lidocaine has been researched along with Cancer of Head in 18 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the effect of doxepin mouthwash or diphenhydramine-lidocaine-antacid mouthwash for the treatment of oral mucositis-related pain." | 9.30 | Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial. ( Curtis, A; Ko, SJ; Le-Rademacher, JG; Leenstra, JL; Loprinzi, CL; Martenson, JA; Miller, RC; Novotny, PJ; Qin, R; Reiter, PL; Rine, G; Singh, AK; Sio, TT; Tan, AD, 2019) |
| " Based on the clinical evidence of pain alleviation by topical morphine in patients with some inflammatory and painful conditions, a clinical study was undertaken to determine this effect on mucositis-associated pain." | 9.10 | Effect of topical morphine for mucositis-associated pain following concomitant chemoradiotherapy for head and neck carcinoma. ( Bonomi, MR; Cerchietti, LC; Menéndez, PR; Navigante, AH; Pogany, CE; Roth, BM; Zaderajko, MA, 2002) |
| "To evaluate the effect of doxepin mouthwash or diphenhydramine-lidocaine-antacid mouthwash for the treatment of oral mucositis-related pain." | 5.30 | Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial. ( Curtis, A; Ko, SJ; Le-Rademacher, JG; Leenstra, JL; Loprinzi, CL; Martenson, JA; Miller, RC; Novotny, PJ; Qin, R; Reiter, PL; Rine, G; Singh, AK; Sio, TT; Tan, AD, 2019) |
| " Based on the clinical evidence of pain alleviation by topical morphine in patients with some inflammatory and painful conditions, a clinical study was undertaken to determine this effect on mucositis-associated pain." | 5.10 | Effect of topical morphine for mucositis-associated pain following concomitant chemoradiotherapy for head and neck carcinoma. ( Bonomi, MR; Cerchietti, LC; Menéndez, PR; Navigante, AH; Pogany, CE; Roth, BM; Zaderajko, MA, 2002) |
| "To report a case of complete upper airway obstruction after topicalization with lidocaine in a completely conscious patient with partial upper airway obstruction." | 3.72 | Total airway obstruction during local anesthesia in a non-sedated patient with a compromised airway. ( Chung, DC; Ho, AM; Karmakar, MK; To, EW, 2004) |
| "Treatment of postoperative pain after ear, nose and throat (ENT) cancer surgery is mainly morphine administration." | 3.11 | Effect of intravenous lidocaine on pain after head and neck cancer surgery (ELICO trial): A randomised controlled trial. ( Aubrun, F; Axiotis, G; Bauer, C; Erbacher, J; Omar, E; Soubirou, JL; Thevenon, S; Wallon, G, 2022) |
| "Pain after major head and neck cancer surgery is underestimated and has both nociceptive and neuropathic characteristics." | 2.90 | Evaluation of intravenous lidocaine in head and neck cancer surgery: study protocol for a randomized controlled trial. ( Aubrun, F; Axiotis, G; Bauer, C; Bouix, C; Omar, E; Soubirou, JL; Wallon, G, 2019) |
| "Three patients with head and neck schwannomas underwent a diagnostic procedure hypothesised to identify the nerve of origin." | 1.48 | A novel technique to identify the nerve of origin in head and neck schwannomas. ( Ching, HH; Reeve, NH; Spinner, AG; Wang, RC, 2018) |
| "Intracutaneous lidocaine is used for anesthesia in dermatologic surgery for skin cancer excision and repair with exceedingly low incidence of reported adverse events." | 1.43 | Safety of Local Intracutaneous Lidocaine Anesthesia Used by Dermatologic Surgeons for Skin Cancer Excision and Postcancer Reconstruction: Quantification of Standard Injection Volumes and Adverse Event Rates. ( Alam, M; Fosko, SW; Geisler, A; Poon, E; Schaeffer, MR; Srivastava, D, 2016) |
| "A patient with extensive metastatic thyroid cancer scheduled for palliative tracheostomy is presented." | 1.30 | Percutaneous dilatational tracheostomy in a patient with thyroid cancer and severe airway obstruction. ( Aadahl, P; Nordgård, S, 1999) |
| "Lidocaine did not increase directly BLM A2-induced breakage of DNA in vitro as measured by loss of form I pAT 153 DNA, but it did increase BLM A2-induced DNA strand breaks in intact L1210 cells coincubated with lidocaine and BLM A2." | 1.27 | Lidocaine potentiation of bleomycin A2 cytotoxicity and DNA strand breakage in L1210 and human A-253 cells. ( Braun, ID; Kennedy, KA; Lazo, JS; Meandzija, B; Pham, ET; Smaldone, LF, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (16.67) | 18.7374 |
| 1990's | 4 (22.22) | 18.2507 |
| 2000's | 5 (27.78) | 29.6817 |
| 2010's | 5 (27.78) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Wallon, G | 2 |
