lidocaine has been researched along with Acute Pain in 30 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Acute Pain: Intensely discomforting, distressful, or agonizing sensation associated with trauma or disease, with well-defined location, character, and timing.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intravenous hydromorphone was superior to intravenous lidocaine both for general abdominal pain and a subset of patients with nephrolithiasis." | 9.30 | Randomized Trial of Intravenous Lidocaine Versus Hydromorphone for Acute Abdominal Pain in the Emergency Department. ( Afrifa, F; Chertoff, A; Chinn, E; Friedman, BW; Gallagher, EJ; Irizarry, E; Jones, MP; Naeem, F; Pearlman, S; Wollowitz, A; Zias, E, 2019) |
| "To compare the efficacy of lidocaine/tetracaine cream and lidocaine/prilocaine cream in reducing self-reported pain during deeper dermal laser treatment of acne keloidalis nuchae (AKN) and tattoos." | 9.24 | Comparison of lidocaine/tetracaine cream and lidocaine/prilocaine cream for local anaesthesia during laser treatment of acne keloidalis nuchae and tattoo removal: results of two randomized controlled trials. ( Greveling, K; Prens, EP; Ten Bosch, N; van Doorn, MB, 2017) |
| "Intraoperative infusion of lidocaine significantly decreases the proportion of patients with acute pain after supratentorial tumor surgery in the PACU." | 9.22 | Lidocaine Reduces Acute Postoperative Pain After Supratentorial Tumor Surgery in the PACU: A Secondary Finding From a Randomized, Controlled Trial. ( Han, R; Kass, IS; Peng, Y; Zhang, W, 2016) |
| "To test the hypotheses that lidocaine 5% patches decrease the severity of acute pain and incidence of persistent incisional pain after robotic cardiac valve surgery." | 9.20 | Lidocaine 5% Patch for Treatment of Acute Pain After Robotic Cardiac Surgery and Prevention of Persistent Incisional Pain: A Randomized, Placebo-Controlled, Double-Blind Trial. ( Gillinov, M; Kapural, L; Mascha, EJ; Mihaljevic, T; Qavi, S; Sarwar, S; Sessler, DI; Vrooman, B, 2015) |
| "Determine the efficacy of intravenous lidocaine when compared to ketorolac for the treatment of acute radicular low back pain." | 9.19 | Intravenous lidocaine for the emergency department treatment of acute radicular low back pain, a randomized controlled trial. ( Danish, DC; Dos Santos, F; Makela, M; Riffenburgh, RH; Shimada, M; Tanen, DA, 2014) |
| "Systemic administration of the local anaesthetic lidocaine is antinociceptive in both acute and chronic pain states, especially in acute postoperative and chronic neuropathic pain." | 9.01 | Molecular mechanisms of action of systemic lidocaine in acute and chronic pain: a narrative review. ( Brandenburger, T; Hermanns, H; Hollmann, MW; Lirk, P; Piegeler, T; Stevens, MF; Werdehausen, R, 2019) |
| "This systematic review evaluates the safety and efficacy of intravenous (IV) lidocaine for the treatment of acute pain in adult patients." | 8.98 | Intravenous Lidocaine for Acute Pain: A Systematic Review. ( Barbas, B; Liang, E; Long, C; Masic, D; Rech, MA; Sterk, EJ, 2018) |
| " Intravenous (iv) lidocaine is beneficial in acute and chronic pain." | 8.93 | The in vitro mechanisms and in vivo efficacy of intravenous lidocaine on the neuroinflammatory response in acute and chronic pain. ( Radema, SA; Scheffer, GJ; Steegers, MA; van Berkum, BF; van den Heuvel, SA; van der Wal, SE; Vaneker, M; Vissers, KC, 2016) |
| " We investigated the efficacy of the lidocaine patch for acute pain management." | 8.91 | Lidocaine patch for acute pain management: a meta-analysis of prospective controlled trials. ( Bai, Y; Gan, TJ; Law, LS; Miller, T; Tan, M, 2015) |
