lidocaine has been researched along with Adenocarcinoma of Lung in 2 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Adenocarcinoma of Lung: A carcinoma originating in the lung and the most common lung cancer type in never-smokers. Malignant cells exhibit distinct features such as glandular epithelial, or tubular morphology. Mutations in KRAS, EGFR, BRAF, and ERBB2 genes are associated with this cancer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "NCI-H838 lung adenocarcinoma cells were incubated with ropivacaine or lidocaine (1 nM-100 µM) in absence/presence of TNFα (20 ng ml(-1)) for 20 min or 4 h, respectively." | 7.81 | Clinically relevant concentrations of lidocaine and ropivacaine inhibit TNFα-induced invasion of lung adenocarcinoma cells in vitro by blocking the activation of Akt and focal adhesion kinase. ( Beck-Schimmer, B; Borgeat, A; Dull, RO; Minshall, RD; Piegeler, T; Schläpfer, M; Schwartz, DE, 2015) |
| "Lidocaine is the most commonly used local anaesthetic in clinical and can inhibit proliferation, suppress invasion and migration and induce apoptosis in human lung adenocarcinoma (LAD) cells." | 3.85 | Lidocaine inhibits the proliferation of lung cancer by regulating the expression of GOLT1A. ( Cheng, Y; Hu, R; Jiang, H; Sun, Y; Wu, X; Xi, S; Zhang, L, 2017) |
| "NCI-H838 lung adenocarcinoma cells were incubated with ropivacaine or lidocaine (1 nM-100 µM) in absence/presence of TNFα (20 ng ml(-1)) for 20 min or 4 h, respectively." | 3.81 | Clinically relevant concentrations of lidocaine and ropivacaine inhibit TNFα-induced invasion of lung adenocarcinoma cells in vitro by blocking the activation of Akt and focal adhesion kinase. ( Beck-Schimmer, B; Borgeat, A; Dull, RO; Minshall, RD; Piegeler, T; Schläpfer, M; Schwartz, DE, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, L | 1 |
| Hu, R | 1 |
| Cheng, Y | 1 |
| Wu, X | 1 |
| Xi, S | 1 |
| Sun, Y | 1 |
| Jiang, H | 1 |
| Piegeler, T | 1 |
| Schläpfer, M | 1 |
| Dull, RO | 1 |
| Schwartz, DE | 1 |
| Borgeat, A | 1 |
| Minshall, RD | 1 |
| Beck-Schimmer, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Improving Perioperative Pain Management for Laparoscopic Surgery Due to Colon Cancer Using the Ultrasound-guided Transmuscular Quadratus Lumborum Block. A Double Blind, Randomized, Placebo Controlled Trial.[NCT03570541] | Phase 4 | 69 participants (Actual) | Interventional | 2018-06-28 | Completed | ||
| Anesthesia and Immunological and Oxidative Stress in Relation to Abdominal Cancer Surgery[NCT03974984] | 0 participants (Actual) | Observational | 2020-06-04 | Withdrawn (stopped due to Not feasable due to logistics) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for lidocaine and Adenocarcinoma of Lung