lidocaine has been researched along with Aging in 74 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the influence of aging on lidocaine requirements for propofol-induced pain on injection." | 9.12 | Influence of aging on lidocaine requirements for pain on injection of propofol. ( Fujii, Y; Shiga, Y, 2006) |
| "To assess whether preservative-free 1% lidocaine is capable of destroying the LECs in age-related cataract (ARC) in order to provide scientific basis for pursuing safe and effective drugs to eliminate LECs in cataract surgery." | 7.74 | [Pathological study on effects of preservative-free 1% lidocaine on lens epithelial cells of patients with age-related cataract]. ( Duan, HX; Guan, HJ; Wu, J; Zhu, RR, 2008) |
| "The proportion of chronic pain patients with suspected neuropathic pain who will have clinically meaningful pain relief with intravenous (IV) lidocaine and the clinical characteristics that identify these patients have not been described previously." | 7.74 | Multivariate analysis of chronic pain patients undergoing lidocaine infusions: increasing pain severity and advancing age predict likelihood of clinically meaningful analgesia. ( Carroll, I; Gaeta, R; Mackey, S, 2007) |
| "To evaluate the influence of aging on lidocaine requirements for propofol-induced pain on injection." | 5.12 | Influence of aging on lidocaine requirements for pain on injection of propofol. ( Fujii, Y; Shiga, Y, 2006) |
| "To assess whether preservative-free 1% lidocaine is capable of destroying the LECs in age-related cataract (ARC) in order to provide scientific basis for pursuing safe and effective drugs to eliminate LECs in cataract surgery." | 3.74 | [Pathological study on effects of preservative-free 1% lidocaine on lens epithelial cells of patients with age-related cataract]. ( Duan, HX; Guan, HJ; Wu, J; Zhu, RR, 2008) |
| "The proportion of chronic pain patients with suspected neuropathic pain who will have clinically meaningful pain relief with intravenous (IV) lidocaine and the clinical characteristics that identify these patients have not been described previously." | 3.74 | Multivariate analysis of chronic pain patients undergoing lidocaine infusions: increasing pain severity and advancing age predict likelihood of clinically meaningful analgesia. ( Carroll, I; Gaeta, R; Mackey, S, 2007) |
| " To determine whether age-related changes in alpha 1-acid glycoprotein influence drug binding in mother and newborn infant and also the effects of sex, pregnancy, and oral contraceptives on drug binding, the binding of lidocaine, diazepam, propranolol, d-tubocurarine, and metocurine was determined by equilibrium dialysis in 17 men, 16 nonpregnant women, 16 nonpregnant women on oral contraceptives, and 15 mothers and their newborn infants at delivery." | 3.66 | Changes in plasma drug binding and alpha 1-acid glycoprotein in mother and newborn infant. ( Wood, AJ; Wood, M, 1981) |
| "The area of punctate hyperalgesia was maintained in older adults over 4 h, while it declined in the young." | 2.74 | The effect of local anaesthetic on age-related capsaicin-induced mechanical hyperalgesia--a randomised, controlled study. ( Gibson, SJ; Helme, RD; McMeeken, JM; Zheng, Z, 2009) |
