 2009 |
fMRI investigation of the effect of local and systemic lidocaine on noxious electrical stimulation-induced activation in spinal cord.
Topics: Anesthetics, Local; Animals; Blood Pressure; Disease Models, Animal; Drug Administration Routes; Ele | 2009 |
Persistent deep mechanical hyperalgesia induced by repeated cold stress in rats.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Chronic Disease; Cold Temperature; Disease Models | 2010 |
Oxidative stress of intracameral lidocaine and levobupivacaine on ocular tissues.
Topics: Anesthetics, Local; Animals; Anterior Chamber; Bupivacaine; Cornea; Corneal Opacity; Disease Models, | 2010 |
Effects of pre-emptive drug treatment on astrocyte activation in the cuneate nucleus following rat median nerve injury.
Topics: Adrenergic alpha-Agonists; Animals; Astrocytes; Citrates; Clonidine; Disease Models, Animal; Dizocil | 2010 |
Cellular basis for atrial fibrillation in an experimental model of short QT1: implications for a pharmacological approach to therapy.
Topics: Action Potentials; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atri | 2010 |
Urodynamic effects of the bladder C-fiber afferent activity modulation in chronic model of overactive bladder in rats.
Topics: Administration, Intravesical; Afferent Pathways; Anesthetics, Local; Animals; Capsaicin; Cystitis; D | 2009 |
Preemptive analgesic effect of lidocaine in a chronic neuropathic pain model.
Topics: Anesthetics, Local; Animals; Chronic Disease; Disease Models, Animal; Lidocaine; Pain, Postoperative | 2009 |
How the heart can fibrillate: when diversity is a disadvantage.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Chlor | 2010 |
Delta oscillation and short-term plasticity in the rat medial prefrontal cortex: modelling NMDA hypofunction of schizophrenia.
Topics: Animals; Biphenyl Compounds; Delta Rhythm; Disease Models, Animal; Dizocilpine Maleate; Electric Sti | 2011 |
[A study of the protective effects of lidocaine and nerve growth factor pretreatment on cerebral ischemia/reperfusion injury in gerbils].
Topics: Animals; Apoptosis; Brain Ischemia; Disease Models, Animal; Gerbillinae; Ischemic Preconditioning; L | 2010 |
Clinically relevant doses of lidocaine and bupivacaine do not impair cutaneous wound healing in mice.
Topics: Aging; Anesthetics, Local; Animals; Bupivacaine; Collagen; Dermatologic Surgical Procedures; Disease | 2010 |
Long-term effect of sciatic nerve block with slow-release lidocaine in a rat model of postoperative pain.
Topics: Animals; Delayed-Action Preparations; Disease Models, Animal; Drug Delivery Systems; Lidocaine; Male | 2010 |
Spinal cord injury immediately changes the state of the brain.
Topics: Afferent Pathways; Analysis of Variance; Animals; Biophysics; Disease Models, Animal; Electric Stimu | 2010 |
Thoracic epidural anesthesia attenuates endotoxin-induced impairment of gastrointestinal organ perfusion.
Topics: Anesthesia, Epidural; Anesthetics, Local; Animals; Catecholamines; Disease Models, Animal; Endotoxem | 2010 |
Differential effects of four xylidine derivatives in the model of ischemia- and re-perfusion-induced arrhythmias in rats in vivo.
Topics: Amides; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; C | 2010 |
Do local anesthetics have antibacterial effect on Staphylococcus aureus under in vivo conditions? An experimental study.
Topics: Anesthetics, Local; Animals; Bupivacaine; Carticaine; Disease Models, Animal; Lidocaine; Male; Prilo | 2010 |
Acute amiodarone promotes drift and early termination of spiral wave re-entry.
Topics: Action Potentials; Amiodarone; Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Disease | 2010 |
The influence of anaesthetics on the reverse-flow fasciocutaneous flaps.
Topics: Anesthesia, Epidural; Anesthetics, Local; Animals; Disease Models, Animal; Lidocaine; Rabbits; Skin | 2011 |
Prolonged suppression of postincisional pain by a slow-release formulation of lidocaine.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Delayed-Action Preparations; Disease Models, Animal; | 2011 |
Changes in the blood flow and prevention of vasospasm of the femoral artery by topical application of lidocaine in rats.
Topics: Administration, Topical; Anesthetics, Local; Animals; Constriction, Pathologic; Disease Models, Anim | 2011 |
Inhibition of cardiac Ca2+ release channels (RyR2) determines efficacy of class I antiarrhythmic drugs in catecholaminergic polymorphic ventricular tachycardia.
Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Calsequestrin; Defi | 2011 |
Transcriptional repression of the M channel subunit Kv7.2 in chronic nerve injury.
Topics: Aminopyridines; Analgesics; Analysis of Variance; Anesthetics, Local; Animals; Chronic Disease; Dise | 2011 |
Lidocaine suppresses the increased extracellular signal-regulated kinase/cyclic AMP response element-binding protein pathway and pro-inflammatory cytokines in a neuropathic pain model of rats.
Topics: Anesthetics, Local; Animals; Cyclic AMP Response Element-Binding Protein; Cytokines; Disease Models, | 2011 |
Effect of local and intravenous lidocaine on ongoing activity in injured afferent nerve fibers.
Topics: Action Potentials; Anesthetics, Local; Animals; Blood Pressure; Disease Models, Animal; Drug Adminis | 2011 |
Time-dependent changes in bladder function and plantar sensitivity in a rat model of fibromyalgia syndrome induced by hydrochloric acid injection into the gluteus.
Topics: Anesthetics, Local; Animals; Case-Control Studies; Chronic Pain; Disease Models, Animal; Female; Fib | 2012 |
Comparison of actions of systemically and locally administrated local anaesthetics in diabetic rats with painful neuropathy.
