licochalcone-c has been researched along with Esophageal-Squamous-Cell-Carcinoma* in 2 studies
2 other study(ies) available for licochalcone-c and Esophageal-Squamous-Cell-Carcinoma
| Article | Year |
|---|---|
Licochalcone H Synthesized by Modifying Structure of Licochalcone C Extracted from Glycyrrhiza inflata Induces Apoptosis of Esophageal Squamous Cell Carcinoma Cells.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Chalcones; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; G2 Phase Cell Cycle Checkpoints; Glycyrrhiza; Humans; Janus Kinases; Membrane Potential, Mitochondrial; p38 Mitogen-Activated Protein Kinases; Reactive Oxygen Species; Signal Transduction | 2020 |
Licochalcone C induces cell cycle G1 arrest and apoptosis in human esophageal squamous carcinoma cells by activation of the ROS/MAPK signaling pathway.
Along with changes in dietary habits and lifestyle, the incidence of esophageal cancer is increasing around the world. Since chemotherapy for esophageal cancer has significant side effects, phytochemicals have attracted attention as an alternative medicine. Licochalcone C (LCC) is a flavonoid compound extracted from Licorice, with a variety of clinical uses including anti-cancer, anti-inflammatory and anti-oxidant effects. Treatment with LCC for 48 h significantly decreased cell viability of esophageal squamous cell carcinoma (ESCC) cells in a dose- and time-dependent manner with IC Topics: Antineoplastic Agents; Apoptosis; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chalcones; Cytochromes c; Dose-Response Relationship, Drug; Endoplasmic Reticulum Chaperone BiP; Esophageal Squamous Cell Carcinoma; G1 Phase; Humans; Membrane Potential, Mitochondrial; Reactive Oxygen Species; Time Factors | 2020 |