| "Pain was recorded on a visual analogue scale by the patient and on a 3-level scale by the physician." | 2.67 | A controlled study of low and high volume anesthetic jelly as a lubricant and pain reliever during cystoscopy. ( Brekkan, E; Ehrnebo, M; Malmström, PU; Norlén, BJ; Wirbrant, A, 1991) |
| "Lidocaine was most detrimental to proliferation in HFB." | 1.43 | Lidocaine Impairs Proliferative and Biosynthetic Functions of Aged Human Dermal Fibroblasts. ( Bentov, I; Damodarasamy, M; Reed, MJ; Spiekerman, C, 2016) |
| "Lidocaine treatment also activated caspase-3/7 in a dose- and time-dependent manner similarly in both ages." | 1.40 | Despite differences in cytosolic calcium regulation, lidocaine toxicity is similar in adult and neonatal rat dorsal root ganglia in vitro. ( Blanck, TJ; Doan, LV; Eydlin, O; Kline, RP; Piskoun, B; Recio-Pinto, E; Rosenberg, AD; Xu, F, 2014) |
| "Isoflurane may not cause long-lasting neuropathological changes." | 1.38 | Lidocaine attenuates cognitive impairment after isoflurane anesthesia in old rats. ( Cao, L; Li, J; Lin, D; Wang, Z; Washington, JM; Zuo, Z, 2012) |
| "Lidocaine's effect was assessed alone and then when given in combination with N-acetylprocainamide, a Class III antiarrhythmic agent." | 1.28 | Rate-dependent effects of lidocaine on His-Purkinje conduction in the intact neonatal heart--characterization and amplification by N-acetylprocainamide. ( Clarkson, CW; Dise, TL; Pickoff, AS; Stolfi, A, 1991) |
| " Fourteen elderly subjects aged 60-72 years (mean 67 years) and five young subjects age 31-48 years (mean 42 years) were compared with respect to dosage requirements to achieve satisfactory local anesthesia, rate and extent of lidocaine systemic absorption, plasma drug levels, elimination half-life, and drug side effects." | 1.28 | Systemic absorption of topical lidocaine in elderly and young adults undergoing bronchoscopy. ( Ameer, B; Burlingame, MB; Harman, EM, 1989) |
| " Pharmacokinetic data derived included the rate constants k21, k12 (drug movement between two compartments), k10 (elimination from the central compartment), and the volume of distribution (V beta)." | 1.27 | The influence of age on lignocaine pharmacokinetics in young puppies. ( Brown, TC; Eyres, RL; Hastings, CL; Oppenheim, RC, 1986) |
| " The collection of serial urine together with a limited number of blood samples from neonates enabled simultaneous computer fitting of data to a pharmacokinetic model." | 1.26 | The pharmacokinetics and metabolism of the anilide local anaesthetics in neonates. I. Lignocaine. ( Mihaly, GW; Moore, RG; Shanks, CA; Thomas, D; Thomas, J; Triggs, EJ, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 35 (47.30) | 18.7374 |
| 1990's | 20 (27.03) | 18.2507 |
| 2000's | 9 (12.16) | 29.6817 |
| 2010's | 10 (13.51) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pavičić Šarić, J | 1 |
| Vidjak, V | 1 |
| Tomulić, K | 1 |
| Zenko, J | 1 |
| Hongpaisan, J | 1 |
