lidocaine has been researched along with Autolysis, Dental Pulp in 2 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The purpose of this prospective, randomized, double-blind study was to compare the pain of infiltration and pain of an incision and drainage procedure by using a buffered versus a nonbuffered 2% lidocaine with 1:100,000 epinephrine solution in symptomatic patients with a diagnosis of pulpal necrosis and associated acute swelling." | 5.17 | Buffered lidocaine for incision and drainage: a prospective, randomized double-blind study. ( Balasco, M; Beck, M; Drum, M; Nusstein, J; Reader, A, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Balasco, M | 1 |
| Drum, M | 2 |
| Reader, A | 2 |
| Nusstein, J | 2 |
| Beck, M | 2 |
| Harreld, TK | 1 |
| Fowler, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pain Perception Associated With Administration of Buffered Lidocaine Versus Conventional Lidocaine in the Pediatric Dental Patient[NCT04055116] | Phase 4 | 64 participants (Actual) | Interventional | 2019-11-11 | Completed | ||
| Buffered Lidocaine for Paracervical Block to Decrease Injection Pain During First Trimester Uterine Aspirations[NCT03107754] | Phase 4 | 98 participants (Actual) | Interventional | 2017-05-15 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Time to gum numbness, assessed using periodontal probe and patient response. (NCT04055116)
Timeframe: Time of injection to 4 minutes post-injection (tested in 15 second intervals).
| Intervention | seconds (Mean) |
|---|---|
| Unbuffered Lidocaine | 102.21 |
| Buffered Lidocaine | 81.07 |
Wong-Baker FACES Pain Rating Scale responses after buffered and non-buffered lidocaine. Range: 0 - No Hurt to 10 - Hurts Worst (higher numbers indicate higher levels of pain). There are no sub-scores. (NCT04055116)
Timeframe: Within 1 minute of anesthetic administration
| Intervention | units on a scale (Mean) |
|---|---|
| Unbuffered Lidocaine | 3.52 |
| Buffered Lidocaine | 3.48 |
Faces, Legs, Arms, Crying Consolability (FLACC) Behavioral Pain Scale. This scale helps clinicians assess patients' pain based on behavioral observations. Range: 0 - 2 per category (higher number indicates more observed agitation/potential pain). A score is given in each of the five categories (Faces, Legs, Arms, Crying, Consolability). The sum of these scores provides the Assessment of Behavioral Score (range: 0 - 10) with higher scores indicating higher levels of pain. (NCT04055116)
Timeframe: During local anesthesia administration
| Intervention | units on a scale (Mean) |
|---|---|
| Unbuffered Lidocaine | 1.88 |
| Buffered Lidocaine | 2.43 |
For the primary outcome, pain immediately after paracervical block injection was measured by a scale. The scale used was the 100-mm visual analog scale. The minimum score was 0 and the maximum score was 100. Higher numbers indicate worse pain. (NCT03107754)
Timeframe: Immediately after injection of the paracervical block
| Intervention | units on a scale (Median) |
|---|---|
| Standard Paracervical Block | 44.5 |
| Buffered Lidocaine Paracervical Block | 30 |
Pain scores were measured at multiple points throughout the procedure. Pain scores were measured using a 100 mm visual analog scale with 0 being no pain and 100 being the worst pain ever. (NCT03107754)
Timeframe: Immediately after speculum placement, cervical dilation, uterine aspiration
| Intervention | units on a scale (Median) | ||
|---|---|---|---|
| After insertion of speculum | After cervical dilation | After uterine aspiration | |
| Buffered Lidocaine Paracervical Block | 17 | 55 | 69 |
| Standard Paracervical Block | 13 | 60.06 | 67.5 |
2 trials available for lidocaine and Autolysis, Dental Pulp
| Article | Year |
|---|---|
Buffered lidocaine for incision and drainage: a prospective, randomized double-blind study.
Topics: Adult; Aged; Anesthetics, Local; Buffers; Dental Pulp Necrosis; Dissection; Double-Blind Method; Dra | 2013 |
Efficacy of a Buffered 4% Lidocaine Formulation for Incision and Drainage: A Prospective, Randomized, Double-blind Study.
Topics: Adult; Aged; Anesthetics, Local; Dental Pulp Necrosis; Double-Blind Method; Drainage; Female; Humans | 2015 |