lg 100268 has been researched along with Obesity in 7 studies
LG 100268: a retinoid X receptor (RXR) selective compound; structure given in first source
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Long-term (2 weeks) oral treatment with the rexinoids LG100268 and LG100324 reduced food intake and body weight gain, whereas rosiglitazone (BRL49653) tended to increase both food intake and weight gain." | 7.70 | The effects of rexinoids and rosiglitazone on body weight and uncoupling protein isoform expression in the Zucker fa/fa rat. ( Cawthorne, MA; Emilsson, V; Heyman, R; Liu, YL; O'Dowd, J; Sennitt, M; Wang, S, 2000) |
| " To determine whether rexinoids lower hyperglycemia by activating the RXR/PPAR-gamma heterodimer in vivo, we compared the effects of a rexinoid (LG100268) and a TZD (rosiglitazone) on gene expression in white adipose tissue, skeletal muscle, and liver of Zucker diabetic fatty rats (ZDFs)." | 3.71 | Differential effects of rexinoids and thiazolidinediones on metabolic gene expression in diabetic rodents. ( Boehm, M; Crombie, DL; Davies, PJ; Depre, C; Heyman, RA; Leibowitz, MD; Liu, S; Nagy, L; Singh Ahuja, H; Tontonoz, P, 2001) |
| "Chronic administration of retinoid X receptor agonists LG 100268 and LG 100324 to Zucker fa/fa rats reduces food intake and body weight gain, lowers plasma insulin concentrations while maintaining normoglycaemia, indicating an improvement of insulin sensitivity." | 3.70 | Retinoid X receptor agonists have anti-obesity effects and improve insulin sensitivity in Zucker fa/fa rats. ( Cawthorne, MA; Crombie, DL; Heyman, RA; Hislop, DC; Liu, YL; Sennitt, MV, 2000) |
| " Long-term (2 weeks) oral treatment with the rexinoids LG100268 and LG100324 reduced food intake and body weight gain, whereas rosiglitazone (BRL49653) tended to increase both food intake and weight gain." | 3.70 | The effects of rexinoids and rosiglitazone on body weight and uncoupling protein isoform expression in the Zucker fa/fa rat. ( Cawthorne, MA; Emilsson, V; Heyman, R; Liu, YL; O'Dowd, J; Sennitt, M; Wang, S, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mukherjee, R | 1 |
| Davies, PJ | 2 |
| Crombie, DL | 3 |
| Bischoff, ED | 1 |
| Cesario, RM | 1 |
| Jow, L | 1 |
| Hamann, LG | 1 |
| Boehm, MF | 1 |
| Mondon, CE | 1 |
| Nadzan, AM | 1 |
| Paterniti, JR | 1 |
| Heyman, RA | 4 |
| Meier, CA | 1 |
| Liu, YL | 2 |
| Sennitt, MV | 1 |
| Hislop, DC | 1 |
| Cawthorne, MA | 2 |
| Emilsson, V | 1 |
| O'Dowd, J | 1 |
| Wang, S | 1 |
| Sennitt, M | 1 |
| Heyman, R | 1 |
| Singh Ahuja, H | 1 |
| Liu, S | 1 |
| Boehm, M | 1 |
| Leibowitz, MD | 2 |
| Depre, C | 1 |
| Nagy, L | 1 |
| Tontonoz, P | 1 |
| Yamauchi, T | 1 |
| Waki, H | 1 |
| Kamon, J | 1 |
| Murakami, K | 1 |
| Motojima, K | 1 |
| Komeda, K | 1 |
| Miki, H | 1 |
| Kubota, N | 1 |
| Terauchi, Y | 1 |
| Tsuchida, A | 1 |
| Tsuboyama-Kasaoka, N | 1 |
| Yamauchi, N | 1 |
| Ide, T | 1 |
| Hori, W | 1 |
| Kato, S | 1 |
| Fukayama, M | 1 |
| Akanuma, Y | 1 |
| Ezaki, O | 1 |
| Itai, A | 1 |
| Nagai, R | 1 |
| Kimura, S | 1 |
| Tobe, K | 1 |
| Kagechika, H | 1 |
| Shudo, K | 1 |
| Kadowaki, T | 1 |
| Ogilvie, KM | 1 |
| Saladin, R | 1 |
| Nagy, TR | 1 |
| Urcan, MS | 1 |
1 review available for lg 100268 and Obesity
| Article | Year |
|---|---|
Novel pharmacological approaches to the prevention and treatment of non-insulin-dependent diabetes mellitus.
Topics: Animals; Diabetes Mellitus, Type 2; Humans; Nicotinic Acids; Obesity; Tetrahydronaphthalenes; Thiazo | 1997 |
6 other studies available for lg 100268 and Obesity
| Article | Year |
|---|---|
Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists.
Topics: Animals; Bexarotene; Blood Glucose; Cells, Cultured; Diabetes Mellitus, Type 2; Female; Glucose Tole | 1997 |
Retinoid X receptor agonists have anti-obesity effects and improve insulin sensitivity in Zucker fa/fa rats.
Topics: Analysis of Variance; Animals; Blood Glucose; Body Weight; Eating; Hypoglycemic Agents; Insulin; Ins | 2000 |
The effects of rexinoids and rosiglitazone on body weight and uncoupling protein isoform expression in the Zucker fa/fa rat.
Topics: Adipose Tissue, Brown; Animals; Body Weight; Carrier Proteins; Eating; Ion Channels; Membrane Protei | 2000 |
Differential effects of rexinoids and thiazolidinediones on metabolic gene expression in diabetic rodents.
Topics: Adipose Tissue; Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Disease | 2001 |
Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes.
Topics: 3T3 Cells; Adipose Tissue; Animals; Benzhydryl Compounds; Benzoates; Biphenyl Compounds; Diabetes Me | 2001 |
Activation of the retinoid X receptor suppresses appetite in the rat.
Topics: Adipose Tissue; Animals; Anticholesteremic Agents; Apoptosis; Appetite Regulation; Brain; Eating; En | 2004 |