| Xu, C | 1 |
| Sen, A | 1 |
| Nelson, TJ | 1 |
| Alkon, DL | 1 |
| Doan, LV | 1 |
| Eydlin, O | 1 |
| Piskoun, B | 1 |
| Kline, RP | 1 |
| Recio-Pinto, E | 1 |
| Rosenberg, AD | 1 |
| Blanck, TJ | 1 |
| Xu, F | 1 |
| Govindapillai, A | 1 |
| Hua, R | 1 |
| Rose, R | 1 |
| Friesen, CH | 1 |
| O'Blenes, SB | 1 |
| Bentov, I | 1 |
| Damodarasamy, M | 1 |
| Spiekerman, C | 1 |
| Reed, MJ | 1 |
| Carçak, N | 1 |
| Aker, RG | 1 |
| Ozdemir, O | 1 |
| Demiralp, T | 1 |
| Onat, FY | 1 |
| Guan, HJ | 1 |
| Duan, HX | 1 |
| Wu, J | 1 |
| Zhu, RR | 1 |
| Zheng, Z | 1 |
| Gibson, SJ | 1 |
| Helme, RD | 1 |
| McMeeken, JM | 1 |
| Heath, JC | 1 |
| Banna, KM | 1 |
| Reed, MN | 1 |
| Pesek, EF | 1 |
| Cole, N | 1 |
| Li, J | 2 |
| Newland, MC | 1 |
| Waite, A | 1 |
| Gilliver, SC | 1 |
| Masterson, GR | 1 |
| Hardman, MJ | 1 |
| Ashcroft, GS | 1 |
| Schebesta, K | 1 |
| Güloglu, E | 1 |
| Chiari, A | 1 |
| Mayer, N | 1 |
| Kimberger, O | 1 |
| Lin, D | 1 |
| Cao, L | 1 |
| Wang, Z | 1 |
| Washington, JM | 1 |
| Zuo, Z | 1 |
| Mutungi, G | 1 |
| Edman, KA | 1 |
| Ranatunga, KW | 1 |
| OERIU, S | 1 |
| TIGHECIU, M | 1 |
| Blumstein, H | 1 |
| Gorevic, PD | 1 |
| Fujii, Y | 1 |
| Shiga, Y | 1 |
| Carroll, I | 1 |
| Gaeta, R | 1 |
| Mackey, S | 1 |
| Morikawa, Y | 2 |
| Rosen, MR | 4 |
| Freund, PR | 2 |
| Bowdle, TA | 2 |
| Slattery, JT | 1 |
| Bell, LE | 1 |
| Pech, C | 1 |
| Boussaton, E | 1 |
| Rigaud, J | 1 |
| Carcarrère, F | 1 |
| Lareng, L | 1 |
| Drayer, DE | 1 |
| Lorenzo, B | 1 |
| Werns, S | 1 |
| Reidenberg, MM | 1 |
| Park, WY | 2 |
| Hagins, FM | 1 |
| Rivat, EL | 1 |
| Macnamara, TE | 2 |
| Knowles, MR | 1 |
| Buntin, WH | 1 |
| Bromberg, PA | 1 |
| Gatzy, JT | 1 |
| Boucher, RC | 1 |
| Poon, KC | 1 |
| Massengale, MD | 1 |
| Lowenthal, DT | 1 |
| Affrime, MB | 1 |
| Goldberg, PB | 3 |
| Roberts, J | 3 |
| Cusack, B | 1 |
| Kelly, JG | 1 |
| Lavan, J | 1 |
| Noel, J | 1 |
| O'Malley, K | 1 |
| Wood, M | 1 |
| Wood, AJ | 1 |
| Manivannan, S | 1 |
| Terakawa, S | 1 |
| Panksepp, J | 1 |
| Normansell, L | 1 |
| Cox, JF | 1 |
| Siviy, SM | 1 |
| Sato, S | 1 |
| Okubo, N | 2 |
| Yamashita, S | 1 |
| Yamamoto, S | 1 |
| Kumagai, M | 2 |
| Kihara, S | 1 |
| Nakayama, H | 1 |
| Pritchard-Davies, R | 1 |
| Gross, AS | 1 |
| Shenfield, GM | 1 |
| Hamra, M | 1 |
| Lehman, PA | 1 |
| Franz, TJ | 1 |
| Tanila, H | 1 |
| Rämä, P | 1 |
| Carlson, S | 1 |
| Roder, JD | 1 |
| Shen, Y | 1 |
| Sangiah, S | 1 |
| Orlando, R | 1 |
| Palatini, P | 1 |
| Watanabe, S | 1 |
| Takeshima, R | 1 |
| Asakura, N | 1 |
| Taguchi, N | 1 |
| Satsumae, T | 1 |
| Bouaziz, H | 1 |
| Malinovsky, JM | 1 |
| Benhamou, D | 1 |
| Samii, K | 1 |
| Mazoit, JX | 1 |
| Brumberg, JC | 1 |
| Nowak, LG | 1 |
| McCormick, DA | 1 |
| Holman, SJ | 1 |
| Bosco, RR | 1 |
| Kao, TC | 1 |
| Mazzilli, MA | 1 |
| Dietrich, KJ | 1 |
| Rolain, RA | 1 |
| Stevens, RA | 1 |
| Vanker, AD | 1 |
| Mizukami, H | 1 |
| Mary-Rabine, L | 1 |
| Mihaly, GW | 1 |
| Moore, RG | 1 |
| Thomas, J | 1 |
| Triggs, EJ | 2 |
| Thomas, D | 1 |
| Shanks, CA | 2 |
| Nation, RL | 1 |
| Selig, M | 1 |
| Otis, TS | 1 |
