lidocaine has been researched along with Adverse Drug Event in 22 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the study was to compare the effectiveness of pain control between lidocaine spray (LS) and paracervical block (PB) with lidocaine during the loop electrosurgical excision procedure (LEEP)." | 5.27 | Lidocaine Spray Versus Paracervical Block During Loop Electrosurgical Excision Procedure: A Randomized Trial. ( Buapaichit, K; Chalapati, W; Limwatanapan, N; Saenpoch, S; Songthamwat, M; Songthamwat, S, 2018) |
| " Symptoms, interventions, and treatment-related adverse events addressed in this issue are management of Alzheimer's agitation with donepezil; needle-free lidocaine powder for minor painful procedures; psychostimulants in depression; anticoagulation for cancer-related venous thromboembolism; effect of waiting for acute pain treatment on risk of chronic pain; and an update on severe cutaneous reactions associated with medications." | 4.85 | Pain and palliative care pharmacotherapy literature summaries and analyses. ( Abernethy, AP; Farrell, TW, 2009) |
| " Pharmacokinetic parameters estimated for phentolamine, lidocaine, and epinephrine included peak plasma concentration (Cmax), time to peak plasma concentration (Tmax), area under the plasma concentration-time curve from 0 to the last time point (AUClast) or from time 0 to infinity (AUCinf), elimination half-life (t1/2), clearance (CL), and volume of distribution (Vd)." | 2.73 | Pharmacokinetics of lidocaine with epinephrine following local anesthesia reversal with phentolamine mesylate. ( Goodson, JM; Hersh, EV; Moore, PA; Navalta, L; Papas, AS; Rogy, S; Rutherford, B; Yagiela, JA, 2008) |
| "Forty-four patients with mild cervical stenosis and 30 patients with moderate to severe cervical stenosis were consecutively enrolled into two groups." | 1.91 | Ultrasound-guided nerve hydrodissection of cervical nerve roots for cervical radicular pain in patients with mild and moderate to severe stenosis: a retrospective cohort study. ( Lin, CH; Wu, CY; Yen, YS, 2023) |
| "Tumescent liposuction under local anesthesia is a safe method, providing it is performed by an experienced surgeon and the guidelines of care for liposuction are strictly followed." | 1.37 | Safety of tumescent liposuction under local anesthesia in a series of 4,380 patients. ( Boeni, R, 2011) |
| " Although the use of topical lidocaine is considered relatively safe, instances of cardiotoxic and neurotoxic adverse events have been reported to occur." | 1.33 | Systemic toxicity from topically applied lidocaine in conjunction with fractional photothermolysis. ( Fincher, EF; Marra, DE; Moy, RL; Yip, D, 2006) |
| "Many patients with HIV/AIDS are now being treated with two or more drugs to reduce HIV viraemia and boost CD4 T-cell counts." | 1.30 | Anti-retroviral drugs--implications for dental prescribing. ( Greenwood, I; Heylen, R; Zakrzewska, JM, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (13.64) | 18.7374 |
| 1990's | 2 (9.09) | 18.2507 |
| 2000's | 5 (22.73) | 29.6817 |
| 2010's | 8 (36.36) | 24.3611 |
| 2020's | 4 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Thumtecho, S | 1 |
| Wainipitapong, S | 1 |
| Saoraya, J | 1 |
| Thanthitaweewat, V | 1 |
| Suteparuk, S | 1 |
| Lin, CH | 1 |
