lidocaine has been researched along with Anoxemia in 93 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We present a case of a patient administered parasternal transdermal lidocaine patch therapy as part of a multimodal analgesic regime designed to diminish opioid-associated delirium after coronary bypass surgery." | 7.88 | Rare cause of delirium and hypoxemia after coronary bypass surgery: transdermal lidocaine patch-associated methemoglobinemia. ( Acevedo, FA; Chyatte, DA; Kim, EJ; Nielsen, VG, 2018) |
| "To determine physiologic responses to apnea-induced severe hypoxemia in anesthetized horses." | 7.83 | Cardiovascular, respiratory and metabolic responses to apnea induced by atlanto-occipital intrathecal lidocaine injection in anesthetized horses. ( Aleman, M; Davis, E; Guedes, A; Tearney, C, 2016) |
| "It was hypothesized that the increased myocardial blood flow known to occur during some types of hypoxia may alter the kinetics and dynamics of cardio-active drugs such as lidocaine that act directly on the myocardium." | 7.72 | The effect of hypoxic hypoxia on the systemic and myocardial pharmacokinetics and dynamics of lidocaine in sheep. ( Huang, YF; Upton, RN, 2003) |
| "In rat carotid artery, levcromakalim produced vasorelaxation mediated by adenosine triphosphate (ATP)-sensitive K(+) channels, whereas hypoxia induced it partly via these channels." | 7.72 | The role of K+ channels in vasorelaxation induced by hypoxia and the modulator effects of lidocaine in the rat carotid artery. ( Dojo, M; Hatano, Y; Iranami, H; Kimoto, Y; Kinoshita, H; Nakahata, K, 2003) |
| " The authors examined the mechanism of apnea in a rabbit model of sudden ventilatory arrest during the combination of epidural anesthesia and hypoxia." | 7.70 | Hypoxia causes apnea during epidural anesthesia in rabbits. ( Amuzu, J; Bosnjak, ZJ; Clifford, PS; Hogan, QH; Kampine, JP, 1998) |
| "During ventilation hyperoxia, mean percent lung uptakes of lidocaine were 41-52% 1 minute after the beginning of lidocaine infusion, and decreased in time-dependent fashion to 7-12% 10 minutes later." | 7.69 | Lung uptake of lidocaine during hyperoxia and hypoxia in the dog. ( Fujimori, M; Hasegawa, K; Hayashi, M; Tatekawa, S; Yukioka, H, 1996) |
| "In this study, the effects of lidocaine and hypoxia on the biosynthesis of phospholipids in the hamster heart were examined." | 7.69 | The effects of lidocaine and hypoxia on phospholipid biosynthesis in the isolated hamster heart. ( Choy, PC; Man, RY; Wong, JT, 1996) |
| "The effect of acute and chronic hypoxia on the disposition of lidocaine and its metabolites, and on regional blood flow has been examined in conscious beagles (n = 5)." | 7.68 | Effect of acute and chronic moderate hypoxia on the kinetics of lidocaine and its metabolites and on regional blood flow. ( Allam, M; du Souich, P; Hartemann, D; Saunier, C, 1992) |
| "The authors studied the effect of lidocaine infusion on the ventilatory response to isocapnic hypoxia in nine healthy male subjects." | 7.67 | The effect of lidocaine infusion on the ventilatory response to hypoxia. ( Apfelbaum, JL; Caldwell, CB; Gross, JB; Shaw, LM, 1984) |
| " The aim of this study was to compare the effects of lidocaine and bupivacaine on the intrinsic pacemaker activity of in vitro sinoatrial nodal cells of the adult and neonatal guinea pig in the presence and absence of hypoxia and acidosis." | 7.67 | Comparison of lidocaine and bupivacaine depression of sinoatrial nodal activity during hypoxia and acidosis in adult and neonatal guinea pigs. ( Bosnjak, ZJ; Kampine, JP; Stowe, DF, 1986) |
| "IV lidocaine can significantly reduce the amount of propofol, the incidence of hypoxia and postoperative pain during gastroscopy in elderly patients, with a higher patient and gastroscopist satisfaction." | 5.51 | Intravenous Lidocaine Significantly Reduces the Propofol Dose in Elderly Patients Undergoing Gastroscopy: A Randomized Controlled Trial. ( Chen, Y; Hou, Q; Hu, S; Ji, Z; Li, S; Liao, L; Liu, F; Lu, Z; Lv, X; Shi, H; Sun, J; Sun, W; Wang, M; Wang, X; Wang, Y; Yang, H; Ye, P; Zhang, W; Zhang, Y; Zheng, L; Zhou, W, 2022) |
| "1." | 5.29 | Lidocaine reduces the hypoxia-induced release of an excitatory amino acid analog from rat striatal slices in superfusion. ( Bustos, G; Díaz, L; Gómez, A, 1995) |
| "We present a case of a patient administered parasternal transdermal lidocaine patch therapy as part of a multimodal analgesic regime designed to diminish opioid-associated delirium after coronary bypass surgery." | 3.88 | Rare cause of delirium and hypoxemia after coronary bypass surgery: transdermal lidocaine patch-associated methemoglobinemia. ( Acevedo, FA; Chyatte, DA; Kim, EJ; Nielsen, VG, 2018) |
| "To determine physiologic responses to apnea-induced severe hypoxemia in anesthetized horses." | 3.83 | Cardiovascular, respiratory and metabolic responses to apnea induced by atlanto-occipital intrathecal lidocaine injection in anesthetized horses. ( Aleman, M; Davis, E; Guedes, A; Tearney, C, 2016) |
| " The present study was designed to examine the effects of hypoxia/reperfusion on the disposition of glutamate and propranolol in the rat isolated perfused liver." | 3.74 | Effects of hypoxia/reperfusion injury on drug disposition in the rat isolated perfused liver. ( Arab, HA; Cheung, K; Hickman, PE; Kadkhodaee, M; Potter, JM; Roberts, MS, 2007) |
| "It was hypothesized that the increased myocardial blood flow known to occur during some types of hypoxia may alter the kinetics and dynamics of cardio-active drugs such as lidocaine that act directly on the myocardium." | 3.72 | The effect of hypoxic hypoxia on the systemic and myocardial pharmacokinetics and dynamics of lidocaine in sheep. ( Huang, YF; Upton, RN, 2003) |
| "In rat carotid artery, levcromakalim produced vasorelaxation mediated by adenosine triphosphate (ATP)-sensitive K(+) channels, whereas hypoxia induced it partly via these channels." | 3.72 | The role of K+ channels in vasorelaxation induced by hypoxia and the modulator effects of lidocaine in the rat carotid artery. ( Dojo, M; Hatano, Y; Iranami, H; Kimoto, Y; Kinoshita, H; Nakahata, K, 2003) |
| "To report a case of complete upper airway obstruction after topicalization with lidocaine in a completely conscious patient with partial upper airway obstruction." | 3.72 | Total airway obstruction during local anesthesia in a non-sedated patient with a compromised airway. ( Chung, DC; Ho, AM; Karmakar, MK; To, EW, 2004) |
| "We describe a 3-year-old child with mollusca contagiosa whose caregiver applied a eutectic mixture of 5% lidocaine and prilocaine (EMLA) in excessive amounts with the subsequent development of adverse reactions, including methemoglobinemia and hypoxemia." | 3.71 | Lidocaine and prilocaine toxicity in a patient receiving treatment for mollusca contagiosa. ( Jackson, JB; Touma, S, 2001) |