Topics: Anesthetics, Local; Animals; Bupivacaine; Diabetes Mellitus, Experimental; Disease Models, Animal; F | 2013 |
Time course of acute neuroprotective effects of lidocaine evaluated by brain impedanciometry in the global ischemia model.
Topics: Animals; Brain; Brain Edema; Brain Ischemia; Disease Models, Animal; Electric Impedance; Lidocaine; | 2011 |
Effect of epidural anesthesia on anastomotic leakage in colonic surgery: experimental study.
Topics: Anastomosis, Surgical; Anastomotic Leak; Anesthesia, Epidural; Anesthetics, Local; Animals; Colonic | 2012 |
Afferent drive elicits ongoing pain in a model of advanced osteoarthritis.
Topics: Afferent Pathways; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, In | 2012 |
Analgesic effects of lidocaine, morphine and diclofenac on movement-induced nociception, as assessed by the Knee-Bend and CatWalk tests in a rat model of osteoarthritis.
Topics: Administration, Oral; Analgesics; Animals; Arthralgia; Diclofenac; Disease Models, Animal; Injection | 2012 |
Hyperalgesia by low doses of the local anesthetic lidocaine involves cannabinoid signaling: an fMRI study in mice.
Topics: Anesthetics, Local; Animals; Cannabinoids; Disease Models, Animal; Female; Hyperalgesia; Lidocaine; | 2012 |
A larval zebrafish model of bipolar disorder as a screening platform for neuro-therapeutics.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Bipolar Disorder; Dark Ada | 2012 |
Differential effects of peripheral versus central coadministration of QX-314 and capsaicin on neuropathic pain in rats.
Topics: Anesthetics, Local; Animals; Antipruritics; Capsaicin; Disease Models, Animal; Drug Administration R | 2012 |
Brainstem injection of lidocaine releases the descending pain-inhibitory mechanisms in a rat model of mononeuropathy.
Topics: Animals; Brain Stem; Cold Temperature; Disease Models, Animal; Female; Hot Temperature; Injections, | 2012 |
Reversal of acute coagulopathy during hypotensive resuscitation using small-volume 7.5% NaCl adenocaine and Mg2+ in the rat model of severe hemorrhagic shock.
Topics: Adenosine; Animals; Blood Coagulation Disorders; Disease Models, Animal; Drug Combinations; Hemodyna | 2012 |
Nebulized lidocaine prevents airway inflammation, peribronchial fibrosis, and mucus production in a murine model of asthma.
Topics: Anesthetics, Local; Animals; Asthma; Bronchi; Disease Models, Animal; Fibrosis; GATA3 Transcription | 2012 |
Effect of local anesthetic on microorganisms in a murine model of surgical site infection.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Disease Models, Animal; Escherichia coli; Female; | 2012 |
Long-term effect of epidural injection with sustained-release lidocaine particles in a rat model of postoperative pain.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Delayed-Action Preparations; Disease Models, Anim | 2012 |
Adenocaine and Mg(2+) reduce fluid requirement to maintain hypotensive resuscitation and improve cardiac and renal function in a porcine model of severe hemorrhagic shock*.
Topics: Adenosine; Animals; Disease Models, Animal; Drug Combinations; Female; Fluid Therapy; Heart; Hypoten | 2012 |
Clinically relevant animal models needed to advance state of the art fluid resuscitation*.
Topics: Adenosine; Animals; Disease Models, Animal; Drug Combinations; Female; Fluid Therapy; Heart; Hypoten | 2012 |
Phenotyping the function of TRPV1-expressing sensory neurons by targeted axonal silencing.
Topics: Action Potentials; Anesthetics, Local; Animals; Axons; Behavior, Animal; Capsaicin; Chronic Pain; Di | 2013 |
A role for abdominal vagal afferents in lipopolysaccharide-induced hypotension.
Topics: Animals; Blood Pressure Determination; Capsaicin; Disease Models, Animal; Drug Interactions; Female; | 2002 |
The effect of local hematoma blocks on early fracture healing.
Topics: Analysis of Variance; Animals; Bupivacaine; Disease Models, Animal; Femoral Fractures; Fracture Fixa | 2002 |
A comparison of the antinociceptive effects of voltage-activated Na+ channel blockers in two rat models of neuropathic pain.
Topics: Analgesics; Analysis of Variance; Anesthetics, Local; Animals; Disease Models, Animal; Dose-Response | 2003 |
Myocardial protective effect of lidocaine during experimental off-pump coronary artery bypass grafting.
Topics: Animals; Coronary Artery Bypass; Disease Models, Animal; Female; Lidocaine; Male; Myocardial Reperfu | 2003 |
Electrical heterogeneity and arrhythmogenesis: importance of conduction velocity dispersion.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Disease Models, Animal; Ele | 2003 |
Involvement of the anterior pretectal nucleus in the control of persistent pain: a behavioral and c-Fos expression study in the rat.
Topics: Anesthetics, Local; Animals; Bupivacaine; Carrageenan; Disease Models, Animal; Dose-Response Relatio | 2003 |
Noradrenaline release in the median preoptic nucleus area caused by hemorrhage in the rat.
Topics: Anesthetics, Local; Animals; Blood; Blood Pressure; Disease Models, Animal; Dose-Response Relationsh | 2003 |
Effect of granulocyte colony-stimulating factor on bleomycin-induced acute lung injury and pulmonary fibrosis.
Topics: Animals; Antibiotics, Antineoplastic; Bleomycin; Cell Adhesion; Disease Models, Animal; Drug Evaluat | 2003 |
Tedisamil and lidocaine enhance each other's antiarrhythmic activity against ischaemia-induced arrhythmias in rats.
Topics: Animals; Anti-Asthmatic Agents; Arrhythmias, Cardiac; Blood Pressure; Bridged Bicyclo Compounds, Het | 2003 |
Attenuation of neuropathic manifestations by local block of the activities of the ventrolateral orbito-frontal area in the rat.
