Page last updated: 2024-10-28

lidocaine and Bronchospasm

lidocaine has been researched along with Bronchospasm in 39 studies

Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.

Research Excerpts

ExcerptRelevanceReference
" The authors performed a prospective, randomized, double-blind, placebo-controlled trial to test the ability of intravenous lidocaine and inhaled albuterol to attenuate airway reactivity after tracheal intubation in asthmatic patients undergoing general anesthesia."9.09Inhaled albuterol, but not intravenous lidocaine, protects against intubation-induced bronchoconstriction in asthma. ( Boughton, R; Darvish, A; Israel, E; Loring, SH; Maslow, AD; Mehrez, M; Regan, MM, 2000)
"Lidocaine inhalation attenuates histamine-induced bronchospasm while evoking airway anesthesia."9.09Airway anesthesia alone does not explain attenuation of histamine-induced bronchospasm by local anesthetics: a comparison of lidocaine, ropivacaine, and dyclonine. ( Groeben, H; Grosswendt, T; Pavlakovic, G; Peters, J; Silvanus, MT, 2001)
"Inhaled topical lidocaine, used to produce anesthesia of the respiratory tract prior to bronchoscopy, may cause bronchoconstriction in asthmatic patients."9.06Lidocaine-induced bronchoconstriction in asthmatic patients. Relation to histamine airway responsiveness and effect of preservative. ( McAlpine, LG; Thomson, NC, 1989)
"Inhaled lidocaine antagonized bronchospasm in animal models and patients, but adverse effects limited its efficacy."7.83JM25-1, a Lidocaine Analog Combining Airway Relaxant and Antiinflammatory Properties: Implications for New Bronchospasm Therapy. ( Anjos-Valotta, EA; Cordeiro, RS; Costa, JC; Cotias, AC; Couto, GC; de Carvalho, KI; Faria, RX; Martins, MA; Neves, JS; Olsen, PC; Pão, CR; Serra, MF; Silva, PM, 2016)
"The authors describe the effect of instilling adrenaline through the endotracheal tube in one case of severe bronchospasms due to intubation with an endotracheal tube lubricated with 10% lidocaine spray in a patient with no history of adverse respiratory or allergic reactions."7.76Adrenaline through the endotracheal tube as an answer to severe bronchospasms caused by lidocaine. ( Araimo, F; Bilotta, F; Caramia, R; Rosa, G, 2010)
" Severe unilateral bronchospasm was probably caused by topical lidocaine injected at the vocal cords and, inadvertently, into the left main bronchus with a Laryngojet device."7.70Severe unilateral bronchospasm mimicking inadvertent endobronchial intubation: a complication of the use of a topical lidocaine Laryngojet injector. ( Farmery, AD, 2000)
"We measured the effect of inhaled lidocaine on pulmonary function in 8 asthmatic subjects."7.66Effects of inhaled lidocaine on airway function in asthmatic subjects. ( Fish, JE; Peterman, VI, 1979)
" The authors performed a prospective, randomized, double-blind, placebo-controlled trial to test the ability of intravenous lidocaine and inhaled albuterol to attenuate airway reactivity after tracheal intubation in asthmatic patients undergoing general anesthesia."5.09Inhaled albuterol, but not intravenous lidocaine, protects against intubation-induced bronchoconstriction in asthma. ( Boughton, R; Darvish, A; Israel, E; Loring, SH; Maslow, AD; Mehrez, M; Regan, MM, 2000)
"Lidocaine inhalation attenuates histamine-induced bronchospasm while evoking airway anesthesia."5.09Airway anesthesia alone does not explain attenuation of histamine-induced bronchospasm by local anesthetics: a comparison of lidocaine, ropivacaine, and dyclonine. ( Groeben, H; Grosswendt, T; Pavlakovic, G; Peters, J; Silvanus, MT, 2001)
"Inhaled topical lidocaine, used to produce anesthesia of the respiratory tract prior to bronchoscopy, may cause bronchoconstriction in asthmatic patients."5.06Lidocaine-induced bronchoconstriction in asthmatic patients. Relation to histamine airway responsiveness and effect of preservative. ( McAlpine, LG; Thomson, NC, 1989)
"Inhaled lidocaine antagonized bronchospasm in animal models and patients, but adverse effects limited its efficacy."3.83JM25-1, a Lidocaine Analog Combining Airway Relaxant and Antiinflammatory Properties: Implications for New Bronchospasm Therapy. ( Anjos-Valotta, EA; Cordeiro, RS; Costa, JC; Cotias, AC; Couto, GC; de Carvalho, KI; Faria, RX; Martins, MA; Neves, JS; Olsen, PC; Pão, CR; Serra, MF; Silva, PM, 2016)
"Propofol and remifentanil may be used safely for bronchoscopy, although remifentanil should be associated with propofol or lidocaine to prevent the potential opioid-mediated bronchospasm."3.79The influence of propofol, remifentanil and lidocaine on the tone of human bronchial smooth muscle. ( Calzetta, L; Capuano, A; Dauri, M; Massullo, D; Matera, MG; Rendina, EA; Rinaldi, B; Rogliani, P, 2013)
"The authors describe the effect of instilling adrenaline through the endotracheal tube in one case of severe bronchospasms due to intubation with an endotracheal tube lubricated with 10% lidocaine spray in a patient with no history of adverse respiratory or allergic reactions."3.76Adrenaline through the endotracheal tube as an answer to severe bronchospasms caused by lidocaine. ( Araimo, F; Bilotta, F; Caramia, R; Rosa, G, 2010)
" Severe unilateral bronchospasm was probably caused by topical lidocaine injected at the vocal cords and, inadvertently, into the left main bronchus with a Laryngojet device."3.70Severe unilateral bronchospasm mimicking inadvertent endobronchial intubation: a complication of the use of a topical lidocaine Laryngojet injector. ( Farmery, AD, 2000)
"We measured the effect of inhaled lidocaine on pulmonary function in 8 asthmatic subjects."3.66Effects of inhaled lidocaine on airway function in asthmatic subjects. ( Fish, JE; Peterman, VI, 1979)
" We performed the distilled water dose-response curves after no treatment and after treatment with cromolyn aerosol, lidocaine aerosol, or atropine aerosol in doses of 0."1.27Mechanism of cough and bronchoconstriction induced by distilled water aerosol. ( Bethel, RA; Boushey, HA; Rizk, NW; Sheppard, D, 1983)
"Pretreatment with aspirin (80 mg X kg -1 iv) did not prevent the bronchoconstriction caused by PAF-acether, and intravenous or intratracheal arachidonic acid caused no bronchial response."1.27Acute effects of intratracheal administration of platelet-activating factor in baboons. ( Arnoux, B; Benveniste, J; Denjean, A; Lockhart, A; Masse, R, 1983)
"Lidocaine, 4%, was administered as an aerosol for 10 minutes before challenge with Ascaris antigen and again during the 10-minute challenge with Ascaris antigen."1.26Lidocaine aerosols do not prevent allergic bronchoconstriction. ( Downes, H; Hirshman, CA, 1981)