| " The authors examined the mechanism of apnea in a rabbit model of sudden ventilatory arrest during the combination of epidural anesthesia and hypoxia." | 3.70 | Hypoxia causes apnea during epidural anesthesia in rabbits. ( Amuzu, J; Bosnjak, ZJ; Clifford, PS; Hogan, QH; Kampine, JP, 1998) |
| "The principal finding of the present study with rat spinal cord slices was the novel demonstration of the [Ca2+]o-independent effect of ischemia on norepinephrine release and its antagonism by tetrodotoxin and low temperature (10 degrees C)." | 3.70 | Na+ channel block prevents the ischemia-induced release of norepinephrine from spinal cord slices. ( Bencsics, A; Nakai, T; Sato, T; Uchihashi, Y; Umeda, E; Vizi, ES, 1998) |
| "During ventilation hyperoxia, mean percent lung uptakes of lidocaine were 41-52% 1 minute after the beginning of lidocaine infusion, and decreased in time-dependent fashion to 7-12% 10 minutes later." | 3.69 | Lung uptake of lidocaine during hyperoxia and hypoxia in the dog. ( Fujimori, M; Hasegawa, K; Hayashi, M; Tatekawa, S; Yukioka, H, 1996) |
| "In this study, the effects of lidocaine and hypoxia on the biosynthesis of phospholipids in the hamster heart were examined." | 3.69 | The effects of lidocaine and hypoxia on phospholipid biosynthesis in the isolated hamster heart. ( Choy, PC; Man, RY; Wong, JT, 1996) |
| "Pulmonary arterial flow-pressure relationships were determined in hyperoxia and hypoxia, at baseline and after alpha-blockade (phentolamine 2 mg/kg + 50 micrograms." | 3.69 | Sympathetic modulation of hypoxic pulmonary vasoconstriction in intact dogs. ( Brichant, JF; Brimioulle, S; Delcroix, M; Lejeune, P; Naeije, R; Vachiéry, JL, 1997) |
| "The effect of acute and chronic hypoxia on the disposition of lidocaine and its metabolites, and on regional blood flow has been examined in conscious beagles (n = 5)." | 3.68 | Effect of acute and chronic moderate hypoxia on the kinetics of lidocaine and its metabolites and on regional blood flow. ( Allam, M; du Souich, P; Hartemann, D; Saunier, C, 1992) |
| "The authors studied the effect of lidocaine infusion on the ventilatory response to isocapnic hypoxia in nine healthy male subjects." | 3.67 | The effect of lidocaine infusion on the ventilatory response to hypoxia. ( Apfelbaum, JL; Caldwell, CB; Gross, JB; Shaw, LM, 1984) |
| "The effect of airway anaesthesia by lidocaine inhalation on the hypoxic ventilatory response was examined together with the heart rate response by the isocapnic progressive hypoxia test in human subjects." | 3.67 | Effect of airway anaesthesia on the ventilatory and heart rate responses to isocapnic progressive hypoxia. ( Honda, Y; Morikawa, T; Tanaka, Y, 1986) |
| " The aim of this study was to compare the effects of lidocaine and bupivacaine on the intrinsic pacemaker activity of in vitro sinoatrial nodal cells of the adult and neonatal guinea pig in the presence and absence of hypoxia and acidosis." | 3.67 | Comparison of lidocaine and bupivacaine depression of sinoatrial nodal activity during hypoxia and acidosis in adult and neonatal guinea pigs. ( Bosnjak, ZJ; Kampine, JP; Stowe, DF, 1986) |
| "However, adverse events such as hypoxemia often occur clinically." | 3.11 | Effects of intravenous lidocaine on hypoxemia induced by propofol-based sedation for gastrointestinal endoscopy procedures: study protocol for a prospective, randomized, controlled trial. ( An, LX; Qi, XR; Sun, JY; Xue, FS; Zhang, K, 2022) |
| " Unsedated PEG insertion appears to be a feasible, well-tolerated, and safe option for stroke-related dysphagia." | 1.51 | Unsedated Outpatient Percutaneous Endoscopic Gastrostomy in Stroke Patients: Is It Feasible and Safe? ( Kapanidis, K; Kotzampassi, K; Michalopoulos, A; Stavrou, G; Tsaousi, G, 2019) |
| "1." | 1.29 | The importance of sodium for anoxic transmission damage in rat hippocampal slices: mechanisms of protection by lidocaine. ( Amorim, P; Chambers, G; Cottrell, JE; Fried, E; Kass, IS, 1995) |
| "1." | 1.29 | Lidocaine reduces the hypoxia-induced release of an excitatory amino acid analog from rat striatal slices in superfusion. ( Bustos, G; Díaz, L; Gómez, A, 1995) |
| "Major cardiac arrhythmias occurred in 11% (8/70) of the patients during the bronchoscopic procedure." | 1.26 | The effect of fiberoptic bronchoscopy on cardiac rhythm. ( Lakshminarayan, S; Shrader, DL, 1978) |
| "The management of cardiac arrests in infants and children is based upon principles common to management of arrests of all age groups." | 1.26 | Cardiac arrests in children. ( Singer, J, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 52 (55.91) | 18.7374 |
| 1990's | 24 (25.81) | 18.2507 |
| 2000's | 8 (8.60) | 29.6817 |
| 2010's | 6 (6.45) | 24.3611 |
| 2020's | 3 (3.23) | 2.80 |
| Authors | Studies |
|---|---|
| Ma, X | 1 |
| Yan, W | 1 |
| He, N | 1 |
| Hu, S | 1 |
| Wang, M | 1 |
| Li, S | 1 |
| Zhou, W | 1 |
| Zhang, Y | 1 |
| Shi, H | 1 |
| Ye, P | 1 |
| Sun, J | 1 |
| Liu, F | 1 |
| Zhang, W | 1 |
| Zheng, L | 1 |
| Hou, Q | 1 |
| Wang, Y | 2 |
| Sun, W | 1 |
| Chen, Y | 1 |
| Lu, Z | 1 |
| Ji, Z | 1 |
| Liao, L | 1 |
| Lv, X | 1 |
| Wang, X | 1 |
| Yang, H | 1 |
| Qi, XR | 1 |
| Sun, JY | 1 |
| An, LX | 1 |
| Zhang, K | 1 |
| Xue, FS | 1 |
| Gordon, RJ | 1 |
| Lombard, FW | 1 |
| Acevedo, FA | 1 |
| Kim, EJ | 1 |
| Chyatte, DA | 1 |
| Nielsen, VG | 1 |
| Kumar, A | 1 |
| Kumar, N | 1 |
| Sinha, C | 1 |
| Tsaousi, G | 1 |
| Stavrou, G | 1 |
| Kapanidis, K | 1 |
| Michalopoulos, A | 1 |
| Kotzampassi, K | 1 |
| Zhang, J | 1 |
| Zhu, J | 1 |
| Yao, X | 1 |
| Duan, Y | 1 |
| Zhou, X | 1 |
| Yang, M | 1 |
| Li, X | 1 |
| Guedes, A | 1 |
| Aleman, M | 1 |
| Davis, E | 1 |
| Tearney, C | 1 |
| Huang, YF | 1 |
| Upton, RN | 1 |
| Kinoshita, H | 1 |
| Kimoto, Y | 1 |
| Nakahata, K | 1 |
| Iranami, H | 1 |
| Dojo, M | 1 |
| Hatano, Y | 1 |
| GORDH, T | 1 |
| KENMORE, PI | 1 |
| ZOHN, D | 1 |
| MIALE, A | 1 |
| ADAMS, JP | 1 |
| MILLER, PB | 1 |
| LEVERETT, SD | 1 |
| Martínez-Sánchez, M | 1 |
| Striggow, F | 1 |
| Schröder, UH | 1 |
| Kahlert, S | 1 |
| Reymann, KG | 1 |
| Reiser, G | 1 |
| Ho, AM | 1 |
| Chung, DC | 1 |
| To, EW | 1 |
| Karmakar, MK | 1 |
| Gutta, R | 1 |
| Louis, PJ | 1 |
| Arab, HA | 1 |
| Cheung, K | 1 |
| Hickman, PE | 1 |
| Potter, JM | 1 |
| Kadkhodaee, M | 1 |
| Roberts, MS | 1 |
| Yonemura, D | 1 |
| Kawasaki, K | 1 |
| Tsuchida, Y | 1 |
| Fujimura, K | 1 |
| Lagneaux, D | 1 |
| Gross, JB | 1 |
| Caldwell, CB | 1 |
| Shaw, LM | 1 |
| Apfelbaum, JL | 1 |
| Sage, DJ | 1 |
| Feldman, HS | 1 |
| Arthur, GR | 1 |
| Datta, S | 1 |
| Ferretti, AM | 1 |
| Norway, SB | 1 |
| Covino, BG | 2 |
| Evans, JJ | 1 |
| Gilmour, RF | 1 |
| Zipes, DP | 1 |
| Deglin, SM | 1 |
| Deglin, JM | 1 |
| Wurtzbacher, J | 1 |
| Litton, M | 1 |
| Rolfe, C | 1 |
| McIntire, C | 1 |
| Halpern, S | 1 |
| Glanc, P | 1 |
| Myhr, T | 1 |
| Ryan, M | 1 |
| Fong, K | 1 |
| Amankwah, K | 1 |
| Ohlsson, A | 1 |