Topics: Adrenergic Agents; Anesthetics, Local; Animals; Cold Temperature; Disease Models, Animal; Electricit | 2003 |
Free radical-induced damage in experimental peripheral nerve injection injury.
Topics: Analysis of Variance; Animals; Biopsy, Needle; Disease Models, Animal; Immunohistochemistry; Injury | 2003 |
Acute pancreatitis possible initial triggering mechanism and prophylaxis.
Topics: Acute Disease; Anesthetics, Local; Animals; Disease Models, Animal; Duodenum; Lidocaine; Male; Pancr | 2003 |
Mechanism of ST elevation and ventricular arrhythmias in an experimental Brugada syndrome model.
Topics: Animals; Disease Models, Animal; Dogs; Electrocardiography; Female; In Vitro Techniques; Lidocaine; | 2004 |
Surfactant lavage with lidocaine improves pulmonary function in piglets after HCl-induced acute lung injury.
Topics: Adjuvants, Immunologic; Animals; Bronchoalveolar Lavage; Disease Models, Animal; Drug Therapy, Combi | 2004 |
Key role of the dorsal root ganglion in neuropathic tactile hypersensibility.
Topics: Anesthetics, Local; Animals; Disease Models, Animal; Ganglia, Spinal; Hindlimb; Hyperesthesia; Lidoc | 2004 |
Lidocaine attenuates apoptosis in the ischemic penumbra and reduces infarct size after transient focal cerebral ischemia in rats.
Topics: Animals; Apoptosis; Caspase 3; Caspases; Cerebral Infarction; Cerebrovascular Circulation; Cytochrom | 2004 |
Primary nerve repair by muscle autografts prepared with local anesthetic.
Topics: Anesthesia, Local; Animals; Disease Models, Animal; Female; Lidocaine; Male; Microscopy, Confocal; M | 2004 |
Pharmacological characterisation of the rat brachial plexus avulsion model of neuropathic pain.
Topics: Acetates; Amines; Analgesics; Analysis of Variance; Animals; Brachial Plexus; Brachial Plexus Neurop | 2004 |
Antinociception induced by stimulating the anterior pretectal nucleus in two models of pain in rats.
Topics: Analgesia; Anesthetics, Local; Animals; Brain; Disease Models, Animal; Efferent Pathways; Electric S | 2004 |
Beneficial effect of trimebutine and N-monodesmethyl trimebutine on trinitrobenzene sulfonic acid-induced colitis in rats.
Topics: Administration, Rectal; Anesthetics, Local; Animals; Bupivacaine; Colitis; Colon; Disease Models, An | 2004 |
Evaluation of the tail formalin test in mice as a new model to assess local analgesic effects.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; D | 2004 |
Mexiletine protects myocardium during acute ischemia by opening sarcolemmal K-ATP channel: studies in closed-chest acute ischemia model in rabbits.
Topics: Acute Disease; Animals; Anti-Arrhythmia Agents; ATP-Binding Cassette Transporters; Disease Models, A | 2004 |
Central neuropathic itch from spinal-cord cavernous hemangioma: a human case, a possible animal model, and hypotheses about pathogenesis.
Topics: Anesthetics, Local; Animals; Disease Models, Animal; Hemangioma, Cavernous; Humans; Laminectomy; Lid | 2005 |
Characterization of a method for measuring primary hyperalgesia of deep somatic tissue.
Topics: Animals; Arthralgia; Carrageenan; Disease Models, Animal; Functional Laterality; Hyperalgesia; Infla | 2005 |
Evidence for the involvement of endogenous ATP and P2X receptors in TMJ pain.
Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents; Arthralgia; Arthritis; Carrageenan; Disea | 2005 |
Intracranial pressure changes during rapid sequence intubation: a swine model.
Topics: Animals; Brain Injuries; Cross-Over Studies; Disease Models, Animal; Emergency Treatment; Intracrani | 2005 |
A simple in vivo atrial fibrillation model of rat induced by transesophageal atrial burst pacing.
Topics: Animals; Atrial Fibrillation; Cardiac Pacing, Artificial; Disease Models, Animal; Electrocardiograph | 2005 |
Local anaesthetics attenuates spinal nociception and HPA-axis activation during experimental laparotomy in pigs.
Topics: Adrenocorticotropic Hormone; Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; C-Reactive | 2005 |
Neuroprotective mechanisms of lidocaine against in vitro ischemic insult of the rat hippocampal CA1 pyramidal neurons.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Brain Infarction; Calcium Signaling; Diseas | 2005 |
On the role of intramural nerves in the pathogenesis of cholera toxin-induced intestinal secretion.
Topics: Anesthetics, Local; Animals; Cats; Celiac Plexus; Cholera; Cholera Toxin; Disease Models, Animal; Fe | 1981 |
Impaired feedforward inhibition of the thalamocortical projection in epileptic Ca2+ channel mutant mice, tottering.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Age Factors; Animals; Calcium Channel Block | 2006 |
Cellular basis for trigger and maintenance of ventricular fibrillation in the Brugada syndrome model: high-resolution optical mapping study.
Topics: Action Potentials; Animals; Cardiovascular Agents; Disease Models, Animal; Dogs; Electrocardiography | 2006 |
Antiarrhythmic activity of taurhythman.
Topics: Aconitine; Alkanesulfonic Acids; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiotonic | 2005 |
Descending facilitation from the rostral ventromedial medulla maintains visceral pain in rats with experimental pancreatitis.
Topics: Animals; Biopsy, Needle; Disease Models, Animal; Drug Interactions; Immunohistochemistry; Injections | 2006 |
Heterotopic inputs facilitate poststimulus afterdischarges of spinal WDR neurons in rats with chronic nerve constriction.
Topics: Action Potentials; Anesthetics, Local; Animals; Behavior, Animal; Chronic Disease; Constriction; Dis | 2006 |
Up-regulation of acid-sensing ion channel 3 in dorsal root ganglion neurons following application of nucleus pulposus on nerve root in rats.