| Mody, I | 1 |
| Rossi, SJ | 1 |
| Schroeder, TJ | 1 |
| Vine, WH | 1 |
| A-Kader, HH | 1 |
| Gremse, DA | 1 |
| Ryckman, FC | 1 |
| Pedersen, SH | 1 |
| Pesce, AJ | 1 |
| Balistreri, WF | 1 |
| Abete, P | 1 |
| Ferrara, N | 1 |
| Leosco, D | 1 |
| Caccese, P | 1 |
| Landino, P | 1 |
| Sederino, S | 1 |
| Balbi, R | 1 |
| Rengo, F | 1 |
| Hunt, CM | 1 |
| Westerkam, WR | 1 |
| Stave, GM | 1 |
| Dise, TL | 1 |
| Stolfi, A | 1 |
| Clarkson, CW | 1 |
| Pickoff, AS | 1 |
| Nye, HE | 1 |
| Seidler, FJ | 2 |
| Slotkin, TA | 2 |
| Fujita, S | 2 |
| Brekkan, E | 1 |
| Ehrnebo, M | 1 |
| Malmström, PU | 1 |
| Norlén, BJ | 1 |
| Wirbrant, A | 1 |
| Anderson-Brown, T | 1 |
| Rosen, TS | 1 |
| Hordof, AJ | 1 |
| Spach, MS | 1 |
| Dolber, PC | 1 |
| Heidlage, JF | 1 |
| Bovianska, N | 1 |
| Duda, K | 1 |
| Kołodziejski, L | 1 |
| Kwiecień, G | 1 |
| Machowska, B | 1 |
| Ameer, B | 1 |
| Burlingame, MB | 1 |
| Harman, EM | 1 |
| Lee, EJ | 1 |
| Benzon, HT | 1 |
| Strichartz, GR | 1 |
| Gissen, AJ | 1 |
| Covino, BG | 1 |
| Datta, S | 1 |
| Finucane, BT | 1 |
| Hammonds, WD | 1 |
| Welch, MB | 1 |
| Whittet, HB | 1 |
| Hayward, AW | 1 |
| Battersby, E | 1 |
| Camboulives, J | 1 |
| Couvely, JP | 1 |
| Alphonsi, R | 1 |
| Unal, D | 1 |
| Hastings, CL | 1 |
| Brown, TC | 1 |
| Eyres, RL | 1 |
| Oppenheim, RC | 1 |
| Tatsuno, J | 1 |
| Kawai, R | 1 |
| Kitagawa, H | 1 |
| Suzuki, T | 1 |
| Kitani, K | 1 |
| Davis, D | 1 |
| Grossman, SH | 1 |
| Kitchell, BB | 1 |
| Shand, DG | 1 |
| Routledge, PA | 1 |
| Bromage, PR | 2 |
| Gertel, M | 1 |
| Robelli, F | 1 |
| De Vita, C | 1 |
| Cadel, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intravenous Lidocaine for Postoperative Recovery in Liver Surgery, a Randomized Double Blinded Placebo-controlled Study[NCT05153785] | Phase 2/Phase 3 | 80 participants (Anticipated) | Interventional | 2021-11-15 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for lidocaine and Aging
| Article | Year |
|---|---|
Rheumatologic illnesses: treatment strategies for older adults.
Topics: Adjuvants, Immunologic; Administration, Topical; Aged; Aging; Analgesics; Anesthetics, Local; Arthri | 2005 |
[Aging and drug metabolism: alteration of liver drug metabolizing ability in male rats. Is it functional deterioration or feminization of the liver?].
Topics: Aging; Animals; Cytochrome P-450 Enzyme System; Diazepam; Electron Transport; Female; Feminization; | 1991 |
9 trials available for lidocaine and Aging
| Article | Year |
|---|---|
Effects of age on minimum effective volume of local anesthetic for ultrasound-guided supraclavicular brachial plexus block.
Topics: Adult; Aged; Aged, 80 and over; Aging; Anesthetics, Local; Arm; Brachial Plexus; Bupivacaine; Dose-R | 2013 |
The effect of local anaesthetic on age-related capsaicin-induced mechanical hyperalgesia--a randomised, controlled study.
Topics: Adult; Aged; Aging; Analysis of Variance; Anesthetics, Local; Capsaicin; Female; Humans; Hyperalgesi | 2009 |
Topical lidocaine reduces the risk of perioperative airway complications in children with upper respiratory tract infections.
