lidocaine has been researched along with Alloxan Diabetes in 23 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lidocaine is used clinically for tactile allodynia associated with diabetes-induced neuropathy." | 7.77 | Lidocaine attenuates the development of diabetic-induced tactile allodynia by inhibiting microglial activation. ( Hasegawa-Moriyama, M; Inada, E; Kamikubo, Y; Sakurai, T; Suzuki, N; Takahashi, Y, 2011) |
| "Rats developed tactile allodynia within days of the onset of diabetes and which persisted for up to 8 weeks." | 5.29 | Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine. ( Calcutt, NA; Chaplan, SR; Jorge, MC; Yaksh, TL, 1996) |
| "Lidocaine is used clinically for tactile allodynia associated with diabetes-induced neuropathy." | 3.77 | Lidocaine attenuates the development of diabetic-induced tactile allodynia by inhibiting microglial activation. ( Hasegawa-Moriyama, M; Inada, E; Kamikubo, Y; Sakurai, T; Suzuki, N; Takahashi, Y, 2011) |
| "Ranolazine's effects were evaluated on cardiac sodium current in normal- and high-glucose medium, with whole-cell patch-clamp technique." | 1.62 | Electrocardiological effects of ranolazine and lidocaine on normal and diabetic rat atrium. ( Khazraei, H; Mirkhani, H; Shabbir, W, 2021) |
| "Levobupivacaine was more potent than lidocaine in all tests employed on diabetic rats." | 1.39 | Comparison of actions of systemically and locally administrated local anaesthetics in diabetic rats with painful neuropathy. ( Gunay, I; Gunes, Y; Mert, T, 2013) |
| "Rats developed tactile allodynia within days of the onset of diabetes and which persisted for up to 8 weeks." | 1.29 | Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine. ( Calcutt, NA; Chaplan, SR; Jorge, MC; Yaksh, TL, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.35) | 18.7374 |
| 1990's | 6 (26.09) | 18.2507 |
| 2000's | 4 (17.39) | 29.6817 |
| 2010's | 9 (39.13) | 24.3611 |
| 2020's | 3 (13.04) | 2.80 |
| Authors | Studies |
|---|---|
| Luo, J | 1 |
| Wu, D | 1 |
| Wu, Q | 1 |
| Chen, Y | 1 |
| Gan, Y | 1 |
| He, M | 1 |
| Sun, W | 1 |
| Ai, Y | 1 |
| Su, Q | 1 |
| Zou, X | 1 |
| Wang, D | 1 |
| Khazraei, H | 1 |
| Mirkhani, H | 1 |
| Shabbir, W | 1 |
| Ouyang, J | 1 |
| Ji, X | 1 |
| Zhang, X | 1 |
| Feng, C | 1 |
| Tang, Z | 1 |
| Kong, N | 1 |
| Xie, A | 1 |
| Wang, J | 1 |
| Sui, X | 1 |
| Deng, L | 1 |
| Liu, Y | 1 |
| Kim, JS | 1 |
| Cao, Y | 1 |
| Tao, W | 1 |
| Végh, D | 1 |
| Somogyi, A | 1 |
| Bányai, D | 1 |
| Lakatos, M | 1 |
| Balogh, M | 1 |
| Al-Khrasani, M | 1 |
| Fürst, S | 1 |
| Vizi, ES | 1 |
| Hermann, P | 1 |
| García-Hernández, L | 1 |
| Navarrete-Vázquez, G | 1 |
| González-Trujano, ME | 1 |
| López-Muñoz, FJ | 1 |
| Déciga-Campos, M | 1 |
| Lehman, PA | 1 |
| Franz, TJ | 1 |
| Kharatmal, SB | 1 |
| Singh, JN | 1 |
| Sharma, SS | 1 |
| Suzuki, N | 1 |
| Hasegawa-Moriyama, M | 1 |
| Takahashi, Y | 1 |
| Kamikubo, Y | 1 |
| Sakurai, T | 1 |
| Inada, E | 1 |
| Mert, T | 2 |
| Gunes, Y | 2 |
