Page last updated: 2024-10-28

lidocaine and Allergic Reaction

lidocaine has been researched along with Allergic Reaction in 24 studies

Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.

Research Excerpts

ExcerptRelevanceReference
"Laryngeal TRPV1 plays an important role in cough sensitivity, but sensitization of capsaicin-sensitive cough receptors in the lower airway may be more responsible for the cough hypersensitivity in patients with UACS."7.79Capsaicin-sensitive cough receptors in lower airway are responsible for cough hypersensitivity in patients with upper airway cough syndrome. ( Lü, H; Qiu, Z; Wang, L; Xu, X; Yang, Z; Yu, L, 2013)
"Nebulized lidocaine enables dosages of oral corticosteroids to be tapered in the treatment of severe asthma."7.71Inhibitory effect of lidocaine on T cells from patients with allergic asthma. ( Adachi, M; Matsuo, H; Minoguchi, K; Oda, N; Okada, S; Tanaka, A; Tasaki, T; Yokoe, T, 2002)
"The analgesic effects on pain-related behaviors following the topical application of hangeshashinto were evaluated in an oral ulcer rat model treated with acetic acid using recently developed methods."3.83The traditional Japanese medicine hangeshashinto alleviates oral ulcer-induced pain in a rat model. ( Hattori, T; Hitomi, S; Imai, R; Inenaga, K; Kase, Y; Kubota, K; Omiya, Y; Ono, K; Terawaki, K; Yamaguchi, K, 2016)
"Laryngeal TRPV1 plays an important role in cough sensitivity, but sensitization of capsaicin-sensitive cough receptors in the lower airway may be more responsible for the cough hypersensitivity in patients with UACS."3.79Capsaicin-sensitive cough receptors in lower airway are responsible for cough hypersensitivity in patients with upper airway cough syndrome. ( Lü, H; Qiu, Z; Wang, L; Xu, X; Yang, Z; Yu, L, 2013)
"Nebulized lidocaine enables dosages of oral corticosteroids to be tapered in the treatment of severe asthma."3.71Inhibitory effect of lidocaine on T cells from patients with allergic asthma. ( Adachi, M; Matsuo, H; Minoguchi, K; Oda, N; Okada, S; Tanaka, A; Tasaki, T; Yokoe, T, 2002)
"Local allergic reaction was registered in one case, no systemic reactions were noticed."1.37[The surface anesthesia in outpatient pediatric department]. ( Bolotov, IuN; Matveevskaia, ES; Minaev, SV; Neshta, ES, 2011)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-199012 (50.00)18.7374
1990's3 (12.50)18.2507
2000's2 (8.33)29.6817
2010's6 (25.00)24.3611
2020's1 (4.17)2.80

Authors

AuthorsStudies
Martis, W1
Chahal, R1
Janas-Naze, A1
Osica, P1
Gallo, L1
Yu, L1
Xu, X1
Wang, L1
Yang, Z1
Lü, H1
Qiu, Z1
Hitomi, S1
Ono, K1
Yamaguchi, K1
Terawaki, K1
Imai, R1
Kubota, K1
Omiya, Y1
Hattori, T1
Kase, Y1
Inenaga, K1
Vieira dos Santos, R1
Metz, M1
Lima, HC1
Martus, P1
Maurer, M1
Bolotov, IuN1
Minaev, SV1
Matveevskaia, ES1
Neshta, ES1
Khokhlov, VD1
Krut', MI1
Sashko, SIu1
MORRISSET, LM1
CICHA, J1
DESCOMPS, H1
LUBENS, HM1
SANKER, JF1
HOLTI, G1
HOOD, FJ1
RAJKA, G2
NOBLE, DS1
PIERCE, GF1
Downes, H1
Gerber, N1
Hirshman, CA1
Jackson, D1
Chen, AH1
Bennett, CR1
Añíbarro, B1
Seoane, FJ1
Tanaka, A1
Minoguchi, K1
Oda, N1
Yokoe, T1
Matsuo, H1
Okada, S1
Tasaki, T1
Adachi, M1
Namimatsu, A1
Go, K1
Tanimoto, H1
Okuda, M1
Fitzgerald, M1
Millard, C1
McIntosh, N1
Delorme, P1
Lokken, P1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Maternal-Fetal Monitoring of Patients With Rheumatic Heart Disease During Dental Procedure Under Local Anesthesia[NCT00482573]Phase 131 participants (Actual)Interventional2004-04-30Completed
Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444]Phase 213 participants (Actual)Interventional2017-05-23Terminated (stopped due to Efficacy was not seen after interim analysis)
The Efficacy of the Eutectic Mixture of Local Anesthetics (EMLA) Cream Versus the Synera Patch for Pain Reduction During Venipuncture in Children[NCT00530803]Phase 2100 participants (Actual)Interventional2007-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Peak Itch Intensity Between the Vehicle and Active Treatments (Individual and KeAmLi-combo).