| "Chronic pain was assessed 3 to 6 months after breast surgery in 51 patients of the lidocaine group and 46 patients of the control group." | 6.55 | Effect of Perioperative Intravenous Lidocaine Infusion on Acute and Chronic Pain after Breast Surgery: A Meta-Analysis of Randomized Controlled Trials. ( Chang, YC; Chen, MJ; Cheng, SP; Liu, CL; Liu, TP; Yang, PS, 2017) |
| " Five RCTs suggest that both benzocaine 10% and 20% may increase the number of people experiencing pain reduction compared with placebo when managing acute irreversible pulpitis (low certainty)." | 5.41 | Injectable and topical local anesthetics for acute dental pain: 2 systematic reviews. ( Azab, M; Brignardello-Petersen, R; Carrasco-Labra, A; Diaz Martinez, JP; He, L; Hersh, EV; Ibrahim, S; Miroshnychenko, A; Moore, PA; Polk, DE; Roldan, Y; Tamilselvan, D; Tampi, M; Urquhart, O, 2023) |
| "Intravenous hydromorphone was superior to intravenous lidocaine both for general abdominal pain and a subset of patients with nephrolithiasis." | 5.30 | Randomized Trial of Intravenous Lidocaine Versus Hydromorphone for Acute Abdominal Pain in the Emergency Department. ( Afrifa, F; Chertoff, A; Chinn, E; Friedman, BW; Gallagher, EJ; Irizarry, E; Jones, MP; Naeem, F; Pearlman, S; Wollowitz, A; Zias, E, 2019) |
| "To compare the efficacy of lidocaine/tetracaine cream and lidocaine/prilocaine cream in reducing self-reported pain during deeper dermal laser treatment of acne keloidalis nuchae (AKN) and tattoos." | 5.24 | Comparison of lidocaine/tetracaine cream and lidocaine/prilocaine cream for local anaesthesia during laser treatment of acne keloidalis nuchae and tattoo removal: results of two randomized controlled trials. ( Greveling, K; Prens, EP; Ten Bosch, N; van Doorn, MB, 2017) |
| "Intraoperative infusion of lidocaine significantly decreases the proportion of patients with acute pain after supratentorial tumor surgery in the PACU." | 5.22 | Lidocaine Reduces Acute Postoperative Pain After Supratentorial Tumor Surgery in the PACU: A Secondary Finding From a Randomized, Controlled Trial. ( Han, R; Kass, IS; Peng, Y; Zhang, W, 2016) |
| "To test the hypotheses that lidocaine 5% patches decrease the severity of acute pain and incidence of persistent incisional pain after robotic cardiac valve surgery." | 5.20 | Lidocaine 5% Patch for Treatment of Acute Pain After Robotic Cardiac Surgery and Prevention of Persistent Incisional Pain: A Randomized, Placebo-Controlled, Double-Blind Trial. ( Gillinov, M; Kapural, L; Mascha, EJ; Mihaljevic, T; Qavi, S; Sarwar, S; Sessler, DI; Vrooman, B, 2015) |
| "Determine the efficacy of intravenous lidocaine when compared to ketorolac for the treatment of acute radicular low back pain." | 5.19 | Intravenous lidocaine for the emergency department treatment of acute radicular low back pain, a randomized controlled trial. ( Danish, DC; Dos Santos, F; Makela, M; Riffenburgh, RH; Shimada, M; Tanen, DA, 2014) |
| "The authors conducted an unfunded randomized controlled trial approved by the Brooke Army Medical Center (BAMC) Institutional Review Board (IRB) to determine the possible efficacy of intra-articular morphine for pain in acute knee injuries." | 5.19 | Intra-articular Morphine versus Lidocaine for Acute Knee Pain. ( Cuenca, PJ; Graham, RF; Hughes, JR; Johnson, AE; Mosely, T, 2014) |
| "Systemic administration of the local anaesthetic lidocaine is antinociceptive in both acute and chronic pain states, especially in acute postoperative and chronic neuropathic pain." | 5.01 | Molecular mechanisms of action of systemic lidocaine in acute and chronic pain: a narrative review. ( Brandenburger, T; Hermanns, H; Hollmann, MW; Lirk, P; Piegeler, T; Stevens, MF; Werdehausen, R, 2019) |
| "We evaluate the safety and efficacy of intravenous lidocaine in adult patients with acute and chronic pain who are undergoing pain management in the emergency department (ED)." | 4.98 | Safety and Efficacy of Intravenous Lidocaine for Pain Management in the Emergency Department: A Systematic Review. ( Bellolio, MF; Cabrera, D; E Silva, LOJ; Erwin, PJ; Motov, S; Murad, MH; Scherber, K; West, CP, 2018) |
