lewis-x-antigen and Bone-Marrow-Neoplasms

lewis-x-antigen has been researched along with Bone-Marrow-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for lewis-x-antigen and Bone-Marrow-Neoplasms

Article	Year
[Expression of Lewis blood group antigens in stomach carcinoma induces metastatic potential]. Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress, 1998, Volume: 115, Issue:Suppl I In a series of gastric cancer patients twenty-eight percent of the primary tumors expressed high levels of the Lewis carbohydrate. This correlated significantly with clinicopathological parameters of advanced disease (tumor size of > 50 mm, M1 stage, UICC stage IIIB/IV). In multivariate analysis, high Lewis expression was found to be a new independent factor of poor prognosis. In addition, Lewis was expressed on solid metastases and micrometastatic cells originating from Lewis positive primary tumors. The data suggest that Lewis positive tumor cells may have an advantage in penetrating secondary organs because, like leukocytes, they can specifically adhere to activated vascular endothelia. Topics: Animals; Bone Marrow; Bone Marrow Neoplasms; Disease Progression; Humans; Lewis X Antigen; Lymph Nodes; Lymphatic Metastasis; Mice; Neoplasm Staging; Prognosis; Stomach; Stomach Neoplasms; Survival Rate	1998
A case of composite Hodgkin's disease and chronic lymphocytic leukemia in bone marrow. Lack of Epstein-Barr virus. Archives of pathology & laboratory medicine, 1996, Volume: 120, Issue:4 We report Hodgkin's disease arising in a 68-year-old patient with a history of chronic lymphocytic leukemia for 8 years. The patient presented with a 4-month history of weakness, loss of appetite, and a 15-pound weight loss. A bone marrow biopsy showed two distinct histologic types of lymphoma: chronic lymphocytic leukemia and Hodgkin's disease. Immunohistochemical studies showed that chronic lymphocytic leukemia cells were composed of kappa-light chain-restricted monoclonal B cells. The Reed-Sternberg cells expressed CD15. Epstein-Barr virus RNA was not identified in either the Reed-Sternberg cells or cells of chronic lymphocytic leukemia by in situ hybridization. To our knowledge, this is the second reported case of composite Hodgkin's disease and chronic lymphocytic leukemia involving the bone marrow. Topics: Aged; Antigens, CD20; Biopsy; Bone Marrow Neoplasms; Female; Herpesvirus 4, Human; Hodgkin Disease; Humans; Immunoenzyme Techniques; Immunohistochemistry; In Situ Hybridization; Leukemia, Lymphocytic, Chronic, B-Cell; Lewis X Antigen; Neoplasms, Multiple Primary; Reed-Sternberg Cells; RNA, Viral	1996

Article

Year

[Expression of Lewis blood group antigens in stomach carcinoma induces metastatic potential].

Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress, 1998, Volume: 115, Issue:Suppl I

In a series of gastric cancer patients twenty-eight percent of the primary tumors expressed high levels of the Lewis carbohydrate. This correlated significantly with clinicopathological parameters of advanced disease (tumor size of > 50 mm, M1 stage, UICC stage IIIB/IV). In multivariate analysis, high Lewis expression was found to be a new independent factor of poor prognosis. In addition, Lewis was expressed on solid metastases and micrometastatic cells originating from Lewis positive primary tumors. The data suggest that Lewis positive tumor cells may have an advantage in penetrating secondary organs because, like leukocytes, they can specifically adhere to activated vascular endothelia.

Topics: Animals; Bone Marrow; Bone Marrow Neoplasms; Disease Progression; Humans; Lewis X Antigen; Lymph Nodes; Lymphatic Metastasis; Mice; Neoplasm Staging; Prognosis; Stomach; Stomach Neoplasms; Survival Rate

1998

A case of composite Hodgkin's disease and chronic lymphocytic leukemia in bone marrow. Lack of Epstein-Barr virus.

Archives of pathology & laboratory medicine, 1996, Volume: 120, Issue:4

We report Hodgkin's disease arising in a 68-year-old patient with a history of chronic lymphocytic leukemia for 8 years. The patient presented with a 4-month history of weakness, loss of appetite, and a 15-pound weight loss. A bone marrow biopsy showed two distinct histologic types of lymphoma: chronic lymphocytic leukemia and Hodgkin's disease. Immunohistochemical studies showed that chronic lymphocytic leukemia cells were composed of kappa-light chain-restricted monoclonal B cells. The Reed-Sternberg cells expressed CD15. Epstein-Barr virus RNA was not identified in either the Reed-Sternberg cells or cells of chronic lymphocytic leukemia by in situ hybridization. To our knowledge, this is the second reported case of composite Hodgkin's disease and chronic lymphocytic leukemia involving the bone marrow.

Topics: Aged; Antigens, CD20; Biopsy; Bone Marrow Neoplasms; Female; Herpesvirus 4, Human; Hodgkin Disease; Humans; Immunoenzyme Techniques; Immunohistochemistry; In Situ Hybridization; Leukemia, Lymphocytic, Chronic, B-Cell; Lewis X Antigen; Neoplasms, Multiple Primary; Reed-Sternberg Cells; RNA, Viral

1996