lidocaine has been researched along with Diabetic Neuropathies in 49 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Diabetic Neuropathies: Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In patients with PHN and painful DPN failing to respond to monotherapy, combination therapy with 5% lidocaine medicated plaster and pregabalin provides additional clinically relevant pain relief and is safe and well-tolerated." | 9.14 | Efficacy and safety of combination therapy with 5% lidocaine medicated plaster and pregabalin in post-herpetic neuralgia and diabetic polyneuropathy. ( Baron, R; Binder, A; Leijon, G; Mayoral, V; Serpell, M; Steigerwald, I, 2009) |
| "To compare efficacy and safety of 5% lidocaine medicated plaster with pregabalin in patients with post-herpetic neuralgia (PHN) or painful diabetic polyneuropathy (DPN)." | 9.14 | 5% lidocaine medicated plaster versus pregabalin in post-herpetic neuralgia and diabetic polyneuropathy: an open-label, non-inferiority two-stage RCT study. ( Baron, R; Binder, A; Leijon, G; Mayoral, V; Serpell, M; Steigerwald, I, 2009) |
| "Significant improvements in BPI measures of pain intensity and pain relief were reported for all groups of patients after 2 weeks of lidocaine patch 5% treatment." | 9.10 | Lidocaine patch 5% with systemic analgesics such as gabapentin: a rational polypharmacy approach for the treatment of chronic pain. ( Drass, M; Nalamachu, S; Patel, N; White, WT, 2003) |
| "In a randomized double-blind, cross-over study the effect of intravenous lidocaine (5 mg/kg body weight) on the symptoms and signs of painful diabetic neuropathy of more than 6 months duration has been evaluated." | 9.06 | Intravenous lidocaine infusion--a new treatment of chronic painful diabetic neuropathy? ( Angelo, HR; Dejgård, A; Hilsted, J; Kastrup, J; Petersen, P, 1987) |
| "Lidocaine is used clinically for tactile allodynia associated with diabetes-induced neuropathy." | 7.77 | Lidocaine attenuates the development of diabetic-induced tactile allodynia by inhibiting microglial activation. ( Hasegawa-Moriyama, M; Inada, E; Kamikubo, Y; Sakurai, T; Suzuki, N; Takahashi, Y, 2011) |
| "Intravenous infusion of lidocaine has a pain-relieving effect in patients with painful diabetic neuropathy." | 7.67 | Lidocaine treatment of painful diabetic neuropathy and endogenous opioid peptides in plasma. ( Angelo, H; Bach, FW; Dejgård, A; Ekman, R; Jensen, S; Kastrup, J; Petersen, P, 1989) |
| " Patients administering lidocaine plaster experienced fewer drug-related adverse events (3." | 6.74 | Efficacy and safety of 5% lidocaine (lignocaine) medicated plaster in comparison with pregabalin in patients with postherpetic neuralgia and diabetic polyneuropathy: interim analysis from an open-label, two-stage adaptive, randomized, controlled trial. ( Baron, R; Binder, A; Leijon, G; Mayoral, V; Serpell, M; Steigerwald, I, 2009) |
| "Allodynia was prevented by insulin therapy that maintained normoglycemia while established allodynia was reversed by insulin therapy and normoglycemia of days but not hours duration." | 5.29 | Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine. ( Calcutt, NA; Chaplan, SR; Jorge, MC; Yaksh, TL, 1996) |
