lg 100268 has been researched along with Alzheimer Disease in 1 studies
LG 100268: a retinoid X receptor (RXR) selective compound; structure given in first source
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previous data demonstrate that bexarotene (Bex), retinoid X receptor (RXR) agonist, reduces soluble and insoluble amyloid-β (Aβ) in Alzheimer disease (AD)-transgenic mice either by increasing the levels of mouse apolipoprotein E (apoE) or increasing ABCA1/ABCG1-induced apoE lipoprotein association/lipidation." | 3.80 | Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo. ( Ben Aissa, M; Collins, NC; Koster, KP; LaDu, MJ; Lee, SH; Luo, J; Tai, LM; Thatcher, GRJ; Wang, YT, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tai, LM | 1 |
| Koster, KP | 1 |
| Luo, J | 1 |
| Lee, SH | 1 |
| Wang, YT | 1 |
| Collins, NC | 1 |
| Ben Aissa, M | 1 |
| Thatcher, GRJ | 1 |
| LaDu, MJ | 1 |
1 other study available for lg 100268 and Alzheimer Disease
| Article | Year |
|---|---|
Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Apolipoproteins E; ATP Bind | 2014 |