| Cave, AC | 1 |
| Horowitz, GL | 1 |
| Apstein, CS | 1 |
| Haigney, MC | 1 |
| Lakatta, EG | 1 |
| Stern, MD | 1 |
| Silverman, HS | 1 |
| Sakura, S | 1 |
| Saito, Y | 1 |
| Kosaka, Y | 1 |
| Mets, B | 1 |
| Hickman, R | 1 |
| Allin, R | 1 |
| Van Dyk, J | 1 |
| Lotz, Z | 1 |
| Díaz, L | 1 |
| Gómez, A | 1 |
| Bustos, G | 1 |
| Ishibe, Y | 1 |
| Shiokawa, Y | 1 |
| Umeda, T | 1 |
| Uno, H | 1 |
| Nakamura, M | 1 |
| Izumi, T | 1 |
| Hasegawa, K | 1 |
| Yukioka, H | 1 |
| Hayashi, M | 1 |
| Tatekawa, S | 1 |
| Fujimori, M | 1 |
| Fried, E | 1 |
| Amorim, P | 1 |
| Chambers, G | 2 |
| Cottrell, JE | 2 |
| Kass, IS | 2 |
| Wong, JT | 1 |
| Man, RY | 1 |
| Choy, PC | 1 |
| Ju, YK | 1 |
| Saint, DA | 1 |
| Gage, PW | 1 |
| Jund, R | 1 |
| Kastenbauer, E | 1 |
| Brimioulle, S | 1 |
| Vachiéry, JL | 1 |
| Brichant, JF | 1 |
| Delcroix, M | 1 |
| Lejeune, P | 1 |
| Naeije, R | 1 |
| Hogan, QH | 1 |
| Amuzu, J | 1 |
| Clifford, PS | 1 |
| Bosnjak, ZJ | 2 |
| Kampine, JP | 2 |
| Uchihashi, Y | 1 |
| Bencsics, A | 1 |
| Umeda, E | 1 |
| Nakai, T | 1 |
| Sato, T | 1 |
| Vizi, ES | 1 |
| Baumgarten, KM | 1 |
| Gerstenblith, G | 1 |
| Weiss, RG | 1 |
| Touma, S | 1 |
| Jackson, JB | 1 |
| Raley-Susman, KM | 1 |
| Newman, RB | 1 |
| Wang, J | 1 |
| Sunamori, M | 1 |
| Harrison, CE | 1 |
| Wolf, PS | 1 |
| Avitall, B | 1 |
| Lazzara, R | 1 |
| Hope, RR | 1 |
| El-Sherif, N | 1 |
| Scherlag, BJ | 1 |
| Shrader, DL | 1 |
| Lakshminarayan, S | 1 |
| Guntheroth, W | 1 |
| Singer, J | 1 |
| Moore, EN | 1 |
| Spear, JF | 1 |
| Hondeghem, LM | 2 |
| Strashnov, VI | 1 |
| Tuleutaev, TB | 1 |
| Bing, OH | 1 |
| Brooks, WW | 1 |
| Messer, JV | 1 |
| Pacini, DJ | 1 |
| Boachie-Ansah, G | 1 |
| Kane, KA | 1 |
| du Souich, P | 2 |
| Saunier, C | 1 |
| Hartemann, D | 1 |
| Allam, M | 1 |
| Bushnell, PG | 1 |
| Brill, RW | 1 |
| Campbell, TJ | 1 |
| Wyse, KR | 1 |
| Hemsworth, PD | 1 |
| Zochodne, DW | 1 |
| Ho, LT | 1 |
| Raine, J | 1 |
| Warner, JO | 1 |
| Dart, AM | 1 |
| Riemersma, RA | 1 |
| Mace, SE | 1 |
| Adamantidis, MM | 1 |
| Caron, JF | 1 |
| Dupuis, BA | 1 |
| Amyes, EW | 1 |
| Garty, M | 1 |
| Ben-Zvi, Z | 1 |
| Hurwitz, A | 1 |
| White, CS | 1 |
| Dolwick, MF | 1 |
| Gravenstein, N | 1 |
| Paulus, DA | 1 |
| Tanaka, Y | 1 |
| Morikawa, T | 1 |
| Honda, Y | 1 |
| Marleau, S | 1 |
| Ong, H | 1 |
| Gariépy, L | 1 |
| Kano, T | 1 |
| Nishi, K | 1 |
| Stowe, DF | 1 |
| Sullivan, TY | 1 |
| DeWeese, EL | 1 |
| Rosen, MA | 1 |
| Thigpen, JW | 1 |
| Shnider, SM | 1 |
| Foutz, SE | 1 |
| Levinson, G | 1 |
| Koike, M | 1 |
| Bennett, A | 1 |
| Stockley, HL | 1 |
| Selzer, A | 1 |
| Cohn, KE | 1 |
| Mason, DT | 1 |
| Zelis, R | 1 |
| Lee, G | 1 |
| Hughes, JL | 1 |
| Spann, JF | 1 |
| Amsterdam, EA | 1 |
| Goodwin, GM | 1 |
| McCloskey, DI | 1 |
| Matthews, PB | 1 |
| Gettes, LS | 1 |
| Polu, JM | 1 |
| Sadoul, P | 1 |
| Dunn, GD | 1 |
| Hayes, P | 1 |
| Breen, KJ | 1 |
| Schenker, S | 1 |
| Grant, AO | 1 |
| Jensen, RA | 1 |
| Katz, RL | 1 |
| Bigger, JT | 1 |
| Patton, RD | 1 |
| Geddes, IC | 1 |
| Fuleihan, FJ | 1 |
| Habaybeh, A | 1 |
| Abdallah, A | 1 |
| Moussa, AH | 1 |
| Saif, M | 1 |
| Srougi, M | 1 |
| Kent, DC | 1 |
| Lee, JA | 1 |
| Mckenna, G | 1 |
| Engle, RP | 1 |
| Brooks, H | 1 |
| Dalen, J | 1 |
| Roberts, H | 1 |
| Boyagian, KV | 1 |
| Boba, A | 1 |
| Linkie, DM | 1 |
| Plotz, EJ | 1 |
| Pedersen, B | 1 |
| Morada, AO | 1 |
| Guz, A | 1 |
| Noble, MI | 1 |
| Widdicombe, JG | 1 |
| Trenchard, D | 1 |
| Mushin, WW | 1 |
| Wetzig, PC | 1 |
| Worlton, JT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Does Intravenous Lidocaine Reduce Propofol Consumption and the Side Effects of Sedation During Gastroscopy in ASA 1 and 2 Patients.[NCT05944887] | 46 participants (Actual) | Interventional | 2023-07-21 | Completed | |||
| Lidocaine For Neuroprotection During Cardiac Surgery[NCT00938964] | 550 participants (Actual) | Interventional | 2009-07-31 | Completed | |||
| The Effect Of A Neurodynamic Treatment On Nerve Conduction In Clients With Low Back Pain[NCT01402895] | 9 participants (Actual) | Interventional | 2011-05-31 | Completed | |||
| Use of Tendon Vibration and Mirror for the Improvement of Upper Limb Function and Pain Reduction After Stroke[NCT01010607] | Phase 1/Phase 2 | 30 participants (Anticipated) | Interventional | 2009-11-30 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Center for Epidemiological Studies Depression Scale (CES-D). The CES-D is a 20-item self-report examination designed to measure symptoms of depression. Subjects rate the degree to which they have experienced a range of symptoms of depression, such as I had crying spells and I felt lonely. Scores range from 0 to 60, with higher scores indicating greater depressive symptoms. Scores greater than 16 are typically considered indicative of clinically significant depression." (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | -1.27 |
| Placebo | -0.89 |
"Center for Epidemiological Studies Depression Scale (CES-D). The CES-D is a 20-item self-report examination designed to measure symptoms of depression. Subjects rate the degree to which they have experienced a range of symptoms of depression, such as I had crying spells and I felt lonely. Scores range from 0 to 60, with higher scores indicating greater depressive symptoms. Scores greater than 16 are typically considered indicative of clinically significant depression." (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 0.57 |
| Placebo | 0.16 |
To characterize cognitive function over time, while minimizing potential redundancy in the cognitive measures, a factor analysis was performed on the 14 cognitive test scores from baseline. We chose a five-factor solution, which represents 5 cognitive domains: structured verbal memory, unstructured verbal memory, executive function, visual memory and attention/concentration. To quantify overall cognitive function, a baseline cognitive index was first calculated as the mean of the 5 preoperative domain scores. The cognitive index score has a mean of zero, thus any positive score is above the mean, any negative score is below the mean. A continuous change score was then calculated by subtracting the baseline from the 1 year cognitive index. The resulting outcome measure is unbounded with standard deviation of 0.35. A negative change score indicating decline and a positive score indicating improvement (NCT00938964)
Timeframe: 1 year after surgery
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 0.09 |
| Placebo | 0.07 |
