lidocaine has been researched along with Acidosis in 44 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Acidosis: A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of pH on brain uptake of lidocaine during status epilepticus was studied by comparing blood and brain lidocaine concentrations and pH in paralyzed and nonparalyzed rats during pentylenetetrazol-induced status." | 7.67 | Motor paralysis increases brain uptake of lidocaine during status epilepticus. ( Benowitz, NL; Culala, S; Simon, RP, 1984) |
| "To test the hypothesis that acidosis can increase the toxicity of bupivacaine more than that of lidocaine by increasing the distribution into the brain, myocardium, or both, studies were performed to measure the in vivo tissue:blood partition coefficients during continuous steady state intravenous infusions of these agents in anesthetized sheep during normal acid-base status and during combined respiratory-metabolic acidosis." | 7.67 | The influence of acidosis on the distribution of lidocaine and bupivacaine into the myocardium and brain of the sheep. ( Mather, LE; Nancarrow, C; Plummer, JL; Runciman, WB; Upton, RN, 1987) |
| "The effect of lidocaine on ischemic myocardial acidosis was investigated in the dog heart, in which the left anterior descending coronary artery was occluded to reduce to about one-third (partial occlusion)." | 7.67 | Effect of lidocaine on the myocardial acidosis induced by coronary artery occlusion in dogs. ( Abiko, Y; Matsumura, H; Matsumura, N, 1987) |
| " The aim of this study was to compare the effects of lidocaine and bupivacaine on the intrinsic pacemaker activity of in vitro sinoatrial nodal cells of the adult and neonatal guinea pig in the presence and absence of hypoxia and acidosis." | 7.67 | Comparison of lidocaine and bupivacaine depression of sinoatrial nodal activity during hypoxia and acidosis in adult and neonatal guinea pigs. ( Bosnjak, ZJ; Kampine, JP; Stowe, DF, 1986) |
| "To investigate whether fetal acidosis increases the placental transfer of lidocaine, resulting in higher fetal blood levels of the drug, lidocaine was infused intravenously into ten pregnant ewes to maintain plasma levels of 2-4 microgram/ml." | 7.66 | Placental transfer of lidocaine: effects of fetal acidosis. ( Biehl, D; Callender, K; Levinson, G; Shnider, SM, 1978) |
| "We report a patient with chronic renal failure and ischemic heart disease who developed clinically significant methemoglobinemia after an axillary block with bupivacaine and additional injection of lidocaine in the operative field." | 5.30 | Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field. ( Dieterich, HJ; Mühlbauer, B; Schroeder, TH, 1999) |
| "The effect of pH on brain uptake of lidocaine during status epilepticus was studied by comparing blood and brain lidocaine concentrations and pH in paralyzed and nonparalyzed rats during pentylenetetrazol-induced status." | 3.67 | Motor paralysis increases brain uptake of lidocaine during status epilepticus. ( Benowitz, NL; Culala, S; Simon, RP, 1984) |
| "To test the hypothesis that acidosis can increase the toxicity of bupivacaine more than that of lidocaine by increasing the distribution into the brain, myocardium, or both, studies were performed to measure the in vivo tissue:blood partition coefficients during continuous steady state intravenous infusions of these agents in anesthetized sheep during normal acid-base status and during combined respiratory-metabolic acidosis." | 3.67 | The influence of acidosis on the distribution of lidocaine and bupivacaine into the myocardium and brain of the sheep. ( Mather, LE; Nancarrow, C; Plummer, JL; Runciman, WB; Upton, RN, 1987) |