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-199019 (48.72)18.7374
1990's4 (10.26)18.2507
2000's9 (23.08)29.6817
2010's6 (15.38)24.3611
2020's1 (2.56)2.80

Authors

AuthorsStudies
Grell, R1
Harrington, M1
Serra, MF1
Neves, JS1
Couto, GC1
Cotias, AC1
Pão, CR1
Olsen, PC1
de Carvalho, KI1
Anjos-Valotta, EA1
Faria, RX1
Costa, JC1
Cordeiro, RS1
Silva, PM1
Martins, MA1
Burches, BR1
Warner, DO1
Sun, HL1
Wu, TJ1
Ng, CC1
Chien, CC1
Huang, CC1
Chie, WC1
Massou, S2
Bakkali, H1
Wali, A1
Belaamari, H1
Kamili, ND1
Araimo, F1
Bilotta, F1
Caramia, R1
Rosa, G1
Dube, SK1
Rath, GP1
Bensghir, M1
Elwali, A1
Azendour, H1
Balkhi, H1
Haimeur, C1
Drissi Kamili, N1
Rogliani, P1
Calzetta, L1
Rendina, EA1
Massullo, D1
Dauri, M1
Rinaldi, B1
Capuano, A1
Matera, MG1
Butler, J1
Jackson, R1
Groeben, H2
Peters, J2
Sheppard, D1
Rizk, NW1
Boushey, HA1
Bethel, RA1
Thiagarajah, S1
Lear, E1
Azar, I1
Salzer, J1
Zeiligsohn, E1
Denjean, A1
Arnoux, B1
Masse, R1
Lockhart, A1
Benveniste, J1
Krasnowska, M1
Liebhart, E1
Małolepszy, J1
Pace, NL1
Matthews, MM1
Stanley, TH1
Downes, H3
Hirshman, CA3
Gerber, N2
van der Bijl, P1
Broeksma, J1
Walls, RM1
Maslow, AD1
Regan, MM1
Israel, E1
Darvish, A1
Mehrez, M1
Boughton, R1
Loring, SH1
Grosswendt, T1
Silvanus, MT1
Pavlakovic, G1
Smith, N1
Nandi, P1
Farmery, AD1
McNally, JF1
Enright, P1
Hirsch, JE1
Souhrada, JF1
Fish, JE1
Peterman, VI1
Yurino, M1
Rosenow, EC1
Andersen, HA1
D'Eramo, EM1
Choudry, NB1
Fuller, RW1
Anderson, N1
Karlsson, JA1
McAlpine, LG1
Thomson, NC1
Kirkpatrick, MB1
Ruffles, SP1
Gayres, JG1
Kurgan, J1
Nakhosteen, JA1
Dohrn, GA1
Wassermann, K1
Oevrenes, A1
Bennett, DJ1
Torda, TA1
Horton, DA1
Wright, JS1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Hemodynamic Study With Pressure Recording Analytical Method (PRAM) of the Cardiovascular Response to the Positioning of the Extraglottic Device in Gynecological Surgery[NCT02918526]94 participants (Anticipated)Interventional2016-10-31Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for lidocaine and Bronchospasm