To characterize cognitive function over time, while minimizing potential redundancy in the cognitive measures, a factor analysis was performed on the 14 cognitive test scores from baseline. We chose a five-factor solution, which represents 5 cognitive domains: structured verbal memory, unstructured verbal memory, executive function, visual memory and attention/concentration. To quantify overall cognitive function, a baseline cognitive index was first calculated as the mean of the 5 preoperative domain scores. The cognitive index score has a mean of zero, thus any positive score is above the mean, any negative score is below the mean. A continuous change score was then calculated by subtracting the baseline from the 6-week cognitive index. The resulting outcome measure is unbounded with standard deviation of 0.35. A negative change score indicating decline and a positive score indicating improvement. (NCT00938964)
Timeframe: Preoperative to 6 weeks after surgery
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 0.07 |
| Placebo | 0.07 |
"The DASI is a 12-item scale of functional capacity that has been found to correlate well with objective measures of maximal exercise capacity. Items reflect activities of personal care, ambulation, household tasks, sexual function, and recreational activities. Activities done with no difficulty receive scores, which are weighted and summed, for a quantitative measure of functional status. Scores range from 0 to 60; a higher-weighted score indicates better function." (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 6.3 |
| Placebo | 6.96 |
"The DASI is a 12-item scale of functional capacity that has been found to correlate well with objective measures of maximal exercise capacity. Items reflect activities of personal care, ambulation, household tasks, sexual function, and recreational activities. Activities done with no difficulty receive scores, which are weighted and summed, for a quantitative measure of functional status. Scores range from 0 to 60; a higher-weighted score indicates better function." (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | -10.98 |
| Placebo | -11.67 |
The National Institutes of Health Stroke Scale (NIHSS) is a 15-item neurologic examination stroke scale used to evaluate the effect of acute cerebral infarction on the levels of consciousness, language, neglect, visual-field loss, extraocular movement, motor strength, ataxia, dysarthria, and sensory loss. A trained observer rates the patent's ability to answer questions and perform activities. Ratings for each item are scored with 3 to 5 grades with 0 as normal, and there is an allowance for untestable items. The range of scores is from 0 (normal) to 42 (profound effect of stroke on patient). (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 0.05 |
| Placebo | 0.07 |
The National Institutes of Health Stroke Scale (NIHSS) is a 15-item neurologic examination stroke scale used to evaluate the effect of acute cerebral infarction on the levels of consciousness, language, neglect, visual-field loss, extraocular movement, motor strength, ataxia, dysarthria, and sensory loss. A trained observer rates the patent's ability to answer questions and perform activities. Ratings for each item are scored with 3 to 5 grades with 0 as normal, and there is an allowance for untestable items. The range of scores is from 0 (normal) to 42 (profound effect of stroke on patient). (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 0.05 |
| Placebo | 0.04 |
The Western perioperative neurologic scale was designed to detect neurologic deficits after cardiac surgery. It includes 14 items classified into eight domains (mentation, speech, cranial nerve function, motor weakness, sensation and cerebellum, reflexes, and gait). Each item is scored from 0 (severe deficit) to3 (normal), and a maximum score of 42 indicates normal neurological function. (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 0.02 |
| Placebo | -0.02 |
The Western perioperative neurologic scale was designed to detect neurologic deficits after cardiac surgery. It includes 14 items classified into eight domains (mentation, speech, cranial nerve function, motor weakness, sensation and cerebellum, reflexes, and gait). Each item is scored from 0 (severe deficit) to3 (normal), and a maximum score of 42 indicates normal neurological function. (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 0.04 |
| Placebo | -0.01 |
"Perceived Social Support Scale: Twelve items indicate how strongly subjects agree that there is a special person who is around when I am in need and my family really tries to help me. Choices range from very strongly disagree to very strongly agree. Items are summed for a range of 12 to 84, with a high score meaning more social support." (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 0.71 |
| Placebo | -1.16 |
"Perceived Social Support Scale: Twelve items indicate how strongly subjects agree that there is a special person who is around when I am in need and my family really tries to help me. Choices range from very strongly disagree to very strongly agree. Items are summed for a range of 12 to 84, with a high score meaning more social support." (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 1.23 |
| Placebo | -0.49 |
"Social Activity: This measure consisted of eight items that indicate the degree of social interaction. Sample items are How often do you talk on the telephone with friends and relatives? and How often do you attend meetings of social groups, clubs, or civic organizations? Scores range from 8 to 32. A lower score indicates more social activity." (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | -0.20 |
| Placebo | 0.03 |
"Social Activity: This measure consisted of eight items that indicate the degree of social interaction. Sample items are How often do you talk on the telephone with friends and relatives? and How often do you attend meetings of social groups, clubs, or civic organizations? Scores range from 8 to 32. A lower score indicates more social activity." (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 0.95 |
| Placebo | 1.59 |
"Spielberger State Anxiety Inventory (STAI): The STAI consists of two 20-item scales that measure anxiety. Representative items include statements such as I feel nervous and I feel worried. These items are rated on a 4-point scale, based on how well they describe the patient's current or typical mood, from not at all to very much so. Scores range from 20 to 80, with higher scores indicating greater anxiety." (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | -6.70 |
| Placebo | -6.39 |
"Spielberger State Anxiety Inventory (STAI): The STAI consists of two 20-item scales that measure anxiety. Representative items include statements such as I feel nervous and I feel worried. These items are rated on a 4-point scale, based on how well they describe the patient's current or typical mood, from not at all to very much so. Scores range from 20 to 80, with higher scores indicating greater anxiety." (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | -7.12 |
| Placebo | -6.31 |