"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes

InterventionIntensity score (Mean)
Topical KeAmLi Combo62.7
Topical Ketamine63.1
Topical Amitriptyline69.2
Topical Lidocaine65.8
Topical Vehicle61.9

Mechanical Thresholds (Mechanical Detection and Pain).

Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes

,,,,
InterventionmN (Mean)
Mechanical Detection ThresholdMechanical Pain Threshold
Topical Amitriptyline3.573423965152.4768146
Topical KeAmLi Combo3.519376956152.3293608
Topical Ketamine3.464204768135.9
Topical Lidocaine3.546037659126.9
Topical Vehicle3.525692637148.7138273

Thermal Threshold Detection (Warmth and Heat Pain)

Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes

,,,,
InterventionDegrees celsius (Mean)
Warm Detection ThresholdHeat Pain Threshold
Topical Amitriptyline33.940.0
Topical KeAmLi Combo33.639.8
Topical Ketamine34.040.0
Topical Lidocaine33.739.4
Topical Vehicle33.839.7

Blinded Observer's Subjective Ratings of Participants' Pain Level at Tourniquet Placement, Using a 6-point NRS

The NRS (Numerical Rating Scale) is a 6-point rating scale where 0= no pain and 5 = worst pain. Blinded observers reported their own subjective evaluation of the level of pain experienced by the participants at tourniquet placement. Total number of participants subjectively evaluated as experiencing each pain level is reported. (NCT00530803)
Timeframe: before venipuncture

,
InterventionParticipants (Count of Participants)
Participants evaluated at NRS = 0 (No pain)Participants evaluated at NRS = 1Participants evaluated at NRS = 2Participants evaluated at NRS = 3Participants evaluated at NRS = 4Participants evaluated at NRS = 5
EMLA Cream4162100
Synera Patch3765110

Blinded Observer's Subjective Ratings of the Participant's Pain Level at 5 Minutes Post Venipuncture Procedure, Using a 6-point NRS

The NRS (Numerical Rating Scale) is a 6-point rating scale where 0= no pain and 5 = worst pain. Blinded observers reported their own subjective evaluation of the level of pain participants were experiencing 5 minutes after the venipuncture was completed. Total number of participants subjectively evaluated as experiencing each pain level is reported. (NCT00530803)
Timeframe: 5 minutes post venipuncture

,
InterventionParticipants (Count of Participants)
Participants evaluated at NRS = 0 (No pain)Participants evaluated at NRS = 1Participants evaluated at NRS = 2Participants evaluated at NRS = 3Participants evaluated at NRS = 4Participants evaluated at NRS = 5
EMLA Cream4531100
Synera Patch4541000

Blinded Observer's Subjective Ratings of the Participant's Pain Level at Needle Insertion, Using a 6-point NRS

The NRS (Numerical Rating Scale) is a 6-point rating scale where 0= no pain and 5 = worst pain. Blinded observers reported their own subjective evaluation of the level of pain experienced by the participants at needle insertion. Total number of participants subjectively evaluated as experiencing each pain level is reported. (NCT00530803)
Timeframe: during needle insertion

,
InterventionParticipants (Count of Participants)
Participants evaluated at NRS = 0 (No pain)Participants evaluated at NRS = 1Participants evaluated at NRS = 2Participants evaluated at NRS = 3Participants evaluated at NRS = 4Participants evaluated at NRS = 5
EMLA Cream32142200
Synera Patch25129220

Parent Rating of Child's Pain Using a 6-point NRS

The Numerical Rating Scale (NRS) is a 6-point rating scale where 0= no pain and 5 = worst pain. Parents reported their own subjective evaluation of participants pain level. Each participant had only one parental assessment. Total number of parental assessment for each pain level on the 6-point NRS is reported as total number of participants experiencing that pain level. (NCT00530803)
Timeframe: immediately after venipuncture is completed

,
InterventionParticipants (Count of Participants)
number of participants with NRS=0 (no pain)number of participants with NRS=1number of participants with NRS=2number of participants with NRS=3number of participants with NRS=4number of participants with NRS=5
EMLA Cream4261100
Synera Patch4151201

Participants Self-rating of Pain Using the Wong-Baker FACES Pain Rating Scale.

