lidocaine has been researched along with Central Nervous System Diseases in 22 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Central Nervous System Diseases: Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this randomized, double-blind trial, we compared parenteral amiodarone, lidocaine, and saline placebo, along with standard care, in adults who had nontraumatic out-of-hospital cardiac arrest, shock-refractory ventricular fibrillation or pulseless ventricular tachycardia after at least one shock, and vascular access." | 9.22 | Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest. ( Aufderheide, TP; Brienza, AM; Brown, SP; Callaway, CW; Christenson, J; Colella, MR; Daya, M; Desvigne-Nickens, P; Dorian, P; Dunford, JV; Egan, D; Gray, PC; Gray, R; Idris, AH; Kudenchuk, PJ; Leroux, B; Morrison, LJ; Nichol, G; Ornato, JP; Rea, T; Seals, N; Stiell, IG; Straight, R; Vaillancourt, C; Vilke, GM; Weisfeldt, ML; Wittwer, L, 2016) |
| "In this study, 8 patients with central pain syndromes, 6 with hemispheric lesions, and 2 with spinal cord lesions were treated with a 1 mg/kg dose of intravenous lidocaine." | 7.68 | Response of central pain syndromes to intravenous lidocaine. ( Backonja, M; Gombar, KA, 1992) |
| " Minor central nervous system side effects were seen in 2 patients and dermatologic adverse reaction was seen in one patient only." | 6.66 | Efficacy and safety of oral tocainide in refractory ventricular arrhythmia: a preliminary report on an open label study. ( Mahapatra, D; Mahapatra, RK, 1986) |
| "In this randomized, double-blind trial, we compared parenteral amiodarone, lidocaine, and saline placebo, along with standard care, in adults who had nontraumatic out-of-hospital cardiac arrest, shock-refractory ventricular fibrillation or pulseless ventricular tachycardia after at least one shock, and vascular access." | 5.22 | Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest. ( Aufderheide, TP; Brienza, AM; Brown, SP; Callaway, CW; Christenson, J; Colella, MR; Daya, M; Desvigne-Nickens, P; Dorian, P; Dunford, JV; Egan, D; Gray, PC; Gray, R; Idris, AH; Kudenchuk, PJ; Leroux, B; Morrison, LJ; Nichol, G; Ornato, JP; Rea, T; Seals, N; Stiell, IG; Straight, R; Vaillancourt, C; Vilke, GM; Weisfeldt, ML; Wittwer, L, 2016) |
| "In this study, 8 patients with central pain syndromes, 6 with hemispheric lesions, and 2 with spinal cord lesions were treated with a 1 mg/kg dose of intravenous lidocaine." | 3.68 | Response of central pain syndromes to intravenous lidocaine. ( Backonja, M; Gombar, KA, 1992) |
| "In various chronic painful states, the sympathetic nerve supply was blocked either by injecting the sympathetic chain and ganglia with local anaesthesia or by the injection of guanethidine during occlusion of the circulation." | 3.66 | Painful peripheral states and sympathetic blocks. ( Loh, L; Nathan, PW, 1978) |
| "Lidocaine 2% was administered to eight dogs before surgery in differing amounts, depending on the volume of the joints involved, and blood samples were taken at predetermined time points." | 2.80 | Intra-articular administration of lidocaine in anaesthetized dogs: pharmacokinetic profile and safety on cardiovascular and nervous systems. ( Bufalari, A; Cagnardi, P; Catanzaro, A; De Monte, V; Della Rocca, G; Di Salvo, A; Marenzoni, ML; Vigorito, V, 2015) |
| " Minor central nervous system side effects were seen in 2 patients and dermatologic adverse reaction was seen in one patient only." | 2.66 | Efficacy and safety of oral tocainide in refractory ventricular arrhythmia: a preliminary report on an open label study. ( Mahapatra, D; Mahapatra, RK, 1986) |
| " We also observed animals for electrocardiographic evidence of toxic effects on cardiac automaticity, conductivity, and rhythmicity." | 1.37 | A comparison of the systemic toxicity of lidocaine versus its quaternary derivative QX-314 in mice. ( Cheung, HM; Lee, SM; MacLeod, BA; Ries, CR; Schwarz, SK, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (59.09) | 18.7374 |