| "The effect of lidocaine on ischemic myocardial acidosis was investigated in the dog heart, in which the left anterior descending coronary artery was occluded to reduce to about one-third (partial occlusion)." | 3.67 | Effect of lidocaine on the myocardial acidosis induced by coronary artery occlusion in dogs. ( Abiko, Y; Matsumura, H; Matsumura, N, 1987) |
| " The aim of this study was to compare the effects of lidocaine and bupivacaine on the intrinsic pacemaker activity of in vitro sinoatrial nodal cells of the adult and neonatal guinea pig in the presence and absence of hypoxia and acidosis." | 3.67 | Comparison of lidocaine and bupivacaine depression of sinoatrial nodal activity during hypoxia and acidosis in adult and neonatal guinea pigs. ( Bosnjak, ZJ; Kampine, JP; Stowe, DF, 1986) |
| "To investigate whether fetal acidosis increases the placental transfer of lidocaine, resulting in higher fetal blood levels of the drug, lidocaine was infused intravenously into ten pregnant ewes to maintain plasma levels of 2-4 microgram/ml." | 3.66 | Placental transfer of lidocaine: effects of fetal acidosis. ( Biehl, D; Callender, K; Levinson, G; Shnider, SM, 1978) |
| " The treatment (ice packs, treatment of acidosis, glucose-insulin, methylprednisolone, lidocaine, verapamil, muscular relaxation and oxygen breathing) was effective." | 3.65 | [A further case of malignant hyperpyrexia and its treatment with lidocaine, methylprednisolone and verapamil (iproveratril) (author's transl)]. ( Bake, I; Buttazzoni, E; Csongrady, A; Pfänder, C; Schneider, M; Tarmann, H, 1976) |
| " Routine use of intravenous sodium bicarbonate is recommended to combat the severe metabolic acidosis accompanying cardiac arrest." | 3.64 | THE CHEMOTHERAPY OF CARDIAC ARREST. ( MINUCK, M, 1965) |
| "We report a patient with chronic renal failure and ischemic heart disease who developed clinically significant methemoglobinemia after an axillary block with bupivacaine and additional injection of lidocaine in the operative field." | 1.30 | Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field. ( Dieterich, HJ; Mühlbauer, B; Schroeder, TH, 1999) |
| "Ventricular fibrillation was then electrically induced and maintained in arrest for 5 mins (n = 12) or 15 mins (n = 20)." | 1.29 | Sodium bicarbonate may improve outcome in dogs with brief or prolonged cardiac arrest. ( Bircher, NG; Radovsky, A; Safar, P; Vukmir, RB, 1995) |
| "Lidocaine has been used in obstetrical anaesthesia for many years but there are still concerns about possible adverse affects of this drug on the foetus in utero." | 1.27 | The effect of lidocaine on regional blood flows and cardiac output in the non-stressed and the stressed foetal lamb. ( Bachman, C; Biehl, D; Friesen, C; Meatheral, R; Yarnell, R, 1986) |
| "Pretreatment with procaine did not prevent the onset of the condition and the administration of procaine when muscle rigidity was present failed to prevent a fatal outcome." | 1.25 | Further studies of porcine malignant hyperthermia. ( Hall, LW; Trim, CM; Woolf, N, 1972) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (77.27) | 18.7374 |
| 1990's | 6 (13.64) | 18.2507 |
| 2000's | 3 (6.82) | 29.6817 |
| 2010's | 1 (2.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Griffin, MJ | 1 |
| Letson, HL | 1 |
| Dobson, GP | 1 |
| Ikeda, Y | 1 |
| Nishikawa, K | 1 |
| Ohashi, K | 1 |
| Mori, T | 1 |
| Asada, A | 1 |
| BENDIXEN, HH | 1 |
| LAVER, MB | 1 |
| FLACKE, WE | 1 |
| MINUCK, M | 1 |
| Seyfried, FJ | 1 |
| Adachi, N | 1 |
| Arai, T | 1 |
| Gremmels, H | 1 |
| Simon, RP | 1 |
| Benowitz, NL | 1 |
| Culala, S | 1 |
| Sage, DJ | 1 |
| Feldman, HS | 1 |
| Arthur, GR | 1 |
| Datta, S | 1 |
| Ferretti, AM | 1 |
| Norway, SB | 1 |
| Covino, BG | 2 |
| Evans, JJ | 1 |
| Gilmour, RF | 1 |
| Zipes, DP | 2 |
| Nattel, S | 1 |
| Elharrar, V | 1 |
| Bailey, JC | 1 |
| Vukmir, RB | 1 |
| Bircher, NG | 1 |
| Radovsky, A | 1 |
| Safar, P | 1 |
| Schroeder, TH | 1 |