| "This qualitative review found insufficient, heterogenous evidence and therefore no recommendation can be made for lidocaine infusion treatment in patients with chronic neuropathic pain due to spinal cord injury, peripheral nerve injury, diabetic neuropathy, postherpetic neuralgia, or complex regional pain syndrome type II." | 5.22 | Intravenous Lidocaine in Chronic Neuropathic Pain: A Systematic Review. ( Argoff, CE; Bhullar, RK; Koutalianos, EP; Lee, JH; Leimer, EM, 2022) |
| "In patients with PHN and painful DPN failing to respond to monotherapy, combination therapy with 5% lidocaine medicated plaster and pregabalin provides additional clinically relevant pain relief and is safe and well-tolerated." | 5.14 | Efficacy and safety of combination therapy with 5% lidocaine medicated plaster and pregabalin in post-herpetic neuralgia and diabetic polyneuropathy. ( Baron, R; Binder, A; Leijon, G; Mayoral, V; Serpell, M; Steigerwald, I, 2009) |
| "To compare efficacy and safety of 5% lidocaine medicated plaster with pregabalin in patients with post-herpetic neuralgia (PHN) or painful diabetic polyneuropathy (DPN)." | 5.14 | 5% lidocaine medicated plaster versus pregabalin in post-herpetic neuralgia and diabetic polyneuropathy: an open-label, non-inferiority two-stage RCT study. ( Baron, R; Binder, A; Leijon, G; Mayoral, V; Serpell, M; Steigerwald, I, 2009) |
| "To determine the impact of the lidocaine patch 5% on pain qualities associated with chronic pain from postherpetic neuralgia (PHN), painful diabetic neuropathy (DN), and low-back pain (LBP), using the Neuropathic Pain Scale (NPS)." | 5.11 | Effectiveness of the lidocaine patch 5% on pain qualities in three chronic pain states: assessment with the Neuropathic Pain Scale. ( Argoff, CE; Galer, BS; Gammaitoni, AR; Jensen, MP; Oleka, N, 2004) |
| "Significant improvements in BPI measures of pain intensity and pain relief were reported for all groups of patients after 2 weeks of lidocaine patch 5% treatment." | 5.10 | Lidocaine patch 5% with systemic analgesics such as gabapentin: a rational polypharmacy approach for the treatment of chronic pain. ( Drass, M; Nalamachu, S; Patel, N; White, WT, 2003) |
| "In a double-blind controlled design, 7 patients with painful diabetic neuropathy received lidocaine 5 mg/kg or saline intravenously over a period of 30 min." | 5.06 | The effect of intravenous lidocaine on nociceptive processing in diabetic neuropathy. ( Bach, FW; Dejgård, A; Jensen, TS; Kastrup, J; Stigsby, B, 1990) |
| "In a randomized double-blind, cross-over study the effect of intravenous lidocaine (5 mg/kg body weight) on the symptoms and signs of painful diabetic neuropathy of more than 6 months duration has been evaluated." | 5.06 | Intravenous lidocaine infusion--a new treatment of chronic painful diabetic neuropathy? ( Angelo, HR; Dejgård, A; Hilsted, J; Kastrup, J; Petersen, P, 1987) |
| "Lidocaine is used clinically for tactile allodynia associated with diabetes-induced neuropathy." | 3.77 | Lidocaine attenuates the development of diabetic-induced tactile allodynia by inhibiting microglial activation. ( Hasegawa-Moriyama, M; Inada, E; Kamikubo, Y; Sakurai, T; Suzuki, N; Takahashi, Y, 2011) |
| "Intravenous infusion of lidocaine has a pain-relieving effect in patients with painful diabetic neuropathy." | 3.67 | Lidocaine treatment of painful diabetic neuropathy and endogenous opioid peptides in plasma. ( Angelo, H; Bach, FW; Dejgård, A; Ekman, R; Jensen, S; Kastrup, J; Petersen, P, 1989) |
