lewis-x-antigen and Hydatidiform-Mole

Murine stage-specific embryonic antigens (SSEA-1, SSEA-3) are well characterized oncofetal antigens and have been identified in several human tumors. The current study was undertaken to determine the localization of SSEA-1 and SSEA-3 in hydatidiform mole, normal human placenta, and gestational choriocarcinoma. SSEA-3 did not react with any cellular components in hydatidiform moles, normal placentas, or choriocarcinoma cell lines. SSEA-1 was detectable in two human gestational choriocarcinoma cell lines, but not in the trophoblastic cells of 10 hydatidiform moles or in nine normal placentas between 6 weeks and term gestation. Therefore, according to this oncofetal marker system, the trophoblast in hydatidiform mole is more like normal trophoblast than gestational choriocarcinoma.

Topics: Antigens, Neoplasm; Cell Line; Choriocarcinoma; Female; Fluorescent Antibody Technique; Gestational Age; Glycolipids; Histocytochemistry; Humans; Hydatidiform Mole; Immunoenzyme Techniques; Lewis X Antigen; Lymph Nodes; Neoplasm Staging; Placenta; Pregnancy; Risk; Trophoblastic Neoplasms; Trophoblasts; Uterine Neoplasms