lewis-x-antigen and Wiskott-Aldrich-Syndrome

Mucin-type O-glycans on leukocytes acquire functions once they contain core 2 branches, which can be synthesized by core 2 beta1,6-N-acetylglucosaminyltransferase (C2GnT). Recently, understanding the roles of mucin-type O-glycans has been significantly advanced by generating transgenic mice overexpressing C2GnT or knockout mice defective in C2GnT. This review article summarizes previous results implicating the roles of mucin-type O-glycans and the most recent studies to test such a hypothesis. These results, taken together, demonstrate that mucin-type O-glycans either facilitate or attenuate cell adhesion depending on the structures of non-reducing termini.

Topics: Animals; Antigens, CD; Biomarkers, Tumor; Carbohydrate Sequence; Cell Adhesion; Cell Line; DNA, Complementary; Humans; Leukosialin; Lewis Blood Group Antigens; Lewis X Antigen; Molecular Sequence Data; Molecular Weight; Mucins; N-Acetylglucosaminyltransferases; Oligosaccharides; Sialoglycoproteins; T-Lymphocytes; Thymus Gland; Tumor Cells, Cultured; Wiskott-Aldrich Syndrome