levoleucovorin and Phagocyte-Bactericidal-Dysfunction

levoleucovorin has been researched along with Phagocyte-Bactericidal-Dysfunction* in 1 studies

Other Studies

1 other study(ies) available for levoleucovorin and Phagocyte-Bactericidal-Dysfunction

Article	Year
Granulocyte dysfunction in transcobalamin II deficiency responding to leucovorin or hydroxocobalamin-plasma transfusion. Journal of inherited metabolic disease, 1980, Volume: 3, Issue:1 Granulocytes from a 6-year-old boy with congenital transcobalamin II (TC II) deficiency were found to have abnormally low antibacterial activity against Staphylococcus aureus and very low intracellular levels of the cobalamin coenzymes. Transfusion of hydroxocobalamin (OH-Cbl) bound to normal plasma temporarily restored granulocyte bactericidal activity and increased cellular levels of the cobalamin coenzymes. Granulocyte function was also temporarily restored by oral Leucovorin. The defect appeared to be causally related to the patient's TC II deficiency and indirectly to a deficiency of cobalamin and folate coenzymes. Topics: Blood Proteins; Blood Transfusion; Child; Granulocytes; Humans; Hydroxocobalamin; Leucovorin; Male; Metabolism, Inborn Errors; Phagocyte Bactericidal Dysfunction; Transcobalamins	1980

Article

Year

Granulocyte dysfunction in transcobalamin II deficiency responding to leucovorin or hydroxocobalamin-plasma transfusion.

Journal of inherited metabolic disease, 1980, Volume: 3, Issue:1

Granulocytes from a 6-year-old boy with congenital transcobalamin II (TC II) deficiency were found to have abnormally low antibacterial activity against Staphylococcus aureus and very low intracellular levels of the cobalamin coenzymes. Transfusion of hydroxocobalamin (OH-Cbl) bound to normal plasma temporarily restored granulocyte bactericidal activity and increased cellular levels of the cobalamin coenzymes. Granulocyte function was also temporarily restored by oral Leucovorin. The defect appeared to be causally related to the patient's TC II deficiency and indirectly to a deficiency of cobalamin and folate coenzymes.

Topics: Blood Proteins; Blood Transfusion; Child; Granulocytes; Humans; Hydroxocobalamin; Leucovorin; Male; Metabolism, Inborn Errors; Phagocyte Bactericidal Dysfunction; Transcobalamins

1980