| "Lidocaine administration reduced mean Neuropathic Pain Symptom Inventory paresthesia/dysesthesia scores when compared with placebo by 1." | 3.01 | Prediction of Individual Analgesic Response to Intravenous Lidocaine in Painful Diabetic Peripheral Neuropathy: A Randomized, Placebo-controlled, Crossover Trial. ( Bakos, K; Bottros, M; Frey, K; Haroutounian, S; Kagan, L; Kraus, K; Lee, JB; Meacham, K; Rao, L; Swarm, RA; Tallchief, D; Todorovic, MS; Zang, X, 2021) |
| "Lidocaine was included in this study and compared with placebo." | 2.80 | Effects of a T-type calcium channel blocker, ABT-639, on spontaneous activity in C-nociceptors in patients with painful diabetic neuropathy: a randomized controlled trial. ( Duan, WR; Liu, W; Locke, C; Nothaft, W; Serra, J; Solà, R, 2015) |
| " Patients administering lidocaine plaster experienced fewer drug-related adverse events (3." | 2.74 | Efficacy and safety of 5% lidocaine (lignocaine) medicated plaster in comparison with pregabalin in patients with postherpetic neuralgia and diabetic polyneuropathy: interim analysis from an open-label, two-stage adaptive, randomized, controlled trial. ( Baron, R; Binder, A; Leijon, G; Mayoral, V; Serpell, M; Steigerwald, I, 2009) |
| "The treatment of painful diabetic polyneuropathy (DPN) is often inadequate and frequently limited by the systemic adverse effects of medications, necessitating the evaluation of novel treatments." | 2.71 | Effectiveness, tolerability, and impact on quality of life of the 5% lidocaine patch in diabetic polyneuropathy. ( Barbano, RL; Dworkin, RH; Hart-Gouleau, S; Herrmann, DN; Lodewick, PA; Pennella-Vaughan, J, 2004) |
| "Chronic pain is now viewed as a biopsychosocial phenomenon, in which biological, psychological, and social factors are at work." | 2.44 | Practical management strategies for the chronic pain patient. ( Forde, G; Stanos, S, 2007) |
| "Neuropathic pain has long been recognised as one of the more difficult types of pain to treat; however, with the current emphasis on providing a multidisciplinary assessment and approach to management, more patients will be offered relief of their symptoms and an improved quality of life." | 2.41 | Management strategies for the treatment of neuropathic pain in the elderly. ( Ahmad, M; Goucke, CR, 2002) |
| " In this rodent model of neuropathy, both pharmacodynamic and pharmacokinetic mechanisms contribute to prolonged nerve block duration." | 1.48 | Pharmacodynamics and Pharmacokinetics of Lidocaine in a Rodent Model of Diabetic Neuropathy. ( de Bruin, K; Hollmann, MW; Horn, J; Lirk, P; Picardi, S; Rigaud, M; Tan, HL; Ten Hoope, W; Verberne, HJ; Verhamme, C; Verkerk, AO, 2018) |
| "Mechanical allodynia, induced by normally innocuous low-threshold mechanical stimulation, represents a cardinal feature of neuropathic pain." | 1.42 | Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade. ( Bang, S; Berta, T; Ji, RR; Kim, YH; Oh, SB; Wang, F; Xu, ZZ; Zhang, Y, 2015) |
| "Following block resolution, a new conus medullaris syndrome was diagnosed." | 1.29 | Conus medullaris injury following both tetracaine and lidocaine spinal anesthesia. ( Ward, MG; Waters, JH; Watson, TB, 1996) |
