lewis-x-antigen and Peritonitis

lewis-x-antigen has been researched along with Peritonitis* in 1 studies

Other Studies

1 other study(ies) available for lewis-x-antigen and Peritonitis

Article	Year
P-selectin blocking potency of multimeric tyrosine sulfates in vitro and in vivo. Bioorganic & medicinal chemistry letters, 2003, May-19, Volume: 13, Issue:10 P-selectin blocking potency was investigated using synthetic monomeric and polymeric anionic compounds containing sulfate groups such as O-sulfotyrosine (sTyr) and/or sulfated Lewis structures. A non-carbohydrate-containing polyacrylamide conjugate sTyr-PAA (80% mol of sTyr) was a remarkably potent inhibitor of P-selectin binding in vitro, having an IC(50) value of 6 ng/mL (equivalent to 10 nM calculated on the basis of sTyr residues or 0.1 nM calculated by the mass of the macromolecule). The inhibitory effect of sTyr-PAA (80%) towards P-selectin is significantly greater than that of fucoidan (IC(50), 100 ng/mL). However, sTyr-PAA (80%) was less effective than fucoidan at reducing neutrophil extravasation in an in vivo rat model of peritonitis. Topics: Acrylic Resins; Animals; Chemotaxis, Leukocyte; Dimerization; Disease Models, Animal; Female; Humans; Inhibitory Concentration 50; Lewis X Antigen; Neutrophils; P-Selectin; Peritonitis; Protein Binding; Rats; Rats, Wistar; Structure-Activity Relationship; Tyrosine	2003

Article

Year

P-selectin blocking potency of multimeric tyrosine sulfates in vitro and in vivo.

Bioorganic & medicinal chemistry letters, 2003, May-19, Volume: 13, Issue:10

P-selectin blocking potency was investigated using synthetic monomeric and polymeric anionic compounds containing sulfate groups such as O-sulfotyrosine (sTyr) and/or sulfated Lewis structures. A non-carbohydrate-containing polyacrylamide conjugate sTyr-PAA (80% mol of sTyr) was a remarkably potent inhibitor of P-selectin binding in vitro, having an IC(50) value of 6 ng/mL (equivalent to 10 nM calculated on the basis of sTyr residues or 0.1 nM calculated by the mass of the macromolecule). The inhibitory effect of sTyr-PAA (80%) towards P-selectin is significantly greater than that of fucoidan (IC(50), 100 ng/mL). However, sTyr-PAA (80%) was less effective than fucoidan at reducing neutrophil extravasation in an in vivo rat model of peritonitis.

Topics: Acrylic Resins; Animals; Chemotaxis, Leukocyte; Dimerization; Disease Models, Animal; Female; Humans; Inhibitory Concentration 50; Lewis X Antigen; Neutrophils; P-Selectin; Peritonitis; Protein Binding; Rats; Rats, Wistar; Structure-Activity Relationship; Tyrosine

2003