| Dieterich, HJ | 1 |
| Mühlbauer, B | 1 |
| Oyamada, Y | 1 |
| Andrzejewski, M | 1 |
| Mückenhoff, K | 1 |
| Scheid, P | 1 |
| Ballantyne, D | 1 |
| Biehl, D | 2 |
| Shnider, SM | 1 |
| Levinson, G | 1 |
| Callender, K | 1 |
| Duck, HJ | 1 |
| Trenckmann, H | 1 |
| Fleischmann, JH | 1 |
| Neugebauer, A | 1 |
| Schauer, J | 1 |
| Clark, DR | 1 |
| Dolara, P | 1 |
| Franconi, F | 1 |
| Brown, WU | 1 |
| Bell, GC | 1 |
| Alper, MH | 1 |
| Strashnov, VI | 1 |
| Tuleutaev, TB | 1 |
| Csongrady, A | 1 |
| Bake, I | 1 |
| Pfänder, C | 1 |
| Tarmann, H | 1 |
| Schneider, M | 1 |
| Buttazzoni, E | 1 |
| Pacini, DJ | 1 |
| Boachie-Ansah, G | 1 |
| Kane, KA | 1 |
| Campbell, TJ | 1 |
| Wyse, KR | 1 |
| Hemsworth, PD | 1 |
| Zochodne, DW | 1 |
| Ho, LT | 1 |
| Moorman, JR | 1 |
| Yee, R | 1 |
| Bjornsson, T | 1 |
| Starmer, CF | 1 |
| Grant, AO | 1 |
| Strauss, HC | 1 |
| Adamantidis, MM | 1 |
| Caron, JF | 1 |
| Dupuis, BA | 1 |
| Mehmel, HC | 1 |
| Echt, DS | 1 |
| Cato, EL | 1 |
| Coxe, DR | 1 |
| Nancarrow, C | 1 |
| Runciman, WB | 1 |
| Mather, LE | 1 |
| Upton, RN | 1 |
| Plummer, JL | 1 |
| Matsumura, N | 1 |
| Matsumura, H | 1 |
| Abiko, Y | 1 |
| Friesen, C | 1 |
| Yarnell, R | 1 |
| Bachman, C | 1 |
| Meatheral, R | 1 |
| Bosnjak, ZJ | 1 |
| Stowe, DF | 1 |
| Kampine, JP | 1 |
| Kühn, P | 1 |
| Koller, H | 1 |
| Kohn, P | 1 |
| Holzhey, P | 1 |
| Selzer, A | 1 |
| Cohn, KE | 1 |
| Grossman, JI | 1 |
| Rubin, IL | 1 |
| Gettes, LS | 1 |
| Teramo, K | 1 |
| Benowitz, N | 1 |
| Heymann, MA | 1 |
| Kahanpää, K | 1 |
| Siimes, A | 1 |
| Rudolph, AM | 1 |
| Hamilton, LA | 1 |
| Gottschalk, W | 1 |
| Vohra, JK | 1 |
| Hall, LW | 1 |
| Trim, CM | 1 |
| Woolf, N | 1 |
| Hickl, EJ | 1 |
| Gennser, G | 1 |
| Fox, GS | 1 |
| Houle, GL | 1 |
| Sykes, MK | 1 |
| Orr, DS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Maternal-Fetal Monitoring of Patients With Rheumatic Heart Disease During Dental Procedure Under Local Anesthesia[NCT00482573] | Phase 1 | 31 participants (Actual) | Interventional | 2004-04-30 | Completed | ||
| The Effect Of A Neurodynamic Treatment On Nerve Conduction In Clients With Low Back Pain[NCT01402895] | 9 participants (Actual) | Interventional | 2011-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for lidocaine and Acidosis
| Article | Year |
|---|---|
Recognition and treatment of cardiac emergencies.
Topics: Acidosis; Animals; Bicarbonates; Calcium; Dog Diseases; Dogs; Electric Countershock; Electrocardiogr | 1977 |
Recent advances in local anaesthesia.
Topics: Acidosis; Anesthesia, Local; Anesthetics, Local; Animals; Arrhythmias, Cardiac; Bupivacaine; Cardiov | 1986 |
Treatment of ventricular extrasystoles and tachyarrhythmias in acute myocardial infarction.
Topics: Acidosis; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Electric Count | 1970 |
The electrophysiologic effects of antiarrhythmic drugs.
Topics: Acetylcholine; Acidosis; Action Potentials; Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Atrop | 1971 |
40 other studies available for lidocaine and Acidosis
| Article | Year |
|---|---|
Small-Volume Adenosine, Lidocaine, and Mg2+ 4-Hour Infusion Leads to 88% Survival after 6 Days of Experimental Sepsis in the Rat without Antibiotics.
Topics: Acidosis; Adenosine; Animals; Anti-Bacterial Agents; C-Reactive Protein; Cytokines; Disease Models, | 2016 |
Epidural clonidine suppresses the baroreceptor-sympathetic response depending on isoflurane concentrations in cats.
Topics: Acidosis; Adrenergic alpha-Agonists; Anesthetics, Inhalation; Anesthetics, Local; Animals; Blood Pre | 2003 |
INFLUENCE OF RESPIRATORY ACIDOSIS ON CIRCULATORY EFFECT OF EPINEPHRINE IN DOGS.
Topics: Acidosis; Acidosis, Respiratory; Animals; Atropine; Blood Circulation; Blood Pressure; Carbon Dioxid | 1963 |
THE CHEMOTHERAPY OF CARDIAC ARREST.