Symptom limitations: Patients were given a list of eight symptoms and asked to rate the degree to which the symptom limited daily activities. The symptoms were angina, shortness of breath, arthritis, back trouble, leg pains, headaches, fatigue, and other. Scores range from 8 to 32, with higher scores indicating greater limitations. (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | -1.39 |
| Placebo | -1.48 |
Symptom limitations: Patients were given a list of eight symptoms and asked to rate the degree to which the symptom limited daily activities. The symptoms were angina, shortness of breath, arthritis, back trouble, leg pains, headaches, fatigue, and other. Scores range from 8 to 32, with higher scores indicating greater limitations. (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | -0.67 |
| Placebo | -0.8 |
"Cognitive Difficulties Scale: a 39-item scale, is a self-report assessment of perceived problems in long- and short-term memory, concentration, attention, and psycho-motor coordination. Sample items are I forget errands I planned to do and I fail to recognize people I know. Scores range from 39 to 164, with higher scores indicating greater cognitive difficulty." (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | -0.46 |
| Placebo | -1.02 |
"Cognitive Difficulties Scale: a 39-item scale, is a self-report assessment of perceived problems in long- and short-term memory, concentration, attention, and psycho-motor coordination. Sample items are I forget errands I planned to do and I fail to recognize people I know. Scores range from 39 to 164, with higher scores indicating greater cognitive difficulty." (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | -3 |
| Placebo | -3.21 |
"Duke Older Americans Resources and Services Procedures- Instrumental Activities of Daily Living (OARS-IADL): This measure contains six items that assess the ability to perform important tasks for daily living (e.g., Could you prepare your own meals? Could you drive a car?). Scores range from 6 to 24. Higher scores indicate increasing difficulty in engaging in daily activities." (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | -0.15 |
| Placebo | -0.31 |
"Duke Older Americans Resources and Services Procedures- Instrumental Activities of Daily Living (OARS-IADL): This measure contains six items that assess the ability to perform important tasks for daily living (e.g., Could you prepare your own meals? Could you drive a car?). Scores range from 6 to 24. Higher scores indicate increasing difficulty in engaging in daily activities." (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Lidocaine | 2.46 |
| Placebo | 2.1 |
To characterize cognitive function over time, while minimizing potential redundancy in the cognitive measures, a factor analysis was performed on the 14 cognitive test scores from baseline. We chose a five-factor solution, which represents 5 cognitive domains: structured verbal memory, unstructured verbal memory, executive function, visual memory and attention/concentration. Each domain score is normally distributed with a mean of zero. A change score was calculated for each domain by subtracting the baseline from the 6-week score. A dichotomous outcome variable of post-operative cognitive deficit was defined as a decline of ≥1 standard deviation in 1 or more of the 5 domains. (NCT00938964)
Timeframe: Preoperative to 6 weeks after surgery
| Intervention | Participants (Count of Participants) |
|---|---|
| Lidocaine | 87 |
| Placebo | 83 |
The Medical Outcomes Study 36-Item Short Form Health Survey (SF-36): The SF-36 was designed to measure general health status. Two scales were used: Work Activities (four items) and General Health (one item). For the work activities scale, the reported score was the sum of four questions, each with values ranging from 1 to 4, the total score could range from 4 to 16. A higher score on Work Activities indicates more health-related problems For the general health question, the patients ranked their health from Excellent (1) to poor (5), the scale ranged from 1 to 5 with 1 being best health and 5 being worst. A high score in General Health indicates poorer health state. (NCT00938964)
Timeframe: baseline, 1-year
| Intervention | units on a scale (Mean) | |
|---|---|---|
| 1 year Change Work Activities | 1 year Change General health perception | |
| Lidocaine | -1.37 | -0.28 |
| Placebo | -1.42 | -0.43 |
The Medical Outcomes Study 36-Item Short Form Health Survey (SF-36): The SF-36 was designed to measure general health status. Two scales were used: Work Activities (four items) and General Health (one item). For the work activities scale, the reported score was the sum of four questions, each with values ranging from 1 to 4, the total score could range from 4 to 16. A higher score on Work Activities indicates more health-related problems For the general health question, the patients ranked their health from Excellent (1) to poor (5), the scale ranged from 1 to 5 with 1 being best health and 5 being worst. A high score in General Health indicates poorer health state. (NCT00938964)
Timeframe: baseline, 6-weeks
| Intervention | units on a scale (Mean) | |
|---|---|---|
| 6-Week Change Work activities | 6-Week Change General health perception | |
| Lidocaine | 2.71 | -0.004 |
| Placebo | 3 | -0.03 |
Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removalime points and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal
| Intervention | Mean linear fluorescence intensity-MLFI (Mean) | |||
|---|---|---|---|---|
| Baseline | Cross-clamp removal | End of Bypass | 6 hours post cross-clamp removal | |
| Lidocaine | -0.15 | 0.02 | -0.73 | -0.10 |
| Placebo | -0.43 | -0.73 | -0.40 | 0.19 |
Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removalime points and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal
| Intervention | Mean linear fluorescence intensity-MLFI (Mean) | |||
|---|---|---|---|---|
| Baseline | Cross-clamp removal | End of Bypass | 6 hours post cross-clamp removal | |
| Lidocaine | -4.22 | -2.46 | -0.34 | 1.21 |
| Placebo | -0.04 | 1.83 | 2.64 | 0.54 |
Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removal and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal
| Intervention | Mean linear fluorescence intensity-MLFI (Mean) | |||
|---|---|---|---|---|
| Baseline | Cross-clamp removal | End of Bypass | 6 hours post cross-clamp removal | |
| Lidocaine | -2.02 | 0.56 | 0.58 | 1.04 |
| Placebo | -0.08 | 0.17 | 1.19 | -0.68 |
Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removalime points and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal
| Intervention | Mean linear fluorescence intensity-MLFI (Mean) | |||
|---|---|---|---|---|
| Baseline | Cross-clamp removal | End of Bypass | 6 hours post cross-clamp removal | |
| Lidocaine | -0.03 | 0.03 | 0.33 | 0.37 |
| Placebo | 0.35 | 0.43 | 0.05 | 0.27 |
9 reviews available for lidocaine and Anoxemia
| Article | Year |
|---|---|
Perioperative Venous Thromboembolism: A Review.