| "Allodynia was prevented by insulin therapy that maintained normoglycemia while established allodynia was reversed by insulin therapy and normoglycemia of days but not hours duration." | 1.29 | Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine. ( Calcutt, NA; Chaplan, SR; Jorge, MC; Yaksh, TL, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (8.16) | 18.7374 |
| 1990's | 14 (28.57) | 18.2507 |
| 2000's | 16 (32.65) | 29.6817 |
| 2010's | 10 (20.41) | 24.3611 |
| 2020's | 5 (10.20) | 2.80 |
| Authors | Studies |
|---|---|
| Todorovic, MS | 1 |
| Frey, K | 1 |
| Swarm, RA | 1 |
| Bottros, M | 1 |
| Rao, L | 1 |
| Tallchief, D | 1 |
| Kraus, K | 1 |
| Meacham, K | 1 |
| Bakos, K | 1 |
| Zang, X | 1 |
| Lee, JB | 1 |
| Kagan, L | 1 |
| Haroutounian, S | 1 |
| Luo, J | 1 |
| Wu, D | 1 |
| Wu, Q | 1 |
| Chen, Y | 1 |
| Gan, Y | 1 |
| He, M | 1 |
| Sun, W | 1 |
| Ai, Y | 1 |
| Su, Q | 1 |
| Zou, X | 1 |
| Wang, D | 1 |
| Lee, JH | 1 |
| Koutalianos, EP | 1 |
| Leimer, EM | 1 |
| Bhullar, RK | 1 |
| Argoff, CE | 2 |
| Überall, M | 1 |
| Bösl, I | 1 |
| Hollanders, E | 1 |
| Sabatschus, I | 1 |
| Eerdekens, M | 1 |
| Wilkinson, ID | 1 |
| Teh, K | 1 |
| Heiberg-Gibbons, F | 1 |
| Awadh, M | 1 |
| Kelsall, A | 1 |
| Shillo, P | 1 |
| Sloan, G | 1 |
| Tesfaye, S | 1 |
| Selvarajah, D | 1 |
| Ten Hoope, W | 1 |
| Hollmann, MW | 1 |
| de Bruin, K | 1 |
| Verberne, HJ | 1 |
| Verkerk, AO | 1 |
| Tan, HL | 1 |
| Verhamme, C | 1 |
| Horn, J | 1 |
| Rigaud, M | 1 |
| Picardi, S | 1 |
| Lirk, P | 1 |
| Sun, X | 1 |
| Xu, J | 1 |
| Ni, Y | 1 |
| Qin, W | 1 |
| Jin, Y | 1 |
| Moulin, DE | 1 |
| Morley-Forster, PK | 1 |
| Pirani, Z | 1 |
| Rohfritsch, C | 1 |
| Stitt, L | 1 |
| Sokov, EL | 1 |
| Kornilova, LE | 1 |
| Artiukov, OP | 1 |
| Serra, J | 1 |
| Duan, WR | 1 |
| Locke, C | 1 |
| Solà, R | 1 |
| Liu, W | 1 |
| Nothaft, W | 1 |
| Xu, ZZ | 1 |
| Kim, YH | 1 |
| Bang, S | 1 |
| Zhang, Y | 1 |
| Berta, T | 1 |
| Wang, F | 1 |
| Oh, SB | 1 |
| Ji, RR | 1 |
| Snyder, MJ | 1 |
| Gibbs, LM | 1 |
| Lindsay, TJ | 1 |
| Forde, G | 2 |
| Stanos, S | 1 |
| Baron, R | 3 |
| Mayoral, V | 3 |
| Leijon, G | 4 |
| Binder, A | 3 |
| Steigerwald, I | 3 |
| Serpell, M | 3 |
| Wolff, RF | 1 |
| Bala, MM | 1 |
| Westwood, M | 1 |
| Kessels, AG | 1 |
| Kleijnen, J | 1 |
| Suzuki, N | 1 |
| Hasegawa-Moriyama, M | 1 |
| Takahashi, Y | 1 |
| Kamikubo, Y | 1 |
| Sakurai, T | 1 |
| Inada, E | 1 |
| Mert, T | 1 |
| Gunes, Y | 1 |
| Ahmad, M | 1 |
| Goucke, CR | 1 |
| Pasero, C | 1 |
| White, WT | 1 |
| Patel, N | 1 |
| Drass, M | 1 |
| Nalamachu, S | 1 |
| Barbano, RL | 1 |
| Herrmann, DN | 1 |
| Hart-Gouleau, S | 1 |
| Pennella-Vaughan, J | 1 |
| Lodewick, PA | 1 |
| Dworkin, RH | 2 |
| Wepner, U | 1 |
| Galer, BS | 2 |
| Jensen, MP | 2 |
| Oleka, N | 1 |
| Gammaitoni, AR | 3 |
| Olaleye, DO | 1 |
| Cornell, RS | 1 |
| Ducic, I | 1 |
| Hilsted, J | 3 |
| Madsbad, S | 1 |
| Sestoft, L | 1 |
| Fukuda, H | 1 |
| Kasuda, H | 1 |
| Nemoto, K | 1 |
| Shimizu, R | 1 |
| Courteix, C | 1 |
| Bardin, M | 1 |
| Chantelauze, C | 1 |
| Lavarenne, J | 1 |
| Eschalier, A | 1 |
| Boulton, AJ | 1 |
| Seidel, C | 2 |
| Bühler-Singer, S | 1 |
| Richter, UG | 2 |
| Hornstein, OP | 2 |
| de Jong, RH | 1 |
| Ogata, K | 1 |
| Masaki, T | 1 |
| Takao, F | 1 |
| Kunimoto, M | 1 |
| Inoue, K | 1 |
| Waters, JH | 1 |
| Watson, TB | 1 |
| Ward, MG | 1 |
| Calcutt, NA | 1 |