Topics: Acid Sensing Ion Channels; Animals; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Intervert | 2006 |
Context-dependent prefrontal cortex regulation of cocaine self-administration and reinstatement behaviors in rats.
Topics: Acoustic Stimulation; Anesthetics, Local; Animals; Cocaine; Cocaine-Related Disorders; Cues; Disease | 2006 |
Preemptive analgesia with lidocaine prevents Failed Back Surgery Syndrome.
Topics: Amino Acids; Analysis of Variance; Anesthetics, Local; Animals; Back Pain; Disease Models, Animal; L | 2007 |
Temperature modulation of ventricular arrhythmogenicity in a canine tissue model of Brugada syndrome.
Topics: Action Potentials; Animals; Body Temperature; Brugada Syndrome; Disease Models, Animal; Dogs; Electr | 2007 |
How can a single mutation cause such arrhythmic havoc?
Topics: Action Potentials; Animals; Body Temperature; Brugada Syndrome; Disease Models, Animal; Dogs; Electr | 2007 |
Effect of prefrontal cortex inactivation on behavioral and neurochemical abnormalities in rats with excitotoxic lesions of the entorhinal cortex.
Topics: Amygdala; Anesthetics, Local; Animals; Denervation; Disease Models, Animal; Dopamine; Dopamine Uptak | 2007 |
Involvement of substance P and calcitonin gene-related peptide in development and maintenance of neuropathic pain from spinal nerve injury model of rat.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Behavior, Animal; Calcitonin Gene-Related Peptide | 2007 |
Limiting sarcolemmal Na+ entry during resuscitation from ventricular fibrillation prevents excess mitochondrial Ca2+ accumulation and attenuates myocardial injury.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Calcium; Coronary Circulation; Disease Models, Anim | 2007 |
Nerve terminal contributes to acetylcholine receptor organization at the dystrophic neuromuscular junction of mdx mice.
Topics: Age Factors; Animals; Disease Models, Animal; Lidocaine; Mice; Mice, Inbred mdx; Microscopy, Confoca | 2007 |
[Protective effects of lidocaine against lung injury after hemorrhagic shock in rabbits].
Topics: Animals; Disease Models, Animal; Lidocaine; Lung; Lung Injury; Malondialdehyde; Rabbits; Shock, Hemo | 2007 |
Expression of the focal adhesion protein PINCH in normal and alkali-injured corneas and the role of PMNs.
Topics: Animals; Anticoagulants; Azepines; Burns, Chemical; Cornea; Corneal Injuries; Disease Models, Animal | 2007 |
The quaternary lidocaine derivative, QX-314, produces long-lasting local anesthesia in animal models in vivo.
Topics: Action Potentials; Anesthesia, Local; Anesthetics, Local; Animals; Disease Models, Animal; Dose-Resp | 2007 |
Restitution analysis of alternans and its relationship to arrhythmogenicity in hypokalaemic Langendorff-perfused murine hearts.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Pacing, Artificial | 2008 |
Lidocaine attenuates lipopolysaccharide-induced acute lung injury through inhibiting NF-kappaB activation.
Topics: Animals; Anti-Inflammatory Agents; Blotting, Western; Cytokines; Disease Models, Animal; Enzyme-Link | 2008 |
Protection of cellular and mitochondrial functions against liver ischemia by N-benzyl-N'-(2-hydroxy-3,4-dimethoxybenzyl)-piperazine (BHDP), a sigma1 ligand.
Topics: Adenosine Triphosphate; Animals; Biotransformation; Cell Membrane; Cell Respiration; Cold Ischemia; | 2008 |
Attenuating phosphorylation of p38 MAPK in the activated microglia: a new mechanism for intrathecal lidocaine reversing tactile allodynia following chronic constriction injury in rats.
Topics: Anesthetics, Local; Animals; Constriction, Pathologic; Disease Models, Animal; Hyperesthesia; Inject | 2008 |
Experimental autoimmune prostatitis induces chronic pelvic pain.
Topics: Amines; Analgesics; Anesthetics, Local; Animals; Autoimmune Diseases; Chronic Disease; Cyclohexaneca | 2008 |
Effects of atrial pacing, isoprenaline and lignocaine on experimental polymorphous ventricular tachycardia.
Topics: Animals; Blood Pressure; Cardiac Pacing, Artificial; Disease Models, Animal; Dogs; Electrocardiograp | 1984 |
Antiarrhythmic and electrophysiologic actions of flecainide in animal models.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Do | 1984 |
[Pharmacological protection of the kidneys from ischemic damage. The effectiveness of anti-ischemia protection of the kidneys in simulating the terminal state in the donors].
Topics: Animals; Death; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Humans; Hypotension; Isc | 1982 |
Indomethacin improves survival in gram-negative sepsis.
Topics: Animals; Blood Pressure; Disease Models, Animal; Escherichia coli Infections; Indomethacin; Leukocyt | 1981 |
[Pharmacologic evaluation of electrical processes in the myocardium].
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Dogs; Drug Evaluation | 1982 |
Localization and mechanism of ventricular tachycardia by ice mapping 1 week after the onset of myocardial infarction in dogs.
Topics: Action Potentials; Animals; Atrioventricular Node; Bundle of His; Cold Temperature; Disease Models, | 1983 |
Coronary artery ligation, early arrhythmias, and determination of the ischemic area in conscious rats.
Topics: Animals; Arrhythmias, Cardiac; Coronary Disease; Coronary Vessels; Disease Models, Animal; Lidocaine | 1983 |
Acute coronary artery occlusion-reperfusion-induced arrhythmias in rats, dogs and pigs: antiarrhythmic evaluation of quinidine, procainamide and lidocaine.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Coronary Disease; Disease Models, Animal; Dogs; Femal | 1982 |
Studies on the preventive method of lowered ventricular fibrillation threshold during experimental acute myocardial infarctions. A comparison between disopyramide phosphate and lidocaine.
