lidocaine has been researched along with Chemical and Drug Induced Liver Injury in 23 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report, for the first time to our knowledge, heart failure and liver abnormalities which developed after 2 months of treatment with tocainide." | 7.67 | Heart failure and hepatitis in a patient taking tocainide. ( Hertzberger, DH; Nauta, IL; Rensing, JB; Ruland, CM, 1984) |
| " A 41-year-old man developed a fever and liver injury after undergoing internal hemorrhoid treatment with a submucosal injection of ALTA with lidocaine." | 3.85 | Liver injury after aluminum potassium sulfate and tannic acid treatment of hemorrhoids. ( Akasu, T; Fushiya, N; Hagiwara, N; Hirose, Y; Imai, N; Iwaku, A; Kawashima, R; Kijima, H; Kinoshita, A; Kobayashi, G; Kobayashi, H; Koike, K; Saruta, M; Shibata, K; Yokota, T; Yoshikawa, K, 2017) |
| "We report, for the first time to our knowledge, heart failure and liver abnormalities which developed after 2 months of treatment with tocainide." | 3.67 | Heart failure and hepatitis in a patient taking tocainide. ( Hertzberger, DH; Nauta, IL; Rensing, JB; Ruland, CM, 1984) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| " 4-compartment model was introduced to analyze pharmacokinetic parameters, and which gave the most reasonable fit with actual results." | 1.28 | [Pharmacokinetics of lidocaine and its metabolites in dog. Comparison between normal and CCl4-induced hepatic lesion]. ( Yamane, J, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (52.17) | 18.7374 |
| 1990's | 1 (4.35) | 18.2507 |
| 2000's | 2 (8.70) | 29.6817 |
| 2010's | 8 (34.78) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Morgan, RE | 2 |
| Trauner, M | 1 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Yoshikawa, K | 1 |
| Kawashima, R | 1 |
| Hirose, Y | 1 |
| Shibata, K | 1 |
| Akasu, T | 1 |
| Hagiwara, N | 1 |
| Yokota, T | 1 |
| Imai, N | 1 |
| Iwaku, A | 1 |
| Kobayashi, G | 1 |
| Kobayashi, H | 1 |
| Kinoshita, A | 1 |
| Fushiya, N | 1 |
| Kijima, H | 1 |
| Koike, K | 1 |
| Saruta, M | 1 |
| Yokogawa, K | 1 |
| Watanabe, M | 1 |
| Takeshita, H | 1 |
| Nomura, M | 1 |
| Mano, Y | 1 |
| Miyamoto, K | 1 |
| Saranteas, T | 1 |
| Mourouzis, C | 1 |
| Anagnostopoulou, S | 1 |
| Danis, K | 1 |
| Tachmintzis, A | 1 |
| Rallis, G | 1 |
| Nauta, IL | 1 |
| Ruland, CM | 1 |
| Hertzberger, DH | 1 |
| Rensing, JB | 1 |
| Farquhar, DL | 1 |
| Davidson, NM | 1 |
| Freeman, RW | 1 |
| Harbison, RD | 1 |
| Fuchshofen, M | 1 |
| Heusler, H | 1 |
| Lutz, B | 1 |
| Mora, E | 1 |
| Richter, E | 1 |
| Uematsu, H | 1 |
| Hiei, K | 1 |
| Kawasaki, H | 1 |
| Colgan, FJ | 1 |
| Prescott, LF | 1 |
| Forrest, JA | 1 |
| Adjepon-Yamoah, KK | 1 |
| Finlayson, ND | 1 |
| Yamane, J | 2 |
| Chindavijak, B | 1 |
| Belpaire, FM | 1 |
| Bogaert, MG | 1 |
| Tucker, LE | 1 |
| Fujii, A | 1 |
| Kobayashi, S | 1 |
| Tamura, T | 1 |
| Farber, HI | 1 |
| McCarthy, JD | 1 |
| Picazo, JG | 1 |
3 reviews available for lidocaine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Problems with postoperative drug therapy.
Topics: Anesthesia; Anesthetics; Anti-Arrhythmia Agents; Chemical and Drug Induced Liver Injury; Drug Therap | 1977 |
Drug metabolism in liver disease.
Topics: Acetaminophen; Acute Disease; Antipyrine; Chemical and Drug Induced Liver Injury; Chronic Disease; H | 1975 |
20 other studies available for lidocaine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Liver injury after aluminum potassium sulfate and tannic acid treatment of hemorrhoids.
Topics: Adult; Alum Compounds; Chemical and Drug Induced Liver Injury; Fever; Hemorrhoids; Humans; Injection | 2017 |
Serum aminotransferase activity as a predictor of clearance of drugs metabolized by CYP isoforms in rats with acute hepatic failure induced by carbon tetrachloride.
Topics: Animals; Area Under Curve; Caffeine; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver | 2004 |
(14)C-lidocaine disposition in serum and tissues of normal and liver diseased rats.
Topics: Anesthetics, Local; Animals; Carbon Radioisotopes; Carbon Tetrachloride; Chemical and Drug Induced L | 2006 |
Heart failure and hepatitis in a patient taking tocainide.
Topics: Amiodarone; Chemical and Drug Induced Liver Injury; Heart Failure; Humans; Lidocaine; Liver Function | 1984 |
Possible hepatoxicity of tocainide.
Topics: Anti-Arrhythmia Agents; Chemical and Drug Induced Liver Injury; Female; Humans; Lidocaine; Liver; Mi | 1984 |
The role of benzoylmethylecgonine in cocaine-induced hepatotoxicity.
Topics: Alanine Transaminase; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Cocaine; L | 1981 |
[Lidocain clearance after oral and intravenous application in rats with low grade ANIT-cholestasis and galactosamine-induced hepatitis (author's transl)].
Topics: 1-Naphthylisothiocyanate; Administration, Oral; Animals; Biological Availability; Chemical and Drug | 1980 |
[Unknown fever and abnormal liver functions after repeated epidural blocks with lidocaine for management of herpes zoster pain].
Topics: Aged; Analgesia, Epidural; Chemical and Drug Induced Liver Injury; Female; Fever of Unknown Origin; | 1994 |
[Pharmacokinetics of lidocaine and its metabolites in dog. Comparison between normal and CCl4-induced hepatic lesion].
Topics: Animals; Chemical and Drug Induced Liver Injury; Dogs; Lidocaine | 1989 |
In-vitro biotransformation of antipyrine, lignocaine and propranolol in the liver of rats with turpentine-induced inflammation.
Topics: Aminopyrine N-Demethylase; Animals; Antipyrine; Biotransformation; Chemical and Drug Induced Liver I | 1987 |
Tocainide-induced granulomatous hepatitis.
Topics: Anti-Arrhythmia Agents; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Granuloma; Hu | 1986 |
[Acute toxicity of local anesthetic in rats bearing carbon tetrachloride-induced hepatic lesion].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry | 1988 |
Fever, vomiting, and liver dysfunction with procainamide therapy.
Topics: Ampicillin; Blood; Chemical and Drug Induced Liver Injury; Digitalis; Drug Hypersensitivity; Female; | 1974 |
Lidocaine in the common bile duct. Effects and possible toxicity.
Topics: Ampulla of Vater; Chemical and Drug Induced Liver Injury; Female; Gallstones; Humans; Injections; Li | 1969 |