ArticleYear
Best evidence topic report. Lignocaine as a pretreatment to rapid sequence intubation in patients with status asthmaticus.
    Emergency medicine journal : EMJ, 2005, Volume: 22, Issue:10

    Topics: Anesthetics, Local; Bronchial Spasm; Emergency Service, Hospital; Evidence-Based Medicine; Humans; I

2005

Trials

6 trials available for lidocaine and Bronchospasm

ArticleYear
Efficacy of oropharyngeal lidocaine instillation on hemodynamic responses to orotracheal intubation.
    Journal of clinical anesthesia, 2009, Volume: 21, Issue:2

    Topics: Administration, Topical; Adult; Anesthesia, General; Anesthetics, Local; Blood Pressure; Bronchial S

2009
Lidocaine exerts its effect on induced bronchospasm by mitigating reflexes, rather than by attenuation of smooth muscle contraction.
    Acta anaesthesiologica Scandinavica, 2007, Volume: 51, Issue:3

    Topics: Adult; Airway Resistance; Anesthetics, Local; Bronchial Provocation Tests; Bronchial Spasm; Double-B

2007
Inhaled albuterol, but not intravenous lidocaine, protects against intubation-induced bronchoconstriction in asthma.
    Anesthesiology, 2000, Volume: 93, Issue:5

    Topics: Administration, Inhalation; Adult; Albuterol; Anesthesia, Inhalation; Anesthetics, Inhalation; Anest

2000
Airway anesthesia alone does not explain attenuation of histamine-induced bronchospasm by local anesthetics: a comparison of lidocaine, ropivacaine, and dyclonine.
    Anesthesiology, 2001, Volume: 94, Issue:3

    Topics: Adult; Aerosols; Amides; Anesthesia, Local; Anesthetics, Local; Bronchial Spasm; Double-Blind Method

2001
Lidocaine-induced bronchoconstriction in asthmatic patients. Relation to histamine airway responsiveness and effect of preservative.
    Chest, 1989, Volume: 96, Issue:5

    Topics: Administration, Inhalation; Adult; Anesthesia, Local; Asthma; Bronchi; Bronchial Provocation Tests;

1989
[Possibility of prevention of histamine-induced bronchospastic reaction with fenoterol, ipratropium bromide and lidocaine in patients with chronic bronchitis].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1985, Feb-04, Volume: 40, Issue:5

    Topics: Adult; Aerosols; Aged; Atropine Derivatives; Bronchial Spasm; Bronchitis; Chronic Disease; Clinical

1985

Other Studies

32 other studies available for lidocaine and Bronchospasm

ArticleYear
Addition of nebulised lidocaine to prevent refractory bronchospasms in a patient receiving serial bronchoscopies.
    BMJ case reports, 2023, Feb-21, Volume: 16, Issue:2

    Topics: Administration, Inhalation; Albuterol; Bronchial Spasm; Bronchoscopy; Humans; Lidocaine

2023
Hitting a nerve to ease asthma.
    Lab animal, 2015, Volume: 44, Issue:8

    Topics: Anesthetics, Local; Animals; Asthma; Bronchial Spasm; Inflammation; Lidocaine; Lung; Mice; Nocicepto