Topics: Animals; Disease Models, Animal; Disopyramide; Dogs; Dose-Response Relationship, Drug; Injections, I | 1981 |
Inhibition of serotonin synthesis within the medulla and posterior hypothalamus by cardiac vagal afferents during acute myocardial ischemia in the rat.
Topics: Afferent Pathways; Animals; Coronary Disease; Disease Models, Animal; Hypothalamus; Lidocaine; Male; | 1981 |
[Effects of antiarrhythmic agents on ventricular arrhythmias following myocardial infarct induced with glass beads in dogs (author's transl)].
Topics: Animals; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Coronary Vessels; Disease Models, | 1981 |
Ventricular tachyarrhythmias in regional myocardial hyperkalemia: efficacy of three antiarrhythmic agents.
Topics: Animals; Coronary Disease; Disease Models, Animal; Dogs; Electrocardiography; Heart Conduction Syste | 1980 |
The paradoxical effect of lidocaine on an experimental model of epilepsy.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electric Stimulation; Electroencephal | 1980 |
Coronary artery ligation in anesthetized rats as a method for the production of experimental dysrhythmias and for the determination of infarct size.
Topics: Androstanols; Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Cor | 1980 |
Prophylactic lignocaine and early post-coronary artery occlusion dysrhythmias in anaesthetized greyhounds.
Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Coronary Vessels; Disease Models, Animal; Dogs; Female; H | 1980 |
Antiarrhythmic effects of bisaramil on triggered arrhythmias produced by intracoronary injection of digitalis and adrenaline in the dog.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bridged Bicyclo Compounds, Heterocyclic; Chlo | 1995 |
Profibrillatory effects of lidocaine in the acutely ischemic porcine heart.
Topics: Action Potentials; Animals; Cardiac Pacing, Artificial; Coronary Disease; Disease Models, Animal; El | 1995 |
Pre-injury lidocaine treatment prevents thermal hyperalgesia and cutaneous thermal abnormalities in a rat model of peripheral neuropathy.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Lidocaine; Ligation; Male; Peripheral Nervous System | 1995 |
Effect of levamisole hydrochloride on the guinea-pig atrium.
Topics: Animals; Arrhythmias, Cardiac; Atropine; Disease Models, Animal; Drug Antagonism; Drug Evaluation, P | 1993 |
Spinal cord amino acid release and content in an arthritis model: the effects of pretreatment with non-NMDA, NMDA, and NK1 receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Arthritis; | 1993 |
Epidural anesthesia accelerates the recovery of postischemic bowel motility in the rat.
Topics: Anesthesia, Epidural; Animals; Disease Models, Animal; Gastrointestinal Motility; Intestines; Ischem | 1994 |
Study of the sensitivity of the diabetes-induced pain model in rats to a range of analgesics.
Topics: Analgesics; Animals; Antidepressive Agents, Tricyclic; Aspirin; Clonidine; Diabetes Mellitus, Experi | 1994 |
An in vitro method for the evaluation of antiarrhythmic and antiischemic agents by using programmed electrical stimulation of rabbit heart.
Topics: Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Electric Stimulation; Glycine; Heart; | 1994 |
The relationship between regional blood flow and absorption of lignocaine.
Topics: Absorption; Animals; Disease Models, Animal; Epinephrine; Forelimb; Half-Life; Hindlimb; Injections, | 1993 |
Effects of amiodarone on refractory ventricular fibrillation in acute myocardial infarction: experimental study.
Topics: Amiodarone; Animals; Disease Models, Animal; Dogs; Electric Stimulation; Epinephrine; Female; Heart | 1994 |
Antifibrillatory and electrophysiologic actions of moricizine alone and in combination with lidocaine: a prospective, randomized trial.
Topics: Animals; Blood Pressure; Disease Models, Animal; Double-Blind Method; Electrocardiography; Lidocaine | 1993 |
Halothane and the reperfusion injury in the intact animal model.
Topics: Animals; Arrhythmias, Cardiac; Disease Models, Animal; Dose-Response Relationship, Drug; Halothane; | 1993 |
Effects of a new amiodarone-like agent, SR 33589, in comparison to amiodarone, D,L-sotalol, and lignocaine, on ischemia-induced ventricular arrhythmias in anesthetized pigs.
Topics: Amiodarone; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzofurans | 1995 |
SR 33589, a new amiodarone-like agent: effect on ischemia- and reperfusion-induced arrhythmias in anesthetized rats.
Topics: Administration, Oral; Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzofurans | 1995 |
Lidocaine reduces reperfusion injury and neutrophil migration in canine lung allografts.
Topics: Animals; CD11 Antigens; Cell Adhesion; Chemotaxis, Leukocyte; Disease Models, Animal; Dogs; Flow Cyt | 1996 |
Neurological decompression illness in swine.
Topics: Animals; Decompression Sickness; Disease Models, Animal; Lidocaine; Male; Purpura; Skin; Spinal Cord | 1996 |
Extrahepatic metabolism of 4-methylumbelliferone and lidocaine in the anhepatic rabbit.
Topics: Anesthetics, Local; Animals; Disease Models, Animal; Hepatectomy; Hymecromone; Indicators and Reagen | 1996 |
Pressure-heart rate relationship in intact and after stepwise elimination of three major baroreflex loops in dogs.
Topics: Action Potentials; Adjuvants, Anesthesia; Anesthetics, Local; Animals; Aorta; Arteriosclerosis; Baro | 1996 |
Lidocaine in the rostroventromedial medulla and the periaqueductal gray attenuates allodynia in neuropathic rats.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Lidocaine; Male; Medulla Oblongat | 1996 |
Spinal somatosensory evoked potentials after epidural isoproterenol in awake sheep.