| 1990's | 2 (9.09) | 18.2507 |
| 2000's | 2 (9.09) | 29.6817 |
| 2010's | 5 (22.73) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Di Salvo, A | 1 |
| Bufalari, A | 1 |
| De Monte, V | 1 |
| Cagnardi, P | 1 |
| Marenzoni, ML | 1 |
| Catanzaro, A | 1 |
| Vigorito, V | 1 |
| Della Rocca, G | 1 |
| Kudenchuk, PJ | 1 |
| Brown, SP | 1 |
| Daya, M | 1 |
| Rea, T | 1 |
| Nichol, G | 1 |
| Morrison, LJ | 1 |
| Leroux, B | 1 |
| Vaillancourt, C | 1 |
| Wittwer, L | 1 |
| Callaway, CW | 1 |
| Christenson, J | 1 |
| Egan, D | 1 |
| Ornato, JP | 1 |
| Weisfeldt, ML | 1 |
| Stiell, IG | 1 |
| Idris, AH | 1 |
| Aufderheide, TP | 1 |
| Dunford, JV | 1 |
| Colella, MR | 1 |
| Vilke, GM | 1 |
| Brienza, AM | 1 |
| Desvigne-Nickens, P | 1 |
| Gray, PC | 1 |
| Gray, R | 1 |
| Seals, N | 1 |
| Straight, R | 1 |
| Dorian, P | 1 |
| Cheung, HM | 1 |
| Lee, SM | 1 |
| MacLeod, BA | 1 |
| Ries, CR | 1 |
| Schwarz, SK | 1 |
| Sambrook, PJ | 1 |
| Smith, W | 1 |
| Elijah, J | 1 |
| Goss, AN | 1 |
| Lange, DB | 1 |
| Schwartz, D | 1 |
| DaRoza, G | 1 |
| Gair, R | 1 |
| Brosh-Nissimov, T | 1 |
| Ingbir, M | 1 |
| Weintal, I | 1 |
| Fried, M | 1 |
| Porat, R | 1 |
| Bithal, PK | 1 |
| Pandia, MP | 1 |
| Chaturvedi, A | 1 |
| Radhakrishnan, M | 1 |
| Prabhakar, H | 1 |
| Sharma, D | 1 |
| Backonja, M | 1 |
| Gombar, KA | 1 |
| Selden, R | 1 |
| Sasahara, AA | 1 |
| Kalso, E | 1 |
| Rosenberg, PH | 1 |
| Bryant, CA | 1 |
| Hoffman, JR | 1 |
| Nichter, LS | 1 |
| Bishop, D | 1 |
| Johnstone, RE | 1 |
| Loh, L | 1 |
| Nathan, PW | 1 |
| Mahapatra, RK | 1 |
| Mahapatra, D | 1 |
| Covino, BG | 1 |
| Swan, HJ | 1 |
| Bleifeld, W | 1 |
| Merx, W | 1 |
| Effert, S | 1 |
| Harrison, DC | 1 |
| Collinsworth, KA | 1 |
| Gueyé, SN | 1 |
| Dosseh, B | 1 |
| Geddes, IC | 1 |
| Krenis, LJ | 1 |
| Liu, PL | 1 |
| Ngai, SH | 1 |
| Coyas, A | 1 |
| Bossinacou, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Amiodarone, Lidocaine or Neither for Out-Of-Hospital Cardiac Arrest Due to Ventricular Fibrillation (VF) or Ventricular Tachycardia (VT)[NCT01401647] | Phase 3 | 3,024 participants (Actual) | Interventional | 2012-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Neurologic status at discharge will be assessed using the modified Rankin Score (MRS). A higher value indicates a worse outcome. 0-No symptoms at all; 1-No significant disability despite symptoms; able to carry out all usual duties and activities, 2-Slight disability; unable to carry out all previous activities, but able to look after own affairs without assistance, 3-Moderate disability; requiring some help, but able to walk without assistance; 4-Moderately severe disability; unable to walk without assistance and unable to attend to own bodily needs without assistance, 5-Severe disability; bedridden, incontinent and requiring constant nursing care and attention; 6-Dead (NCT01401647)
Timeframe: Patients will be followed from the time of the cardiac arrest until death, hospital discharge, or December 31, 2015, whichever occurs first.
| Intervention | Participants (Count of Participants) |
|---|---|
| Amiodarone | 182 |
| Lidocaine | 172 |
| Normal Saline | 175 |
Patients may die in the field (outside of the hospital at the time of the cardiac arrest), at the emergency room, in the hospital, or they are discharged alive from the hospital. (NCT01401647)
Timeframe: Patients will be followed from the time of the cardiac arrest until death, hospital discharge, or December 31, 2015, whichever occurs first.
| Intervention | participants (Number) |
|---|---|
| Amiodarone | 237 |
| Lidocaine | 233 |
| Normal Saline | 222 |
3 reviews available for lidocaine and Central Nervous System Diseases
| Article | Year |
|---|---|
Bupivacaine and intravenous regional anaesthesia--a matter of controversy.
Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Bupivacaine; Central Nervous System Diseases; Human | 1984 |
Recent advances in local anaesthesia.
Topics: Acidosis; Anesthesia, Local; Anesthetics, Local; Animals; Arrhythmias, Cardiac; Bupivacaine; Cardiov | 1986 |
Antiarrhythmic actions of lidocaine.
Topics: Action Potentials; Animals; Cell Membrane; Central Nervous System Diseases; Digitalis; Drug Interact | 1974 |
4 trials available for lidocaine and Central Nervous System Diseases
| Article | Year |
|---|---|
Intra-articular administration of lidocaine in anaesthetized dogs: pharmacokinetic profile and safety on cardiovascular and nervous systems.
Topics: Anesthesia, General; Anesthetics, Local; Animals; Area Under Curve; Cardiovascular Diseases; Central | 2015 |
Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest.
Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Cardiopulmonary Resuscitation; Central Nervous Syst | 2016 |
Lidocaine infiltration of the scalp does not completely abolish increased intraocular pressure due to skull pin insertion.
Topics: Adult; Anesthetics, Local; Blood Pressure; Central Nervous System Diseases; Female; Heart Rate; Huma | 2006 |
Efficacy and safety of oral tocainide in refractory ventricular arrhythmia: a preliminary report on an open label study.
Topics: Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Central Nervous Sy | 1986 |
15 other studies available for lidocaine and Central Nervous System Diseases
| Article | Year |
|---|---|
A comparison of the systemic toxicity of lidocaine versus its quaternary derivative QX-314 in mice.
Topics: Anesthetics, Local; Animals; Central Nervous System Diseases; Dose-Response Relationship, Drug; Elec | 2011 |
Severe adverse reactions to dental local anaesthetics: systemic reactions.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Anesthesia, Den | 2011 |
Use of intravenous lipid emulsion to reverse central nervous system toxicity of an iatrogenic local anesthetic overdose in a patient on peritoneal dialysis.
Topics: Adult; Anesthetics, Local; Central Nervous System Diseases; Drug Overdose; Fat Emulsions, Intravenou | 2012 |
Central nervous system toxicity following topical skin application of lidocaine.
Topics: Administration, Topical; Adult; Anesthetics, Local; Central Nervous System Diseases; Dose-Response R | 2004 |
Response of central pain syndromes to intravenous lidocaine.
Topics: Adult; Aged; Central Nervous System Diseases; Female; Humans; Injections, Intravenous; Lidocaine; Ma | 1992 |
Central nervous system toxicity induced by lidocaine. Report of a case in a patient with liver disease.
Topics: Adult; Central Nervous System Diseases; Humans; Injections, Intravenous; Lidocaine; Liver Cirrhosis; | 1967 |
Pitfalls and perils of intravenous lidocaine.
Topics: Aged; Central Nervous System Diseases; Female; Humans; Injections, Intravenous; Lidocaine | 1983 |
Lidocaine toxicity treated with low-dose propofol.
Topics: Aged; Central Nervous System Diseases; Dose-Response Relationship, Drug; Endarterectomy, Carotid; Hu | 1993 |
Painful peripheral states and sympathetic blocks.
Topics: Anesthesia, Local; Bupivacaine; Central Nervous System Diseases; Differential Threshold; Female; Gua | 1978 |
Cooperative study on cardiac catheterization. Complications involving the nervous system.
Topics: Adolescent; Adult; Angiocardiography; Cardiac Catheterization; Central Nervous System Diseases; Chil | 1968 |
[Clinical pharmacology and adverse effects of various anti-arrhythmic drugs].
Topics: Adrenergic beta-Antagonists; Aged; Anti-Arrhythmia Agents; Bone Marrow Diseases; Central Nervous Sys | 1971 |
[Complications of local anesthesia using lignocaine].
Topics: Adult; Anesthesia, Local; Central Nervous System Diseases; Child; Coma; Developing Countries; Female | 1972 |
Local anaesthetics.
Topics: Amides; Anesthetics, Local; Brain Edema; Cardiovascular Diseases; Central Nervous System Diseases; C | 1971 |
The effect of local anesthetics on the central nervous system toxicity of hyperbaric oxygen.
Topics: Animals; Brain Chemistry; Central Nervous System Diseases; Cocaine; Dopamine; Hyperbaric Oxygenation | 1971 |
Xylocaine and its effect on vertigo.
Topics: Ankylosis; Central Nervous System Diseases; Cervical Vertebrae; Humans; Lidocaine; Meniere Disease; | 1969 |