2015
JM25-1, a Lidocaine Analog Combining Airway Relaxant and Antiinflammatory Properties: Implications for New Bronchospasm Therapy.
    Anesthesiology, 2016, Volume: 124, Issue:1

    Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents; Bronchial Spasm; Disease Models, Animal; Infl

2016
Bronchospasm after intravenous lidocaine.
    Anesthesia and analgesia, 2008, Volume: 107, Issue:4

    Topics: Anesthetics, Local; Asthma; Bronchial Spasm; Female; Humans; Infant; Injections, Intravenous; Intuba

2008
[Bronchospasm after laryngeal block].
    Revue de pneumologie clinique, 2009, Volume: 65, Issue:5

    Topics: Adult; Anesthesia, Local; Anesthetics, Local; Bronchial Spasm; Humans; Intubation, Intratracheal; La

2009
Adrenaline through the endotracheal tube as an answer to severe bronchospasms caused by lidocaine.
    Minerva anestesiologica, 2010, Volume: 76, Issue:1

    Topics: Anesthetics, Local; Bronchial Spasm; Epinephrine; Female; Humans; Intubation, Intratracheal; Lidocai

2010
Cough and bronchospasm after rapid intravenous administration of phenytoin.
    Journal of neurosurgical anesthesiology, 2012, Volume: 24, Issue:3

    Topics: Anesthetics, Local; Anticonvulsants; Bronchial Spasm; Cough; Female; Humans; Infusions, Intravenous;

2012
[Unilateral bronchospasm during general anesthesia].
    Revue de pneumologie clinique, 2012, Volume: 68, Issue:3

    Topics: Anesthetics, Local; Bronchial Spasm; Diagnosis, Differential; Humans; Intubation, Intratracheal; Lid

2012
The influence of propofol, remifentanil and lidocaine on the tone of human bronchial smooth muscle.
    Pulmonary pharmacology & therapeutics, 2013, Volume: 26, Issue:3

    Topics: Bronchi; Bronchial Spasm; Electric Stimulation; Female; Humans; Hypnotics and Sedatives; In Vitro Te

2013
Mechanism of cough and bronchoconstriction induced by distilled water aerosol.
    The American review of respiratory disease, 1983, Volume: 127, Issue:6

    Topics: Adolescent; Adult; Aerosols; Airway Resistance; Asthma; Bronchi; Bronchial Spasm; Cough; Cromolyn So

1983
Bronchospasm following interscalene brachial plexus block.
    Anesthesiology, 1984, Volume: 61, Issue:6

    Topics: Adult; Autonomic Nerve Block; Brachial Plexus; Bronchi; Bronchial Spasm; Bupivacaine; Humans; Lidoca

1984
Acute effects of intratracheal administration of platelet-activating factor in baboons.
    Journal of applied physiology: respiratory, environmental and exercise physiology, 1983, Volume: 55, Issue:3

    Topics: Anesthesia, Local; Animals; Aspirin; Atropine; Bronchi; Bronchial Spasm; Lidocaine; Papio; Platelet

1983
[Effect of lidocaine on histamine-induced bronchial spasm].
    Pneumonologia polska, 1983, Volume: 51, Issue:12

    Topics: Adult; Aged; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Female; Histamine; Histamine Anta

1983
Anesthetic management of the first permanent, orthotopic, prosthetic cardiac replacement (total artificial heart) in man.
    Anesthesia and analgesia, 1984, Volume: 63, Issue:7

    Topics: Adjuvants, Anesthesia; Anesthesia, General; Anesthesia, Intravenous; Bronchial Spasm; Cardiac Output

1984
Lidocaine aerosols do not prevent allergic bronchoconstriction.
    Anesthesia and analgesia, 1981, Volume: 60, Issue:1

    Topics: Aerosols; Airway Resistance; Animals; Antigens; Ascaris; Bronchial Spasm; Citrates; Dogs; Lidocaine;

1981
Intravenous lidocaine in reflex and allergic bronchoconstriction.
    Proceedings of the Western Pharmacology Society, 1980, Volume: 23

    Topics: Aerosols; Animals; Antigens; Ascaris; Bronchial Spasm; Citrates; Dogs; Hypersensitivity; Injections,

1980
I.V. lignocaine in reflex and allergic bronchoconstriction.
    British journal of anaesthesia, 1980, Volume: 52, Issue:9

