lhrh--his(5)-trp(7)-tyr(8)- and Osteosarcoma

lhrh--his(5)-trp(7)-tyr(8)- has been researched along with Osteosarcoma* in 1 studies

Other Studies

1 other study(ies) available for lhrh--his(5)-trp(7)-tyr(8)- and Osteosarcoma

ArticleYear
The effects of common variants in MDM2 and GNRH2 genes on the risk and survival of osteosarcoma in Han populations from Northwest China.
    Scientific reports, 2020, 09-29, Volume: 10, Issue:1

    Accumulating evidence has shown that both MDM2 and GNRH2 might be related to Osteosarcoma (OS) susceptibility. The study aimed to evaluate the effects of common variants in MDM2 and GNRH2 genes on the risk and survival of osteosarcoma in Han populations from Northwest China. In the study, we recruited 2292 subjects including 596 OS patients and 1696 healthy controls and genotyped 16 selected tag SNPs (6 from GNRH2 and 10 from MDM2). Genetic association analyses were performed at the genotypic and allelic levels. Survival curves were made for OS patients with different genotypes. Two SNPs, rs1690916 (MDM2, P = 0.0002) and rs3761243 (GNRH2, P = 0.0004), were identified to be significantly associated with OS risk. Moreover, SNP rs3761243 was strongly associated with pathological fracture (P = 2.61 × 10

    Topics: Adult; Alleles; Asian People; Case-Control Studies; China; Ethnicity; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genetic Variation; Genotype; Gonadotropin-Releasing Hormone; Humans; Male; Middle Aged; Osteosarcoma; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins c-mdm2; Survival Analysis

2020