lhrh--n-ac-naphthyl(1)-(4-cl-phe)(2)-trp(3)-arg(6)-ala(10)- has been researched along with Infertility--Male* in 1 studies
1 other study(ies) available for lhrh--n-ac-naphthyl(1)-(4-cl-phe)(2)-trp(3)-arg(6)-ala(10)- and Infertility--Male
| Article | Year |
|---|---|
On the maintenance of male fertility in the absence of native testosterone secretion: site-directed hormonal therapy in the rat.
A method of direct percutaneous injection of testosterone (T)-laden microspheres directly into the testis was used in an attempt to achieve the maintenance of normal intratesticular T concentrations, spermatogenesis, and fertility. Rats were divided into three groups: (1) sham operated/injection controls; (2) animals receiving 250 micrograms/d gonadotropin-releasing hormone (GnRH)-antagonist; and (3) animals receiving GnRH-antagonist as in group 1 plus 20 mg T-laden microspheres/testis. Treatment periods were 45 and 90 days. Serum T, testicular interstitial fluid T, testis weights, epididymal weights, daily sperm production (sperm x 10(6)/g/d), cauda sperm motility, and fertility were assessed in all animals. Gonadotropin-releasing hormone antagonist treatment reduced serum and testicular interstitial fluid to below detectable levels at day 45 and to similar levels at day 90. Supplementation with T-laden microspheres maintained testicular interstitial fluid T at concentrations not different from controls without elevation of serum T concentrations. All other values, including fertility were suppressed by GnRH-antagonist treatment and maintained by supplementation with T-laden microspheres. Topics: Animals; Epididymis; Gonadotropin-Releasing Hormone; Infertility, Male; Male; Microspheres; Organ Size; Rats; Rats, Inbred Strains; Sperm Motility; Spermatogenesis; Testis; Testosterone | 1990 |