| Jorge, MC | 1 |
| Yaksh, TL | 1 |
| Chaplan, SR | 1 |
| Horiuchi, J | 1 |
| Sato, Y | 1 |
| Pertovaara, A | 1 |
| Wei, H | 1 |
| Kalmari, J | 1 |
| Ruotsalainen, M | 1 |
| Ziegler, D | 1 |
| Gries, FA | 1 |
| Ackerman, WE | 1 |
| Colclough, GW | 1 |
| Juneja, MM | 1 |
| Bellinger, K | 1 |
| Coe, AJ | 1 |
| Dean, J | 1 |
| McClone, F | 1 |
| Bowsher, D | 1 |
| Bühler, S | 1 |
| Bach, FW | 2 |
| Jensen, TS | 1 |
| Kastrup, J | 5 |
| Stigsby, B | 1 |
| Dejgård, A | 5 |
| Petersen, P | 4 |
| Ekman, R | 1 |
| Jensen, S | 1 |
| Angelo, H | 2 |
| Angelo, HR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Role of Intravenous (IV) Lidocaine in the Management of Chronic Neuropathic Pain of Peripheral Nerve Origin[NCT01669967] | 34 participants (Actual) | Interventional | 2011-09-30 | Completed | |||
| Microneurographic Assessment of Peripheral Nerves in Healthy Volunteers and Individuals With Sensory Dysfunction Caused by Inherited Mutations in the PIEZO2 Gene[NCT06052631] | 16 participants (Anticipated) | Observational | 2024-01-03 | Not yet recruiting | |||
| A Randomized, Double-blind, Placebo and Active-controlled Study of the Electrophysiological Effects of ABT-639 on Spontaneous Activity in C-Nociceptors in Patients With Painful Diabetic Peripheral Neuropathy[NCT01589432] | Phase 2 | 39 participants (Actual) | Interventional | 2012-04-30 | Completed | ||
| Impact of Direct Current Neuromuscular Electrical Stimulation on Physical Therapy Treatment of Peripheral Neuropathy[NCT05442021] | 148 participants (Actual) | Interventional | 2022-08-01 | Completed | |||
| The Benefits of Astaxanthin as Add on Therapy in the Management of Painful Diabetic Neuropathy Patient: Randomized Clinical Trial[NCT04689984] | Phase 2/Phase 3 | 60 participants (Anticipated) | Interventional | 2020-11-03 | Recruiting | ||
| Safety and Efficacy of Lidocaine 5% Medicated Plaster in Comparison to Systemic Treatment in Postherpetic Neuralgia and Diabetic Polyneuropathic Pain.[NCT00414349] | Phase 3 | 431 participants (Actual) | Interventional | 2006-12-31 | Completed | ||
| Diode Laser as a Biomarker for Neuropathic Pain of Peripheral Origin.[NCT06030297] | 301 participants (Anticipated) | Interventional | 2022-11-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for lidocaine and Diabetic Neuropathies
| Article | Year |
|---|---|
Intravenous Lidocaine in Chronic Neuropathic Pain: A Systematic Review.
Topics: Adult; Chronic Pain; Diabetic Neuropathies; Humans; Lidocaine; Neuralgia; Peripheral Nerve Injuries; | 2022 |
Treating Painful Diabetic Peripheral Neuropathy: An Update.
Topics: Administration, Topical; Amines; Amitriptyline; Analgesics; Analgesics, Opioid; Anesthetics, Local; | 2016 |
Treating Painful Diabetic Peripheral Neuropathy: An Update.
Topics: Administration, Topical; Amines; Amitriptyline; Analgesics; Analgesics, Opioid; Anesthetics, Local; | 2016 |
Treating Painful Diabetic Peripheral Neuropathy: An Update.
Topics: Administration, Topical; Amines; Amitriptyline; Analgesics; Analgesics, Opioid; Anesthetics, Local; | 2016 |
Treating Painful Diabetic Peripheral Neuropathy: An Update.
Topics: Administration, Topical; Amines; Amitriptyline; Analgesics; Analgesics, Opioid; Anesthetics, Local; | 2016 |
Practical management strategies for the chronic pain patient.