| Erbacher, J | 1 |
| Omar, E | 2 |
| Bauer, C | 2 |
| Axiotis, G | 2 |
| Thevenon, S | 1 |
| Soubirou, JL | 2 |
| Aubrun, F | 2 |
| Zelickson, BR | 1 |
| Goldberg, LH | 1 |
| Rubenzik, MK | 1 |
| Wu, WJ | 1 |
| Ching, HH | 1 |
| Spinner, AG | 1 |
| Reeve, NH | 1 |
| Wang, RC | 1 |
| Bouix, C | 1 |
| Sio, TT | 1 |
| Le-Rademacher, JG | 1 |
| Leenstra, JL | 1 |
| Loprinzi, CL | 1 |
| Rine, G | 1 |
| Curtis, A | 1 |
| Singh, AK | 1 |
| Martenson, JA | 1 |
| Novotny, PJ | 1 |
| Tan, AD | 1 |
| Qin, R | 1 |
| Ko, SJ | 1 |
| Reiter, PL | 1 |
| Miller, RC | 1 |
| Alam, M | 1 |
| Schaeffer, MR | 1 |
| Geisler, A | 1 |
| Poon, E | 1 |
| Fosko, SW | 1 |
| Srivastava, D | 1 |
| Landers, C | 1 |
| Turner, D | 1 |
| Makin, C | 1 |
| Zaglul, H | 1 |
| Brown, R | 1 |
| Cerchietti, LC | 1 |
| Navigante, AH | 1 |
| Bonomi, MR | 1 |
| Zaderajko, MA | 1 |
| Menéndez, PR | 1 |
| Pogany, CE | 1 |
| Roth, BM | 1 |
| Joglekar, DM | 1 |
| Joshi, MY | 1 |
| Paranjape, SY | 1 |
| Sowani, AS | 1 |
| Ho, AM | 1 |
| Chung, DC | 1 |
| To, EW | 1 |
| Karmakar, MK | 1 |
| Meredith, R | 1 |
| Salter, M | 1 |
| Kim, R | 1 |
| Spencer, S | 1 |
| Weppelmann, B | 1 |
| Rodu, B | 1 |
| Smith, J | 1 |
| Lee, J | 1 |
| Chafin, JB | 1 |
| Wax, MK | 1 |
| Johnstone, R | 1 |
| Bishop, D | 1 |
| Cannon, CR | 1 |
| Replogle, B | 1 |
| Aadahl, P | 1 |
| Nordgård, S | 1 |
| Desai, PM | 1 |
| Desai, KP | 1 |
| Lazo, JS | 1 |
| Braun, ID | 1 |
| Meandzija, B | 1 |
| Kennedy, KA | 1 |
| Pham, ET | 1 |
| Smaldone, LF | 1 |
| Osguthorpe, JD | 1 |
| Adkins, WY | 1 |
| Tromovitch, TA | 1 |
| Stegeman, SJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intravenous Lidocaine in Carcinologic ENT Surgery: A Randomized Controlled Trial for Evaluation of Opioid Saving Strategy and Chronic Post-surgical Pain[NCT02894710] | Phase 3 | 143 participants (Actual) | Interventional | 2016-12-31 | Completed | ||
| A Randomized Study of a New Medical Device for Oral Mucositis (MDOM Trial)[NCT05104268] | Phase 1/Phase 2 | 100 participants (Anticipated) | Interventional | 2021-11-30 | Not yet recruiting | ||
| A Phase 1/Phase 2 Study for the Prevention of Oral Mucositis (SPOM)[NCT05338398] | Phase 1/Phase 2 | 100 participants (Anticipated) | Interventional | 2022-04-15 | Enrolling by invitation | ||
| A Phase III Placebo-Controlled, Randomized Three-Arm Study of Doxepin and a Topical Rinse in the Treatment of Acute Oral Mucositis Pain in Patients Receiving Radiotherapy With or Without Chemotherapy[NCT02229539] | Phase 3 | 275 participants (Actual) | Interventional | 2014-11-30 | Completed | ||
| Evaluating the Effectiveness of Topical Morphine Compared With a Routine Mouthwash in Managing Cancer Treatment-induced Mucositis in Patients With Head and Neck Cancer in Isfahan[NCT01837446] | Phase 2/Phase 3 | 30 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| Vapocoolant Spray as a Novel Local Anesthetic for Cutaneous Abscess Incision and Drainage[NCT01673061] | Phase 4 | 21 participants (Actual) | Interventional | 2012-08-31 | Terminated (stopped due to Vapocoolant not effective controlling pain compared with Lidocaine.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Total pain reduction (mouth and throat) was measured by the numerical analogue scale of mouth pain on a scale of 0 to 10, with 0=no pain and 10=worst pain in the questionnaires taken at baseline, and 5, 15, 30, 60, 120, 240 minutes after assigned treatment for doxepin or DLA vs. placebo. The total pain reduction was calculated by the (average of mouth and throat) area under the curve (AUC) adjusting for baseline, with time scale (baseline, 5, 15, 30, 60, 120 and 240 minutes post treatment) replaced by a numerical scale of 0, 1, 2, 3, 4, 5 and 6 respectively. The AUC was prorated when there are terminal missing data. If the missing data were intermittent, simple imputation by trapezoidal rules were applied to calculate the AUC. If a patient cancelled, was missing baseline data, or only provided baseline data, he/she was excluded from the statistical analysis. (NCT02229539)
Timeframe: Baseline, 5, 15, 30, 60, 120, 240 minutes post treatment
| Intervention | units on a scale*time scale (Mean) |
|---|---|
| Doxepin | 11.9 |
| DLA (Diphenhydramine, Lidocaine and Antacid) | 11.7 |
| Placebo | 8.7 |
7 trials available for lidocaine and Cancer of Head
| Article | Year |
|---|---|
Effect of intravenous lidocaine on pain after head and neck cancer surgery (ELICO trial): A randomised controlled trial.
