lidocaine and Dehydration studies

Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.

Dehydration: The condition that results from excessive loss of water from a living organism.

Research Excerpts

Excerpt	Relevance	Reference
"An 81-year-old woman developed pilsicainide intoxication associated with dehydration."	7.70	Pilsicainide intoxication in a patient with dehydration. ( Matsuo, S; Ozeki, S; Utsunomiya, T; Yano, K, 1999)
"This is a secondary analysis of a randomized placebo-controlled trial of viscous lidocaine versus placebo in children aged 6 months to 8 years with acute infectious ulcerative mouth conditions (gingivostomatitis, ulcerative pharyngitis, or hand foot and mouth disease) and poor oral fluid intake."	5.24	What do Clinicians Perceive as a Successful "Trial of Fluids"?: A Secondary Assessment of a Randomized Controlled Trial. ( Babl, FE; Hopper, SM; Lee, KJ; McCarthy, M; Orsini, F; Tancharoen, C, 2017)
"An 81-year-old woman developed pilsicainide intoxication associated with dehydration."	3.70	Pilsicainide intoxication in a patient with dehydration. ( Matsuo, S; Ozeki, S; Utsunomiya, T; Yano, K, 1999)
" The present study aimed to investigate the effect of dehydration and hyperosmolal hydration on the disposition of lignocaine and two of its metabolites, monoethylglycinexylidide (MEGX) and glycinexylidide (GX)."	3.69	Effect of dehydration and hyperosmolal hydration on lignocaine and metabolites disposition in conscious rabbits. ( Chamelian, M; du Souich, P; Lécrivain, A; Robichaud, A, 1994)
"Lidocaine was administered intravenously at a dose of 1 mg/kg to adult female camels when water was given ad libitum (stage 1) and to the same camels after 14 days of dehydration."	2.68	Lidocaine elimination and monoethylglycinexylidide formation in the dehydrated camel. ( Ben-Zvi, Z; Goldin, G; Van Creveld, C; Yagil, R, 1995)
"The elderly patients are susceptible to acute renal failure due to dehydration or infection."	1.36	[Two elderly case reports of renal excretion type drug poisoning caused by dehydration that was due to poor eating in home care]. ( Doi, S; Hata, A; Hinokiyama, H; Ibata, T; Iijima, H; Komuro, R; Mito, S; Nakashita, C; Sato, M; Shiki, S, 2010)
"Hexamethonium and atropine were used to study the importance of the autonomic nervous system in bowel obstruction."	1.29	Small-bowel obstruction and the effects of lidocaine, atropine and hexamethonium on inflammation and fluid losses. ( Bojö, L; Cassuto, J; Jönsson, A; Nellgård, P; Tarnow, P, 1996)

Research

Studies (8)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Median Number of Pain Medication Doses

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	5 (62.50)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (37.50)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Hopper, SM	1
McCarthy, M	1
Tancharoen, C	1
Lee, KJ	1
Orsini, F	1
Babl, FE	1
Ibata, T	1
Hinokiyama, H	1
Nakashita, C	1
Mito, S	1
Doi, S	1
Shiki, S	1
Hata, A	1
Sato, M	1
Komuro, R	1
Iijima, H	1
Moss, JR	1
Cofer, S	1
Hersey, S	1
Goudy, S	1
Werkhaven, J	1
Swanson, E	1
Mantle, C	1
Stowell, N	1
Byrne, D	1
Wang, L	1
Labadie, R	1
Chamelian, M	1
Lécrivain, A	1
Robichaud, A	1
du Souich, P	1
Tonelli, L	1
Chiaraviglio, E	1
Nellgård, P	1
Jönsson, A	1
Bojö, L	1
Tarnow, P	1
Cassuto, J	1
Ben-Zvi, Z	1
Goldin, G	1
Van Creveld, C	1
Yagil, R	1
Ozeki, S	1
Utsunomiya, T	1
Matsuo, S	1
Yano, K	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Pediatric Tonsillectomy Pain Reduction Study, a Randomized, Placebo Controlled, Double-Blind Clinical Trial Using Clonidine and Local Anesthetics[NCT00678379]	Phase 3	120 participants (Actual)	Interventional	2008-04-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

The median number of intravenous fentanyl doses administered in the PACU due to pain (NCT00678379)
Timeframe: in recovery room

Total Number of Post-operative Doses of Analgesics.

Intervention	number of doses (Median)
Normal Saline	3.0
Lidocaine (1%) + Bupivacaine 0.5%	3
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	3

The total number of intravenous fentanyl doses given PACU which will be compared between the three randomized groups (arms) (NCT00678379)
Timeframe: Post-operative thru day 7

Total Time Until Discharge From Hospital.