Topics: Administration, Cutaneous; Amines; Analgesics; Antidepressive Agents, Tricyclic; Carbamazepine; Chro | 2007 |
5% lidocaine medicated plaster in painful diabetic peripheral neuropathy (DPN): a systematic review.
Topics: Aged; Anesthetics, Local; Casts, Surgical; Diabetic Neuropathies; Female; Humans; Lidocaine; Male; M | 2010 |
Management strategies for the treatment of neuropathic pain in the elderly.
Topics: Aged; Analgesics, Opioid; Anesthetics, Local; Anticonvulsants; Antidepressive Agents; Capsaicin; Cog | 2002 |
Lidocaine patch 5%.
Topics: Administration, Cutaneous; Anesthetics, Local; Diabetic Neuropathies; Drug Administration Schedule; | 2003 |
Adjuvant analgesics for the treatment of neuropathic pain: evaluating efficacy and safety profiles.
Topics: Administration, Cutaneous; Amines; Analgesics; Analgesics, Opioid; Antidepressive Agents; Arthritis; | 2007 |
Painful diabetic neuropathy.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Diabetic Neuropathies; Humans; Lidoc | 2008 |
Causes of neuropathic pain.
Topics: Animals; Blood Glucose; Diabetic Neuropathies; Humans; Leg; Lidocaine; Mexiletine; Pain; Regional Bl | 1993 |
17 trials available for lidocaine and Diabetic Neuropathies
| Article | Year |
|---|---|
Prediction of Individual Analgesic Response to Intravenous Lidocaine in Painful Diabetic Peripheral Neuropathy: A Randomized, Placebo-controlled, Crossover Trial.
Topics: Analgesics; Anesthetics, Local; Cross-Over Studies; Diabetes Mellitus; Diabetic Neuropathies; Double | 2021 |
Determinants of Treatment Response in Painful Diabetic Peripheral Neuropathy: A Combined Deep Sensory Phenotyping and Multimodal Brain MRI Study.
Topics: Adolescent; Adult; Aged; Brain; Cohort Studies; Diabetic Neuropathies; Female; Humans; Lidocaine; Ma | 2020 |
Intravenous lidocaine in the management of chronic peripheral neuropathic pain: a randomized-controlled trial.
Topics: Aged; Anesthetics, Local; Chronic Pain; Cross-Over Studies; Diabetic Neuropathies; Diphenhydramine; | 2019 |
[Intraosseous blocks in the treatment of symmetrical distal diabetic polyneuropathy].
Topics: Aged; Amitriptyline; Analgesics, Non-Narcotic; Anesthetics, Local; Diabetic Neuropathies; Female; Fo | 2013 |
Effects of a T-type calcium channel blocker, ABT-639, on spontaneous activity in C-nociceptors in patients with painful diabetic neuropathy: a randomized controlled trial.
Topics: Adolescent; Adult; Aged; Calcium Channel Blockers; Diabetic Neuropathies; Double-Blind Method; Femal | 2015 |
Effects of a T-type calcium channel blocker, ABT-639, on spontaneous activity in C-nociceptors in patients with painful diabetic neuropathy: a randomized controlled trial.
Topics: Adolescent; Adult; Aged; Calcium Channel Blockers; Diabetic Neuropathies; Double-Blind Method; Femal | 2015 |
Effects of a T-type calcium channel blocker, ABT-639, on spontaneous activity in C-nociceptors in patients with painful diabetic neuropathy: a randomized controlled trial.
Topics: Adolescent; Adult; Aged; Calcium Channel Blockers; Diabetic Neuropathies; Double-Blind Method; Femal | 2015 |
Effects of a T-type calcium channel blocker, ABT-639, on spontaneous activity in C-nociceptors in patients with painful diabetic neuropathy: a randomized controlled trial.
Topics: Adolescent; Adult; Aged; Calcium Channel Blockers; Diabetic Neuropathies; Double-Blind Method; Femal | 2015 |
Efficacy and safety of 5% lidocaine (lignocaine) medicated plaster in comparison with pregabalin in patients with postherpetic neuralgia and diabetic polyneuropathy: interim analysis from an open-label, two-stage adaptive, randomized, controlled trial.
