levoleucovorin and Tracheal-Neoplasms

levoleucovorin has been researched along with Tracheal-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for levoleucovorin and Tracheal-Neoplasms

Article	Year
Primary chemoradiation as definitive treatment for unresectable cancer of the trachea. Canadian respiratory journal, 2003, Volume: 10, Issue:3 A 64-year-old man was diagnosed with unresectable cancer of the trachea. He was treated definitively with a novel chemoradiation regimen. Cisplatin-based chemotherapy (ChT) was given for two cycles as induction, followed by concurrent administration of this ChT with external beam radiotherapy (RT) (total dose 60 Gy). An unexpected partial tumour response was noted after the induction of ChT alone. Six weeks after finishing ChT/RT, complete response of the lesion was noted on computed tomography imaging. Two years later, the patient was free of disease. Primary chemoradiation appears to be effective in managing locally advanced tracheal cancer. Topics: Anticoagulants; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Diarrhea; Drug Administration Schedule; Epirubicin; Esophagitis; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Peripheral Nervous System Diseases; Radiography, Thoracic; Radiotherapy Dosage; Tracheal Neoplasms; Treatment Outcome; Venous Thrombosis	2003
[Effect of nedaplatin, 5-FU, and leucovorin combined with radiation therapy in unresectable esophageal carcinoma]. Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:5 A 51-year-old male was assessed as having esophageal squamous cell carcinoma with trachea invasion and cervical lymph node metastasis. After one course of chemotherapy using cisplatin (CDDP), 5-fluorouracil (5-FU) and Leucovorin (LV), the patient had progressive disease (PD) of the primary lesion and metastatic lymph nodes, and a side effect of severe nausea. One course of nedaplatin, 5-FU and LV combined with radiation was performed alternatively. The effect was evaluated as a partial response (PR) of the primary lesion and metastatic lymph nodes. There were no adverse side effects such as nausea or renal dysfunction except for pancytopenia of grade 2. Increased serum levels of vascular endothelial growth factor (s-VEGF) decreased after the chemoradiotherapy and increased again during continued radiotherapy alone. More information is needed as to whether changes in s-VEGF relate to the clinical effects of the treatment. Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Combined Modality Therapy; Drug Administration Schedule; Endothelial Growth Factors; Esophageal Neoplasms; Fluorouracil; Humans; Intercellular Signaling Peptides and Proteins; Leucovorin; Lymphatic Metastasis; Lymphokines; Male; Middle Aged; Organoplatinum Compounds; Tracheal Neoplasms; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2003

Article

Year

Primary chemoradiation as definitive treatment for unresectable cancer of the trachea.

Canadian respiratory journal, 2003, Volume: 10, Issue:3

A 64-year-old man was diagnosed with unresectable cancer of the trachea. He was treated definitively with a novel chemoradiation regimen. Cisplatin-based chemotherapy (ChT) was given for two cycles as induction, followed by concurrent administration of this ChT with external beam radiotherapy (RT) (total dose 60 Gy). An unexpected partial tumour response was noted after the induction of ChT alone. Six weeks after finishing ChT/RT, complete response of the lesion was noted on computed tomography imaging. Two years later, the patient was free of disease. Primary chemoradiation appears to be effective in managing locally advanced tracheal cancer.

Topics: Anticoagulants; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Diarrhea; Drug Administration Schedule; Epirubicin; Esophagitis; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Peripheral Nervous System Diseases; Radiography, Thoracic; Radiotherapy Dosage; Tracheal Neoplasms; Treatment Outcome; Venous Thrombosis

2003

[Effect of nedaplatin, 5-FU, and leucovorin combined with radiation therapy in unresectable esophageal carcinoma].

Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:5

A 51-year-old male was assessed as having esophageal squamous cell carcinoma with trachea invasion and cervical lymph node metastasis. After one course of chemotherapy using cisplatin (CDDP), 5-fluorouracil (5-FU) and Leucovorin (LV), the patient had progressive disease (PD) of the primary lesion and metastatic lymph nodes, and a side effect of severe nausea. One course of nedaplatin, 5-FU and LV combined with radiation was performed alternatively. The effect was evaluated as a partial response (PR) of the primary lesion and metastatic lymph nodes. There were no adverse side effects such as nausea or renal dysfunction except for pancytopenia of grade 2. Increased serum levels of vascular endothelial growth factor (s-VEGF) decreased after the chemoradiotherapy and increased again during continued radiotherapy alone. More information is needed as to whether changes in s-VEGF relate to the clinical effects of the treatment.

Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Combined Modality Therapy; Drug Administration Schedule; Endothelial Growth Factors; Esophageal Neoplasms; Fluorouracil; Humans; Intercellular Signaling Peptides and Proteins; Leucovorin; Lymphatic Metastasis; Lymphokines; Male; Middle Aged; Organoplatinum Compounds; Tracheal Neoplasms; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2003