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lg 100268 and Obesity

lg 100268 has been researched along with Obesity in 7 studies

LG 100268: a retinoid X receptor (RXR) selective compound; structure given in first source

Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).

Research Excerpts

ExcerptRelevanceReference
" Long-term (2 weeks) oral treatment with the rexinoids LG100268 and LG100324 reduced food intake and body weight gain, whereas rosiglitazone (BRL49653) tended to increase both food intake and weight gain."7.70The effects of rexinoids and rosiglitazone on body weight and uncoupling protein isoform expression in the Zucker fa/fa rat. ( Cawthorne, MA; Emilsson, V; Heyman, R; Liu, YL; O'Dowd, J; Sennitt, M; Wang, S, 2000)
" To determine whether rexinoids lower hyperglycemia by activating the RXR/PPAR-gamma heterodimer in vivo, we compared the effects of a rexinoid (LG100268) and a TZD (rosiglitazone) on gene expression in white adipose tissue, skeletal muscle, and liver of Zucker diabetic fatty rats (ZDFs)."3.71Differential effects of rexinoids and thiazolidinediones on metabolic gene expression in diabetic rodents. ( Boehm, M; Crombie, DL; Davies, PJ; Depre, C; Heyman, RA; Leibowitz, MD; Liu, S; Nagy, L; Singh Ahuja, H; Tontonoz, P, 2001)
"Chronic administration of retinoid X receptor agonists LG 100268 and LG 100324 to Zucker fa/fa rats reduces food intake and body weight gain, lowers plasma insulin concentrations while maintaining normoglycaemia, indicating an improvement of insulin sensitivity."3.70Retinoid X receptor agonists have anti-obesity effects and improve insulin sensitivity in Zucker fa/fa rats. ( Cawthorne, MA; Crombie, DL; Heyman, RA; Hislop, DC; Liu, YL; Sennitt, MV, 2000)
" Long-term (2 weeks) oral treatment with the rexinoids LG100268 and LG100324 reduced food intake and body weight gain, whereas rosiglitazone (BRL49653) tended to increase both food intake and weight gain."3.70The effects of rexinoids and rosiglitazone on body weight and uncoupling protein isoform expression in the Zucker fa/fa rat. ( Cawthorne, MA; Emilsson, V; Heyman, R; Liu, YL; O'Dowd, J; Sennitt, M; Wang, S, 2000)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (28.57)18.2507
2000's5 (71.43)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mukherjee, R1
Davies, PJ2
Crombie, DL3
Bischoff, ED1
Cesario, RM1
Jow, L1
Hamann, LG1
Boehm, MF1
Mondon, CE1
Nadzan, AM1
Paterniti, JR1
Heyman, RA4
Meier, CA1
Liu, YL2
Sennitt, MV1
Hislop, DC1
Cawthorne, MA2
Emilsson, V1
O'Dowd, J1
Wang, S1
Sennitt, M1
Heyman, R1
Singh Ahuja, H1
Liu, S1
Boehm, M1
Leibowitz, MD2
Depre, C1
Nagy, L1
Tontonoz, P1
Yamauchi, T1
Waki, H1
Kamon, J1
Murakami, K1
Motojima, K1
Komeda, K1
Miki, H1
Kubota, N1
Terauchi, Y1
Tsuchida, A1
Tsuboyama-Kasaoka, N1
Yamauchi, N1
Ide, T1
Hori, W1
Kato, S1
Fukayama, M1
Akanuma, Y1
Ezaki, O1
Itai, A1
Nagai, R1
Kimura, S1
Tobe, K1
Kagechika, H1
Shudo, K1
Kadowaki, T1
Ogilvie, KM1
Saladin, R1
Nagy, TR1
Urcan, MS1

Reviews

1 review available for lg 100268 and Obesity

ArticleYear
Novel pharmacological approaches to the prevention and treatment of non-insulin-dependent diabetes mellitus.
    European journal of endocrinology, 1997, Volume: 137, Issue:3

    Topics: Animals; Diabetes Mellitus, Type 2; Humans; Nicotinic Acids; Obesity; Tetrahydronaphthalenes; Thiazo

1997

Other Studies

6 other studies available for lg 100268 and Obesity

ArticleYear
Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists.
    Nature, 1997, Mar-27, Volume: 386, Issue:6623

    Topics: Animals; Bexarotene; Blood Glucose; Cells, Cultured; Diabetes Mellitus, Type 2; Female; Glucose Tole

1997
Retinoid X receptor agonists have anti-obesity effects and improve insulin sensitivity in Zucker fa/fa rats.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 2000, Volume: 24, Issue:8

    Topics: Analysis of Variance; Animals; Blood Glucose; Body Weight; Eating; Hypoglycemic Agents; Insulin; Ins

2000
The effects of rexinoids and rosiglitazone on body weight and uncoupling protein isoform expression in the Zucker fa/fa rat.
    Metabolism: clinical and experimental, 2000, Volume: 49, Issue:12

    Topics: Adipose Tissue, Brown; Animals; Body Weight; Carrier Proteins; Eating; Ion Channels; Membrane Protei

2000
Differential effects of rexinoids and thiazolidinediones on metabolic gene expression in diabetic rodents.
    Molecular pharmacology, 2001, Volume: 59, Issue:4

    Topics: Adipose Tissue; Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Disease

2001
Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes.
    The Journal of clinical investigation, 2001, Volume: 108, Issue:7

    Topics: 3T3 Cells; Adipose Tissue; Animals; Benzhydryl Compounds; Benzoates; Biphenyl Compounds; Diabetes Me

2001
Activation of the retinoid X receptor suppresses appetite in the rat.
    Endocrinology, 2004, Volume: 145, Issue:2

    Topics: Adipose Tissue; Animals; Anticholesteremic Agents; Apoptosis; Appetite Regulation; Brain; Eating; En

2004