| Yen, YS | 1 |
| Wu, CY | 1 |
| Matveev, AV | 1 |
| Krasheninnikov, AE | 1 |
| Yagudina, RI | 1 |
| Egorova, EA | 1 |
| Konyaeva, EI | 1 |
| Bahar, E | 1 |
| Yoon, H | 1 |
| Wendt-Hornickle, E | 1 |
| Goudie-DeAngelis, E | 1 |
| Baldo, C | 1 |
| Limwatanapan, N | 1 |
| Chalapati, W | 1 |
| Songthamwat, S | 1 |
| Saenpoch, S | 1 |
| Buapaichit, K | 1 |
| Songthamwat, M | 1 |
| Moore, PA | 1 |
| Hersh, EV | 1 |
| Papas, AS | 1 |
| Goodson, JM | 1 |
| Yagiela, JA | 1 |
| Rutherford, B | 1 |
| Rogy, S | 1 |
| Navalta, L | 1 |
| Abernethy, AP | 1 |
| Farrell, TW | 1 |
| Braam, SR | 1 |
| Tertoolen, L | 1 |
| van de Stolpe, A | 1 |
| Meyer, T | 1 |
| Passier, R | 1 |
| Mummery, CL | 1 |
| Thyen, AB | 1 |
| McAllister, RK | 1 |
| Councilman, LM | 1 |
| Fu, B | 1 |
| Sharp, H | 1 |
| Boeni, R | 1 |
| Suzuki, J | 1 |
| Nikko, H | 1 |
| Kaiho, F | 1 |
| Yamaguchi, K | 1 |
| Wada, H | 1 |
| Suzuki, M | 1 |
| Marra, DE | 1 |
| Yip, D | 1 |
| Fincher, EF | 1 |
| Moy, RL | 1 |
| Doody, MM | 1 |
| Linet, MS | 1 |
| Glass, AG | 1 |
| Curtis, RE | 1 |
| Pottern, LM | 1 |
| Rush, BB | 1 |
| Boice, JD | 1 |
| Fraumeni, JF | 1 |
| Friedman, GD | 1 |
| Greenwood, I | 1 |
| Heylen, R | 1 |
| Zakrzewska, JM | 1 |
| Karim, A | 1 |
| Ahmed, S | 1 |
| Siddiqui, R | 1 |
| Mattana, J | 1 |
| Colgan, FJ | 1 |
| Yaffe, SJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phentolamine Mesylate as a Reversal of Local Anesthesics[NCT03740386] | 90 participants (Actual) | Interventional | 2016-01-01 | Completed | |||
| A Phase 4, Multicenter, Randomized, Double-Blinded, Controlled Study of OraVerse® for Safety and Efficacy in Pediatric Dental Patients Undergoing Mandibular and Maxillary Procedures[NCT01474382] | Phase 4 | 150 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| Does Use of Lidocaine Spray on an Endoscope Immediately Before Insertion Improve Patient Tolerance to Endoscopy? A Single Center, Case-Control Study.[NCT02307773] | 497 participants (Actual) | Observational | 2013-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for lidocaine and Adverse Drug Event
| Article | Year |
|---|---|
Lidocaine: A Local Anesthetic, Its Adverse Effects and Management.
Topics: Anesthesia, Local; Anesthetics, Local; Drug Hypersensitivity; Drug-Related Side Effects and Adverse | 2021 |
Pain and palliative care pharmacotherapy literature summaries and analyses.
Topics: Alzheimer Disease; Amphetamines; Anesthetics, Local; Anticoagulants; Antidepressive Agents; Depressi | 2009 |
Problems with postoperative drug therapy.
Topics: Anesthesia; Anesthetics; Anti-Arrhythmia Agents; Chemical and Drug Induced Liver Injury; Drug Therap | 1977 |
2 trials available for lidocaine and Adverse Drug Event
| Article | Year |
|---|---|
Lidocaine Spray Versus Paracervical Block During Loop Electrosurgical Excision Procedure: A Randomized Trial.
Topics: Adult; Aerosols; Aged; Anesthesia, Local; Anesthesia, Obstetrical; Anesthetics, Local; Cervix Uteri; | 2018 |
Pharmacokinetics of lidocaine with epinephrine following local anesthesia reversal with phentolamine mesylate.
Topics: Administration, Oral; Adolescent; Adrenergic alpha-Antagonists; Adult; Anesthesia Recovery Period; A | 2008 |
Pharmacokinetics of lidocaine with epinephrine following local anesthesia reversal with phentolamine mesylate.