Topics: Anticoagulants; Aspirin; Fibrinolytic Agents; Hemorrhage; Humans; Hydroxymethylglutaryl-CoA Reductas | 2017 |
Recent advances in local anaesthesia.
Topics: Acidosis; Anesthesia, Local; Anesthetics, Local; Animals; Arrhythmias, Cardiac; Bupivacaine; Cardiov | 1986 |
Treatment of ventricular extrasystoles and tachyarrhythmias in acute myocardial infarction.
Topics: Acidosis; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Electric Count | 1970 |
Current concepts and treatment of digitalis toxicity.
Topics: Adenosine Triphosphatases; Arrhythmias, Cardiac; Binding Sites; Biological Transport; Calcium; Catec | 1971 |
The electrophysiologic effects of antiarrhythmic drugs.
Topics: Acetylcholine; Acidosis; Action Potentials; Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Atrop | 1971 |
[Medical treatment of arrhythmia during acute respiratory insufficiency].
Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Catecholamines; Electric Stimulation; Electrocard | 1971 |
The liver in congestive heart failure: a review.
Topics: Alkaline Phosphatase; Anticoagulants; Ascites; Bilirubin; Digitalis Glycosides; Diuretics; Heart Fai | 1973 |
Cardiac arrhythmias during anesthesia and operation.
Topics: Acidosis, Respiratory; Age Factors; Anesthesia; Anesthetics; Animals; Arrhythmia, Sinus; Arrhythmias | 1970 |
Management of arrhythmias in acute myocardial infarction.
Topics: Acid-Base Equilibrium; Adams-Stokes Syndrome; Arrhythmias, Cardiac; Atropine; Bradycardia; Cardiac O | 1971 |
4 trials available for lidocaine and Anoxemia
| Article | Year |
|---|---|
Intravenous Lidocaine Significantly Reduces the Propofol Dose in Elderly Patients Undergoing Gastroscopy: A Randomized Controlled Trial.
Topics: Aged; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; Gastroscopy; Humans; Hypoxi | 2022 |
Effects of intravenous lidocaine on hypoxemia induced by propofol-based sedation for gastrointestinal endoscopy procedures: study protocol for a prospective, randomized, controlled trial.
Topics: Conscious Sedation; Endoscopy, Gastrointestinal; Humans; Hypotension; Hypoxia; Lidocaine; Midazolam; | 2022 |
Pharmacokinetics of Lidocaine Hydrochloride Metabolized by CYP3A4 in Chinese Han Volunteers Living at Low Altitude and in Native Han and Tibetan Chinese Volunteers Living at High Altitude.
Topics: Adult; Altitude; Anesthetics, Local; Animals; Asian People; Cytochrome P-450 CYP3A; Female; Healthy | 2016 |
Incidence of oxygen desaturation during oral surgery outpatient procedures.
Topics: Adolescent; Adult; Anesthesia, Dental; Blood Pressure Determination; Diazepam; Humans; Hypoxia; Lido | 1989 |
80 other studies available for lidocaine and Anoxemia
| Article | Year |
|---|---|
Lidocaine attenuates hypoxia/reoxygenation‑induced inflammation, apoptosis and ferroptosis in lung epithelial cells by regulating the p38 MAPK pathway.
Topics: A549 Cells; Apoptosis; Ferroptosis; Humans; Hypoxia; Inflammation; Lidocaine; Lung; Oxidative Stress | 2022 |
Rare cause of delirium and hypoxemia after coronary bypass surgery: transdermal lidocaine patch-associated methemoglobinemia.
Topics: Aged, 80 and over; Anesthetics, Local; Coronary Artery Bypass; Delirium; Humans; Hypoxia; Lidocaine; | 2018 |
Oxygen through suction port: use of a three way stopcock during fiberoptic bronchoscopy.
Topics: Alveolitis, Extrinsic Allergic; Analgesics, Opioid; Anesthetics, Local; Bronchoscopy; Equipment Desi | 2019 |
Unsedated Outpatient Percutaneous Endoscopic Gastrostomy in Stroke Patients: Is It Feasible and Safe?
Topics: Aged; Aged, 80 and over; Anesthesia, Local; Anesthetics, Local; Deglutition Disorders; Enteral Nutri | 2019 |
Cardiovascular, respiratory and metabolic responses to apnea induced by atlanto-occipital intrathecal lidocaine injection in anesthetized horses.
Topics: Anesthesia; Anesthetics; Animals; Apnea; Cardiovascular System; Female; Horses; Hypoxia; Injections, | 2016 |
The effect of hypoxic hypoxia on the systemic and myocardial pharmacokinetics and dynamics of lidocaine in sheep.
Topics: Animals; Female; Hemodynamics; Hypoxia; Lidocaine; Myocardium; Sheep | 2003 |
The role of K+ channels in vasorelaxation induced by hypoxia and the modulator effects of lidocaine in the rat carotid artery.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Carotid Artery, Common; Cromakalim; Dose-Re | 2003 |
HEART-VOLUME STUDIES III. PHONOCARDIOGRAPHIC AND ELECTROCARDIOGRAPHIC CHANGES DURING DILATATION OF THE HEART IN THE RABBIT.
Topics: Aged; Dilatation; Electrocardiography; Heart; Humans; Hypoxia; Lidocaine; Phonocardiography; Shock; | 1964 |
REGIONAL INTRAVENOUS ANESTHESIA.
Topics: Administration, Intravenous; Anesthesia; Anesthesia, Conduction; Anesthesia, Intravenous; Anesthesio | 1964 |
TOLERANCE TO TRANSVERSE (+GX) AND HEADWARD (+GZ) ACCELERATION AFTER PROLONGED BED REST.
Topics: Acceleration; Bed Rest; Heart; Heart Rate; Humans; Hypoxia; Lidocaine; Physiology; Rest; Vision, Ocu | 1965 |
Na(+) and Ca(2+) homeostasis pathways, cell death and protection after oxygen-glucose-deprivation in organotypic hippocampal slice cultures.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Boron Compounds; Calcium; Calcium Channel Blocker | 2004 |
Total airway obstruction during local anesthesia in a non-sedated patient with a compromised airway.
Topics: Aged; Airway Obstruction; Anesthesia, General; Anesthesia, Local; Anesthetics, Local; Atropine; Bron | 2004 |
Methemoglobinemia--an unusual cause of intraoperative hypoxia.
Topics: Administration, Topical; Adult; Aerosols; Anesthesia, Dental; Anesthetics, Combined; Anesthetics, Lo | 2007 |
Effects of hypoxia/reperfusion injury on drug disposition in the rat isolated perfused liver.
Topics: Adrenergic beta-Antagonists; Animals; Aspartate Aminotransferases; Carbon Dioxide; Carbon Radioisoto | 2007 |
[Effects of intravitreous injection of several chemicals and inhalation of hypoxic air on rabbit ERG].
Topics: Animals; Cyanides; Electroretinography; Eye; Hypoxia; Injections; Lidocaine; Pentobarbital; Rabbits; | 1966 |
[Technical difficulties raised by the suppression of ventilatory responses from peripheral chemoreceptors in the rat].
Topics: Animals; Chemoreceptor Cells; Hypoxia; Lidocaine; Methods; Rats; Rats, Inbred Strains; Respiration; | 1984 |
The effect of lidocaine infusion on the ventilatory response to hypoxia.
