levorphanol and Common-Cold

In a five-day, randomized, double-blind study, the efficacy and safety of a syrup containing a combination of azatadine maleate, pseudoephedrine sulfate, and dextromethorphan hydrobromide (SCH 399 syrup) were compared with those of an expectorant containing the antihistamine diphenhydramine hydrochloride in 60 children with symptoms of the common cold and associated cough. One-half teaspoonful of assigned medication was administered three or four times daily. The severity of signs and symptoms was graded on days 0, 3, and 5. At days 3 and 5, patients treated with SCH 399 experienced a significantly greater degree of relief (P less than 0.001) than did patients treated with the expectorant product. Differences between treatment groups in overall therapeutic response, as evaluated by the physician, were statistically significant (P less than 0.001) at each visit, favoring patients treated with SCH 399. More than 75% of the patients treated with SCH 399 demonstrated an excellent therapeutic response. Tolerance to both study medications was excellent.

Topics: Antitussive Agents; Child; Child, Preschool; Clinical Trials as Topic; Common Cold; Cyproheptadine; Dextromethorphan; Diphenhydramine; Double-Blind Method; Drug Combinations; Ephedrine; Expectorants; Histamine H1 Antagonists; Humans; Levorphanol; Pseudoephedrine

A rhinomanometric technique was used to evaluate the nasal decongestant effect of a single dose of Day Nurse over a 4-hour post-dosing period in human volunteers suffering from nasal congestion due to a common cold. A significant improvement in nasal congestion was obtained at the 1 hour, 2 hour, 3 hour and 4 hour post-dosing interval, from initial values compared to a placebo group. The study therefore demonstrated by an objective technique that Day Nurse provides relief of nasal congestion and related symptoms in cold sufferers.

Topics: Acetaminophen; Adolescent; Adult; Aged; Ascorbic Acid; Codeine; Common Cold; Dextromethorphan; Double-Blind Method; Drug Combinations; Female; Humans; Levorphanol; Male; Manometry; Middle Aged; Multi-Ingredient Cold, Flu, and Allergy Medications; Nose; Phenylpropanolamine; Pressure; Pseudoephedrine; Random Allocation; Time Factors