licocoumarone has been researched along with Diabetes-Mellitus--Type-2* in 1 studies
1 other study(ies) available for licocoumarone and Diabetes-Mellitus--Type-2
Article | Year |
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Prenylflavonoids from Glycyrrhiza uralensis and their protein tyrosine phosphatase-1B inhibitory activities.
Two new 2-arylbenzofurans, glycybenzofuran (1) and cyclolicocoumarone (2), together with 10 known flavonoids including licocoumarone (3), glycyrrhisoflavone (4), glisoflavone (5), cycloglycyrrhisoflavone (6), isoliquiritigenin (7), licoflavone A (8), apigenin (9), isokaempferide (10), glycycoumarin (11), and isoglycycoumarin (12), were isolated from the roots of Glycyrrhiza uralensis and their structures were determined by extensive spectroscopic analyses. Compounds 1 and 5 showed significant protein tyrosine phosphatase-1B (PTP1B) inhibitory activity in vitro with the IC50 values of 25.5 and 27.9 microM, respectively. The structure-activity relationship indicated that the presence of prenyl group and ortho-hydroxy group is important for exhibiting the activity. Kinetic analysis indicated that compound 1 inhibits PTP1B by a competitive mode, whereas compound 5 by a mixed mode. Topics: Diabetes Mellitus, Type 2; Flavonoids; Glycyrrhiza uralensis; Humans; Inhibitory Concentration 50; Plant Extracts; Plant Roots; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Structure-Activity Relationship | 2010 |