Mean Visual Analog Scale Pain Number.

Intervention	number of doses (Median)
Normal Saline	12
Lidocaine (1%) + Bupivacaine 0.5%	12
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	14

Intervention	minutes (Median)
Normal Saline	122
Lidocaine (1%) + Bupivacaine 0.5%	111
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	120

Visual analog pain scale range is 0-10 with 0=no pain and 10 = worst pain ever (NCT00678379)
Timeframe: in recovery room; post-operative days 1,3,5 & 7

Number and Percent of Participants Able to Tolerate a Regular Diet

Intervention	pain score (Mean)
	In recovery room	day 1	day 3	day 5	day 7
Lidocaine (1%) + Bupivacaine 0.5%	3	4	2.5	2	2
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	3	5	3	3	2
Normal Saline	3	3	3	3	2.5

The number and percent of patients whose post-operative diet has to a regular diet on post-operative days 1, 3, 5 & 7 (NCT00678379)
Timeframe: post-operative days 1,3,5 & 7.

Number and Percent of Participants Able to Tolerate Only a Soft Diet

Intervention	Participants (Count of Participants)
	post-op day 1	post-op day 3	post op day 5	post op day 7
Lidocaine (1%) + Bupivacaine 0.5%	4	8	18	26
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	1	12	14	22
Normal Saline	7	18	21	24

The number and percent of patients whose post-operative diet has only advanced to a soft diet on post-operative days 1, 3, 5 & 7 (NCT00678379)
Timeframe: post-operative days 1,3,5 & 7.

Number and Percent of Participants Able to Tolerate Only Liquids

Intervention	Participants (Count of Participants)
	post-op day 1	post-op day 3	post op day 5	post op day 7
Lidocaine (1%) + Bupivacaine 0.5%	22	26	17	10
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	26	18	18	14
Normal Saline	26	18	13	13

The number and percent of patients whose post-operative diet has advanced to liquids only on post-op days 1, 3, 5 & 7 (NCT00678379)
Timeframe: post-operative days 1,3,5 & 7.

Article	Year
What do Clinicians Perceive as a Successful "Trial of Fluids"?: A Secondary Assessment of a Randomized Controlled Trial. Pediatric emergency care, 2017, Volume: 33, Issue:4 Topics: Child; Child, Preschool; Dehydration; Female; Fluid Therapy; Hand, Foot and Mouth Disease; Humans; I	2017
Comparison of clonidine, local anesthetics, and placebo for pain reduction in pediatric tonsillectomy. Archives of otolaryngology--head & neck surgery, 2011, Volume: 137, Issue:6 Topics: Adenoids; Adolescent; Age Factors; Analgesics; Anesthetics, Local; Bupivacaine; Child; Child, Presch	2011
Lidocaine elimination and monoethylglycinexylidide formation in the dehydrated camel. Journal of veterinary pharmacology and therapeutics, 1995, Volume: 18, Issue:6 Topics: Anesthetics, Local; Animals; Biotransformation; Camelus; Cross-Over Studies; Cytochrome P-450 Enzyme	1995

Article	Year
[Two elderly case reports of renal excretion type drug poisoning caused by dehydration that was due to poor eating in home care]. Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37 Suppl 2 Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dehydrat	2010
Effect of dehydration and hyperosmolal hydration on lignocaine and metabolites disposition in conscious rabbits. British journal of pharmacology, 1994, Volume: 113, Issue:1 Topics: Animals; Arginine Vasopressin; Atrial Natriuretic Factor; Dehydration; Dinoprostone; Lidocaine; Male	1994
Enhancement of water intake in rats after lidocaine injection in the zona incerta. Brain research bulletin, 1993, Volume: 31, Issue:1-2 Topics: Angiotensin II; Animals; Brain; Dehydration; Drinking; Injections; Injections, Intravenous; Lidocain	1993
Small-bowel obstruction and the effects of lidocaine, atropine and hexamethonium on inflammation and fluid losses. Acta anaesthesiologica Scandinavica, 1996, Volume: 40, Issue:3 Topics: Administration, Topical; Anesthetics, Local; Animals; Anti-Inflammatory Agents; Atropine; Coloring A	1996
Pilsicainide intoxication in a patient with dehydration. Japanese circulation journal, 1999, Volume: 63, Issue:3 Topics: Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Dehydration; Electrocardiograp	1999

lidocaine and Dehydration