Topics: Administration, Topical; Aging; Anesthesia; Anesthesia Recovery Period; Anesthetics, Local; Child; C | 2010 |
Influence of aging on lidocaine requirements for pain on injection of propofol.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Anesthesia, Intravenous; Anesthetics, Intravenou | 2006 |
Pharmacokinetics of lignocaine in the elderly [proceedings].
Topics: Adult; Aged; Aging; Humans; Kinetics; Lidocaine | 1980 |
The effect of liver disease and food on plasma MEGX concentrations.
Topics: Adult; Aged; Aging; Eating; Female; Humans; Injections, Intravenous; Lidocaine; Liver Cirrhosis; Liv | 1994 |
The effect of age on retrieval of local anesthetic solution from the epidural space.
Topics: Adult; Aged; Aged, 80 and over; Aging; Anesthesia, Epidural; Anesthetics, Local; Epidural Space; Epi | 1997 |
What constitutes an effective but safe initial dose of lidocaine to test a thoracic epidural catheter?
Topics: Adult; Aged; Aging; Anesthesia, Epidural; Anesthetics, Local; Cardiac Output; Cardiography, Impedanc | 2001 |
A controlled study of low and high volume anesthetic jelly as a lubricant and pain reliever during cystoscopy.
Topics: Aging; Anesthesia, Local; Cystoscopes; Cystoscopy; Female; Gels; Humans; Lidocaine; Lubrication; Mal | 1991 |
63 other studies available for lidocaine and Aging
| Article | Year |
|---|---|
PKC activation during training restores mushroom spine synapses and memory in the aged rat.
Topics: Aging; Anesthetics, Local; Animals; Brain-Derived Neurotrophic Factor; Bryostatins; Caprylates; Dend | 2013 |
Despite differences in cytosolic calcium regulation, lidocaine toxicity is similar in adult and neonatal rat dorsal root ganglia in vitro.
Topics: Aging; Anesthetics, Local; Animals; Animals, Newborn; Apoptosis; Calcium; Calcium Signaling; Caspase | 2014 |
Discussion.
Topics: Age Factors; Aging; Animals; Cardiac Surgical Procedures; Cardioplegic Solutions; Heart Arrest, Indu | 2013 |
Protecting the aged heart during cardiac surgery: use of del Nido cardioplegia provides superior functional recovery in isolated hearts.
Topics: Age Factors; Aging; Animals; Biomarkers; Cardiac Output; Cardiac Surgical Procedures; Cardioplegic S | 2013 |
Lidocaine Impairs Proliferative and Biosynthetic Functions of Aged Human Dermal Fibroblasts.
Topics: Adult; Aged, 80 and over; Aging; Anesthetics, Local; Cell Proliferation; Cells, Cultured; Dermis; Fi | 2016 |
The relationship between age-related development of spike-and-wave discharges and the resistance to amygdaloid kindling in rats with genetic absence epilepsy.
Topics: Aging; Amygdala; Analysis of Variance; Animals; Electric Stimulation; Electroencephalography; Epilep | 2008 |
[Pathological study on effects of preservative-free 1% lidocaine on lens epithelial cells of patients with age-related cataract].
Topics: Adult; Aged; Aged, 80 and over; Aging; Cataract; Epithelial Cells; Female; Humans; Lens, Crystalline | 2008 |
Dietary selenium protects against selected signs of aging and methylmercury exposure.
Topics: Aging; Animals; Diet; Dose-Response Relationship, Drug; Environmental Pollutants; Female; Hand Stren | 2010 |
Clinically relevant doses of lidocaine and bupivacaine do not impair cutaneous wound healing in mice.
Topics: Aging; Anesthetics, Local; Animals; Bupivacaine; Collagen; Dermatologic Surgical Procedures; Disease | 2010 |
Lidocaine attenuates cognitive impairment after isoflurane anesthesia in old rats.
Topics: Aging; Amyloid beta-Peptides; Anesthetics, Inhalation; Anesthetics, Local; Animals; Brain; Cognition | 2012 |
A mechanical stretch induces contractile activation in unstimulated developing rat skeletal muscle in vitro.
Topics: Aging; Animals; Animals, Newborn; Butylene Glycols; Calcium; In Vitro Techniques; Intracellular Memb | 2003 |
OXIDIZED GLUTATHIONE AS A TEST OF SENESCENCE.