| Gunay, I | 1 |
| Zhang, L | 1 |
| Xiong, XQ | 1 |
| Fan, ZD | 1 |
| Gan, XB | 1 |
| Gao, XY | 1 |
| Zhu, GQ | 1 |
| Kroin, JS | 1 |
| Buvanendran, A | 1 |
| Tuman, KJ | 1 |
| Kerns, JM | 1 |
| Anaga, AO | 1 |
| Njoku, CJ | 1 |
| Ekejiuba, ES | 1 |
| Esiaka, MN | 1 |
| Asuzu, IU | 1 |
| Kodama, SI | 1 |
| Mikawa, K | 1 |
| Nishina, K | 1 |
| Obara, H | 1 |
| Gawronska-Szklarz, B | 1 |
| Musial, HD | 1 |
| Loniewski, I | 1 |
| Paprota, B | 1 |
| Drozdzik, M | 1 |
| Courteix, C | 1 |
| Bardin, M | 1 |
| Chantelauze, C | 1 |
| Lavarenne, J | 1 |
| Eschalier, A | 1 |
| Wallace, W | 1 |
| Ahlers, ST | 1 |
| Gotlib, J | 1 |
| Bragin, V | 1 |
| Sugar, J | 1 |
| Gluck, R | 1 |
| Shea, PA | 1 |
| Davis, KL | 1 |
| Haroutunian, V | 1 |
| de Jong, RH | 1 |
| Calcutt, NA | 2 |
| Jorge, MC | 1 |
| Yaksh, TL | 1 |
| Chaplan, SR | 1 |
| Esmerino, LA | 1 |
| Ranali, J | 1 |
| Rodrigues, AL | 1 |
| Pertovaara, A | 1 |
| Wei, H | 1 |
| Kalmari, J | 1 |
| Ruotsalainen, M | 1 |
| Kalichman, MW | 1 |
| Meftah, NM | 1 |
| Skett, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Difference in Duration of Sciatic Nerve Block Between Diabetic and Non-diabetic Patients[NCT02482831] | 53 participants (Anticipated) | Observational | 2014-09-30 | Recruiting | |||
| Can Ultrasound Predict Nerve Injury Following Posterior Tibial Nerve Block in Patients With Peripheral Neuropathy?[NCT01002053] | 40 participants (Actual) | Observational | 2012-02-29 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
23 other studies available for lidocaine and Alloxan Diabetes
| Article | Year |
|---|---|
Lidocaine Ameliorates Diabetic Peripheral Neuropathy in Streptozotocin-Induced Diabetic Rats through Modulating the c-Jun Signaling Pathway.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Humans; Lidocaine; Rats; Signal Tra | 2022 |
Electrocardiological effects of ranolazine and lidocaine on normal and diabetic rat atrium.
Topics: Acetanilides; Action Potentials; Animals; Diabetes Mellitus, Experimental; Lidocaine; Piperazines; R | 2021 |
In situ sprayed NIR-responsive, analgesic black phosphorus-based gel for diabetic ulcer treatment.
Topics: Anesthetics, Local; Animals; Cell Line; Cell Proliferation; Diabetes Mellitus, Experimental; Diabeti | 2020 |
Effects of articaine on [
Topics: Adrenergic Neurons; Anesthesia, Local; Animals; Axons; Brain; Carticaine; Diabetes Mellitus, Experim | 2017 |
Antihyperalgesic activity of a novel synthesized analogue of lidocaine in diabetic rats.
Topics: Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Diabetes Complications; | 2013 |
Effect of induced acute diabetes and insulin therapy on stratum corneum barrier function in rat skin.
Topics: Animals; Diabetes Mellitus, Experimental; Epidermis; Ethanol; Hydrocortisone; Hypoglycemic Agents; I | 2014 |
Comparative evaluation of in vitro and in vivo high glucose-induced alterations in voltage-gated tetrodotoxin-resistant sodium channel: Effects attenuated by sodium channel blockers.