| "This systematic review evaluates the safety and efficacy of intravenous (IV) lidocaine for the treatment of acute pain in adult patients." | 4.98 | Intravenous Lidocaine for Acute Pain: A Systematic Review. ( Barbas, B; Liang, E; Long, C; Masic, D; Rech, MA; Sterk, EJ, 2018) |
| " Intravenous (iv) lidocaine is beneficial in acute and chronic pain." | 4.93 | The in vitro mechanisms and in vivo efficacy of intravenous lidocaine on the neuroinflammatory response in acute and chronic pain. ( Radema, SA; Scheffer, GJ; Steegers, MA; van Berkum, BF; van den Heuvel, SA; van der Wal, SE; Vaneker, M; Vissers, KC, 2016) |
| " We investigated the efficacy of the lidocaine patch for acute pain management." | 4.91 | Lidocaine patch for acute pain management: a meta-analysis of prospective controlled trials. ( Bai, Y; Gan, TJ; Law, LS; Miller, T; Tan, M, 2015) |
| " We report 2 cases that demonstrate the use of intravenous lidocaine for the management of acute pain, secondary to trauma, in an austere environment." | 4.12 | The Use of Intravenous Lidocaine as an Analgesic Modality in the Austere Environment: Two Cases. ( Dhanjal, ST; Dryden, B; Higgins, S; Kerr, WB; Tou, K, 2022) |
| " The objective of this clinical trial was to evaluate the effects of either a lidocaine cornual nerve block or a topical anesthetic incorporated into caustic paste on the acute pain of caustic paste disbudding." | 3.85 | Clinical trial of local anesthetic protocols for acute pain associated with caustic paste disbudding in dairy calves. ( Duffield, TF; Godkin, MA; Haley, DB; LeBlanc, SJ; Lissemore, KD; Winder, CB, 2017) |
| "Chronic pain was assessed 3 to 6 months after breast surgery in 51 patients of the lidocaine group and 46 patients of the control group." | 2.55 | Effect of Perioperative Intravenous Lidocaine Infusion on Acute and Chronic Pain after Breast Surgery: A Meta-Analysis of Randomized Controlled Trials. ( Chang, YC; Chen, MJ; Cheng, SP; Liu, CL; Liu, TP; Yang, PS, 2017) |
| "The outcomes observed were migraine pain before and after administration within the same initial encounter of receiving an occipital nerve block using a numeric pain rating scale, injection direction, medications used, duration of effect and frequency of additional injections, and adverse reactions." | 1.56 | Evaluation of Occipital Nerve Blocks for Acute Pain Relief of Migraines. ( Dang, T; Ebied, AM; Nguyen, DT, 2020) |
| "Severe acute postoperative pain (VNPS ≥70) was predicted by severe ILA pain with a sensitivity of 91." | 1.42 | Severe pain during local infiltration for spinal anaesthesia predicts post-caesarean pain. ( Artiuch, A; Aviram, A; Eidelman, LA; Fireman, S; Ioscovich, A; Kadechenko, T; Klein, Z; Landau, R; Mazarib, N; Orbach-Zinger, S; Reuveni, A, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 25 (83.33) | 24.3611 |
| 2020's | 5 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Dryden, B | 1 |
| Kerr, WB | 1 |
| Higgins, S | 1 |
| Tou, K | 1 |
| Dhanjal, ST | 1 |
| Miroshnychenko, A | 1 |
| Ibrahim, S | 1 |
| Azab, M | 1 |
| Roldan, Y | 1 |
| Diaz Martinez, JP | 1 |
| Tamilselvan, D | 1 |
| He, L | 1 |
| Urquhart, O | 1 |
| Tampi, M | 1 |
| Polk, DE | 1 |
| Moore, PA | 1 |
| Hersh, EV | 1 |
| Carrasco-Labra, A | 1 |
| Brignardello-Petersen, R | 1 |
| Ebied, AM | 1 |
| Nguyen, DT | 1 |
| Dang, T | 1 |
| Reedman, CN | 1 |
| Duffield, TF | 2 |
| DeVries, TJ | 1 |
| Lissemore, KD | 2 |
| Karrow, NA | 1 |
| Li, Z | 1 |
| Winder, CB | 2 |
| Ishizuka, K | 1 |
| Yokokawa, D | 1 |
| Mori, T | 1 |
| Kato, T | 1 |
| Ikusaka, M | 1 |
| Sin, B | 1 |
| Gritsenko, D | 1 |
| Tam, G | 1 |
| Koop, K | 1 |
| Mok, E | 1 |
| LeBlanc, SJ | 1 |
| Haley, DB | 1 |
| Godkin, MA | 1 |
| Tsutsui, Y | 1 |