Topics: Aging; Animals; Biomedical Research; Blood Chemical Analysis; Corrinoids; Cysteine; Folic Acid; Geri | 1964 |
Multivariate analysis of chronic pain patients undergoing lidocaine infusions: increasing pain severity and advancing age predict likelihood of clinically meaningful analgesia.
Topics: Adolescent; Adult; Aged; Aging; Analysis of Variance; Anesthetics, Local; Chronic Disease; Cohort St | 2007 |
Developmental changes in the effects of lidocaine on the electrophysiological properties of canine Purkinje fibers.
Topics: Action Potentials; Aging; Animals; Dogs; Drug Interactions; Female; Heart Conduction System; In Vitr | 1984 |
Caudal anesthesia with lidocaine or bupivacaine: plasma local anesthetic concentration and extent of sensory spread in old and young patients.
Topics: Adult; Aging; Anesthesia, Caudal; Anesthesia, Epidural; Bupivacaine; Epinephrine; Humans; Lidocaine; | 1984 |
[Axillary block of the brachial plexus and flunitrazepam premedication in surgery of the upper limb (study of 1,500 cases)].
Topics: Adolescent; Adult; Aged; Aging; Arm; Axilla; Brachial Plexus; Bupivacaine; Child; Child, Preschool; | 1984 |
Plasma levels, protein binding, and elimination data of lidocaine and active metabolites in cardiac patients of various ages.
Topics: Aged; Aging; Aspartate Aminotransferases; Bilirubin; Biotransformation; Blood Proteins; Creatinine; | 1983 |
Age and epidural dose response in adult men.
Topics: Adult; Aged; Aging; Anesthesia, Epidural; Dose-Response Relationship, Drug; Drug Combinations; Epine | 1982 |
Measurements of transepithelial electric potential differences in the trachea and bronchi of human subjects in vivo.
Topics: Adolescent; Adult; Aged; Aging; Amiloride; Bronchi; Epithelium; Female; Humans; Lidocaine; Male; Mem | 1982 |
Direction of the needle bevel and epidural anesthetic spread.
Topics: Adult; Aged; Aging; Anesthesia, Epidural; Epinephrine; Humans; Lidocaine; Male; Middle Aged; Needles | 1982 |
Cardiovascular drugs for the geriatric patient.
Topics: Aged; Aging; Antihypertensive Agents; Cardiovascular Agents; Cardiovascular Physiological Phenomena; | 1981 |
Age-related changes in rat atrial sensitivity to lidocaine.
Topics: Action Potentials; Aging; Animals; Heart; Heart Atria; In Vitro Techniques; Lidocaine; Male; Membran | 1981 |
Changes in plasma drug binding and alpha 1-acid glycoprotein in mother and newborn infant.
Topics: Adult; Aging; Blood Proteins; Contraceptives, Oral; Diazepam; Female; Humans; Infant, Newborn; Lidoc | 1981 |
Rapid sprouting of filopodia in nerve terminals of chromaffin cells, PC12 cells, and dorsal root neurons induced by electrical stimulation.
Topics: Aging; Animals; Calcium; Cattle; Cells, Cultured; Chromaffin System; Colchicine; Electric Stimulatio | 1994 |
Effects of neonatal decortication on the social play of juvenile rats.
Topics: Aging; Animals; Animals, Newborn; Appetitive Behavior; Brain Mapping; Cerebral Cortex; Cerebral Deco | 1994 |
Age-related decrease in toe-thumb temperature difference with lumbar epidural anaesthesia.
Topics: Adult; Aged; Aging; Anesthesia, Epidural; Blood Pressure; Ephedrine; Hallux; Heart Rate; Humans; Lid | 1994 |
The influence of pH on the use-dependent effects of lidocaine in adult and neonatal canine Purkinje fibers.
Topics: Action Potentials; Aging; Animals; Animals, Newborn; Dogs; Electrophysiology; Hydrogen-Ion Concentra | 1993 |
Effect of age and diet on stratum corneum barrier function in the Fischer 344 female rat.
