lewis-x-antigen and Chromosome-Deletion

Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antigens, CD; Antigens, CD20; Antineoplastic Agents; CD79 Antigens; Cell Differentiation; Chromosome Deletion; Chromosomes, Human, Pair 6; Epstein-Barr Virus Infections; fas Receptor; Hodgkin Disease; Humans; Immunohistochemistry; Ki-1 Antigen; Kidney Transplantation; Leukocyte Common Antigens; Lewis X Antigen; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoproliferative Disorders; Male; Postoperative Complications; Receptors, Antigen, B-Cell; Rituximab; Treatment Outcome

Among 72 Chinese patients with acute lymphoblastic leukemia (ALL), 50 had clonal chromosomal abnormalities. Structural abnormalities were detected in 42 patients: these included t(9;22) in 9, t(1;19) in 6, t(4;11) in 5, del(11)(q23) in 4, and del(6q) in 4. Adults had a higher incidence of t(9;22) and t(1;19) but a lower incidence of t(4;11) and hyperdiploid greater than 50 karyotype than children. A significant difference was also noted in white blood cell (WBC) count among various karyotypic groups. Patients with chromosomal abnormalities t(9;22), t(1;19), t(4;11) and del(11) (q23) had a shorter complete remission duration as compared with patients free of these abnormalities. Immunophenotyping was performed on 69 patients. All patients with t(9;22), t(1;19), and t(4;11) had B-lineage ALL restricted to certain stages of maturation: groups III and IV, groups IV and V, and group II, respectively (according to the classification of Foon and Tood). Among patients with t(9;22), t(4;11), and del(11)(q23), which have been considered to be associated with acute mixed-lineage leukemia, one each, respectively, showed myeloid antigen expression on the leukemic blasts (My+ ALL). No cross-lineage rearrangements of immunoglobulin (Ig) or T-cell receptor (TCR) genes were detected in these karyotypic subgroups of patients who underwent gene analysis.

Topics: Adolescent; Adult; Aged; Antigens, Neoplasm; Blotting, Southern; Bone Marrow Cells; Chi-Square Distribution; Child; Child, Preschool; Chromosome Aberrations; Chromosome Deletion; Chromosomes, Human; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 19; Chromosomes, Human, Pair 22; Chromosomes, Human, Pair 4; Chromosomes, Human, Pair 9; Female; Gene Rearrangement; Gene Rearrangement, B-Lymphocyte, Heavy Chain; Gene Rearrangement, T-Lymphocyte; Humans; Immunoglobulin Heavy Chains; Infant; Lewis X Antigen; Male; Middle Aged; Polyploidy; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Antigen, T-Cell; Translocation, Genetic; Trisaccharides