| Sunada, K | 1 |
| Farahmand, S | 1 |
| Hamrah, H | 1 |
| Arbab, M | 1 |
| Sedaghat, M | 1 |
| Basir Ghafouri, H | 1 |
| Bagheri-Hariri, S | 1 |
| E Silva, LOJ | 1 |
| Scherber, K | 1 |
| Cabrera, D | 1 |
| Motov, S | 1 |
| Erwin, PJ | 1 |
| West, CP | 1 |
| Murad, MH | 1 |
| Bellolio, MF | 1 |
| Masic, D | 1 |
| Liang, E | 1 |
| Long, C | 1 |
| Sterk, EJ | 1 |
| Barbas, B | 1 |
| Rech, MA | 1 |
| Jimenez, RE | 1 |
| Adcock, SJJ | 1 |
| Tucker, CB | 1 |
| Chinn, E | 1 |
| Friedman, BW | 1 |
| Naeem, F | 1 |
| Irizarry, E | 1 |
| Afrifa, F | 1 |
| Zias, E | 1 |
| Jones, MP | 1 |
| Pearlman, S | 1 |
| Chertoff, A | 1 |
| Wollowitz, A | 1 |
| Gallagher, EJ | 1 |
| Puri, L | 1 |
| Morgan, KJ | 1 |
| Anghelescu, DL | 1 |
| Hermanns, H | 1 |
| Hollmann, MW | 1 |
| Stevens, MF | 1 |
| Lirk, P | 1 |
| Brandenburger, T | 1 |
| Piegeler, T | 1 |
| Werdehausen, R | 1 |
| Pasero, C | 1 |
| McCarberg, B | 1 |
| D'Arcy, Y | 1 |
| Tanen, DA | 1 |
| Shimada, M | 1 |
| Danish, DC | 1 |
| Dos Santos, F | 1 |
| Makela, M | 1 |
| Riffenburgh, RH | 1 |
| Graham, RF | 1 |
| Hughes, JR | 1 |
| Johnson, AE | 1 |
| Cuenca, PJ | 1 |
| Mosely, T | 1 |
| Bai, Y | 1 |
| Miller, T | 1 |
| Tan, M | 1 |
| Law, LS | 1 |
| Gan, TJ | 1 |
| Orbach-Zinger, S | 1 |
| Aviram, A | 1 |
| Fireman, S | 1 |
| Kadechenko, T | 1 |
| Klein, Z | 1 |
| Mazarib, N | 1 |
| Artiuch, A | 1 |
| Reuveni, A | 1 |
| Ioscovich, A | 1 |
| Eidelman, LA | 1 |
| Landau, R | 1 |
| Vrooman, B | 1 |
| Kapural, L | 1 |
| Sarwar, S | 1 |
| Mascha, EJ | 1 |
| Mihaljevic, T | 1 |
| Gillinov, M | 1 |
| Qavi, S | 1 |
| Sessler, DI | 1 |
| Peng, Y | 1 |
| Zhang, W | 1 |
| Kass, IS | 1 |
| Han, R | 1 |
| van der Wal, SE | 1 |
| van den Heuvel, SA | 1 |
| Radema, SA | 1 |
| van Berkum, BF | 1 |
| Vaneker, M | 1 |
| Steegers, MA | 1 |
| Scheffer, GJ | 1 |
| Vissers, KC | 1 |
| Chang, YC | 1 |
| Liu, CL | 1 |
| Liu, TP | 1 |
| Yang, PS | 1 |
| Chen, MJ | 1 |
| Cheng, SP | 1 |
| Greveling, K | 1 |
| Prens, EP | 1 |
| Ten Bosch, N | 1 |
| van Doorn, MB | 1 |
| Taddio, A | 1 |
| Riddell, RP | 1 |
| Ipp, M | 1 |
| Moss, S | 1 |
| Baker, S | 1 |
| Tolkin, J | 1 |
| Malini, D | 1 |
| Feerasta, S | 1 |
| Govan, P | 1 |
| Fletcher, E | 1 |
| Wong, H | 1 |
| McNair, C | 1 |
| Mithal, P | 1 |
| Stephens, D | 1 |
| Poonai, N | 1 |
| Alawi, K | 1 |
| Rieder, M | 1 |
| Lynch, T | 1 |
| Lim, R | 1 |
| Gilhooly, D | 1 |
| McGarvey, B | 1 |
| O'Mahony, H | 1 |
| O'Connor, TC | 1 |
| López Ramírez, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Trial Evaluating Lidocaine Intravenous in the Emergency Department For Sickle Cell Crisis - RELIEF-SCC[NCT04614610] | Phase 2 | 100 participants (Anticipated) | Interventional | 2024-01-01 | Not yet recruiting | ||
| Intranasal Lidocaine for Prevention of Postoperative Nausea and Vomiting. A Prospective Double Blind Randomized Controlled Study.[NCT04810494] | Phase 4 | 0 participants (Actual) | Interventional | 2022-10-01 | Withdrawn (stopped due to Change in study team) | ||
| A Prospective, Randomized, Active-Comparator, Open-Label, Non-Inferiority Study of the Efficacy of Continuous Nerve Block vs Single Block Plus Intravenous Lidocaine for Postoperative Pain.[NCT04208516] | Phase 4 | 17 participants (Actual) | Interventional | 2021-05-26 | Terminated (stopped due to Recruitment was unable to be obtained in a timely fashion, so the study was stopped.) | ||
| Intravenous Lidocaine Versus Hydromorphone for Acute Abdominal Pain. A Randomized Trial[NCT03300674] | Phase 4 | 154 participants (Actual) | Interventional | 2018-01-10 | Completed | ||
| High Dose Intravenous Lidocaine vs Hydromorphone for Acute Abdominal Pain in the Emergency Department: A Randomized, Comparative Efficacy Trial[NCT04398316] | Phase 4 | 187 participants (Anticipated) | Interventional | 2021-02-18 | Recruiting | ||