Topics: Aging; Animals; Cell Membrane Permeability; Diet; Female; Hydrocortisone; Lidocaine; Rats; Rats, Inb | 1993 |
The effects of prefrontal intracortical microinjections of an alpha-2 agonist, alpha-2 antagonist and lidocaine on the delayed alternation performance of aged rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Imidazoles; Lidocaine; Male | 1996 |
The effects of verapamil and lidocaine on the duration of propofol and xylazine-ketamine anesthesia in broiler chickens.
Topics: Aging; Analysis of Variance; Anesthesia; Anesthetics; Animals; Calcium Channel Blockers; Chickens; D | 1996 |
The effect of age on plasma MEGX concentrations.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Fluorescence Polarization Immunoassay; Humans; Li | 1997 |
The age-related effects of epidural lidocaine, with and without epinephrine, on spinal cord blood flow in anesthetized rabbits.
Topics: Aging; Anesthesia, Epidural; Anesthetics, Local; Animals; Cardiac Output; Epinephrine; Lidocaine; Ma | 1999 |
Ionic mechanisms underlying repetitive high-frequency burst firing in supragranular cortical neurons.
Topics: Action Potentials; Aging; Animals; Calcium; Chelating Agents; Cycloleucine; Egtazic Acid; Female; Fe | 2000 |
Changes in the activity of acetylcholinesterase from the brain of the Mongolian gerbil (Meriones unguiculatus) with age.
Topics: Acetylcholinesterase; Aging; Animals; Animals, Newborn; Brain; Gerbillinae; Kinetics; Lidocaine; Mep | 1979 |
Changes in responsiveness of the heart to drugs during aging.
Topics: Aging; Animals; Anti-Arrhythmia Agents; Heart; Heart Atria; Heart Rate; Heart Ventricles; Lidocaine; | 1979 |
Lidocaine effects on action potentials of Purkinje fibers from neonatal and adult dogs.
Topics: Action Potentials; Aging; Animals; Animals, Newborn; Dogs; Heart Conduction System; In Vitro Techniq | 1978 |
The pharmacokinetics and metabolism of the anilide local anaesthetics in neonates. I. Lignocaine.
Topics: Adult; Aging; Biotransformation; Humans; Infant, Newborn; Intestinal Absorption; Kinetics; Lidocaine | 1978 |
Lignocaine kinetics in cardiac patients and aged subjects.
Topics: Adult; Aged; Aging; Half-Life; Heart Diseases; Humans; Infusions, Parenteral; Injections, Intravenou | 1977 |
Changes in cardiac membranes as a function of age with particular emphasis on reactivity to drugs.
Topics: Action Potentials; Aging; Animals; Heart; Heart Conduction System; Heart Rate; Hydroxydopamines; In | 1975 |
Modulation of decay kinetics and frequency of GABAA receptor-mediated spontaneous inhibitory postsynaptic currents in hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Anesthetics, Local; Animal | 1992 |
Monoethylglycinexylide formation in assessing pediatric donor liver function.
Topics: Adult; Aging; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Ch | 1992 |
Age-related effects of ischemia, lidocaine and verapamil on overdrive-induced suppression of ventricular pacemakers in isolated rat heart.
Topics: Aging; Animals; Coronary Disease; In Vitro Techniques; Lidocaine; Male; Rats; Rats, Inbred Strains; | 1992 |
Effect of age and gender on the activity of human hepatic CYP3A.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alcohol Drinking; Aryl Hydrocarbon Hydroxylases; Body Weight; | 1992 |
Rate-dependent effects of lidocaine on His-Purkinje conduction in the intact neonatal heart--characterization and amplification by N-acetylprocainamide.
Topics: Acecainide; Aging; Animals; Animals, Newborn; Atrial Function; Bundle of His; Dogs; Drug Synergism; | 1991 |
Developmental shift from local to central control of norepinephrine release in the cardiac-sympathetic axis: effects of cocaine and related drugs.
Topics: Abnormalities, Drug-Induced; Aging; Animals; Cocaine; Female; Heart; Lidocaine; Myocardium; Nerve En | 1991 |
Cocaine acutely inhibits DNA synthesis in developing rat brain regions: evidence for direct actions.