Topics: Acidosis; Arrhythmias, Cardiac; Bicarbonates; Brugada Syndrome; Cardiac Conduction System Disease; C | 1965 |
Suppression of energy requirement by lidocaine in the ischemic mouse brain.
Topics: Acidosis; Acidosis, Lactic; Adenosine Diphosphate; Adenosine Triphosphate; Anaerobiosis; Anesthetics | 2005 |
[Lidocaine: local anaesthetic with systemic toxicity].
Topics: Acidosis; Anesthetics, Local; Area Under Curve; Blood-Brain Barrier; Humans; Lidocaine | 2008 |
Motor paralysis increases brain uptake of lidocaine during status epilepticus.
Topics: Acidosis; Animals; Brain; Lidocaine; Male; Paralysis; Rats; Rats, Inbred Strains; Status Epilepticus | 1984 |
Influence of lidocaine and bupivacaine on isolated guinea pig atria in the presence of acidosis and hypoxia.
Topics: Acidosis; Animals; Bupivacaine; Guinea Pigs; Heart Atria; Heart Rate; Hypoxia; In Vitro Techniques; | 1984 |
The effects of lidocaine and quinidine on impulse propagation across the canine Purkinje-muscle junction during combined hyperkalemia, hypoxia, and acidosis.
Topics: Acidosis; Action Potentials; Animals; Barium; Dogs; Electric Conductivity; Electric Stimulation; Fem | 1984 |
pH-dependent electrophysiological effects of quinidine and lidocaine on canine cardiac purkinje fibers.
Topics: Acidosis; Action Potentials; Animals; Dogs; Dose-Response Relationship, Drug; Electrophysiology; Fem | 1981 |
Sodium bicarbonate may improve outcome in dogs with brief or prolonged cardiac arrest.
Topics: Acidosis; Animals; Atropine; Blood Circulation; Dogs; Epinephrine; Heart Arrest; Hemodynamics; Hydro | 1995 |
Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field.
Topics: Acidosis; Alkalies; Anesthetics, Local; Antidotes; Axilla; Bupivacaine; Drug Interactions; Female; H | 1999 |
Locus coeruleus neurones in vitro: pH-sensitive oscillations of membrane potential in an electrically coupled network.
Topics: Acidosis; Animals; Cadmium; Calcium; Cells, Cultured; Culture Media; Hydrogen-Ion Concentration; Hyp | 1999 |
Placental transfer of lidocaine: effects of fetal acidosis.
Topics: Acidosis; Animals; Bicarbonates; Blood Pressure; Female; Fetal Diseases; Heart Rate; Hydrogen-Ion Co | 1978 |
[Drug therapy of myocardial infarct in ambulatory practice].
Topics: Acidosis; Adrenergic beta-Antagonists; Aftercare; Ajmaline; Ambulatory Care; Anticoagulants; Arrhyth | 1975 |
Hypertonic sodium chloride and lidocaine in a case of imipramine intoxication.
Topics: Acidosis; Child, Preschool; Electrocardiography; Humans; Hypertonic Solutions; Imipramine; Lidocaine | 1977 |
Acidosis, local anesthetics, and the newborn.
Topics: Acidosis; Anesthesia, Epidural; Anesthesia, Obstetrical; Female; Fetal Blood; Fetal Heart; Humans; I | 1976 |
[Intensive acre and resuscitation in bronchial asthma and the asthmatic state].
Topics: Acidosis; Adolescent; Adult; Aminophylline; Anesthesia; Asthma; Critical Care; Droperidol; Ephedrine | 1975 |
[A further case of malignant hyperpyrexia and its treatment with lidocaine, methylprednisolone and verapamil (iproveratril) (author's transl)].
Topics: Acidosis; Adult; Calcium; Cryotherapy; Glucose; Halothane; Humans; Insulin; Lidocaine; Male; Maligna | 1976 |
Modification by hypoxia, hyperkalaemia and acidosis of the cardiac electrophysiological effects of a range of antiarrhythmic drugs.
Topics: Acidosis; Action Potentials; Animals; Anti-Arrhythmia Agents; Disopyramide; Electrocardiography; Ele | 1992 |
Effects of hyperkalemia, acidosis, and hypoxia on the depression of maximum rate of depolarization by class I antiarrhythmic drugs in guinea pig myocardium: differential actions of class Ib and Ic agents.
Topics: Acidosis; Action Potentials; Amiodarone; Animals; Anti-Arrhythmia Agents; Electric Stimulation; Elec | 1991 |
Stimulation-induced peripheral nerve hyperemia: mediation by fibers innervating vasa nervorum?
