liarozole has been researched along with Breast Neoplasms in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (41.67) | 18.2507 |
| 2000's | 6 (50.00) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brodie, AM; Clement, OO; Gediya, LK; Goloubeva, OG; Handratta, VD; Huynh, CK; Nanne, IP; Njar, VC; Patel, JB; Soprano, DR | 1 |
| Muftuoglu, Y; Mustata, G | 1 |
| Goss, PE; Hu, H; Qi, S; Strasser-Weippl, K | 1 |
| Borgers, M; De Coster, R; Ramaekers, F; Smets, G; Van heusden, J; Wouters, W; Xhonneux, B | 1 |
| Coene, MC; Cools, W; Dillen, L; Krekels, MD; van Dun, J; Van Hove, C; Verhoeven, A; Wouters, W | 1 |
| Borgers, M; Dillen, L; Krekels, MD; Ramaekers, FC; Smets, G; Van heusden, J; Wouters, W | 1 |
| Petkovich, M; Schulkes, RK; Sonneveld, E; van den Brink, CE; van der Burg, B; van der Leede, BM; van der Saag, PT | 1 |
| Bruynseels, J; Crump, M; De Coster, R; Goel, R; Goss, PE; Nabholtz, JM; Oza, A; Reid, C; Tye, LM; Wadden, N | 1 |
| Beex, L; Boes, GH; Coleman, R; Hamilton, A; Klijn, J; Mauriac, L; Palmer, P; Paridaens, R; Piccart, M; Roy, JA; van Vreckem, A | 1 |
| Abdolell, M; Blackstein, M; Clemons, M; Crump, M; De Coster, R; Goel, R; Goss, PE; Kaizer, L; Marques, R; Nabholtz, JM; Oza, A; Qi, S; Sterns, EE; Strasser, K | 1 |
| Bruwiere, H; Dillen, L; Floren, W; Janicot, M; Janssen, B; Moelans, P; Sanz, G; van der Leede, BJ; van Dun, J; Van Ginckel, R; Van Heusden, J; Van Hove, C; Venet, M; Willemsens, G; Wouters, W | 1 |
| Coene, MC; Cools, W; De Coster, R; Dillen, A; van Dun, J; Wouters, W | 1 |
3 trial(s) available for liarozole and Breast Neoplasms
| Article | Year |
|---|---|
Liarozole fumarate (R85246): a novel imidazole in the treatment of receptor positive postmenopausal metastatic breast cancer.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Breast Neoplasms; Disease Progression; Estrogens; Female; Humans; Imidazoles; Middle Aged; Postmenopause; Quality of Life; Receptors, Estrogen; Skin Diseases | 2000 |
EORTC 10941: A phase II study of liarozole in postmenopausal patients with 'chemotherapy-resistant' or 'potentially hormone sensitive' metastatic breast cancer.
Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Breast Neoplasms; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Humans; Imidazoles; Middle Aged; Postmenopause; Receptors, Estrogen; Treatment Outcome | 2000 |
Liarozole fumarate (R85246): in the treatment of ER negative, tamoxifen refractory or chemotherapy resistant postmenopausal metastatic breast cancer.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Disease Progression; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Estradiol; Female; Humans; Imidazoles; Mammary Neoplasms, Experimental; Middle Aged; Neoplasm Metastasis; Postmenopause; Quality of Life; Rats; Receptors, Estrogen; Tamoxifen; Treatment Outcome | 2000 |
9 other study(ies) available for liarozole and Breast Neoplasms
| Article | Year |
|---|---|
Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and prostate cancer cells in vitro and a human breast tumor xenograft in nude mice.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cricetinae; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Male; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Microsomes, Liver; Neoplasm Transplantation; Prostatic Neoplasms; Retinoic Acid 4-Hydroxylase; Stereoisomerism; Transplantation, Heterologous; Tretinoin | 2004 |
Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19).
Topics: Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Binding Sites; Breast Neoplasms; Computer Simulation; Drug Design; Female; Humans; Models, Chemical; Models, Molecular; Structure-Activity Relationship | 2010 |
Effects of liarozole fumarate (R85246) in combination with tamoxifen on N-methyl-N-nitrosourea (MNU)-induced mammary carcinoma and uterus in the rat model.
Topics: Animals; Breast Neoplasms; Cell Proliferation; Disease Models, Animal; Drug Therapy, Combination; Female; Imidazoles; Methylnitrosourea; Ovariectomy; Rats; Rats, Sprague-Dawley; Tamoxifen; Uterus | 2007 |
Liarozole potentiates the all-trans-retinoic acid-induced structural remodelling in human breast carcinoma MCF-7 cells in vitro.
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Carcinoma; Cell Adhesion Molecules; Cell Division; Cytoskeletal Proteins; Cytoskeleton; Dose-Response Relationship, Drug; Drug Synergism; Female; Humans; Imidazoles; Neoplasm Proteins; Tretinoin | 1996 |
Induction of the oxidative catabolism of retinoid acid in MCF-7 cells.
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cytosol; Female; Humans; Imidazoles; Keratolytic Agents; Oxidation-Reduction; Reproducibility of Results; Retinoids; Retinol-Binding Proteins; Tretinoin; Tumor Cells, Cultured | 1997 |
The antiproliferative activity of all-trans-retinoic acid catabolites and isomers is differentially modulated by liarozole-fumarate in MCF-7 human breast cancer cells.
Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Division; Chromatography, High Pressure Liquid; DNA Replication; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Synergism; Female; Humans; Imidazoles; Stereoisomerism; Tretinoin; Tumor Cells, Cultured | 1998 |
Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells.
Topics: Blotting, Northern; Blotting, Western; Breast Neoplasms; Chromatography; Colonic Neoplasms; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA; Enzyme Induction; Female; Humans; Hydroxylation; Imidazoles; Microsomes; Receptors, Retinoic Acid; Retinoic Acid 4-Hydroxylase; Retinoic Acid Receptor alpha; Retinoic Acid Receptor gamma; Substrate Specificity; Transfection; Tretinoin; Tumor Cells, Cultured | 1998 |
Inhibition of all-TRANS-retinoic acid metabolism by R116010 induces antitumour activity.
Topics: Animals; Antineoplastic Agents; Benzothiazoles; Breast Neoplasms; Cell Division; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Female; Humans; Imidazoles; Mammary Neoplasms, Experimental; Mice; Mice, Inbred Strains; Mixed Function Oxygenases; Retinoic Acid 4-Hydroxylase; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Tretinoin; Tumor Cells, Cultured | 2002 |
Effects of liarozole, a new antitumoral compound, on retinoic acid-induced inhibition of cell growth and on retinoic acid metabolism in MCF-7 human breast cancer cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Cytochrome P-450 Enzyme Inhibitors; Drug Synergism; Female; Humans; Imidazoles; Kinetics; Tretinoin; Tritium; Tumor Cells, Cultured | 1992 |