Topics: Aging; Animals; Brain; Cell Division; Cocaine; DNA; Female; Leucine; Lidocaine; Methoxamine; Nerve T | 1990 |
Developmental changes in the effects of lidocaine and quinidine on the canine heart.
Topics: Aging; Animals; Dogs; Electrocardiography; Heart; Lidocaine; Quinidine | 1987 |
Influence of the passive anisotropic properties on directional differences in propagation following modification of the sodium conductance in human atrial muscle. A model of reentry based on anisotropic discontinuous propagation.
Topics: Action Potentials; Adolescent; Adult; Aged; Aging; Cardiac Complexes, Premature; Child; Child, Presc | 1988 |
[Plasma concentrations of 2% lidocaine during epidural analgesia in urology].
Topics: Adult; Aged; Aged, 80 and over; Aging; Analgesia, Epidural; Chromatography, High Pressure Liquid; Do | 1989 |
[Effect of age and intravenous dose of lidocaine on the circulatory reaction during bronchoscopy].
Topics: Adult; Aging; Bronchoscopy; Hemodynamics; Humans; Lidocaine; Male; Middle Aged | 1989 |
Systemic absorption of topical lidocaine in elderly and young adults undergoing bronchoscopy.
Topics: Administration, Topical; Adult; Aged; Aging; Bronchoscopy; Female; Humans; Intestinal Absorption; Li | 1989 |
Disposition of drugs in the elderly.
Topics: Adrenergic beta-Antagonists; Aged; Aging; Benzodiazepines; Digoxin; Diuretics; Half-Life; Humans; In | 1987 |
Developmental neurophysiology of mammalian peripheral nerves and age-related differential sensitivity to local anaesthetic.
Topics: Action Potentials; Aging; Animals; Autonomic Fibers, Preganglionic; In Vitro Techniques; Lidocaine; | 1988 |
Influence of age on vascular absorption of lidocaine from the epidural space.
Topics: Absorption; Adult; Aging; Anesthesia, Epidural; Epidural Space; Humans; Immunoenzyme Techniques; Kin | 1987 |
The effect of age on plasma clearance of epidural lidocaine and bupivacaine.
Topics: Adult; Aged; Aging; Bupivacaine; Humans; Injections, Epidural; Lidocaine; Male; Middle Aged | 1988 |
Plasma lignocaine levels during paediatric endoscopy of the upper respiratory tract. Relationship with mucosal moistness.
Topics: Administration, Topical; Aging; Atropine; Body Fluids; Child; Child, Preschool; Endoscopy; Humans; I | 1988 |
[Plasma determination of lidocaine and bupivacaine after caudal anesthesia in children].
Topics: Adolescent; Aging; Anesthesia, Caudal; Anesthesia, Epidural; Bupivacaine; Child; Child, Preschool; F | 1986 |
The influence of age on lignocaine pharmacokinetics in young puppies.
Topics: Aging; Animals; Animals, Newborn; Dogs; Infusions, Parenteral; Kinetics; Lidocaine | 1986 |
Age associated alteration of lidocaine metabolism is position selective.
Topics: Aging; Animals; Chromatography, High Pressure Liquid; Lidocaine; Microsomes, Liver; Rats; Rats, Inbr | 1985 |
The effects of age and smoking on the plasma protein binding of lignocaine and diazepam.
Topics: Adolescent; Adult; Aged; Aging; Diazepam; Female; Humans; Lidocaine; Male; Middle Aged; Orosomucoid; | 1985 |
Improved brachial plexus blockade with bupivacaine hydrochloride and carbonated lidocaine.
Topics: Adolescent; Adult; Age Factors; Aged; Aging; Anesthesia, Conduction; Anesthetics, Local; Brachial Pl | 1972 |
Ageing and epidural dose requirements: segmental spread and predictability of epidural analgesia in youth and extreme age.
Topics: Adolescent; Adult; Age Factors; Aged; Aging; Anesthesia, Spinal; Anesthetics; Child; Child, Preschoo | 1969 |
[Therapy of acute myocardial infarct with particular reference to arrhythmia and myocardial contractibility disorders].
Topics: Adult; Aged; Aging; Arrhythmias, Cardiac; Atropine; Cardiac Glycosides; Cortisone; Electric Counters | 1971 |