Topics: Adrenergic beta-Agonists; Anesthesia, Epidural; Anesthetics, Local; Animals; Disease Models, Animal; | 1997 |
Effects of lidocaine on salicylate-induced discharge of neurons in the inferior colliculus of the guinea pig.
Topics: Action Potentials; Anesthetics, Local; Animals; Auditory Pathways; Disease Models, Animal; Electroph | 1997 |
Susceptibility of isolated rat facial nerve to anaerobic stress.
Topics: Action Potentials; Anaerobiosis; Anesthetics, Local; Animals; Anticonvulsants; Cyanides; Disease Mod | 1997 |
The effect of the sodium channel blocker QX-314 on recovery after acute spinal cord injury.
Topics: Anesthetics, Local; Animals; Disease Models, Animal; Female; Lidocaine; Rats; Rats, Wistar; Spinal C | 1997 |
Effects of lidocaine and diltiazem on recovery of electrophysiologic activity during partial reperfusion following severe myocardial ischemia in canine hearts.
Topics: Animals; Anti-Arrhythmia Agents; Blood Flow Velocity; Coronary Vessels; Diltiazem; Disease Models, A | 1997 |
Effects of lidocaine, ajmaline, and diltiazem on ventricular defibrillation energy requirements in isolated rabbit heart.
Topics: Ajmaline; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Cardiovascular Agents; Defibrillato | 1997 |
[Effect of lidocaine on ultrastructural changes in jejunum, kidney medulla and lungs of suckling rabbits, caused by vibrio cholerae].
Topics: Anesthetics, Local; Animals; Animals, Newborn; Cholera; Cytoplasm; Dinoprostone; Disease Models, Ani | 1997 |
Auditory evoked responses under total spinal anesthesia in rats.
Topics: Action Potentials; Anesthesia, Spinal; Anesthetics, Local; Animals; Auditory Pathways; Cochlear Micr | 1997 |
Effects of intravenous lipid as a source of energy in parenteral nutrition associated hepatic dysfunction and lidocaine elimination: a study using isolated rat liver perfusion.
Topics: Amino Acids; Animals; Biomarkers; Body Weight; Chromatography, High Pressure Liquid; Disease Models, | 1997 |
Drug-induced vasodilation: in vitro and in vivo study on the effects of lidocaine and papaverine on rabbit carotid artery.
Topics: Animals; Carotid Arteries; Disease Models, Animal; Dose-Response Relationship, Drug; In Vitro Techni | 1998 |
Relationship between action potential, contraction-relaxation pattern, and intracellular Ca2+ transient in cardiomyocytes of dogs with chronic heart failure.
Topics: Action Potentials; Animals; Calcium; Cells, Cultured; Disease Models, Animal; Dogs; Electrophysiolog | 1998 |
Cellular mechanisms underlying spontaneous interictal spikes in an acute model of focal cortical epileptogenesis.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Acute Disease; | 1999 |
High extracellular K+ during hypoxic preconditioning episodes attenuates the post-ischemic contractile and ionic benefits of preconditioning.
Topics: Animals; Calcium; Disease Models, Animal; Dose-Response Relationship, Drug; Edetic Acid; Hypoxia; Is | 1999 |
Selective protection of gray and white matter during spinal cord ischemic injury.
Topics: Animals; Brain; Disease Models, Animal; Evaluation Studies as Topic; Excitatory Amino Acid Antagonis | 1999 |
Lidocaine attenuates acute lung injury induced by a combination of phospholipase A2 and trypsin.
Topics: Animals; Blood Gas Analysis; Disease Models, Animal; Disease Progression; Drug Evaluation, Preclinic | 2000 |
[Antiarrhythmic effects of pilsicainide hydrochloride and effects on cardiac function and ECG in dogs: comparison with disopyramide].
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Disease Models, | 2000 |
[Effect of mexiletine on spontaneous sensory afferent activity in spontaneous diabetic rats (WBN/Kob rats)].
Topics: Action Potentials; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Depression, Chemical; Diabet | 2000 |
Effects of sodium channel blockade on ibutilide induced prolongation of repolarization in the isolated rabbit ventricle.
Topics: Action Potentials; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Culture Techniques; Diseas | 2000 |
Lack of pre-emptive analgesic effects of local anaesthetics on neuropathic pain.
Topics: Anesthetics, Local; Animals; Bupivacaine; Disease Models, Animal; Lidocaine; Male; Pain Threshold; P | 2000 |
Topical iodine preparation as therapy against sulfur mustard-induced skin lesions.
Topics: Administration, Topical; Animals; Anti-Infective Agents, Local; Dermatologic Agents; Disease Models, | 2000 |
Treatment of skin injuries induced by sulfur mustard with calmodulin antagonists, using the pig model.
Topics: Administration, Topical; Anesthetics, Local; Animals; Blister; Calmodulin; Dermatologic Agents; Dise | 2000 |
Reassessment of monoethylglycinexylidide as preoperative liver function test in a rat model of liver cirrhosis and man.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Disease Models, Animal; Hepat | 2001 |
Measurement of the glucose transport time delay between the blood and aqueous humor of the eye for the eventual development of a noninvasive glucose sensor.
Topics: Anesthetics, Local; Animals; Aqueous Humor; Biological Transport; Blood Glucose; Blood Glucose Self- | 2001 |
The midline thalamus: alterations and a potential role in limbic epilepsy.
Topics: Anatomy, Cross-Sectional; Animals; Cell Count; Disease Models, Animal; Electric Stimulation; Electro | 2001 |
Effects of lidocaine on blood flow and endoneurial fluid pressure in a rat model of herniated nucleus pulposus.
Topics: Anesthetics, Local; Animals; Disease Models, Animal; Extracellular Space; Female; Ganglia, Spinal; H | 2001 |
Development of a behavioral model of TMJ pain in rats: the TMJ formalin test.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Behavior, Animal; Disease Models, Animal; Lidocaine | 2001 |
Involvement of the central nervous system in the protective effect of melanocortins in myocardial ischaemia/reperfusion injury.
