licochalcone-a and Malaria

licochalcone-a has been researched along with Malaria* in 2 studies

Reviews

1 review(s) available for licochalcone-a and Malaria

Article	Year
Targeting the liver stage of malaria parasites: a yet unmet goal. Journal of medicinal chemistry, 2012, Feb-09, Volume: 55, Issue:3 Topics: Animals; Antimalarials; Humans; Life Cycle Stages; Liver; Malaria; Plasmodium; Structure-Activity Relationship	2012

Other Studies

1 other study(ies) available for licochalcone-a and Malaria

Article	Year
Licochalcone A, a new antimalarial agent, inhibits in vitro growth of the human malaria parasite Plasmodium falciparum and protects mice from P. yoelii infection. Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:7 Licochalcone A, isolated from Chinese licorice roots, inhibited the in vitro growth of both chloroquine-susceptible (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum strains in a [3H]hypoxanthine uptake assay. The growth inhibition of the chloroquine-resistant strain by licochalcone A was similar to that of the chloroquine-susceptible strain. To examine the activity of licochalcone A on the different asexual blood stages of the parasite, licochalcone A was added to highly synchronized cultures containing rings, trophozoites, and schizonts. The growth of the parasites at all stages was inhibited by licochalcone A. The in vivo activity of licochalcone A was tested in a mouse model of infection with P. yoelii. Licochalcone A administered either intraperitoneally or orally for 3 to 6 days protected the mice from the otherwise lethal P. yoelii infection. These results demonstrate that licochalcone A exhibits potent antimalarial activity and might be developed into a new antimalarial drug. Topics: Animals; Antimalarials; Chalcone; Chalcones; Chloroquine; Drug Resistance; Female; Hypoxanthines; Malaria; Mice; Mice, Inbred BALB C; Plasmodium falciparum; Plasmodium yoelii	1994

Article

Year

Licochalcone A, a new antimalarial agent, inhibits in vitro growth of the human malaria parasite Plasmodium falciparum and protects mice from P. yoelii infection.

Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:7

Licochalcone A, isolated from Chinese licorice roots, inhibited the in vitro growth of both chloroquine-susceptible (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum strains in a [3H]hypoxanthine uptake assay. The growth inhibition of the chloroquine-resistant strain by licochalcone A was similar to that of the chloroquine-susceptible strain. To examine the activity of licochalcone A on the different asexual blood stages of the parasite, licochalcone A was added to highly synchronized cultures containing rings, trophozoites, and schizonts. The growth of the parasites at all stages was inhibited by licochalcone A. The in vivo activity of licochalcone A was tested in a mouse model of infection with P. yoelii. Licochalcone A administered either intraperitoneally or orally for 3 to 6 days protected the mice from the otherwise lethal P. yoelii infection. These results demonstrate that licochalcone A exhibits potent antimalarial activity and might be developed into a new antimalarial drug.

Topics: Animals; Antimalarials; Chalcone; Chalcones; Chloroquine; Drug Resistance; Female; Hypoxanthines; Malaria; Mice; Mice, Inbred BALB C; Plasmodium falciparum; Plasmodium yoelii

1994