lidocaine has been researched along with Apnea, Sleep in 5 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moss, JR | 1 |
| Cofer, S | 1 |
| Hersey, S | 1 |
| Goudy, S | 1 |
| Werkhaven, J | 1 |
| Swanson, E | 1 |
| Mantle, C | 1 |
| Stowell, N | 1 |
| Byrne, D | 1 |
| Wang, L | 1 |
| Labadie, R | 1 |
| Deegan, PC | 1 |
| Mulloy, E | 1 |
| McNicholas, WT | 1 |
| Berry, RB | 2 |
| Kouchi, KG | 1 |
| Bower, JL | 1 |
| Light, RW | 2 |
| McNellis, MI | 1 |
| Kouchi, K | 1 |
| White, DP | 1 |
| Cadieux, RJ | 1 |
| Lombard, RM | 1 |
| Bixler, EO | 1 |
| Kales, A | 1 |
| Zwillich, CW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pediatric Tonsillectomy Pain Reduction Study, a Randomized, Placebo Controlled, Double-Blind Clinical Trial Using Clonidine and Local Anesthetics[NCT00678379] | Phase 3 | 120 participants (Actual) | Interventional | 2008-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The median number of intravenous fentanyl doses administered in the PACU due to pain (NCT00678379)
Timeframe: in recovery room
| Intervention | number of doses (Median) |
|---|---|
| Normal Saline | 3.0 |
| Lidocaine (1%) + Bupivacaine 0.5% | 3 |
| Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg | 3 |
The total number of intravenous fentanyl doses given PACU which will be compared between the three randomized groups (arms) (NCT00678379)
Timeframe: Post-operative thru day 7
| Intervention | number of doses (Median) |
|---|---|
| Normal Saline | 12 |
| Lidocaine (1%) + Bupivacaine 0.5% | 12 |
| Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg | 14 |
(NCT00678379)
Timeframe: Day of Surgery
| Intervention | minutes (Median) |
|---|---|
| Normal Saline | 122 |
| Lidocaine (1%) + Bupivacaine 0.5% | 111 |
| Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg | 120 |
Visual analog pain scale range is 0-10 with 0=no pain and 10 = worst pain ever (NCT00678379)
Timeframe: in recovery room; post-operative days 1,3,5 & 7
| Intervention | pain score (Mean) | ||||
|---|---|---|---|---|---|
| In recovery room | day 1 | day 3 | day 5 | day 7 | |
| Lidocaine (1%) + Bupivacaine 0.5% | 3 | 4 | 2.5 | 2 | 2 |
| Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg | 3 | 5 | 3 | 3 | 2 |
| Normal Saline | 3 | 3 | 3 | 3 | 2.5 |
The number and percent of patients whose post-operative diet has to a regular diet on post-operative days 1, 3, 5 & 7 (NCT00678379)
Timeframe: post-operative days 1,3,5 & 7.
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| post-op day 1 | post-op day 3 | post op day 5 | post op day 7 | |
| Lidocaine (1%) + Bupivacaine 0.5% | 4 | 8 | 18 | 26 |
| Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg | 1 | 12 | 14 | 22 |
| Normal Saline | 7 | 18 | 21 | 24 |
The number and percent of patients whose post-operative diet has only advanced to a soft diet on post-operative days 1, 3, 5 & 7 (NCT00678379)
Timeframe: post-operative days 1,3,5 & 7.
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| post-op day 1 | post-op day 3 | post op day 5 | post op day 7 | |
| Lidocaine (1%) + Bupivacaine 0.5% | 22 | 26 | 17 | 10 |
| Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg | 26 | 18 | 18 | 14 |
| Normal Saline | 26 | 18 | 13 | 13 |
The number and percent of patients whose post-operative diet has advanced to liquids only on post-op days 1, 3, 5 & 7 (NCT00678379)
Timeframe: post-operative days 1,3,5 & 7.
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| post-op day 1 | post-op day 3 | post op day 5 | post op day 7 | |
| Lidocaine (1%) + Bupivacaine 0.5% | 33 | 13 | 10 | 11 |
| Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg | 30 | 23 | 19 | 10 |
| Normal Saline | 16 | 8 | 13 | 6 |
5 trials available for lidocaine and Apnea, Sleep
| Article | Year |
|---|---|
Comparison of clonidine, local anesthetics, and placebo for pain reduction in pediatric tonsillectomy.
Topics: Adenoids; Adolescent; Age Factors; Analgesics; Anesthetics, Local; Bupivacaine; Child; Child, Presch | 2011 |
Topical oropharyngeal anesthesia in patients with obstructive sleep apnea.
Topics: Bupivacaine; Humans; Lidocaine; Male; Middle Aged; Respiration; Respiratory Function Tests; Sleep Ap | 1995 |
Effect of upper airway anesthesia on obstructive sleep apnea.
Topics: Anesthesia, Local; Arousal; Esophagus; Humans; Lidocaine; Male; Mechanoreceptors; Middle Aged; Polys | 1995 |
Upper airway anesthesia reduces phasic genioglossus activity during sleep apnea.
Topics: Anesthesia, Local; Anesthetics, Local; Electromyography; Esophagus; Humans; Larynx; Lidocaine; Male; | 1997 |
The effects of nasal anesthesia on breathing during sleep.
Topics: Adult; Anesthesia, Local; Humans; Lidocaine; Male; Middle Aged; Nose; Respiration; Sleep; Sleep Apne | 1985 |