| Intravenous Lidocaine and Time to Regression of the Sensory Block After Spinal Anesthesia With Isobaric Bupivacaine in Patients Undergoing Surgery to Treat Skin and Soft Tissue Tumors of the Lower Limbs[NCT04741880] | Phase 2/Phase 3 | 66 participants (Anticipated) | Interventional | 2021-06-17 | Recruiting | ||
| Preventive Application Of Lidocaine Patch In Adjunction To Intravenous Morphine Analgesia For Management Of Post-Thoracotomy Pain: Results Of A Randomized, Double Blind, Placebo Controlled Study[NCT02751619] | 90 participants (Actual) | Interventional | 2013-01-31 | Completed | |||
| Do Cervical Interlaminar Epidural Steroid Injections With Low-dose Lidocaine Cause Transient Objective Upper Extremity Weakness? A Prospective Randomized[NCT03382925] | Phase 4 | 16 participants (Actual) | Interventional | 2017-12-20 | Terminated (stopped due to Not enough cervical interlaminar patients who meet criteria in order to meet recruitment goals.) | ||
| Effectiveness of Parent-Led Interventions in Reducing Infant Hypersensitivity to Pain: A Longitudinal Randomized Controlled Trial[NCT01503060] | Phase 3 | 352 participants (Anticipated) | Interventional | 2011-12-31 | Recruiting | ||
| Lidocaine Patches After Cesarean Section[NCT04443569] | Phase 3 | 93 participants (Actual) | Interventional | 2021-10-10 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Nausea and vomiting requiring treatment, hypotension, or bradycardia or tachycardia (NCT04208516)
Timeframe: From time of surgery to discharge, on average 1-4 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Continuous Nerve Blocks | 0 |
| Single Nerve Blocks Plus IV Lidocaine Infusion | 0 |
Local anesthetic consumption after surgery is reported in mg of lidocaine (NCT04208516)
Timeframe: 12 hours after surgery
| Intervention | mg (Mean) |
|---|---|
| Continuous Nerve Blocks | 574.29 |
| Single Nerve Blocks Plus IV Lidocaine Infusion | 600 |
Local anesthetic consumption after surgery is reported in mg of lidocaine (NCT04208516)
Timeframe: 24 hours after surgery
| Intervention | mg (Mean) |
|---|---|
| Continuous Nerve Blocks | 1096.07 |
| Single Nerve Blocks Plus IV Lidocaine Infusion | 1139.29 |
Local anesthetic consumption after surgery is reported in mg of lidocaine (NCT04208516)
Timeframe: 48 hours after surgery
| Intervention | mg (Mean) |
|---|---|
| Continuous Nerve Blocks | 1973.57 |
| Single Nerve Blocks Plus IV Lidocaine Infusion | 2308.33 |
Local anesthetic consumption after surgery is reported in mg of lidocaine (NCT04208516)
Timeframe: 72 hours after surgery
| Intervention | mg (Mean) |
|---|---|
| Continuous Nerve Blocks | 2721.79 |
| Single Nerve Blocks Plus IV Lidocaine Infusion | 2570.0 |
Opioids will be converted to oral morphine equivalents (NCT04208516)
Timeframe: 24 hours after surgery
| Intervention | OME (Mean) |
|---|---|
| Continuous Nerve Blocks | 34.93 |
| Single Nerve Blocks Plus IV Lidocaine Infusion | 46.50 |
Opioids will be converted to oral morphine equivalents (NCT04208516)
Timeframe: 48 hours after surgery
| Intervention | OME (Mean) |
|---|---|
| Continuous Nerve Blocks | 61.5 |
| Single Nerve Blocks Plus IV Lidocaine Infusion | 84.75 |
Opioids will be converted to oral morphine equivalents (NCT04208516)
Timeframe: 72 hours after surgery
| Intervention | OME (Mean) |
|---|---|
| Continuous Nerve Blocks | 88.57 |
| Single Nerve Blocks Plus IV Lidocaine Infusion | 128.1 |
By numeric pain rating scale, 0 = no pain and 10 = worst possible pain (NCT04208516)
Timeframe: 12 hours after surgery
| Intervention | score on a scale (Mean) |
|---|---|
| Continuous Nerve Blocks | 6.17 |
| Single Nerve Blocks Plus IV Lidocaine Infusion | 6.07 |
By numeric pain rating scale, 0 = no pain and 10 = worst possible pain (NCT04208516)
Timeframe: 24 hours after surgery
| Intervention | score on a scale (Mean) |
|---|---|
