levoleucovorin and Retinitis

Acquired multifocal white retinal lesions in an immunosuppressed patient are diagnostically challenging.. Case report of a 34-year-old woman who underwent bone marrow transplantation for chronic myelogenous leukemia. Four months after the transplant, while on relatively high doses of immunosuppressive drugs, she developed bilateral multifocal retinitis versus leukemic retinal infiltration. Fine-needle aspiration biopsy was performed on one eye in an attempt to establish a cytological diagnosis.. The aspirate was found to contain individual crescent-shaped intraretinal organisms and cysts, consistent with the diagnosis of toxoplasmic retinitis. The patient was started immediately on an anti-toxoplasmosis regimen consisting of sulfadiazine, pyrimethamine, and folinic acid. Follow-up examinations revealed complete inactivation of the retinitis and no delayed complications of the biopsy.. Fine-needle aspiration biopsy can be a useful diagnostic tool in selected patients with acquired retinal infiltrates.

Topics: Adult; Antiprotozoal Agents; Biopsy, Fine-Needle; Bone Marrow Transplantation; Drug Therapy, Combination; Female; Humans; Immunocompromised Host; Immunosuppressive Agents; Leucovorin; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Pyrimethamine; Retinitis; Sulfadiazine; Toxoplasmosis, Ocular; Vitreous Body

Topics: Animals; Antibodies, Protozoan; Antiprotozoal Agents; Child; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Glucocorticoids; Humans; Immunocompetence; Immunoglobulin G; Leucovorin; Magnetic Resonance Imaging; Male; Optic Atrophy; Prednisone; Pyrimethamine; Retinitis; Sulfadiazine; Toxoplasma; Toxoplasmosis, Ocular