Topics: Adult; Blood Pressure; Heart Rate; Humans; Hypoxia; Infusions, Parenteral; Injections, Intravenous; | 1984 |
Influence of lidocaine and bupivacaine on isolated guinea pig atria in the presence of acidosis and hypoxia.
Topics: Acidosis; Animals; Bupivacaine; Guinea Pigs; Heart Atria; Heart Rate; Hypoxia; In Vitro Techniques; | 1984 |
The effects of lidocaine and quinidine on impulse propagation across the canine Purkinje-muscle junction during combined hyperkalemia, hypoxia, and acidosis.
Topics: Acidosis; Action Potentials; Animals; Barium; Dogs; Electric Conductivity; Electric Stimulation; Fem | 1984 |
Rapid serum lidocaine determination in the coronary care unit.
Topics: Aged; Arrhythmias, Cardiac; Coronary Care Units; Diagnostic Errors; Female; Humans; Hypotension, Ort | 1980 |
Uterine and umbilical blood flow velocity during epidural anaesthesia for caesarean section.
Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Arteries; Blood Flow Velocity; Cesarean Sectio | 1994 |
Can ischemic preconditioning protect against hypoxia-induced damage? Studies of contractile function in isolated perfused rat hearts.
Topics: Animals; Arrhythmias, Cardiac; Coronary Circulation; Energy Metabolism; Heart; Hypoxia; Lidocaine; M | 1994 |
Sodium channel blockade reduces hypoxic sodium loading and sodium-dependent calcium loading.
Topics: Amiloride; Animals; Benzofurans; Benzothiazoles; Calcium; Calcium Channel Blockers; Cell Separation; | 1994 |
Effect of extradural anaesthesia on the ventilatory response to hypoxaemia.
Topics: Adult; Aged; Anesthesia, Epidural; Carbon Dioxide; Female; Humans; Hypoxia; Lidocaine; Male; Middle | 1993 |
Effect of hypoxia on the hepatic metabolism of lidocaine in the isolated perfused pig liver.
Topics: Analysis of Variance; Animals; Energy Metabolism; Hypoxia; In Vitro Techniques; Kinetics; Lidocaine; | 1993 |
Lidocaine reduces the hypoxia-induced release of an excitatory amino acid analog from rat striatal slices in superfusion.
Topics: Animals; Aspartic Acid; Corpus Striatum; Hypoxia; Lidocaine; Male; Neurotoxins; Rats; Rats, Sprague- | 1995 |
The effect of thoracic epidural anesthesia on hypoxic pulmonary vasoconstriction in dogs: an analysis of the pressure-flow curve.
Topics: Analysis of Variance; Anesthesia, Epidural; Anesthetics, Local; Animals; Blood Pressure; Cardiac Out | 1996 |
Lung uptake of lidocaine during hyperoxia and hypoxia in the dog.
Topics: Adsorption; Anesthetics, Local; Animals; Dogs; Female; Hyperoxia; Hypoxia; Lidocaine; Lung; Male | 1996 |
The importance of sodium for anoxic transmission damage in rat hippocampal slices: mechanisms of protection by lidocaine.
Topics: Adenosine Triphosphate; Animals; Dose-Response Relationship, Drug; Evoked Potentials; Hippocampus; H | 1995 |
The effects of lidocaine and hypoxia on phospholipid biosynthesis in the isolated hamster heart.
Topics: Animals; Cricetinae; Heart; Hypoxia; In Vitro Techniques; Lidocaine; Mesocricetus; Myocardium; Phosp | 1996 |
Hypoxia increases persistent sodium current in rat ventricular myocytes.
Topics: Animals; Anti-Arrhythmia Agents; Electrophysiology; Heart Ventricles; Hypoxia; Ion Channel Gating; L | 1996 |
Susceptibility of isolated rat facial nerve to anaerobic stress.
Topics: Action Potentials; Anaerobiosis; Anesthetics, Local; Animals; Anticonvulsants; Cyanides; Disease Mod | 1997 |
Sympathetic modulation of hypoxic pulmonary vasoconstriction in intact dogs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthesia, Epidural; Animals; Arteries; | 1997 |
Hypoxia causes apnea during epidural anesthesia in rabbits.
Topics: Anesthesia, Epidural; Anesthetics, Local; Animals; Apnea; Atropine; Blood Pressure; Epinephrine; Gan | 1998 |
Na+ channel block prevents the ischemia-induced release of norepinephrine from spinal cord slices.
Topics: 4-Aminopyridine; Anesthetics, Local; Animals; Calcium; Calcium Channel Blockers; Cold Temperature; H | 1998 |
High extracellular K+ during hypoxic preconditioning episodes attenuates the post-ischemic contractile and ionic benefits of preconditioning.
Topics: Animals; Calcium; Disease Models, Animal; Dose-Response Relationship, Drug; Edetic Acid; Hypoxia; Is | 1999 |
Lidocaine and prilocaine toxicity in a patient receiving treatment for mollusca contagiosa.
Topics: Administration, Topical; Anesthetics, Combined; Child, Preschool; Female; Follow-Up Studies; Humans; | 2001 |
Sodium influx blockade and hypoxic damage to CA1 pyramidal neurons in rat hippocampal slices.
Topics: Adenosine Triphosphate; Anesthetics, Local; Animals; Calcium; Cytosol; Electrophysiology; Hippocampu | 2001 |
Myocardial respiration and edema following hypothermic cardioplegia and anoxic arrest.
Topics: Animals; Dogs; Edema, Cardiac; Heart Arrest, Induced; Heart Failure; Hypothermia, Induced; Hypoxia; | 1979 |
Arrhythmias in chronic pulmonary disease.
Topics: Arrhythmias, Cardiac; Chronic Disease; Digoxin; Humans; Hypokalemia; Hypoxia; Lidocaine; Lung Diseas | 1979 |
Strength-interval curves of isolated rat papillary muscle during hypoxia and reoxygenation: effect of lidocaine.
Topics: Animals; Electrophysiology; Hypoxia; Lidocaine; Oxygen Consumption; Papillary Muscles; Rats | 1979 |
Effects of lidocaine on hypoxic and ischemic cardiac cells.
Topics: Action Potentials; Animals; Coronary Disease; Dogs; Electric Stimulation; Endocardium; Heart Conduct | 1978 |
The effect of fiberoptic bronchoscopy on cardiac rhythm.
Topics: Adult; Aged; Arrhythmias, Cardiac; Atropine; Bronchoscopy; Coronary Disease; Electrocardiography; Fe | 1978 |
Neonatal and pediatric cardiovascular crises.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Bradycardia; Cardiovascular Diseases; Digoxin; Emerge | 1975 |
Cardiac arrests in children.
Topics: Age Factors; Airway Obstruction; Atropine; Bicarbonates; Blood Circulation; Blood Pressure; Calcium | 1977 |
Ventricular fibrillation threshold; its physiological and pharmacological importance.
Topics: Acidosis, Respiratory; Action Potentials; Aminophylline; Animals; Digitalis Glycosides; Dogs; Electr | 1975 |
Selective depression of the ischemic and hypoxic myocardium by lidocaine.
Topics: Animals; Coronary Disease; Depression, Chemical; Dogs; Electric Stimulation; Heart; Hypoxia; In Vitr | 1975 |
[Intensive acre and resuscitation in bronchial asthma and the asthmatic state].