| Continuous Nerve Blocks | 4.5 |
| Single Nerve Blocks Plus IV Lidocaine Infusion | 6.43 |
By numeric pain rating scale, 0 = no pain and 10 = worst possible pain (NCT04208516)
Timeframe: 48 hours after surgery
| Intervention | score on a scale (Mean) |
|---|---|
| Continuous Nerve Blocks | 5.86 |
| Single Nerve Blocks Plus IV Lidocaine Infusion | 4.83 |
By numeric pain rating scale, 0 = no pain and 10 = worst possible pain (NCT04208516)
Timeframe: 6 hours after surgery
| Intervention | score on a scale (Mean) |
|---|---|
| Continuous Nerve Blocks | 6.17 |
| Single Nerve Blocks Plus IV Lidocaine Infusion | 6.14 |
By numeric pain rating scale, 0 = no pain and 10 = worst possible pain (NCT04208516)
Timeframe: 72 hours after surgery
| Intervention | score on a scale (Mean) |
|---|---|
| Continuous Nerve Blocks | 5.36 |
| Single Nerve Blocks Plus IV Lidocaine Infusion | 5.0 |
Serum lidocaine level measured via a blood test. Lidocaine has a therapeutic drug range of 1.5 to 5.0 mcg/mL. (NCT04208516)
Timeframe: 24 hours after surgery
| Intervention | mcg/mL (Mean) |
|---|---|
| Continuous Nerve Blocks | 2.5 |
Serum lidocaine level measured via a blood test. Lidocaine has a therapeutic drug range of 1.5 to 5.0 mcg/mL. (NCT04208516)
Timeframe: 48 hours after surgery
| Intervention | mcg/mL (Number) |
|---|---|
| Single Nerve Blocks Plus IV Lidocaine Infusion | 5.8 |
Serum lidocaine level measured via a blood test. Lidocaine has a therapeutic drug range of 1.5 to 5.0 mcg/mL. (NCT04208516)
Timeframe: 72 hours after surgery
| Intervention | mcg/mL (Number) |
|---|---|
| Single Nerve Blocks Plus IV Lidocaine Infusion | 1.5 |
Hospital length of stay is measured in days from admission until discharge. (NCT04208516)
Timeframe: From admission to discharge, on average 1-4 days
| Intervention | days (Mean) |
|---|---|
| Continuous Nerve Blocks | 9.04 |
| Single Nerve Blocks Plus IV Lidocaine Infusion | 4.94 |
Any new symptom development after administration of investigational medication (NCT03300674)
Timeframe: 4 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Hydromorphone | 28 |
| Intravenous Lidocaine | 23 |
Participants were asked to describe their pain on a scale from 0 to 10 with 0= no pain and 10= the worst pain imaginable (NCT03300674)
Timeframe: up to 90 minutes
| Intervention | units on a scale (Mean) |
|---|---|
| Intravenous Hydromorphone | 5.0 |
| Intravenous Lidocaine | 3.8 |
no need for off-protocol parenteral pain medication during the ED visit. The following parenteral medications will be considered off protocol pain medication: any opioid, any non-steroidal anti-inflammatory drug (NCT03300674)
Timeframe: 4 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Hydromorphone | 20 |
| Intravenous Lidocaine | 39 |
The primary outcome of this study would be the total average milligrams of narcotic, or opioid, medication that a patient receives calculated in morphine equivalents (NCT04443569)
Timeframe: the first 72 hours post-operative
| Intervention | mg morphine equivalents (Mean) |
|---|---|
| Lidocaine Patch Group | 51.3 |
| Control Group | 29.7 |
daily pain scores conducted by the nursing staff every morning and prior to medication administration. This will be a repeated measure using the subjective 0-10 pain scale. The scores will be averaged over each 24 hour (day) period and then compared. Lower scores indicate less pain. (NCT04443569)
Timeframe: the first 72 hours post-operative, up to 4 days
| Intervention | score on a scale (Mean) | |||
|---|---|---|---|---|
| Post-Op Day 1 | Post-Op Day 2 | Post-Op Day 3 | Post-Op Day 4 | |
| Control Group | 4.1 | 5.2 | 4.3 | 4.5 |
| Lidocaine Patch Group | 3.5 | 5.2 | 5.2 | 5.7 |
8 reviews available for lidocaine and Acute Pain
| Article | Year |
|---|---|
Injectable and topical local anesthetics for acute dental pain: 2 systematic reviews.
