levomecol and Peritonitis

Topics: Anti-Infective Agents, Local; Appendicitis; Chloramphenicol; Decamethonium Compounds; Drug Combinations; Duodenitis; Female; Hernia, Abdominal; Humans; Male; Middle Aged; Nitrofurazone; Peritonitis; Sodium Chloride; Tissue Adhesions; Uracil

There was given evidence, using the complex of morphological, morphometrical, biochemical and microbiological investigations in experiment, of the peritonitis treatment efficacy applying photochemically activated laevomecol ointment. The experiment was performed in 120 adult male white mongrel rats, following the recommendations of Vancouver's convention for biomedical investigations.

Topics: Animals; Anti-Infective Agents, Local; Chloramphenicol; Chlorhexidine; Disease Models, Animal; Drainage; Drug Combinations; Laparotomy; Male; Ointment Bases; Peritonitis; Photochemistry; Polyethylene Glycols; Rats; Uracil

The authors describe results of treatment of 117 patients with obstetric and gynecological peritonites. The first group consisted of 43 patients treated by conventional methods. The second group included 74 patients treated by unguent sanitation of the abdominal cavity and prolonged intraarterial catheter (PIAC) against the background of unguent sanitation. The unguent sanitation of the abdominal cavity with water-soluble antibacterial ointments has decreased the number of intra-abdominal and extra-abdominal complications. However in especially severe cases and at high virulence of the abdominal cavity microflora the application of the unguent sanitation alone was not sufficiently effective. So, in 19 patients PIAC was used by the developed scheme. The complex treatment with the unguent sanitation of the abdominal cavity and PIAC allowed to perform the adequate sanitation of the abdominal cavity with lower microbe dissemination of the abdominal cavity up to the critical level on the third day after operation and resulted in less number of intra-abdominal complications from 39.0 to 19.6%, extra-abdominal complications from 15.0 to 7.5% and lethality from 23.2 to 10.8%.

Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Catheterization; Chloramphenicol; Drug Combinations; Drug Therapy, Combination; Female; Genital Diseases, Female; Gynecologic Surgical Procedures; Humans; Infusions, Intra-Arterial; Obstetric Labor Complications; Ointments; Organic Chemicals; Peritonitis; Povidone; Pregnancy; Treatment Outcome; Uracil