Topics: Administration, Oral; Adolescent; Adrenergic alpha-Antagonists; Adult; Anesthesia Recovery Period; A | 2008 |
Pharmacokinetics of lidocaine with epinephrine following local anesthesia reversal with phentolamine mesylate.
Topics: Administration, Oral; Adolescent; Adrenergic alpha-Antagonists; Adult; Anesthesia Recovery Period; A | 2008 |
Pharmacokinetics of lidocaine with epinephrine following local anesthesia reversal with phentolamine mesylate.
Topics: Administration, Oral; Adolescent; Adrenergic alpha-Antagonists; Adult; Anesthesia Recovery Period; A | 2008 |
17 other studies available for lidocaine and Adverse Drug Event
| Article | Year |
|---|---|
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Lidocaine overdose: tumescent liposuction jeopardy.
Topics: Anesthetics, Local; Cardiovascular Agents; Drug-Related Side Effects and Adverse Reactions; Humans; | 2022 |
Ultrasound-guided nerve hydrodissection of cervical nerve roots for cervical radicular pain in patients with mild and moderate to severe stenosis: a retrospective cohort study.
Topics: Animals; Coleoptera; Constriction, Pathologic; Drug-Related Side Effects and Adverse Reactions; Huma | 2023 |
[Adverse drug reactions of local anesthetics used in dentistry].
Topics: Adverse Drug Reaction Reporting Systems; Anesthetics, Local; Carticaine; Dentistry; Drug-Related Sid | 2020 |
Anesthesia Case of the Month.
Topics: Anesthesia; Anesthetics, Local; Animals; Diagnosis, Differential; Dog Diseases; Dogs; Drug-Related S | 2017 |
Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes.
Topics: Animals; Cell Line; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; E | 2010 |
Epidural pump programming error leading to inadvertent 10-fold dosing error during epidural labor analgesia with ropivacaine.
Topics: Adult; Amides; Analgesia, Epidural; Anesthetics, Local; Drug Overdose; Drug-Related Side Effects and | 2010 |
Moffett's solution - is it safe? The UK experience.
Topics: Anesthetics, Local; Attitude of Health Personnel; Cocaine; Dose-Response Relationship, Drug; Drug Ap | 2011 |
Safety of tumescent liposuction under local anesthesia in a series of 4,380 patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Local; Anesthetics, Local; Doxycycline; Drug | 2011 |
[The problems of multiple-chemical sensitivity patients in using medicinal drugs].
Topics: Adult; Aspirin; Caffeine; Contraindications; Drug Hypersensitivity; Drug-Related Side Effects and Ad | 2004 |
Systemic toxicity from topically applied lidocaine in conjunction with fractional photothermolysis.
Topics: Administration, Cutaneous; Anesthetics, Local; Diagnosis, Differential; Drug-Related Side Effects an | 2006 |
Risks of non-Hodgkin's lymphoma, multiple myeloma, and leukemia associated with common medications.
Topics: Adult; Aged; Amphetamines; California; Case-Control Studies; Chloramphenicol; Confidence Intervals; | 1996 |
Anti-retroviral drugs--implications for dental prescribing.
Topics: Acquired Immunodeficiency Syndrome; Anesthesia, Dental; Anesthetics, Intravenous; Anesthetics, Local | 1998 |
Methemoglobinemia complicating topical lidocaine used during endoscopic procedures.
Topics: Adult; Aged; AIDS-Related Opportunistic Infections; Anesthetics, Local; Bronchoscopy; Drug-Related S | 2001 |
A clinical look at the problem of drugs in pregnancy and their effect on the fetus.
Topics: Abnormalities, Drug-Induced; Anesthesia, Obstetrical; Aspirin; Drug-Related Side Effects and Adverse | 1975 |
Interruption of a drug regimen before anesthesia.
Topics: Anesthesia; Anti-Infective Agents; Anticoagulants; Anticonvulsants; Antidepressive Agents; Antihyper | 1974 |