Topics: Animals; Antibiotics, Antineoplastic; Cells, Cultured; Diabetes Mellitus, Experimental; Disease Mode | 2015 |
Lidocaine attenuates the development of diabetic-induced tactile allodynia by inhibiting microglial activation.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Cells, Cultured; Chemokine CCL2; Chemotaxis; Diabetes | 2011 |
Comparison of actions of systemically and locally administrated local anaesthetics in diabetic rats with painful neuropathy.
Topics: Anesthetics, Local; Animals; Bupivacaine; Diabetes Mellitus, Experimental; Disease Models, Animal; F | 2013 |
Involvement of enhanced cardiac sympathetic afferent reflex in sympathetic activation in early stage of diabetes.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Arrhythmia Agents; Bradykinin | 2012 |
Safety of local anesthetics administered intrathecally in diabetic rats.
Topics: Anesthetics, Local; Animals; Bupivacaine; Diabetes Mellitus, Experimental; Epinephrine; Injections, | 2012 |
Antinociceptive activities of lidocaine and the nav1.8 blocker a803467 in diabetic rats.
Topics: Analgesics; Aniline Compounds; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Fema | 2012 |
Investigations of the methanolic leaf extract of Costus afer. Ker for pharmacological activities in vitro and in vivo.
Topics: Abortifacient Agents; Anesthetics, Local; Animals; Artemia; Blood Glucose; Costus; Diabetes Mellitus | 2004 |
Lidocaine attenuates streptozotocin-induced diaphragmatic dysfunction in rats.
Topics: Anesthetics, Local; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diaphragm; In Vitro Tec | 2004 |
Lidocaine metabolism in isolated perfused liver from streptozotocin-induced diabetic rats.
Topics: Anesthetics, Local; Animals; Body Weight; Diabetes Mellitus, Experimental; In Vitro Techniques; Lido | 2006 |
Study of the sensitivity of the diabetes-induced pain model in rats to a range of analgesics.
Topics: Analgesics; Animals; Antidepressive Agents, Tricyclic; Aspirin; Clonidine; Diabetes Mellitus, Experi | 1994 |
Amyloid precursor protein in the cerebral cortex is rapidly and persistently induced by loss of subcortical innervation.
Topics: 5,7-Dihydroxytryptamine; Acetylcholine; Actins; Afferent Pathways; Amyloid beta-Protein Precursor; A | 1993 |
Does diabetes reduce local anesthetic requirement?
Topics: Anesthetics, Local; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response R | 1993 |
Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine.
Topics: Aldehyde Reductase; Anesthetics, Local; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dia | 1996 |
Blood glucose determination in normal and alloxan-diabetic rats after administration of local anesthetics containing vasoconstrictors.
Topics: Alloxan; Analysis of Variance; Anesthetics, Local; Animals; Blood Glucose; Bupivacaine; Diabetes Mel | 1998 |
Pain behavior and response properties of spinal dorsal horn neurons following experimental diabetic neuropathy in the rat: modulation by nitecapone, a COMT inhibitor with antioxidant properties.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analysis of Variance; Anesthetics, Local; Animals; Antioxid | 2001 |
Local anesthetic-induced conduction block and nerve fiber injury in streptozotocin-diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Lidocaine; Nerve Fibers; Neural Conduction; Procai | 1992 |
Local anesthetic-induced conduction block and nerve fiber injury in streptozotocin-diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Lidocaine; Nerve Fibers; Neural Conduction; Procai | 1992 |
Local anesthetic-induced conduction block and nerve fiber injury in streptozotocin-diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Lidocaine; Nerve Fibers; Neural Conduction; Procai | 1992 |
Local anesthetic-induced conduction block and nerve fiber injury in streptozotocin-diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Lidocaine; Nerve Fibers; Neural Conduction; Procai | 1992 |
The role of microsomal phospholipids and their fatty acid composition in the control of hepatic metabolism of lignocaine.
Topics: Animals; Diabetes Mellitus, Experimental; Endoplasmic Reticulum; Fatty Acids; Female; Lidocaine; Liv | 1989 |