Topics: Acute Pain; Anesthesia, Local; Anesthetics, Local; Benzocaine; Bupivacaine; Epinephrine; Humans; Lid | 2023 |
Safety and Efficacy of Intravenous Lidocaine for Pain Management in the Emergency Department: A Systematic Review.
Topics: Acute Pain; Administration, Intravenous; Anesthetics, Local; Chronic Pain; Emergency Service, Hospit | 2018 |
Intravenous Lidocaine for Acute Pain: A Systematic Review.
Topics: Acute Pain; Anesthetics, Local; Gastrointestinal Diseases; Humans; Infusions, Intravenous; Lidocaine | 2018 |
Intravenous Lidocaine for Acute Pain: A Systematic Review.
Topics: Acute Pain; Anesthetics, Local; Gastrointestinal Diseases; Humans; Infusions, Intravenous; Lidocaine | 2018 |
Intravenous Lidocaine for Acute Pain: A Systematic Review.
Topics: Acute Pain; Anesthetics, Local; Gastrointestinal Diseases; Humans; Infusions, Intravenous; Lidocaine | 2018 |
Intravenous Lidocaine for Acute Pain: A Systematic Review.
Topics: Acute Pain; Anesthetics, Local; Gastrointestinal Diseases; Humans; Infusions, Intravenous; Lidocaine | 2018 |
Molecular mechanisms of action of systemic lidocaine in acute and chronic pain: a narrative review.
Topics: Acute Pain; Analgesics; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; H | 2019 |
Options in topical therapies in the management of patients with acute pain.
Topics: Acute Pain; Administration, Cutaneous; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; | 2013 |
Lidocaine patch for acute pain management: a meta-analysis of prospective controlled trials.
Topics: Acute Pain; Analgesics, Opioid; Anesthetics, Local; Humans; Lidocaine; Pain Management; Pain Measure | 2015 |
The in vitro mechanisms and in vivo efficacy of intravenous lidocaine on the neuroinflammatory response in acute and chronic pain.
Topics: Acute Pain; Administration, Intravenous; Anesthetics, Local; Animals; Calcium Channels; Chronic Pain | 2016 |
Effect of Perioperative Intravenous Lidocaine Infusion on Acute and Chronic Pain after Breast Surgery: A Meta-Analysis of Randomized Controlled Trials.
Topics: Acute Pain; Analgesics; Chronic Pain; Female; Humans; Infusions, Intravenous; Lidocaine; Mastectomy; | 2017 |
11 trials available for lidocaine and Acute Pain
| Article | Year |
|---|---|
Randomized control trial assessing the efficacy of pain control strategies for caustic paste disbudding in dairy calves younger than 9 days of age.
Topics: Acute Pain; Analgesia; Anesthesia, Local; Anesthetics, Local; Animal Welfare; Animals; Anti-Inflamma | 2020 |
Pain management of acute limb trauma patients with intravenous lidocaine in emergency department.
Topics: Acute Pain; Administration, Intravenous; Adult; Analgesics, Opioid; Anesthetics, Local; Arm Injuries | 2018 |
Acute pain responses in dairy calves undergoing cornual nerve blocks with or without topical anesthetic.
Topics: Acute Pain; Administration, Topical; Anesthesia, Local; Anesthetics, Local; Animals; Cattle; Cattle | 2019 |
Randomized Trial of Intravenous Lidocaine Versus Hydromorphone for Acute Abdominal Pain in the Emergency Department.
Topics: Abdominal Pain; Acute Pain; Administration, Intravenous; Adult; Analgesics, Opioid; Anesthetics, Loc | 2019 |
Randomized Trial of Intravenous Lidocaine Versus Hydromorphone for Acute Abdominal Pain in the Emergency Department.
Topics: Abdominal Pain; Acute Pain; Administration, Intravenous; Adult; Analgesics, Opioid; Anesthetics, Loc | 2019 |
Randomized Trial of Intravenous Lidocaine Versus Hydromorphone for Acute Abdominal Pain in the Emergency Department.
Topics: Abdominal Pain; Acute Pain; Administration, Intravenous; Adult; Analgesics, Opioid; Anesthetics, Loc | 2019 |
Randomized Trial of Intravenous Lidocaine Versus Hydromorphone for Acute Abdominal Pain in the Emergency Department.
Topics: Abdominal Pain; Acute Pain; Administration, Intravenous; Adult; Analgesics, Opioid; Anesthetics, Loc | 2019 |
Intravenous lidocaine for the emergency department treatment of acute radicular low back pain, a randomized controlled trial.