Topics: Adrenocorticotropic Hormone; Animals; Central Nervous System; Disease Models, Animal; Dose-Response | 2002 |
Dissociable effects of lidocaine inactivation of the rostral and caudal basolateral amygdala on the maintenance and reinstatement of cocaine-seeking behavior in rats.
Topics: Acoustic Stimulation; Amygdala; Anesthetics, Local; Animals; Behavior, Animal; Cocaine-Related Disor | 2002 |
Stimulus-response functions of the lateral dorsal striatum and regulation of behavior studied in a cocaine maintenance/cue reinstatement model in rats.
Topics: Acoustic Stimulation; Anesthetics, Local; Animals; Association Learning; Behavior, Animal; Cocaine; | 2002 |
Continual systemic infusion of lidocaine provides analgesia in an animal model of neuropathic pain.
Topics: Anesthetics, Local; Animals; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Dr | 2002 |
Effects of lidocaine on the electrophysiological properties of subendocardial Purkinje fibers surviving acute myocardial infarction.
Topics: Animals; Disease Models, Animal; Dogs; Electrophysiology; Heart Conduction System; Heart Ventricles; | 1979 |
The effects of lidocaine on hyperoxic seizure activity in the rat.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperbaric Oxygenation; L | 1978 |
Arterial hypertension induced by femoral lengthening. A canine model.
Topics: Anesthesia, Spinal; Animals; Blood Pressure; Bone Lengthening; Disease Models, Animal; Dogs; Femur; | 1978 |
A comparison of immunologic asthma to two types of cholinergic respiratory responses in the rhesus monkey.
Topics: Acetylcholine; Aerosols; Airway Resistance; Animals; Antigens; Ascaris; Asthma; Atropine; Carbachol; | 1976 |
Reduction of ischemic myocardial damage in the dog by lidocaine infusion.
Topics: Animals; Biopsy; Body Temperature; Cardiopulmonary Bypass; Coronary Disease; Disease Models, Animal; | 1977 |
Proceedings: Effects of barbiturates on blood pressure in lidocaine hydrochloride injected SHR.
Topics: Animals; Barbiturates; Blood Pressure; Disease Models, Animal; Drug Therapy, Combination; Female; Hy | 1976 |
Pharmacological modification of arrhythmias after experimentally induced acute myocardial infarction. Drugs acting on the nervous system.
Topics: Acute Disease; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compounds; Chlordiaz | 1975 |
Effects of SUN-1165, N-(2,6-dimethylphenyl)-8-pyrrolizidine acetamide hydrochloride hemihydrate, a new class I antiarrhythmic drug, on ventricular arrhythmias, intraventricular conduction, and the refractory period in canine myocardial infarction.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Dogs; Electric Stimul | 1992 |
Concentration-dependent effects of lidocaine on corneal epithelial wound healing.
Topics: Animals; Cell Division; Cell Movement; Cornea; Disease Models, Animal; Dose-Response Relationship, D | 1992 |
Monoethylglycinexylidide production parallels changes in hepatic blood flow and oxygen delivery in lung injury managed with positive end-expiratory pressure.
Topics: Animals; Blood Flow Velocity; Critical Illness; Disease Models, Animal; Dogs; Evaluation Studies as | 1992 |
A canine model for studying laryngospasm and its prevention.
Topics: Administration, Topical; Anesthesia, Inhalation; Animals; Clinical Protocols; Disease Models, Animal | 1992 |
Effect of lidocaine on somatosensory evoked response and cerebral blood flow after canine cerebral air embolism.
Topics: Animals; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; Dogs; | 1992 |
Vasodepressor reaction induced by inferior vena caval occlusion and isoproterenol.
Topics: Animals; Atropine; Disease Models, Animal; Drug Administration Routes; Heart Rate; Hypotension; Infu | 1992 |
Effects of flecainide on ventricular arrhythmias, abnormal automaticity and activation in a canine model of myocardial infarction.
Topics: Animals; Arrhythmias, Cardiac; Disease Models, Animal; Dogs; Electrocardiography; Flecainide; Heart | 1992 |
Isolated paced guinea pig left atrium: a new ouabain-induced arrhythmia model.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Function, Left; Clonidine; Disease Mod | 1991 |
Studies in autotomy: its pathophysiology and usefulness as a model of chronic pain.
Topics: Afferent Pathways; Animals; Behavior, Animal; Chronic Disease; Denervation; Disease Models, Animal; | 1991 |
Selective 3-hydroxylation deficiency of lidocaine and its metabolite in Dark Agouti rats.
Topics: Animals; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Disease Models, Animal; Female; Hy | 1991 |
The role of lidocaine, epinephrine, and flap elevation in wound healing after chemical peel.
Topics: Animals; Chemexfoliation; Cicatrix; Disease Models, Animal; Epinephrine; Humans; Lidocaine; Rats; Ra | 1991 |
Cocaine-base smoking in rhesus monkeys: reinforcing and physiological effects.
Topics: Animals; Blood Pressure; Cocaine; Disease Models, Animal; Dose-Response Relationship, Drug; Heart Ra | 1990 |
Bretylium tosylate versus lidocaine in experimental cardiac arrest.
Topics: Animals; Bretylium Tosylate; Disease Models, Animal; Dogs; Electric Countershock; Heart Arrest; Hemo | 1990 |
Inducible monomorphic sustained ventricular tachycardia in the conscious pig.
Topics: Animals; Coronary Vessels; Disease Models, Animal; Heart Ventricles; Hemodynamics; Lidocaine; Ligati | 1990 |
Ventricular arrhythmias following one-stage and two-stage coronary reperfusion: evidence for both reentry and enhanced automaticity.