"Participants were asked to report their level of pain using a 6-point Wong-Baker FACES Pain Rating Scale ranging from 0, no pain, to 5, the most pain you can have. The Wong-Baker FACES Pain Rating Scale is a validated tool for measuring pain in patients as young as 3 years old. A FACES pain score less than or equal to 2 is considered no pain to mild pain, and is clinically acceptable. Studies have shown average FACES pain scores for children receiving vascular access with placebo to be 2.2 to 3.5." (NCT00530803)
Timeframe: immediately after completion of venipuncture

,
InterventionParticipants (Count of Participants)
Participants with FACES Score = 0 (No pain)Participants with FACES Score = 1Participants with FACES Score = 2Participants with FACES Score = 3Participants with FACES Score = 4Participants with FACES Score = 5
EMLA Cream4262000
Synera Patch3883100

Reviews

1 review available for lidocaine and Allergic Reaction

ArticleYear
[Anaphylactic shock following administration of lidocaine after negative skin test].
    Klinicheskaia meditsina, 2012, Volume: 90, Issue:7

    Topics: Anaphylaxis; Anesthetics, Local; Angioedema; Fatal Outcome; Female; Humans; Hypersensitivity; Inject

2012

Trials

2 trials available for lidocaine and Allergic Reaction

ArticleYear
Differential effects of skin nerves on allergic skin inflammation.
    Allergy, 2009, Volume: 64, Issue:3

    Topics: Anesthetics, Local; Double-Blind Method; Humans; Hypersensitivity; Inflammation; Lidocaine; Lidocain

2009
Cutaneous hypersensitivity following peripheral tissue damage in newborn infants and its reversal with topical anaesthesia.
    Pain, 1989, Volume: 39, Issue:1

    Topics: Anesthetics, Local; Ankle Injuries; Blood Specimen Collection; Double-Blind Method; Drug Combination

1989

Other Studies

21 other studies available for lidocaine and Allergic Reaction

ArticleYear
Expedited awake tracheal intubation using ropivacaine topicalisation for the evacuation of a postoperative neck haematoma in the presence of lignocaine allergy.
    BMJ case reports, 2023, Dec-01, Volume: 16, Issue:12

    Topics: Fiber Optic Technology; Hematoma; Humans; Hypersensitivity; Intubation, Intratracheal; Lidocaine; Ma

2023
The incidence of lidocaine allergy in dentists: an evaluation of 100 general dental practitioners.
    International journal of occupational medicine and environmental health, 2019, Jun-14, Volume: 32, Issue:3

    Topics: Adult; Anaphylaxis; Anesthetics, Local; Angioedema; Dentists; Female; Humans; Hypersensitivity; Inci

2019
Patients affected by premature ejaculation due to glans hypersensitivity refuse circumcision as a potential definite treatment for their problem.
    Andrologia, 2014, Volume: 46, Issue:4

    Topics: Adult; Anesthetics, Local; Circumcision, Male; Humans; Hypersensitivity; Lidocaine; Male; Penis; Pre

2014
Capsaicin-sensitive cough receptors in lower airway are responsible for cough hypersensitivity in patients with upper airway cough syndrome.
    Medical science monitor : international medical journal of experimental and clinical research, 2013, Dec-03, Volume: 19

    Topics: Adult; Anesthetics, Local; Capsaicin; Case-Control Studies; Cough; Dinoprostone; Enzyme-Linked Immun

2013
The traditional Japanese medicine hangeshashinto alleviates oral ulcer-induced pain in a rat model.
    Archives of oral biology, 2016, Volume: 66

    Topics: Acetic Acid; Administration, Topical; Analgesics; Animals; Disease Models, Animal; Drugs, Chinese He

2016
[The surface anesthesia in outpatient pediatric department].
    Khirurgiia, 2011, Issue:2

    Topics: Administration, Topical; Adolescent; Ambulatory Surgical Procedures; Anesthesia, Local; Anesthetics,

2011
Fatal anaphylactic reaction to lidocaine.
    United States Armed Forces medical journal, 1957, Volume: 8, Issue:5

    Topics: Anaphylaxis; Humans; Hypersensitivity; Immune System Diseases; Lidocaine

1957
[Contribution to the study of experimental allergy in the body].
    Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove, 1962, Volume: 5(Suppl)