Topics: Administration, Cutaneous; Administration, Oral; Aged; Analgesics; Anesthetics, Local; Capsules; Dia | 2009 |
Efficacy and safety of combination therapy with 5% lidocaine medicated plaster and pregabalin in post-herpetic neuralgia and diabetic polyneuropathy.
Topics: Aged; Algorithms; Analgesics; Casts, Surgical; Diabetic Neuropathies; Drug Combinations; Female; gam | 2009 |
5% lidocaine medicated plaster versus pregabalin in post-herpetic neuralgia and diabetic polyneuropathy: an open-label, non-inferiority two-stage RCT study.
Topics: Aged; Algorithms; Analgesics; Casts, Surgical; Diabetic Neuropathies; Female; gamma-Aminobutyric Aci | 2009 |
Lidocaine patch 5% with systemic analgesics such as gabapentin: a rational polypharmacy approach for the treatment of chronic pain.
Topics: Acetates; Activities of Daily Living; Aged; Aged, 80 and over; Amines; Analgesics; Anesthetics, Loca | 2003 |
Effectiveness, tolerability, and impact on quality of life of the 5% lidocaine patch in diabetic polyneuropathy.
Topics: Administration, Topical; Analysis of Variance; Diabetic Neuropathies; Dosage Forms; Humans; Lidocain | 2004 |
Effectiveness of the lidocaine patch 5% on pain qualities in three chronic pain states: assessment with the Neuropathic Pain Scale.
Topics: Administration, Cutaneous; Aged; Anesthetics, Local; Chronic Disease; Diabetic Neuropathies; Female; | 2004 |
Symptom profiles differ in patients with neuropathic versus non-neuropathic pain.
Topics: Administration, Topical; Adult; Aged; Anesthetics, Local; Diabetic Neuropathies; Female; Humans; Lid | 2007 |
[Systemic infusion therapy versus retrograde intravenous perfusion: comparative results in patients with diabetic neuropathic plantar ulcer].
Topics: Adult; Anesthesia, Conduction; Chemotherapy, Cancer, Regional Perfusion; Dexamethasone; Diabetic Neu | 1993 |
Drug therapy of diabetic neuropathic foot ulcers: transvenous retrograde perfusion versus systemic regimen.
Topics: Aged; Dexamethasone; Diabetic Neuropathies; Drug Therapy, Combination; Foot Ulcer; Gentamicins; Hepa | 1991 |
The effect of intravenous lidocaine on nociceptive processing in diabetic neuropathy.
Topics: Adult; Diabetic Neuropathies; Double-Blind Method; H-Reflex; Humans; Injections, Intravenous; Lidoca | 1990 |
Treatment of chronic painful diabetic neuropathy with intravenous lidocaine infusion.
Topics: Adult; Chronic Disease; Clinical Trials as Topic; Diabetic Neuropathies; Double-Blind Method; Female | 1986 |
Intravenous lidocaine infusion--a new treatment of chronic painful diabetic neuropathy?
Topics: Adult; Chronic Disease; Diabetic Neuropathies; Double-Blind Method; Female; Humans; Infusions, Intra | 1987 |
23 other studies available for lidocaine and Diabetic Neuropathies
| Article | Year |
|---|---|
Lidocaine Ameliorates Diabetic Peripheral Neuropathy in Streptozotocin-Induced Diabetic Rats through Modulating the c-Jun Signaling Pathway.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Humans; Lidocaine; Rats; Signal Tra | 2022 |
Painful diabetic peripheral neuropathy: real-world comparison between topical treatment with lidocaine 700 mg medicated plaster and oral treatments.
Topics: Analgesics; Cohort Studies; Diabetes Mellitus; Diabetic Neuropathies; Humans; Lidocaine; Neuralgia, | 2022 |
Pharmacodynamics and Pharmacokinetics of Lidocaine in a Rodent Model of Diabetic Neuropathy.
Topics: Anesthetics, Local; Animals; Diabetic Neuropathies; Disease Models, Animal; Lidocaine; Male; Nerve B | 2018 |
CT-Guided Consecutive Neurolytic Celiac Plexus Block for the Management of Refractory Abdominal Neuralgia Caused by Diabetic Neuropathy.