    Topics: Animals; Bronchial Provocation Tests; Bronchial Spasm; Dogs; Infusions, Parenteral; Lidocaine; Refle

1980
Acute bronchospasm following administration of lidocaine.
    Anesthesia & pain control in dentistry, 1993,Fall, Volume: 2, Issue:4

    Topics: Adult; Bronchial Spasm; Female; Humans; Lidocaine

1993
Lidocaine and rapid sequence intubation.
    Annals of emergency medicine, 1996, Volume: 27, Issue:4

    Topics: Anesthetics, Local; Asthma; Bronchial Spasm; Humans; Intubation, Intratracheal; Lidocaine

1996
Unilateral bronchospasm.
    British journal of anaesthesia, 2001, Volume: 86, Issue:6

    Topics: Aged; Albuterol; Anesthetics, Local; Bronchial Spasm; Bronchodilator Agents; Female; Humans; Lidocai

2001
Severe unilateral bronchospasm mimicking inadvertent endobronchial intubation: a complication of the use of a topical lidocaine Laryngojet injector.
    British journal of anaesthesia, 2000, Volume: 85, Issue:6

    Topics: Adult; Anesthetics, Local; Bronchi; Bronchial Spasm; Diagnosis, Differential; Female; Foreign Bodies

2000
The attenuation of exercise-induced bronchoconstriction by oropharyngeal anesthesia.
    The American review of respiratory disease, 1979, Volume: 119, Issue:2

    Topics: Adolescent; Anesthesia, Local; Bronchial Spasm; Child; Female; Forced Expiratory Flow Rates; Forced

1979
Effects of inhaled lidocaine on airway function in asthmatic subjects.
    Respiration; international review of thoracic diseases, 1979, Volume: 37, Issue:4

    Topics: Adult; Aerosols; Anesthesia, Inhalation; Asthma; Atropine; Bronchial Spasm; Female; Forced Expirator

1979
[Bronchospasm induced by lidocaine (author's transl)].
    Masui. The Japanese journal of anesthesiology, 1979, Volume: 28, Issue:9

    Topics: Bronchial Spasm; Humans; Intubation, Intratracheal; Lidocaine; Male; Middle Aged

1979
Bronchoscopically induced bronchospasm.
    Chest, 1976, Volume: 70, Issue:4

    Topics: Bronchial Spasm; Bronchoscopy; Humans; Lidocaine; Premedication

1976
Morbidity and mortality with outpatient anesthesia: the Massachusetts experience.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1992, Volume: 50, Issue:7

    Topics: Aged; Ambulatory Surgical Procedures; Anesthesia, Dental; Anesthesia, General; Anesthesia, Intraveno

1992
Separation of cough and reflex bronchoconstriction by inhaled local anaesthetics.
    The European respiratory journal, 1990, Volume: 3, Issue:5

    Topics: Administration, Inhalation; Adult; Anesthetics, Local; Bronchial Spasm; Capsaicin; Cough; Female; Hu

1990
Lidocaine topical anesthesia for flexible bronchoscopy.
    Chest, 1989, Volume: 96, Issue:5

    Topics: Administration, Inhalation; Anesthesia, Local; Bronchial Spasm; Bronchoscopy; Fiber Optic Technology

1989
Fatal bronchospasm after topical lignocaine before bronchoscopy.
    British medical journal (Clinical research ed.), 1987, Jun-27, Volume: 294, Issue:6588

    Topics: Administration, Topical; Aged; Bronchial Spasm; Bronchoscopy; Drug Hypersensitivity; Humans; Lidocai

1987
Fatal bronchospasm after topical lignocaine before bronchoscopy.
    British medical journal (Clinical research ed.), 1987, Sep-05, Volume: 295, Issue:6598

    Topics: Bronchial Spasm; Bronchoscopy; Drug Hypersensitivity; Humans; Lidocaine; Male

1987
[Severe complications following topical inhalation anesthesia with 10% lidocaine for bronchoscopies with local anesthesia].
    Praxis und Klinik der Pneumologie, 1985, Volume: 39, Issue:9

    Topics: Adult; Anesthesia, Inhalation; Anesthesia, Local; Bronchial Spasm; Bronchoscopy; Heart Arrest; Human

1985
Severe bronchospasm complicating thoracotomy.
    Archives of surgery (Chicago, Ill. : 1960), 1970, Volume: 101, Issue:5

    Topics: Adult; Asthma; Bronchial Spasm; Female; Humans; Lidocaine; Male; Mitral Valve Insufficiency; Mitral

1970