lg 100268 has been researched along with Disease Models, Animal in 7 studies
LG 100268: a retinoid X receptor (RXR) selective compound; structure given in first source
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To determine whether rexinoids lower hyperglycemia by activating the RXR/PPAR-gamma heterodimer in vivo, we compared the effects of a rexinoid (LG100268) and a TZD (rosiglitazone) on gene expression in white adipose tissue, skeletal muscle, and liver of Zucker diabetic fatty rats (ZDFs)." | 3.71 | Differential effects of rexinoids and thiazolidinediones on metabolic gene expression in diabetic rodents. ( Boehm, M; Crombie, DL; Davies, PJ; Depre, C; Heyman, RA; Leibowitz, MD; Liu, S; Nagy, L; Singh Ahuja, H; Tontonoz, P, 2001) |
| "Pancreatic cancer is the fourth leading cause of cancer-related deaths in the United States and is nearly always fatal." | 1.36 | Synthetic triterpenoids prolong survival in a transgenic mouse model of pancreatic cancer. ( Hruban, RH; Liby, KT; Maitra, A; Risingsong, R; Royce, DB; Sporn, MB; Williams, CR, 2010) |
| "Bexarotene treatment at a dose of 250 mg/kg diet was associated with reductions in tumor multiplicity of 84% (P < 0." | 1.33 | Neu-induced retroviral rat mammary carcinogenesis: a novel chemoprevention model for both hormonally responsive and nonresponsive mammary carcinomas. ( Brose, HL; Gould, MN; Haag, JD; Hitt, AA; Hu, R; Kim, K; Lindstrom, MJ; Lubet, RA; Mau, B; Monson, DM; Steele, VE; Waller, JL; Watson, PA; Woditschka, S; Zheng, Y, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Liby, KT | 1 |
| Royce, DB | 2 |
| Risingsong, R | 2 |
| Williams, CR | 2 |
| Maitra, A | 1 |
| Hruban, RH | 1 |
| Sporn, MB | 2 |
| Hede, K | 1 |
| Woditschka, S | 1 |
| Haag, JD | 1 |
| Waller, JL | 1 |
| Monson, DM | 1 |
| Hitt, AA | 1 |
| Brose, HL | 1 |
| Hu, R | 1 |
| Zheng, Y | 1 |
| Watson, PA | 1 |
| Kim, K | 1 |
| Lindstrom, MJ | 1 |
| Mau, B | 1 |
| Steele, VE | 1 |
| Lubet, RA | 1 |
| Gould, MN | 1 |
| Liby, K | 1 |
| Rendi, M | 1 |
| Suh, N | 1 |
| Lamph, W | 1 |
| Labrie, F | 1 |
| Krajewski, S | 1 |
| Xu, X | 1 |
| Kim, H | 1 |
| Brown, P | 1 |
| Singh Ahuja, H | 1 |
| Liu, S | 1 |
| Crombie, DL | 1 |
| Boehm, M | 1 |
| Leibowitz, MD | 1 |
| Heyman, RA | 1 |
| Depre, C | 1 |
| Nagy, L | 1 |
| Tontonoz, P | 1 |
| Davies, PJ | 1 |
| Kosters, A | 1 |
| Tian, F | 1 |
| Wan, YJ | 1 |
| Wan, YY | 1 |
| Karpen, SJ | 1 |
7 other studies available for lg 100268 and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Synthetic triterpenoids prolong survival in a transgenic mouse model of pancreatic cancer.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Disease Models, Animal; Mice; Mice, Transgenic; N | 2010 |
Rexinoids may be ready for prime time in prevention, but challenges remain.
Topics: Animals; Anticarcinogenic Agents; Bexarotene; Breast Neoplasms; Clinical Trials as Topic; Disease Mo | 2004 |
Neu-induced retroviral rat mammary carcinogenesis: a novel chemoprevention model for both hormonally responsive and nonresponsive mammary carcinomas.
Topics: Animals; Anticarcinogenic Agents; Bexarotene; Body Weight; Disease Models, Animal; Female; Genes, er | 2006 |
The combination of the rexinoid, LG100268, and a selective estrogen receptor modulator, either arzoxifene or acolbifene, synergizes in the prevention and treatment of mammary tumors in an estrogen receptor-negative model of breast cancer.
Topics: Animals; Cell Division; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; H | 2006 |
Differential effects of rexinoids and thiazolidinediones on metabolic gene expression in diabetic rodents.
Topics: Adipose Tissue; Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Disease | 2001 |
Gene-specific alterations of hepatic gene expression by ligand activation or hepatocyte-selective inhibition of retinoid X receptor-α signalling during inflammation.
Topics: Animals; Cell Nucleus; Disease Models, Animal; Gene Expression; Hepatocytes; Inflammation; Ligands; | 2012 |