Topics: Acute Pain; Administration, Intravenous; Adult; Anesthetics, Local; Cyclooxygenase Inhibitors; Doubl | 2014 |
Intra-articular Morphine versus Lidocaine for Acute Knee Pain.
Topics: Acute Pain; Adolescent; Adult; Aged; Analgesics, Opioid; Anesthetics, Local; Drug Therapy, Combinati | 2014 |
Lidocaine 5% Patch for Treatment of Acute Pain After Robotic Cardiac Surgery and Prevention of Persistent Incisional Pain: A Randomized, Placebo-Controlled, Double-Blind Trial.
Topics: Acute Pain; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Local; Cardiac Sur | 2015 |
Lidocaine Reduces Acute Postoperative Pain After Supratentorial Tumor Surgery in the PACU: A Secondary Finding From a Randomized, Controlled Trial.
Topics: Acute Pain; Adolescent; Adult; Aged; Anesthesia Recovery Period; Anesthetics, Local; Female; Humans; | 2016 |
Comparison of lidocaine/tetracaine cream and lidocaine/prilocaine cream for local anaesthesia during laser treatment of acne keloidalis nuchae and tattoo removal: results of two randomized controlled trials.
Topics: Acne Keloid; Acute Pain; Adult; Anesthetics, Combined; Anesthetics, Local; Cosmetic Techniques; Doub | 2017 |
Relative effectiveness of additive pain interventions during vaccination in infants.
Topics: Acute Pain; Administration, Cutaneous; Anesthetics, Local; Audiovisual Aids; Double-Blind Method; Fe | 2017 |
A comparison of amethocaine and liposomal lidocaine cream as a pain reliever before venipuncture in children: a randomized control trial.
Topics: Acute Pain; Administration, Cutaneous; Analgesics; Anesthetics, Local; Child; Child, Preschool; Doub | 2012 |
11 other studies available for lidocaine and Acute Pain
| Article | Year |
|---|---|
The Use of Intravenous Lidocaine as an Analgesic Modality in the Austere Environment: Two Cases.
Topics: Acute Pain; Administration, Intravenous; Analgesics; Anesthetics, Local; Double-Blind Method; Humans | 2022 |
Evaluation of Occipital Nerve Blocks for Acute Pain Relief of Migraines.
Topics: Acute Pain; Adult; Aged; Anesthetics, Local; Bupivacaine; Dexamethasone; Female; Florida; Glucocorti | 2020 |
Lateral Cutaneous Nerve Entrapment Syndrome (LACNES).
Topics: Acute Pain; Adult; Anesthetics, Local; Chest Pain; Diagnosis, Differential; Humans; Hyperesthesia; I | 2021 |
The Use of Intravenous Lidocaine for the Management of Acute Pain Secondary to Traumatic Ankle Injury: A Case Report.
Topics: Acute Pain; Adolescent; Anesthetics, Local; Ankle Injuries; Humans; Lidocaine; Male; Pain Management | 2018 |
Clinical trial of local anesthetic protocols for acute pain associated with caustic paste disbudding in dairy calves.
Topics: Acute Pain; Anesthetics, Local; Animals; Cattle; Caustics; Horns; Lidocaine; Nerve Block; Ointments | 2017 |
Dexmedetomidine Increases the Latency of Thermal Antinociception in Rats.
Topics: Acute Pain; Adrenergic alpha-2 Receptor Agonists; Anesthetics, Local; Animals; Dexmedetomidine; Dise | 2017 |
Ketamine and lidocaine infusions decrease opioid consumption during vaso-occlusive crisis in adolescents with sickle cell disease.
Topics: Acute Pain; Adolescent; Age Factors; Analgesics, Opioid; Anemia, Sickle Cell; Female; Humans; Infusi | 2019 |
Lidocaine patch 5% for acute pain management.
Topics: Acute Pain; Administration, Cutaneous; Anesthetics, Local; Humans; Lidocaine; Pain; Pain Management | 2013 |
Severe pain during local infiltration for spinal anaesthesia predicts post-caesarean pain.
Topics: Acute Pain; Adult; Anesthesia, Spinal; Anesthetics, Local; Cesarean Section; Female; Humans; Lidocai | 2015 |
Topical lidocaine patch 5% for acute postoperative pain control.
Topics: Acute Pain; Administration, Topical; Adult; Anesthetics, Local; Cesarean Section; Female; Humans; Li | 2011 |
Treatment of acute and chronic focal neuropathic pain in cancer patients with lidocaine 5 % patches. A radiation and oncology department experience.
Topics: Acute Pain; Aged; Aged, 80 and over; Anesthetics, Local; Chronic Pain; Female; Humans; Lidocaine; Ma | 2013 |