Topics: Animals; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Cardiac Pacing, Artificial; Coronary Ci | 1985 |
Development of an in vivo model for assessment of drug-induced vascular injury.
Topics: Animals; Diazepam; Disease Models, Animal; Ear; Female; Infusions, Intravenous; Lidocaine; Male; Pre | 1989 |
Acute induction of sustained ventricular tachycardia: a new porcine model.
Topics: Animals; Disease Models, Animal; Electric Stimulation; Electrocardiography; Heart; Heart Ventricles; | 1989 |
Role of noradrenergic system in limbic seizures induced by pilocarpine. I. Importance of beta-adrenergic receptor.
Topics: Albuterol; Animals; Disease Models, Animal; Lidocaine; Limbic System; Male; Pilocarpine; Propranolol | 1988 |
Model of electrocardiographic changes seen with subarachnoid hemorrhage in rabbits.
Topics: Animals; Arrhythmias, Cardiac; Dinoprost; Disease Models, Animal; Electrocardiography; Injections; L | 1989 |
[Croton oil-induced hemorrhoid model in rat: comparison of anti-inflammatory activity of diflucortolone valerate with other glucocorticoids].
Topics: Animals; Anti-Inflammatory Agents; Croton Oil; Diflucortolone; Disease Models, Animal; Drug Combinat | 1988 |
[Neriproct: its anti-inflammatory effect on an experimentally induced hemorrhoid model in the rat].
Topics: Animals; Anti-Inflammatory Agents; Croton Oil; Diflucortolone; Disease Models, Animal; Dosage Forms; | 1988 |
Effects of lidocaine infusion in cats after unilateral labyrinthectomy.
Topics: Adaptation, Physiological; Animals; Cats; Disease Models, Animal; Ear, Inner; Electronystagmography; | 1988 |
Electrical and contractile behavior of large intestinal musculature of piebald mouse model for Hirschsprung's disease.
Topics: Animals; Disease Models, Animal; Electric Stimulation; Epinephrine; Hirschsprung Disease; Intestine, | 1986 |
Ventricular fibrillation threshold in canine hearts with quinidine induced prolonged QT interval: effects of atrial pacing, isoproterenol, and lignocaine.
Topics: Animals; Cardiac Pacing, Artificial; Disease Models, Animal; Dogs; Female; Heart; Isoproterenol; Lid | 1986 |
Spinal Wada test.
Topics: Animals; Disease Models, Animal; Embolization, Therapeutic; Lidocaine; Macaca mulatta; Pentobarbital | 1986 |
Resolution of experimental microvascular spasm and improvement in anastomotic patency by direct topical agent application.
Topics: Administration, Topical; Animals; Chlorpromazine; Disease Models, Animal; Drug Evaluation; Epinephri | 1986 |
The effect of antiarrhythmic drugs on life-threatening arrhythmias induced by the interaction between acute myocardial ischemia and sympathetic hyperactivity.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cats; Coronary Disease; Disease M | 1985 |
Inhomogeneity of ventricular refractory period in canine heart with quinidine-induced long QT interval: a comparative study on effects of heart rate, isoprenaline, and lignocaine.
Topics: Animals; Disease Models, Animal; Dogs; Electric Stimulation; Female; Heart; Heart Rate; Isoprotereno | 1985 |
Lidocaine in experimental epilepsy: correlation of anticonvulsant effect with blood concentrations.
Topics: Animals; Anticonvulsants; Cats; Disease Models, Animal; Electroencephalography; Epilepsy; Female; In | 1973 |
Diazepam prevents and aborts lidocaine convulsions in monkeys.
Topics: Animals; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Haplorhini; Injections, | 1974 |
Anti-arrhythmic effects of lidocaine metabolites.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Drug Evaluation; Ethy | 1974 |
Local anesthesia and experimental epilepsy.
Topics: Animals; Benzocaine; Cats; Disease Models, Animal; Female; Lidocaine; Male; Procaine; Seizures; Time | 1974 |
Experimental model for study of "sudden death" from ventricular fibrillation or asystole.
Topics: Angiocardiography; Animals; Aorta, Thoracic; Arrhythmias, Cardiac; Autopsy; Coronary Angiography; Co | 1973 |
The prevention of ethanol withdrawal seizures in mice by lidocaine.
Topics: Alcoholism; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Hum | 1973 |
Relationships between increased automaticity and depressed conduction in the main intraventricular conducting fascicles of the human and canine heart.
Topics: Aged; Animals; Bundle-Branch Block; Carotid Sinus; Disease Models, Animal; Dogs; Electrocardiography | 1974 |
Antiarrhythmic and circulatory effects of Astra W36095, a new lidocaine-like agent.
Topics: Anilides; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Chemical Phenomena; | 1974 |
Letter: Effect of lidocaine on "gating" mechanism.
Topics: Animals; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Heart; Heart Conduction Sys | 1974 |
Antiarrhythmic effects in dogs of lidocaine administered orally and intravenously.
Topics: Administration, Oral; Animals; Arrhythmias, Cardiac; Blood Pressure; Coronary Vessels; Disease Model | 1972 |
Observations on models used for the evaluation of antiarrhythmic drugs.
Topics: Alkaloids; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutte | 1971 |
[Lysis of mechanically produced spasms of small arteries through local drug administration].
Topics: Animals; Chlorpromazine; Disease Models, Animal; Lidocaine; Rabbits; Renal Artery; Spasm; Vascular D | 1971 |
A comparison of the effects of bretylium, lignocaine and propranolol on experimental cardiac arrhythmias.
Topics: Animals; Arrhythmias, Cardiac; Bretylium Compounds; Disease Models, Animal; Dogs; Epinephrine; Lidoc | 1969 |
Experimental myocardial infarction in calves. Coronary embolization and vessel occlusion.
Topics: Animals; Blood Pressure; Cattle; Coronary Vessels; Disease Models, Animal; Electrocardiography; Embo | 1971 |