licochalcone-a and Neuroblastoma

Hypoxic cellular proliferation is a common feature of tumor cells and is associated with tumor progression. Therefore, the inhibition of hypoxic cellular proliferation is expected to regulate malignancy processes. Licochalcone A (LicA) is known to show inhibitory effects on cell growth in normoxia, but it is unclear whether LicA exerts similar effects in hypoxia. Here, we studied the inhibitory activity of LicA in the hypoxic cellular proliferation of tumor cells and its molecular mechanism using human cell lines derived from various tumors including neuroblastoma and colorectal cancer. LicA inhibited cell growth at a 50% inhibitory concentration between 7.0 and 31.1 µM in hypoxia. LicA significantly suppressed hypoxic induction of tropomyosin receptor kinase B (

Topics: Brain-Derived Neurotrophic Factor; Cell Hypoxia; Chalcones; Colorectal Neoplasms; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Membrane Glycoproteins; Neoplasm Proteins; Neuroblastoma; Receptor, trkB