Topics: Acidosis; Adolescent; Adult; Aminophylline; Anesthesia; Asthma; Critical Care; Droperidol; Ephedrine | 1975 |
Prolongation of tension on reoxygenation following myocardial hypoxia: a possible role for mitochondria in muscle relaxation.
Topics: Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Dinitrophenols; Glycolysis; Heart; Hypoxia; Insu | 1976 |
Modification by hypoxia, hyperkalaemia and acidosis of the cardiac electrophysiological effects of a range of antiarrhythmic drugs.
Topics: Acidosis; Action Potentials; Animals; Anti-Arrhythmia Agents; Disopyramide; Electrocardiography; Ele | 1992 |
Effect of acute and chronic moderate hypoxia on the kinetics of lidocaine and its metabolites and on regional blood flow.
Topics: Animals; Dogs; Hypoxia; Kinetics; Lidocaine; Regional Blood Flow | 1992 |
Oxygen transport and cardiovascular responses in skipjack tuna (Katsuwonus pelamis) and yellowfin tuna (Thunnus albacares) exposed to acute hypoxia.
Topics: Animals; Biological Transport; Blood Pressure; Cardiac Output; Cardiovascular Physiological Phenomen | 1992 |
Effects of hyperkalemia, acidosis, and hypoxia on the depression of maximum rate of depolarization by class I antiarrhythmic drugs in guinea pig myocardium: differential actions of class Ib and Ic agents.
Topics: Acidosis; Action Potentials; Amiodarone; Animals; Anti-Arrhythmia Agents; Electric Stimulation; Elec | 1991 |
Stimulation-induced peripheral nerve hyperemia: mediation by fibers innervating vasa nervorum?
Topics: Acidosis; Animals; Blood Gas Analysis; Blood Vessels; Electric Stimulation; Hydrogen-Ion Concentrati | 1991 |
Fibreoptic bronchoscopy without general anaesthetic.
Topics: Adolescent; Adult; Anesthesia, Local; Bronchoscopes; Bronchoscopy; Child; Child, Preschool; Consciou | 1991 |
Noradrenaline release from the rat heart during anoxia: effects of changes in extracellular sodium concentration and inhibition of sodium uptake mechanisms.
Topics: Amiloride; Animals; Extracellular Space; Hypoxia; In Vitro Techniques; Lidocaine; Male; Myocardium; | 1991 |
Effect of hypoxemia on pharmacokinetics of endotracheal lidocaine in dogs.
Topics: Animals; Dogs; Hypoxia; Intubation, Intratracheal; Lidocaine | 1990 |
Triggered activity induced by combined mild hypoxia and acidosis in guinea-pig Purkinje fibers.
Topics: Acidosis; Animals; Arrhythmias, Cardiac; Calcium; Female; Guinea Pigs; Heart Conduction System; Hypo | 1986 |
Lidocaine in treatment of hypoxia.
Topics: Humans; Hypoxia; Ischemic Attack, Transient; Lidocaine | 1989 |
Interaction of clonidine and morphine with lidocaine in mice and rats.
Topics: Animals; Blood Gas Analysis; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Hypoxia; L | 1989 |
Effect of airway anaesthesia on the ventilatory and heart rate responses to isocapnic progressive hypoxia.
Topics: Adult; Carbon Dioxide; Heart Rate; Humans; Hypoxia; Lidocaine; Male; Middle Aged; Respiration; Spiro | 1986 |
Lidocaine and indocyanine green kinetics: effect of hypoxemia and/or hypercapnia.
Topics: Animals; Arteries; Carbon Dioxide; Hydrogen-Ion Concentration; Hypercapnia; Hypoxia; Indocyanine Gre | 1987 |
External pH dependency of delayed afterdepolarization in rabbit myocardium.
Topics: Animals; Doxorubicin; Electrophysiology; Female; Hydrogen-Ion Concentration; Hypoxia; In Vitro Techn | 1986 |
Comparison of lidocaine and bupivacaine depression of sinoatrial nodal activity during hypoxia and acidosis in adult and neonatal guinea pigs.
Topics: Acidosis; Action Potentials; Age Factors; Animals; Animals, Newborn; Bupivacaine; Depression, Chemic | 1986 |
Lack of effect of airway anesthesia on hypoxic ventilation.
Topics: Adult; Airway Resistance; Anesthesia, Local; Forced Expiratory Flow Rates; Forced Expiratory Volume; | 1985 |
Bupivacaine-induced cardiotoxicity in hypoxic and acidotic sheep.
Topics: Acidosis, Respiratory; Animals; Arrhythmias, Cardiac; Blood Pressure; Bupivacaine; Dose-Response Rel | 1985 |
Electrically induced contractions of guinea-pig isolated ileum resistant to tetrodotoxin.
Topics: Acetylcholine; Animals; Cocaine; Cold Temperature; Drug Resistance; Electric Stimulation; Guinea Pig | 1973 |
The contribution of muscle afferents to kinaesthesia shown by vibration induced illusions of movement and by the effects of paralysing joint afferents.
Topics: Elbow; Humans; Hypoxia; Illusions; Joints; Kinesthesis; Lidocaine; Movement; Muscle Contraction; Mus | 1972 |
Antiarrhythmic drug action: selective depression of hypoxic cardiac cells.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Electrophysiol | 1974 |
Local anaesthetics.
Topics: Amides; Anesthetics, Local; Brain Edema; Cardiovascular Diseases; Central Nervous System Diseases; C | 1971 |
Respiratory function in moderate schistosomal infection. Effect of chemotherapy.
Topics: Adolescent; Adult; Anthelmintics; Antimony; Blood Gas Analysis; Humans; Hypoxia; Isoproterenol; Lido | 1969 |
The effects of local analgesics on respiration.
Topics: Apnea; Humans; Hypotension; Hypoxia; Lidocaine | 1970 |
Cardiac arrhythmias during electroshock therapy: significance, prevention, and treatment.
Topics: Acidosis, Respiratory; Aged; Arrhythmias, Cardiac; Blood Gas Analysis; Coronary Disease; Electrocard | 1970 |
Electrocardiographic changes associated with the use of epinephrine during general anaesthesia.
Topics: Adult; Anesthesia, General; Cardiovascular System; Electrocardiography; Epinephrine; Female; Heart; | 1970 |
Fetal effects of spinal hypotension. Observations in the dog at term of pregnancy.
Topics: Anesthesia, Spinal; Animals; Blood Pressure; Bradycardia; Dogs; Female; Fetal Diseases; Fetal Heart; | 1971 |
Blind nasotracheal intubation. A review and a new guided technique.
Topics: Adolescent; Adult; Aged; Analgesia; Anesthesia, General; Anesthesia, Local; Arteries; Blood Pressure | 1971 |
Cardiac arrhythmias. II.
Topics: Arrhythmias, Cardiac; Electroencephalography; Humans; Hypoxia; Lidocaine; Male; Middle Aged; Myocard | 1971 |
Postmortem pulmonary edema. Differential susceptibility in newborn and adult rabbits.
Topics: Age Factors; Animals; Animals, Newborn; Body Weight; Drug Synergism; Heart; Hypoxia; Lidocaine; Lung | 1968 |
Peripheral chemoreceptor block in man.
Topics: Adult; Carotid Body; Denervation; Glossopharyngeal Nerve; Humans; Hyperventilation; Hypoxia; Lidocai | 1966 |
The treatment of diabetic retinopathy by light coagulation. (A preliminary study).
Topics: Adult; Aged; Anesthesia, Local; Diabetic Retinopathy; Female; Follow-Up Studies; Humans; Hypoxia; Li | 1966 |