licochalcone-a and Enterovirus-Infections

Enterovirus A71 (EV-A71) is one of the main causative agents of hand-foot-mouth disease (HFMD) and causes serious neurological complications. However, no effective therapy is currently available for treating these infections. Therefore, effective drugs to prevent and treat EV-A71 infections are urgently needed. Here, we demonstrated that treatment with Licochalcone A (LCA) significantly inhibited EV-A71 replication in a dose-dependent manner, with an EC

Topics: Animals; Animals, Newborn; Antiviral Agents; Cell Line, Tumor; Chalcones; Chlorocebus aethiops; Enterovirus A, Human; Enterovirus Infections; Hand, Foot and Mouth Disease; Humans; Mice; Vero Cells; Viral Load; Virus Replication