Topics: Abdomen; Abdominal Pain; Anesthetics, Local; Autonomic Nerve Block; Celiac Plexus; Diabetes Mellitus | 2018 |
Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade.
Topics: Adult; Aged; Anesthetics, Local; Animals; Antineoplastic Agents; Capsaicin; Diabetic Neuropathies; F | 2015 |
Lidocaine attenuates the development of diabetic-induced tactile allodynia by inhibiting microglial activation.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Cells, Cultured; Chemokine CCL2; Chemotaxis; Diabetes | 2011 |
Antinociceptive activities of lidocaine and the nav1.8 blocker a803467 in diabetic rats.
Topics: Analgesics; Aniline Compounds; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Fema | 2012 |
[Not only diabetics have experienced the pain... distressing neuralgia].
Topics: Acyclovir; Aged; Analgesics, Opioid; Anesthesia, Local; Anticonvulsants; Antidepressive Agents, Tric | 2004 |
Effectiveness of lidocaine patch 5% in patients with or without allodynia.
Topics: Administration, Cutaneous; Anesthetics, Local; Diabetic Neuropathies; Humans; Hyperalgesia; Lidocain | 2006 |
Subcutaneous blood flow during insulin-induced hypoglycaemia: studies in juvenile diabetics with and without autonomic neuropathy and in normal subjects.
Topics: Adult; Ankle; Blood Circulation; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Neuropathies; He | 1982 |
[Intravenous lidocaine in the treatment of post treatment neuropathy].
Topics: Administration, Oral; Aged; Diabetes Mellitus; Diabetic Neuropathies; Drug Therapy, Combination; Hum | 1994 |
Study of the sensitivity of the diabetes-induced pain model in rats to a range of analgesics.
Topics: Analgesics; Animals; Antidepressive Agents, Tricyclic; Aspirin; Clonidine; Diabetes Mellitus, Experi | 1994 |
Does diabetes reduce local anesthetic requirement?
Topics: Anesthetics, Local; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response R | 1993 |
[Therapeutic trials with topical capsaicin cream and iontophoretically applied lidocaine for diabetic painful truncal neuropathy].
Topics: Capsaicin; Diabetic Neuropathies; Humans; Hyperesthesia; Iontophoresis; Lidocaine; Male; Middle Aged | 1996 |
Conus medullaris injury following both tetracaine and lidocaine spinal anesthesia.
Topics: Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Cauda Equina; Circumcision, Male; Diabetes Mell | 1996 |
Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine.
Topics: Aldehyde Reductase; Anesthetics, Local; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dia | 1996 |
[Effect of mexiletine on spontaneous sensory afferent activity in spontaneous diabetic rats (WBN/Kob rats)].
Topics: Action Potentials; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Depression, Chemical; Diabet | 2000 |
Pain behavior and response properties of spinal dorsal horn neurons following experimental diabetic neuropathy in the rat: modulation by nitecapone, a COMT inhibitor with antioxidant properties.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analysis of Variance; Anesthetics, Local; Animals; Antioxid | 2001 |
[Treatment of pain in diabetic polyneuropathy].
Topics: Analgesics; Antidepressive Agents; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Carbamaze | 1991 |
The management of oral mexiletine and intravenous lidocaine to treat chronic painful symmetrical distal diabetic neuropathy.
Topics: Chronic Disease; Diabetic Neuropathies; Drug Therapy, Combination; Female; Humans; Infusions, Intrav | 1991 |
On "The effect of intravenous lidocaine on nociceptive processing in diabetic neuropathy" by Bach et al. in Pain, 40 (1990) 29-34.
Topics: Diabetic Neuropathies; Humans; Injections, Intravenous; Lidocaine; Nociceptors; Pain | 1991 |
Intravenous lidocaine and cerebral blood flow: impaired microvascular reactivity in diabetic patients.
Topics: Adult; Blood Pressure; Cerebrovascular Circulation; Diabetes Mellitus, Type 1; Diabetic Neuropathies | 1990 |
Lidocaine treatment of painful diabetic neuropathy and endogenous opioid peptides in plasma.
Topics: Adult; beta-Endorphin; Diabetic Neuropathies; Dynorphins; Endorphins; Female; Humans; Lidocaine; Mal | 1989 |