Topics: Acidosis; Animals; Blood Gas Analysis; Blood Vessels; Electric Stimulation; Hydrogen-Ion Concentrati | 1991 |
pKa does not predict pH potentiation of sodium channel blockade by lidocaine and W6211 in guinea pig ventricular myocardium.
Topics: Acidosis; Action Potentials; Animals; Diastole; Drug Synergism; Guinea Pigs; Heart; Hydrogen-Ion Con | 1986 |
Triggered activity induced by combined mild hypoxia and acidosis in guinea-pig Purkinje fibers.
Topics: Acidosis; Animals; Arrhythmias, Cardiac; Calcium; Female; Guinea Pigs; Heart Conduction System; Hypo | 1986 |
[Therapy of acute myocardial infarct].
Topics: Acidosis; Analgesics; Atropine; Bicarbonates; Bradycardia; Cardiac Complexes, Premature; Critical Ca | 1985 |
pH-dependent effects of lidocaine on defibrillation energy requirements in dogs.
Topics: Acid-Base Equilibrium; Acidosis; Alkalosis, Respiratory; Animals; Dogs; Electric Countershock; Elect | 1989 |
The influence of acidosis on the distribution of lidocaine and bupivacaine into the myocardium and brain of the sheep.
Topics: Acidosis; Acidosis, Respiratory; Animals; Brain; Bupivacaine; Female; Hydrogen-Ion Concentration; Li | 1987 |
Effect of lidocaine on the myocardial acidosis induced by coronary artery occlusion in dogs.
Topics: Acidosis; Animals; Blood Pressure; Coronary Disease; Dogs; Female; Heart Rate; Lidocaine; Male; Myoc | 1987 |
The effect of lidocaine on regional blood flows and cardiac output in the non-stressed and the stressed foetal lamb.
Topics: Acidosis; Animals; Blood Pressure; Cardiac Output; Cerebrovascular Circulation; Female; Fetal Blood; | 1986 |
Comparison of lidocaine and bupivacaine depression of sinoatrial nodal activity during hypoxia and acidosis in adult and neonatal guinea pigs.
Topics: Acidosis; Action Potentials; Age Factors; Animals; Animals, Newborn; Bupivacaine; Depression, Chemic | 1986 |
[Arrhythmias in acute myocardial infarct].
Topics: Acidosis; Acute Disease; Arrhythmias, Cardiac; Aspartic Acid; Atrial Fibrillation; Atrial Flutter; B | 1973 |
Cardiopulmonary resuscitation. II.
Topics: Acidosis; Aftercare; Bradycardia; Heart Arrest; Humans; Hyperkalemia; Hypokalemia; Isoproterenol; Li | 1969 |
Standards for cardiopulmonary resuscitation (CPR) and emergency cardiac care (ECC). 3. Advanced life support.
Topics: Acidosis; Adolescent; Adult; Age Factors; Arrhythmias, Cardiac; Bicarbonates; Child; Child, Preschoo | 1974 |
Effects of lidocaine on heart rate, blood pressure, and electrocorticogram in fetal sheep.
Topics: Acid-Base Equilibrium; Acidosis; Amniotic Fluid; Animals; Animals, Newborn; Blood; Blood Pressure; C | 1974 |
Paracervical block: advantages and disadvantages.
Topics: Acidosis; Anesthesia, Obstetrical; Anesthetics, Local; Bradycardia; Cervix Uteri; Female; Fetal Dise | 1974 |
Cardiovascular abnormalities following tricyclic antidepressant drug overdosage.
Topics: Acidosis; Antidepressive Agents; Arrhythmias, Cardiac; Bicarbonates; Bradycardia; Heart Rate; Humans | 1974 |
Further studies of porcine malignant hyperthermia.
Topics: Acidosis; Anesthesia, General; Anesthetics; Animals; Chloroform; Cyclopropanes; Fever; Halothane; Ke | 1972 |
[The effect of paracervical block on the fetus].
Topics: Acidosis; Anesthesia, Conduction; Anesthesia, Obstetrical; Anesthetics, Local; Asphyxia Neonatorum; | 1972 |
Acid-base studies in elective caesarean sections during epidural and general anaesthesia.
Topics: Acid-Base Equilibrium; Acidosis; Acidosis, Respiratory; Anesthesia, Inhalation; Anesthesia, Obstetri | 1971 |
Cardio-pulmonary resuscitation. A report on two years' experience.
Topics: Acidosis; Adolescent; Adult; Aged; Bicarbonates; Child; Child, Preschool; Electric Countershock; Hea | 1966 |