Topics: Analgesics; Analgesics, Opioid; Anesthetics, Local; Double-Blind Method; Head and Neck Neoplasms; Hu | 2022 |
Finer Needles Reduce Pain Associated With Injection of Local Anesthetic Using a Minimal Insertion Injection Technique.
Topics: Aged; Anesthetics, Local; Female; Head and Neck Neoplasms; Humans; Injections; Lidocaine; Male; Midd | 2018 |
Evaluation of intravenous lidocaine in head and neck cancer surgery: study protocol for a randomized controlled trial.
Topics: Anesthetics, Local; Data Interpretation, Statistical; Double-Blind Method; Head and Neck Neoplasms; | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Met | 2019 |
Effect of topical morphine for mucositis-associated pain following concomitant chemoradiotherapy for head and neck carcinoma.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Anesthetics, Local; Ant | 2002 |
Sucralfate for radiation mucositis: results of a double-blind randomized trial.
Topics: Anti-Ulcer Agents; Diphenhydramine; Double-Blind Method; Drug Therapy, Combination; Esophageal Neopl | 1997 |
Fine-needle aspiration biopsy: is anesthesia necessary?
Topics: Anesthetics, Local; Biopsy, Needle; Ethyl Chloride; Female; Head and Neck Neoplasms; Humans; Lidocai | 1999 |
11 other studies available for lidocaine and Cancer of Head
| Article | Year |
|---|---|
A novel technique to identify the nerve of origin in head and neck schwannomas.
Topics: Adolescent; Adult; Anesthetics, Local; Cranial Nerve Neoplasms; Cranial Nerves; Diagnostic Technique | 2018 |
Safety of Local Intracutaneous Lidocaine Anesthesia Used by Dermatologic Surgeons for Skin Cancer Excision and Postcancer Reconstruction: Quantification of Standard Injection Volumes and Adverse Event Rates.
Topics: Anesthesia, Local; Anesthetics, Local; Cross-Sectional Studies; Epinephrine; Head and Neck Neoplasms | 2016 |
Propofol associated hiccups and treatment with lidocaine.
Topics: Anesthetics, Intravenous; Anesthetics, Local; Child, Preschool; Female; Head and Neck Neoplasms; Hic | 2008 |
Use of lidocaine spray for pain relief and improved quality of life in terminally ill cancer patients.
Topics: Administration, Topical; Anesthetics, Local; Deglutition Disorders; Head and Neck Neoplasms; Humans; | 2002 |
Total airway obstruction during local anesthesia in a non-sedated patient with a compromised airway.
Topics: Aged; Airway Obstruction; Anesthesia, General; Anesthesia, Local; Anesthetics, Local; Atropine; Bron | 2004 |
The use of lidocaine in microvascular reconstruction.
Topics: Absorption; Adult; Aged; Anesthetics, Local; Constriction, Pathologic; Drug Monitoring; Female; Graf | 1997 |
Percutaneous dilatational tracheostomy in a patient with thyroid cancer and severe airway obstruction.
Topics: Aged; Airway Obstruction; Anesthesia, Local; Anesthetics, Local; Carcinoma, Medullary; Catheterizati | 1999 |
Combined fluphenazine and lidocaine for pain relief in head and neck cancers.
Topics: Anesthetics, Local; Dopamine Antagonists; Drug Therapy, Combination; Female; Fluphenazine; Head and | 2000 |
Lidocaine potentiation of bleomycin A2 cytotoxicity and DNA strand breakage in L1210 and human A-253 cells.
Topics: Animals; Bleomycin; Calmodulin; Carcinoma, Squamous Cell; Cell Survival; Cells, Cultured; DNA Repair | 1985 |
Carotid arteriospasm.
Topics: Adult; Branchioma; Carotid Artery Diseases; Cerebrovascular Disorders; Coma; Female; Head and Neck N | 1985 |
Microscopically controlled excision of skin tumors.
Topics: Acetates; Carcinoma, Basal Cell; Cheek; Ear Neoplasms; Epinephrine; Eye Neoplasms; Eyelid Neoplasms; | 1974 |