    Topics: Blood Transfusion; Castration; Humans; Hypersensitivity; Lidocaine; Male; Orchiectomy; Splenectomy;

1962
[STIMULATION OF HYPOTHALAMO-HYPOPHYSIAL SECRETIONS IN MAN BY RETRO-STYLOID ANESTHETIC INFILTRATION].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1963, Sep-10, Volume: 39

    Topics: Adrenocorticotropic Hormone; Anesthetics; Asthma; Autonomic Nerve Block; Eczema; Endocrinology; Huma

1963
ANESTHETIC SKIN PATCH.
    Annals of allergy, 1964, Volume: 22

    Topics: Adolescent; Anesthesia; Anesthesia, Local; Anesthetics; Child; Humans; Hypersensitivity; Lidocaine;

1964
AN ANAPHYLACTOID REACTION TO LIGNOCAINE.
    The Dental practitioner and dental record, 1965, Volume: 15

    Topics: Anaphylaxis; Hypersensitivity; Lidocaine; Pharmacology; Toxicology; Vascular Diseases

1965
[Some remarks on llaocaine allergy].
    Svenska lakartidningen, 1960, Apr-22, Volume: 57

    Topics: Humans; Hypersensitivity; Immune System Diseases; Lidocaine

1960
Allergy to lignocaine. A casehistory.
    Lancet (London, England), 1961, Dec-30, Volume: 2, Issue:7218

    Topics: Humans; Hypersensitivity; Lidocaine; Medical Records

1961
[On lidocaine allergy].
    Allergie und Asthma, 1961, Volume: 7

    Topics: Drug Hypersensitivity; Humans; Hypersensitivity; Immune System Diseases; Lidocaine

1961
Intravenous lidocaine in reflex and allergic bronchoconstriction.
    Proceedings of the Western Pharmacology Society, 1980, Volume: 23

    Topics: Aerosols; Animals; Antigens; Ascaris; Bronchial Spasm; Citrates; Dogs; Hypersensitivity; Injections,

1980
Identifying true lidocaine allergy.
    Journal of the American Dental Association (1939), 1994, Volume: 125, Issue:10

    Topics: Anesthesia, Dental; Anesthesia, Local; Dental Anxiety; Diagnosis, Differential; Drug Hypersensitivit

1994
Identifying true lidocaine allergy.
    Journal of the American Dental Association (1939), 1994, Volume: 125, Issue:10

    Topics: Anesthesia, Dental; Anesthesia, Local; Dental Anxiety; Diagnosis, Differential; Drug Hypersensitivit

1994
Identifying true lidocaine allergy.
    Journal of the American Dental Association (1939), 1994, Volume: 125, Issue:10

    Topics: Anesthesia, Dental; Anesthesia, Local; Dental Anxiety; Diagnosis, Differential; Drug Hypersensitivit

1994
Identifying true lidocaine allergy.
    Journal of the American Dental Association (1939), 1994, Volume: 125, Issue:10

    Topics: Anesthesia, Dental; Anesthesia, Local; Dental Anxiety; Diagnosis, Differential; Drug Hypersensitivit

1994
Adverse reaction to lidocaine.
    Allergy, 1998, Volume: 53, Issue:7

    Topics: Adolescent; Akathisia, Drug-Induced; Anesthetics, Local; Dizziness; Double-Blind Method; Euphoria; F

1998
Inhibitory effect of lidocaine on T cells from patients with allergic asthma.
    The Journal of allergy and clinical immunology, 2002, Volume: 109, Issue:3

    Topics: Allergens; Animals; Anti-Inflammatory Agents; Asthma; CD4-Positive T-Lymphocytes; Cytokines; Dexamet

2002
Mechanism of nasal secretion mediated via nerve reflex in guinea pigs and evaluation of antiallergic drugs.
    International archives of allergy and immunology, 1992, Volume: 97, Issue:2

    Topics: Allergens; Aminopyridines; Animals; Atropine Derivatives; Bronchodilator Agents; Capsaicin; Ganglion

1992
Localized heat urticaria.
    The Journal of allergy, 1969, Volume: 43, Issue:5

    Topics: Adult; Anesthetics, Local; Chlorpheniramine; Desensitization, Immunologic; Female; Histamine H1 Anta

1969
[Local anesthetics and their pharmacology].
    Den Norske tannlaegeforenings tidende, 1968, Volume: 78, Issue:10

    Topics: Action Potentials; Anesthetics, Local; Chemistry, Pharmaceutical; Hyperemia; Hypersensitivity; Injec

1968